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["This work is licensed under a Creative Commons Attribution 4.0 International License."]
[]
["To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA."]

{"sheet":"User Guide","index":1,"n_rows":30,"n_cols":2,"rows_kept":30,"cut":false,"hidden":false,"merged":[[38,0,38,3],[28,0,28,3],[32,0,32,3],[33,0,33,3],[34,0,34,3],[35,0,35,3],[36,0,36,3],[37,0,37,3],[24,1,24,3],[25,1,25,3],[29,0,29,3],[30,0,30,3],[31,0,31,3],[26,0,26,3],[27,0,27,3],[19,1,19,3],[20,1,20,3],[21,1,21,3],[22,1,22,3],[23,1,23,3],[18,0,18,3],[12,0,12,3],[13,0,13,3],[14,0,14,3],[15,0,15,3],[16,0,16,3],[17,0,17,3],[6,0,6,3],[7,0,7,3],[8,0,8,3],[9,0,9,3],[10,0,10,3],[11,0,11,3],[0,0,0,3],[1,0,1,3],[2,0,2,3],[3,0,3,3],[4,0,4,3],[5,0,5,3]]}
["Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting"]
["Economic Model"]
[]
["User Guide"]
[]
["Introduction"]
["This Excel workbook contains an economic model used for conducting an economic evaluation (cost-effectiveness analysis) of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting. It accompanies an article published in PLOS ONE by Snowsill et al.:"]
["Snowsill TM, Ryan NAJ, Crosbie EJ, Frayling IM, Evans DG, Hyde CJ. Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting. PLOS ONE (accepted)."]
["This workbook has been made open access (see License) for a number of reasons:"]
["1) To aid users in understanding the analysis (transparency and reproducibility)"]
["Journal publications typically cannot contain sufficient detail to allow other researchers to exactly reproduce the results. By making the code and simulation data freely available it can be explored and interrogated."]
["2) To improve the likely validity of the work"]
["While making data open is not sufficient to make work more valid, researchers are likely to take more care over their work if it is to be made fully open, and it is possible for errors to be identified later and corrections issued if necessary."]
["3) To make it easier for others to extend the work"]
[" This economic evaluation can be extended, or applied in alternative settings by researchers, provided suitable attribution is given in accordance with the License. This substantially lowers the barrier for entry for researchers or decision makers attempting to evaluate the cost-effectiveness of reflex testing for Lynch syndrome in their setting."]
["If you have difficulties using this workbook, or believe there is an error, please contact Tristan Snowsill by email <t.m.snowsill@exeter.ac.uk> or on Twitter (https://www.twitter.com/TMSnowsill)"]
[]
["Navigating the workbook"]
["For the base case (deterministic) analysis, there are several key worksheets to be aware of:"]
["Results","Brings together the results for the different diagnostic strategies and calculates ICERs."]
["Parameters","Contains all of the inputs for the model, including parameters for natural history, test accuracy, surveillance effectiveness, costs and utility values."]
["Decision tree - Probands","Simulates reflex testing strategies, how patients are categorised by different tests and what effect that has on costs and utilities."]
["Decision tree - Relatives","Simulates testing of relatives after a proband or index patient has received testing."]
["MM-Summary","Brings together long-term cost and QALY estimates from the Markov model worksheets."]
["MM-Pro-F-MLH1-TP to MM-Rel-M-Sporadic-TN","Markov models for different sets of patients. The worksheet name is MM-{Type}-{Sex}-{Genotype}-{Diagnosis}, where Type is Pro/Rel for proband/relative, Sex is F/M for female/male, Genotype is MLH1/MSH2/MSH6/PMS2/Sporadic and Diagnosis is TP/LL/FN/FP/TN for true positive, putative Lynch syndrome, false negative, false positive and true negative."]
["Relative age DT","The base case analysis incorporates heterogeneity in the ages of relatives and this is implemented through the use of an Excel data table. This is a macro-free way of calculating results based on multiple different input values."]
["For the probabilistic sensitivity analysis, the sheet PSA is used to track the parameter values and outputs of each PSA iteration and contains the PSA iterations used in the article. The sheet PSA Results mirrors the sheet Results but takes outputs from the PSA instead of the live model."]
["The one-way sensitivity analysis is conducted in the OWSA sheet and the Scenario analyses are conducted in the Scenarios sheet."]
["To conduct new sensitivity analyses use the buttons on the Control sheet. The base case (deterministic) analysis does not require the use of any macros."]
["Other worksheets are hopefully self-explanatory."]

{"sheet":"Control","index":2,"n_rows":6,"n_cols":3,"rows_kept":6,"cut":false,"hidden":false,"merged":[]}
[]
[]
[]
["Analysis","Deterministic",{"$f":"VLOOKUP($B$4,tbl_analysis,2,FALSE)","v":1}]
[]
["PSA iterations",1000]

{"sheet":"Results","index":3,"n_rows":60,"n_cols":32,"rows_kept":60,"cut":false,"hidden":false,"merged":[]}
["Strategy",1,2,3,4,5,6,null,null,null,null,null,null,null,null,null,"S1","S2","S3","S4"]
["Description","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening",null,null,null,null,null,null,null,null,null,"PREMM","MMRpredict","MMRpro","MMRpro + IHC",null,null,"PROBANDS",null,null,null,null,null,"RELATIVES"]
["Diagnostic Outcomes (Probands)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Diagnostic Outcomes (Probands)",null,null,null,null,2,null,"LS status",null,null,null,2,null,"LS status"]
["True Positives",{"$f":"'Decision tree - Probands'!BB355","v":1.8019932738440214E-2},{"$f":"'Decision tree - Probands'!BC355","v":1.783768391925775E-2},{"$f":"'Decision tree - Probands'!BD355","v":1.723388361294971E-2},{"$f":"'Decision tree - Probands'!BE355","v":1.6043703107700237E-2},{"$f":"'Decision tree - Probands'!BF355","v":1.6114690950341164E-2},{"$f":"'Decision tree - Probands'!BG355","v":0},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!AL$45","v":1.2268861851910656E-2},{"$f":"'Supplementary decision trees'!AM$45","v":1.3632068724345173E-2},{"$f":"'Supplementary decision trees'!AN$45","v":1.0905654979476136E-2},{"$f":"'Supplementary decision trees'!AO$45","v":1.2899335795241581E-2},null,"IHC with methylation",null,"Has LS","Sporadic","Total",null,"IHC with methylation",null,"Has LS","Sporadic","Total"]
["False Positives",{"$f":"'Decision tree - Probands'!BH355","v":3.3233784945270739E-2},{"$f":"'Decision tree - Probands'!BI355","v":7.4801269946237169E-3},{"$f":"'Decision tree - Probands'!BJ355","v":3.0130818577484127E-2},{"$f":"'Decision tree - Probands'!BK355","v":9.9359903896965134E-3},{"$f":"'Decision tree - Probands'!BL355","v":0},{"$f":"'Decision tree - Probands'!BM355","v":0},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!AP$45","v":7.4672491268610751E-3},{"$f":"'Supplementary decision trees'!AQ$45","v":1.8342370338464115E-2},{"$f":"'Supplementary decision trees'!AR$45","v":7.661351932910977E-3},{"$f":"'Supplementary decision trees'!AS$45","v":5.8582214757687675E-3},null,"Result","Pathogenic variant found",{"$f":"'Decision tree - Probands'!$CA$355","v":1.6696310662076202E-2},0,{"$f":"SUM(X5:Y5)","v":1.6696310662076202E-2},null,"Result","Pathogenic variant found",{"$f":"'Decision tree - Relatives'!$AK$134","v":2.4537643974031992E-2},0,{"$f":"SUM(AD5:AE5)","v":2.4537643974031992E-2}]
["False Negatives",{"$f":"'Decision tree - Probands'!BN355","v":2.1769427632772533E-2},{"$f":"'Decision tree - Probands'!BO355","v":2.1951676451954998E-2},{"$f":"'Decision tree - Probands'!BP355","v":2.2555476758263041E-2},{"$f":"'Decision tree - Probands'!BQ355","v":2.374565726351251E-2},{"$f":"'Decision tree - Probands'!BR355","v":2.3674669420871583E-2},{"$f":"'Decision tree - Probands'!BS355","v":3.9789360371212744E-2},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!AT$45","v":2.7520498519302099E-2},{"$f":"'Supplementary decision trees'!AU$45","v":2.615729164686758E-2},{"$f":"'Supplementary decision trees'!AV$45","v":2.8883705391736614E-2},{"$f":"'Supplementary decision trees'!AW$45","v":2.6890024575971172E-2},null,null,"Diagnosed LL",{"$f":"'Decision tree - Probands'!$CG$355","v":1.1413732571815514E-3},{"$f":"'Decision tree - Probands'!$BI$355","v":7.4801269946237169E-3},{"$f":"SUM(X6:Y6)","v":8.6215002518052683E-3},null,null,"Diagnosed LL",{"$f":"'Decision tree - Relatives'!$AQ$134","v":1.0712452236925053E-2},{"$f":"'Decision tree - Relatives'!$BC$134","v":2.8413163308002587E-2},{"$f":"SUM(AD6:AE6)","v":3.912561554492764E-2}]
["True Negatives",{"$f":"'Decision tree - Probands'!BT355","v":0.92697685468351643},{"$f":"'Decision tree - Probands'!BU355","v":0.95273051263416353},{"$f":"'Decision tree - Probands'!BV355","v":0.93007982105130316},{"$f":"'Decision tree - Probands'!BW355","v":0.95027464923909077},{"$f":"'Decision tree - Probands'!BX355","v":0.96021063962878728},{"$f":"'Decision tree - Probands'!BY355","v":0.96021063962878728},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!AX$45","v":0.95274339050192625},{"$f":"'Supplementary decision trees'!AY$45","v":0.94186826929032319},{"$f":"'Supplementary decision trees'!AZ$45","v":0.95254928769587632},{"$f":"'Supplementary decision trees'!BA$45","v":0.95435241815301852},null,null,"Diagnosed sporadic",{"$f":"'Decision tree - Probands'!$BO$355","v":2.1951676451954998E-2},{"$f":"'Decision tree - Probands'!$BU$355","v":0.95273051263416353},{"$f":"SUM(X7:Y7)","v":0.97468218908611848},null,null,"Diagnosed sporadic",{"$f":"'Decision tree - Relatives'!$AW$134","v":6.9793815169044607E-2},{"$f":"'Decision tree - Relatives'!$BI$134","v":5.8665429253119958},{"$f":"SUM(AD7:AE7)","v":5.9363367404810408}]
["Sensitivity",{"$f":"B4/(B4+B6)","v":0.45288319717442543},0.44830285666424424,0.43312793802582139,0.40321590892694303,0.40500000000000003,0,null,null,null,null,null,null,null,null,null,{"$f":"Q4/(Q4+Q6)","v":0.30834528973195224},0.34260587747994697,0.27408470198395751,0.3241905794639045,null,null,"Total",{"$f":"SUM(X5:X7)","v":3.9789360371212751E-2},{"$f":"SUM(Y5:Y7)","v":0.96021063962878728},{"$f":"SUM(X8:Y8)","v":1},null,null,"Total",{"$f":"SUM(AD5:AD7)","v":0.10504391138000166},{"$f":"SUM(AE5:AE7)","v":5.8949560886199981},{"$f":"SUM(AD8:AE8)","v":6}]
["Specificity",{"$f":"B7/(B5+B7)","v":0.96538906821724157},0.99220991031976535,0.96862061579620429,0.98965228046885867,1,1,null,null,null,null,null,null,null,null,null,{"$f":"Q7/(Q5+Q7)","v":0.99222332182264938},0.98089755561805148,0.99202117575381921,0.99389902461606394]
["PPV",{"$f":"B4/(B4+B5)","v":0.35158293979067134},0.70455079943256671,0.36385499783487302,0.61754782092821336,1,{"$error":"#DIV/0!"},null,null,null,null,null,null,null,null,null,{"$f":"Q4/(Q4+Q5)","v":0.62164536190068598},0.426342701354882,0.58736742173561363,0.68768740027665543,null,"S4",null,"LS status",null,null,null,"S4",null,"LS status"]
["NPV",{"$f":"B7/(B7+B6)","v":0.97705453181895563},0.97747811881887647,0.97632307262797646,0.97562098335631664,0.97593757198820352,0.96021063962878728,null,null,null,null,null,null,null,null,null,{"$f":"Q7/(Q7+Q6)","v":0.97192541842301194},0.97297871801903302,0.97056986508995613,0.97259594224115931,null,"MMRpro + IHC",null,"Has LS","Sporadic","Total",null,"MMRpro + IHC",null,"Has LS","Sporadic","Total"]
["Diagnostic Costs (Probands)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Diagnostic Costs (Probands)",null,null,null,null,"Result","Pathogenic variant found",{"$f":"'Supplementary decision trees'!$BE$45","v":1.1481826367193056E-2},0,{"$f":"SUM(X12:Y12)","v":1.1481826367193056E-2},null,"Result","Pathogenic variant found",{"$f":"'Supplementary decision trees'!$BB$122","v":1.6874204922993574E-2},0,{"$f":"SUM(AD12:AE12)","v":1.6874204922993574E-2}]
["IHC",{"$f":"'Decision tree - Probands'!O359","v":211.97132895501142},{"$f":"'Decision tree - Probands'!P359","v":211.97132895501142},{"$f":"'Decision tree - Probands'!Q359","v":0},{"$f":"'Decision tree - Probands'!R359","v":0},{"$f":"'Decision tree - Probands'!S359","v":0},{"$f":"'Decision tree - Probands'!T359","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Diagnosed LL",{"$f":"'Supplementary decision trees'!$BI$45","v":1.4175094280485252E-3},{"$f":"'Supplementary decision trees'!$AS$45","v":5.8582214757687675E-3},{"$f":"SUM(X13:Y13)","v":7.2757309038172929E-3},null,null,"Diagnosed LL",{"$f":"'Supplementary decision trees'!$BF$122","v":7.9167585770621562E-3},{"$f":"'Supplementary decision trees'!$AP$122","v":2.1650468874225774E-2},{"$f":"SUM(AD13:AE13)","v":2.9567227451287932E-2}]
["MSI",{"$f":"'Decision tree - Probands'!O360","v":0},{"$f":"'Decision tree - Probands'!P360","v":0},{"$f":"'Decision tree - Probands'!Q360","v":203.77122708967119},{"$f":"'Decision tree - Probands'!R360","v":203.77122708967119},{"$f":"'Decision tree - Probands'!S360","v":0},{"$f":"'Decision tree - Probands'!T360","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Diagnosed sporadic",{"$f":"'Supplementary decision trees'!$AW$45","v":2.6890024575971172E-2},{"$f":"'Supplementary decision trees'!$BA$45","v":0.95435241815301852},{"$f":"SUM(X14:Y14)","v":0.98124244272898964},null,null,"Diagnosed sporadic",{"$f":"'Supplementary decision trees'!$AT$122","v":8.0252947879945941E-2},{"$f":"'Supplementary decision trees'!$AX$122","v":5.8733056197457731},{"$f":"SUM(AD14:AE14)","v":5.953558567625719}]
["Methylation",{"$f":"'Decision tree - Probands'!O361","v":0},{"$f":"'Decision tree - Probands'!P361","v":27.811123047161153},{"$f":"'Decision tree - Probands'!Q361","v":0},{"$f":"'Decision tree - Probands'!R361","v":34.754329331270867},{"$f":"'Decision tree - Probands'!S361","v":0},{"$f":"'Decision tree - Probands'!T361","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Total",{"$f":"SUM(X12:X14)","v":3.9789360371212751E-2},{"$f":"SUM(Y12:Y14)","v":0.96021063962878728},{"$f":"SUM(X15:Y15)","v":1},null,null,"Total",{"$f":"SUM(AD12:AD14)","v":0.10504391138000167},{"$f":"SUM(AE12:AE14)","v":5.894956088619999},{"$f":"SUM(AD15:AE15)","v":6.0000000000000009}]
["Pre-test counselling",{"$f":"'Decision tree - Probands'!O362","v":61.495462419865547},{"$f":"'Decision tree - Probands'!P362","v":20.157295945044119},{"$f":"'Decision tree - Probands'!Q362","v":56.164595294283913},{"$f":"'Decision tree - Probands'!R362","v":23.269157509437242},{"$f":"'Decision tree - Probands'!S362","v":200.96660215415051},{"$f":"'Decision tree - Probands'!T362","v":0}]
["Genetic testing and post-test counselling",{"$f":"'Decision tree - Probands'!O363","v":123.94299102903349},{"$f":"'Decision tree - Probands'!P363","v":40.626664995677878},{"$f":"'Decision tree - Probands'!Q363","v":113.19872486168951},{"$f":"'Decision tree - Probands'!R363","v":46.898565633253646},{"$f":"'Decision tree - Probands'!S363","v":399.66582212018034},{"$f":"'Decision tree - Probands'!T363","v":0}]
["Total diagnostic costs",{"$f":"SUM(B13:B17)","v":397.40978240391041},300.56641294289454,373.13454724564463,308.69327956363298,600.63242427433079,0,null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!K$45","v":221.64986234227547},{"$f":"'Supplementary decision trees'!L$45","v":353.77905870523068},{"$f":"'Supplementary decision trees'!M$45","v":222.18077791984581},{"$f":"'Supplementary decision trees'!N$45","v":413.01246230021712}]
["Long-term Costs (Probands)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Long-term Costs (Probands)"]
["Total long-term costs",{"$f":"'Decision tree - Probands'!V$355","v":231.85732830957949},{"$f":"'Decision tree - Probands'!W$355","v":186.85108878745319},{"$f":"'Decision tree - Probands'!X$355","v":225.092836290722},{"$f":"'Decision tree - Probands'!Y$355","v":187.91644161814909},{"$f":"'Decision tree - Probands'!Z$355","v":171.31809216666238},{"$f":"'Decision tree - Probands'!AA$355","v":142.60634693736495},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!P$45","v":176.76437620326871},{"$f":"'Supplementary decision trees'!Q$45","v":198.00577966651556},{"$f":"'Supplementary decision trees'!R$45","v":174.74708587252402},{"$f":"'Supplementary decision trees'!S$45","v":175.05884037128271}]
["TOTAL COSTS (Probands)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"TOTAL COSTS (Probands)"]
["Total costs",{"$f":"'Decision tree - Probands'!AB$355","v":629.26711071349018},{"$f":"'Decision tree - Probands'!AC$355","v":487.41750173034779},{"$f":"'Decision tree - Probands'!AD$355","v":598.22738353636669},{"$f":"'Decision tree - Probands'!AE$355","v":496.60972118178211},{"$f":"'Decision tree - Probands'!AF$355","v":771.95051644099317},{"$f":"'Decision tree - Probands'!AG$355","v":142.60634693736495},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!T$45","v":398.41423854554421},{"$f":"'Supplementary decision trees'!U$45","v":551.78483837174622},{"$f":"'Supplementary decision trees'!V$45","v":396.92786379236986},{"$f":"'Supplementary decision trees'!W$45","v":588.07130267149989}]
["QALYs (Probands)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"QALYs (Probands)"]
["Short term",{"$f":"'Decision tree - Probands'!AI355","v":0},{"$f":"'Decision tree - Probands'!AJ355","v":0},{"$f":"'Decision tree - Probands'!AK355","v":0},{"$f":"'Decision tree - Probands'!AL355","v":0},{"$f":"'Decision tree - Probands'!AM355","v":0},{"$f":"'Decision tree - Probands'!AN355","v":0},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!Y$45","v":0},{"$f":"'Supplementary decision trees'!Z$45","v":0},{"$f":"'Supplementary decision trees'!AA$45","v":0},{"$f":"'Supplementary decision trees'!AB$45","v":0}]
["Long term",{"$f":"'Decision tree - Probands'!AP355","v":9.0193703192010624},{"$f":"'Decision tree - Probands'!AQ355","v":9.0188098938634766},{"$f":"'Decision tree - Probands'!AR355","v":9.0187812151177553},{"$f":"'Decision tree - Probands'!AS355","v":9.0176555405373335},{"$f":"'Decision tree - Probands'!AT355","v":9.0177337683938816},{"$f":"'Decision tree - Probands'!AU355","v":9.0064692241702051},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!AD$45","v":9.0149015476192389},{"$f":"'Supplementary decision trees'!AE$45","v":9.0159985423582434},{"$f":"'Supplementary decision trees'!AF$45","v":9.0139809365950327},{"$f":"'Supplementary decision trees'!AG$45","v":9.0153031152299175}]
["Total QALYs",{"$f":"'Decision tree - Probands'!AV355","v":9.0193703192010624},{"$f":"'Decision tree - Probands'!AW355","v":9.0188098938634766},{"$f":"'Decision tree - Probands'!AX355","v":9.0187812151177553},{"$f":"'Decision tree - Probands'!AY355","v":9.0176555405373335},{"$f":"'Decision tree - Probands'!AZ355","v":9.0177337683938816},{"$f":"'Decision tree - Probands'!BA355","v":9.0064692241702051},null,null,null,null,null,null,null,null,null,{"$f":"Q24+Q25","v":9.0149015476192389},{"$f":"R24+R25","v":9.0159985423582434},9.0139809365950327,9.0153031152299175]
["TOTAL COSTS (Relatives)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"TOTAL COSTS (Relatives)"]
["Total costs",{"$f":"'Decision tree - Relatives'!J134","v":4889.9947588963778},{"$f":"'Decision tree - Relatives'!K134","v":4743.1611702651098},{"$f":"'Decision tree - Relatives'!L134","v":4865.8459138947683},{"$f":"'Decision tree - Relatives'!M134","v":4741.7197399376892},{"$f":"'Decision tree - Relatives'!N134","v":4690.1583230254646},{"$f":"'Decision tree - Relatives'!O134","v":4550.3915585108889},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!Q$122","v":4695.0021178282877},{"$f":"'Supplementary decision trees'!R$122","v":4769.0545169319203},{"$f":"'Supplementary decision trees'!S$122","v":4684.8438751204922},{"$f":"'Supplementary decision trees'!T$122","v":4690.9307320012431}]
["QALYs (Relatives)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"QALYs (Relatives)"]
["Total QALYs",{"$f":"'Decision tree - Relatives'!AD134","v":96.281677747203631},{"$f":"'Decision tree - Relatives'!AE134","v":96.280006840705568},{"$f":"'Decision tree - Relatives'!AF134","v":96.280402471005573},{"$f":"'Decision tree - Relatives'!AG134","v":96.277706904179112},{"$f":"'Decision tree - Relatives'!AH134","v":96.278247501544328},{"$f":"'Decision tree - Relatives'!AI134","v":96.254410396023459},null,null,null,null,null,null,null,null,null,{"$f":"'Supplementary decision trees'!AE$122","v":96.271644244806438},{"$f":"'Supplementary decision trees'!AF$122","v":96.274080716091959},{"$f":"'Supplementary decision trees'!AG$122","v":96.26978253240911},{"$f":"'Supplementary decision trees'!AH$122","v":96.272426388238941}]
["TOTAL COSTS",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"TOTAL COSTS"]
["Total costs",{"$f":"B22+B28","v":5519.261869609868},{"$f":"C22+C28","v":5230.5786719954576},5464.073297431135,5238.3294611194715,5462.1088394664575,4692.9979054482537,null,null,null,null,null,null,null,null,null,{"$f":"Q22+Q28","v":5093.4163563738321},{"$f":"R22+R28","v":5320.8393553036667},5081.771738912862,5279.0020346727433]
["QALYs",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"QALYs"]
["Total QALYs",{"$f":"B26+B30","v":105.30104806640469},{"$f":"C26+C30","v":105.29881673456904},105.29918368612333,105.29536244471645,105.29598126993821,105.26087962019366,null,null,null,null,null,null,null,null,null,{"$f":"Q26+Q30","v":105.28654579242567},{"$f":"R26+R30","v":105.29007925845021},105.28376346900414,105.28772950346885]
["NMB",{"$f":"B34*threshold-B32","v":2100501.6994584841},2100745.7560193855,2100519.6004250352,2100668.9194332091,2100457.5165592982,2100524.5944984253,null,null,null,null,null,null,null,null,null,{"$f":"Q34*threshold-Q32","v":2100637.4994921396},2100480.7458137008,2100593.4976411699,2100475.5880347043]
[]
["QALY rank",{"$f":"_xlfn.RANK.AVG(B34,$B$34:$G$34,1)","v":6},{"$f":"_xlfn.RANK.AVG(C34,$B$34:$G$34,1)","v":4},5,2,3,1]
["Cost rank",{"$f":"_xlfn.RANK.AVG(B32,$B$32:$G$32,1)","v":6},{"$f":"_xlfn.RANK.AVG(C32,$B$32:$G$32,1)","v":2},5,3,4,1]
["ICER points",{"$f":"B37*COUNT($B$37:$G$37)+B38","v":42},{"$f":"C37*COUNT($B$37:$G$37)+C38","v":26},35,15,22,7]
["ICER rank",{"$f":"_xlfn.RANK.AVG(B39,$B$39:$G$39,1)","v":6},{"$f":"_xlfn.RANK.AVG(C39,$B$39:$G$39,1)","v":4},5,2,3,1]
[]
[]
[null,"QALYs",null,"Costs",null,"ICER","INHB @ £20k/QALY"]
[null,"Absolute","vs. No screening","Absolute","vs. No screening","vs. No screening","vs. No screening"]
[{"$f":"INDEX($B$2:$G$2,I45)","v":"No screening"},{"$f":"INDEX($B$34:$G$34,1,I45)","v":105.26087962019366},{"$f":"B45-$G$34","v":0},{"$f":"INDEX($B$32:$G$32,I45)","v":4692.9979054482537},{"$f":"D45-$G$32","v":0},{"$f":"E45/C45","v":{"$error":"#DIV/0!"}},{"$f":"C45-E45/20000","v":0},1,{"$f":"MATCH(H45,$B$40:$G$40,0)","v":6}]
[{"$f":"INDEX($B$2:$G$2,I46)","v":"MSI with methylation"},{"$f":"INDEX($B$34:$G$34,1,I46)","v":105.29536244471645},{"$f":"B46-$G$34","v":3.4482824522783062E-2},{"$f":"INDEX($B$32:$G$32,I46)","v":5238.3294611194715},{"$f":"D46-$G$32","v":545.33155567121776},{"$f":"E46/C46","v":15814.584890252047},{"$f":"C46-E46/20000","v":7.2162467392221756E-3},2,{"$f":"MATCH(H46,$B$40:$G$40,0)","v":4}]
["Direct mutation testing",105.29598126993821,3.5101649744547103E-2,5462.1088394664575,769.11093401820381,21910.962579121569,-3.353896956363088E-3,3,5]
["IHC with methylation",105.29881673456904,3.7937114375381498E-2,5230.5786719954576,537.58076654720389,14170.312513174586,1.1058076048021302E-2,4,2]
["MSI",105.29918368612333,3.8304065929665398E-2,5464.073297431135,771.07539198288123,20130.379719968721,-2.497036694786639E-4,5,3]
["IHC",105.30104806640469,4.0168446211026776E-2,5519.261869609868,826.26396416161424,20569.975742173312,-1.1447519970539388E-3,6,1]
[]
[]
[]
[]
[null,"IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening"]
["IHC",null,{"$f":"(HLOOKUP(C$55,$B$2:$G$34,31,FALSE)-HLOOKUP($A56,$B$2:$G$34,31,FALSE))/(HLOOKUP(C$55,$B$2:$G$34,33,FALSE)-HLOOKUP($A56,$B$2:$G$34,33,FALSE))","v":129377.08009303157},29601.563978371469,49411.027306175973,11279.914344599561,20569.975742173312]
["IHC with methylation",null,null,636309.13320789114,-2243.8155032599402,-81655.106874977078,14170.312513174586]
["MSI",null,null,null,59076.046832603206,613.42993887125135,20130.379719968721]
["MSI with methylation",null,null,null,null,361619.67947763036,15814.584890252047]
["Direct mutation testing",null,null,null,null,null,21910.962579121569]

{"sheet":"ImpactOfAge","index":4,"n_rows":45,"n_cols":21,"rows_kept":45,"cut":false,"hidden":true,"merged":[]}
[null,"Net monetary benefit at £20,000 per QALY"]
[null,"IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening"]
[null,{"$f":"Results!B$35","v":2100501.6994584841},{"$f":"Results!C$35","v":2100745.7560193855},{"$f":"Results!D$35","v":2100519.6004250352},{"$f":"Results!E$35","v":2100668.9194332091},{"$f":"Results!F$35","v":2100457.5165592982},{"$f":"Results!G$35","v":2100524.5944984253}]
["Live",{"$f":"B3-$G$3","v":-22.895039941184223},{"$f":"C3-$G$3","v":221.16152096027508},-4.9940733900293708,144.32493478385732,-67.07793912710622]
["Proband age",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Age group","2017 cancer registrations","Weighted INMB (assuming proband age at top of age group)","Cumulative"]
[40,3248.7402411433868,3407.123475314118,3123.1913854666054,3058.7857418381609,3006.5608141417615,null,null,null,null,null,null,null,null,null,null,null,"35-39 ",75,{"$f":"C6*S6","v":255534.26064855885},{"$f":"T6","v":255534.26064855885}]
[45,2286.011397942435,2474.7315411330201,2202.6534203407355,2197.4619608768262,2107.8926226412877,null,null,null,null,null,null,null,null,null,null,null,"40-44 ",106,{"$f":"C7*S7","v":262321.54336010013},{"$f":"U6+T7","v":517855.80400865898}]
[50,1305.2983547113836,1521.6432385230437,1265.0315704485402,1324.3961936533451,1190.2148802448064,null,null,null,null,null,null,null,null,null,null,null,"45-49 ",278,423016.82030940615,{"$f":"U7+T8","v":940872.62431806512}]
[55,514.35529049485922,748.80866947304457,508.77044940041378,621.47088256571442,444.33885459136218,null,null,null,null,null,null,null,null,null,null,null,"50-54 ",640,479237.54846274853,1420110.1727808136]
[60,-22.895039941184223,221.16152096027508,-4.9940733900293708,144.32493478385732,-67.07793912710622,null,null,null,null,null,null,null,null,null,null,null,"55-59 ",966,213642.02924762573,1633752.2020284394]
[65,-323.0667599469889,-79.18849093420431,-292.36397089180537,-125.46547562582418,-361.48209118284285,null,null,null,null,null,null,null,null,null,null,null,"60-64 ",1092,-86473.832100151107,1547278.3699282883]
[70,-462.53687266050838,-224.81738442345522,-426.26475680922158,-255.00512785185128,-507.08949911314994,null,null,null,null,null,null,null,null,null,null,null,"65-69 ",1223,-274951.66114988574,1272326.7087784025]
[75,-505.51661900989711,-282.04463338130154,-468.32616271870211,-304.18631902849302,-568.39255856187083,null,null,null,null,null,null,null,null,null,null,null,"70-74 ",1209,-340991.96175799356,931334.74702040898]
[80,-526.44189254171215,-302.15610554907471,-488.29741970333271,-322.10492632980458,-588.7590946527198,null,null,null,null,null,null,null,null,null,null,null,"75-79 ",921,-278285.77321069781,653048.97380971117]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["Proband age holding prevalence and gene distribution fixed"]
[40,176.31748066935688,441.04654732253402,187.26904040575027,344.46361596370116,145.8202969962731]
[45,144.01233576564118,403.4951455257833,155.98862422537059,310.95185430254787,109.3689918727614]
[50,96.018781576305628,350.49681397760287,109.70619532791898,263.46937044290826,58.670590464491397]
[55,42.369772801641375,290.30233688652515,57.91060805413872,209.70679583027959,0.9119106587022543]
[60,-19.56880824174732,222.13717402983457,-1.799381943885237,148.71102814562619,-64.146242490503937]
[65,-79.117317611351609,153.87179027730599,-59.383625220274553,87.943210635334253,-129.95792043791153]
[70,-138.69236505869776,84.649874476250261,-117.05473580444232,26.412861279211938,-196.91916449717246]
[75,-187.25982866692357,21.349237209418789,-164.52168941148557,-29.157155107473955,-259.77451296639629]
[]
["Prevalence holding age and gene distribution fixed"]
[1.4999999999999999E-2,-369.56062691379339,-114.88101420877501,-336.07435823092237,-156.78789280820638,-394.63107314845547]
[0.02,-296.84040817152709,-44.856416313908994,-266.61973644047976,-93.312270887661725,-325.96395610645413]
[2.5000000000000001E-2,-224.12018942832947,25.168181580491364,-197.16511464957148,-29.83664896665141,-257.29683906398714]
[0.03,-151.39997068699449,95.192779474891722,-127.71049285912886,33.638972953427583,-188.62972202245146]
[3.5000000000000003E-2,-78.679751944262534,165.21737736882642,-58.255871068686247,97.114594873506576,-119.96260498045012]
[0.04,-5.9595332015305758,235.24197526322678,11.19875072222203,160.59021679544821,-51.295487938448787]
[4.4999999999999998E-2,66.760685541201383,305.26657315855846,80.653372513130307,224.06583871552721,17.371629103086889]
[0.05,139.48090428300202,375.29117105342448,150.10799430403858,287.54146063607186,86.038746145553887]

{"sheet":"Tumour strategy DTA","index":5,"n_rows":37,"n_cols":14,"rows_kept":37,"cut":false,"hidden":true,"merged":[]}
["IHC"]
[null,null,"D"]
[null,null,"D+","D-"]
["T","T+",{"$f":"C6*sens_IHC","v":3.7575578448884275E-2},{"$f":"D6-D5","v":0.24222618128233409},{"$f":"C4+D4","v":0.27980175973121835},"PPV",{"$f":"C4/E4","v":0.13429357443991749}]
[null,"T-",{"$f":"C6-C4","v":2.2137819223284755E-3},{"$f":"D6*spec_IHC","v":0.71798445834645319},{"$f":"C5+D5","v":0.72019824026878165},"NPV",{"$f":"D5/E5","v":0.99692614922038369}]
[null,null,{"$f":"p_EC_LS","v":3.9789360371212751E-2},{"$f":"1-p_EC_LS","v":0.96021063962878728}]
[null,null,"Sens","Spec"]
[null,null,{"$f":"C4/C6","v":0.94436246519986466},{"$f":"D5/D6","v":0.74773641190231188}]
[]
[]
["IHC with MLH1 methylation"]
[null,null,"path_MLH1","path_MSH2","path_MSH6","path_PMS2","Sporadic"]
["IHC dMLH1",null,{"$f":"C18*sens_IHC*p_dMLH1_pathMLH1","v":3.691101132460638E-3},{"$f":"D18*sens_IHC*p_dMLH1_pathNonMLH1","v":6.6960050662373449E-5},{"$f":"E18*sens_IHC*p_dMLH1_pathNonMLH1","v":1.2075536749953791E-4},{"$f":"F18*sens_IHC*p_dMLH1_pathNonMLH1","v":2.1178892306001484E-5},{"$f":"G18*(1-spec_IHC)*p_dMLH1_sporadic","v":0.20059355637443288},null,null,"D+","D-"]
["IHC absent and MLH1 methylated","T-",{"$f":"C13*p_methylated_dMLH1_pathMLH1","v":1.845550566230319E-4},{"$f":"D13*p_methylated_dMLH1_pathMSH2","v":6.2658356017075923E-5},{"$f":"E13*p_methylated_dMLH1_pathMSH6","v":1.1299771629370346E-4},{"$f":"F13*p_methylated_dMLH1_pathPMS2","v":1.9818303018436114E-5},{"$f":"G13*p_methylated_dMLH1_sporadic","v":0.18770688411535755},null,"T+",{"$f":"SUM(C15:F16)","v":3.719554901693202E-2},{"$f":"SUM(G15:G16)","v":5.4519297166976496E-2},{"$f":"SUM(J14:K14)","v":9.1714846183908516E-2},"PPV",{"$f":"J14/L14","v":0.40555646729589157}]
["IHC absent and MLH1 not methylated","T+",{"$f":"C13*(1-p_methylated_dMLH1_pathMLH1)","v":3.5065460758376059E-3},{"$f":"D13*(1-p_methylated_dMLH1_pathMSH2)","v":4.301694645297532E-6},{"$f":"E13*(1-p_methylated_dMLH1_pathMSH6)","v":7.7576512058344589E-6},{"$f":"F13*(1-p_methylated_dMLH1_pathPMS2)","v":1.3605892875653686E-6},{"$f":"G13*(1-p_methylated_dMLH1_sporadic)","v":1.2886672259075329E-2},null,"T-",{"$f":"SUM(C14:F14,C17:F17)","v":2.5938113542807229E-3},{"$f":"SUM(G14,G17)","v":0.90569134246181071},{"$f":"SUM(J15:K15)","v":0.90828515381609143},"NPV",{"$f":"K15/L15","v":0.99714427639449676}]
["IHC other","T+",{"$f":"C18*sens_IHC*(1-p_dMLH1_pathMLH1)","v":4.6138764155757996E-4},{"$f":"D18*sens_IHC*(1-p_dMLH1_pathNonMLH1)","v":1.0646648055317377E-2},{"$f":"E18*sens_IHC*(1-p_dMLH1_pathNonMLH1)","v":1.9200103432426528E-2},{"$f":"F18*sens_IHC*(1-p_dMLH1_pathNonMLH1)","v":3.3674438766542357E-3},{"$f":"G18*(1-spec_IHC)*(1-p_dMLH1_sporadic)","v":4.1632624907901164E-2},null,null,{"$f":"SUM(J14:J15)","v":3.9789360371212744E-2},{"$f":"SUM(K14:K15)","v":0.96021063962878717}]
["IHC complete","T-",{"$f":"C18*(1-sens_IHC)","v":2.4464572363400091E-4},{"$f":"D18*(1-sens_IHC)","v":6.3119698822983867E-4},{"$f":"E18*(1-sens_IHC)","v":1.138296992375573E-3},{"$f":"F18*(1-sens_IHC)","v":1.9964221808906258E-4},{"$f":"G18*spec_IHC","v":0.71798445834645319},null,null,"Sens","Spec"]
[null,null,{"$f":"p_EC_LS * p_LS_MLH1","v":4.3971344976522185E-3},{"$f":"p_EC_LS * p_LS_MSH2","v":1.1344805094209589E-2},{"$f":"p_EC_LS * p_LS_MSH6","v":2.0459155792301641E-2},{"$f":"p_EC_LS * p_LS_PMS2","v":3.5882649870492998E-3},{"$f":"1-p_EC_LS","v":0.96021063962878728},null,null,{"$f":"J14/J16","v":0.93481143375812281},{"$f":"K15/K16","v":0.94322152357314704}]
[]
[]
["MSI"]
[null,null,"D"]
[null,null,"D+","D-"]
["T","T+",{"$f":"C26*sens_MSI","v":3.5936490722627758E-2},{"$f":"D26*(1-spec_MSI)","v":0.21961004847789334},{"$f":"C24+D24","v":0.25554653920052112},"PPV",{"$f":"C24/E24","v":0.14062601213483572}]
[null,"T-",{"$f":"C26*(1-sens_MSI)","v":3.8528696485849909E-3},{"$f":"D26*spec_MSI","v":0.74060059115089394},{"$f":"C25+D25","v":0.74445346079947894},"NPV",{"$f":"D25/E25","v":0.9948245661395041}]
[null,null,{"$f":"p_EC_LS","v":3.9789360371212751E-2},{"$f":"1-p_EC_LS","v":0.96021063962878728}]
[null,null,"Sens","Spec"]
[null,null,{"$f":"C24/C26","v":0.90316834418447922},{"$f":"D25/D26","v":0.77128971559532655}]
[]
[]
["MSI with MLH1 methylation"]
[null,null,"path_MLH1","path_MSH2","path_MSH6","path_PMS2","Sporadic",null,null,"D+","D-"]
["MSI",null,{"$f":"C37*sens_MSI","v":3.9713526834010068E-3},{"$f":"D37*sens_MSI","v":1.0246268832032921E-2},{"$f":"E37*sens_MSI","v":1.8478061860345372E-2},{"$f":"F37*sens_MSI","v":3.2408073468484584E-3},{"$f":"G37*(1-spec_MSI)","v":0.21961004847789334},null,"T+",{"$f":"SUM(C35:F35)","v":3.3454698942798657E-2},{"$f":"G35","v":7.2418986080507952E-2},{"$f":"SUM(J33:K33)","v":0.1058736850233066},"PPV",{"$f":"J33/L33","v":0.31598691341889229}]
["MSI and MLH1 methylated","T-",{"$f":"C33*p_methylated_MSI_pathMLH1","v":1.9856763417005035E-4},{"$f":"D33*p_methylated_MSI_pathMSH2","v":7.3187634514520865E-4},{"$f":"E33*p_methylated_MSI_pathMSH6","v":1.3198615614532408E-3},{"$f":"F33*p_methylated_MSI_pathPMS2","v":2.3148623906060417E-4},{"$f":"G33*p_methylated_MSI_sporadic","v":0.14719106239738539},null,"T-",{"$f":"SUM(C34:F34,C36:F36)","v":6.3346614284140951E-3},{"$f":"SUM(G34,G36)","v":0.88779165354827927},{"$f":"SUM(J34:K34)","v":0.89412631497669337},"NPV",{"$f":"K34/L34","v":0.99291524997944025}]
["MSI and MLH1 not methylated","T+",{"$f":"C33-C34","v":3.7727850492309564E-3},{"$f":"D33-D34","v":9.5143924868877124E-3},1.7158200298892132E-2,3.0093211077878543E-3,{"$f":"G33*(1-p_methylated_MSI_sporadic)","v":7.2418986080507952E-2},null,null,{"$f":"SUM(J33:J34)","v":3.9789360371212751E-2},{"$f":"SUM(K33:K34)","v":0.96021063962878728}]
["MSS","T-",{"$f":"C37*(1-sens_MSI)","v":4.25781814251212E-4},{"$f":"D37*(1-sens_MSI)","v":1.0985362621766684E-3},{"$f":"E37*(1-sens_MSI)","v":1.9810939319562684E-3},{"$f":"F37*(1-sens_MSI)","v":3.4745764020084152E-4},{"$f":"G37*spec_MSI","v":0.74060059115089394},null,null,"Sens","Spec"]
[null,null,{"$f":"p_EC_LS * p_LS_MLH1","v":4.3971344976522185E-3},{"$f":"p_EC_LS * p_LS_MSH2","v":1.1344805094209589E-2},{"$f":"p_EC_LS * p_LS_MSH6","v":2.0459155792301641E-2},{"$f":"p_EC_LS * p_LS_PMS2","v":3.5882649870492998E-3},{"$f":"1-p_EC_LS","v":0.96021063962878728},null,null,{"$f":"J33/J35","v":0.84079509272541197},{"$f":"K34/K35","v":0.92458010451904094}]

{"sheet":"Parameters","index":6,"n_rows":373,"n_cols":36,"rows_kept":139,"cut":true,"hidden":false,"merged":[[290,11,312,11]],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
["Parameter","Live value","Deterministic","PSA","Description","Source","One-way sensitivity analysis",null,null,null,"Scenario analysis",null,null,null,null,"Calculations"]
[null,null,null,null,null,null,"Low value","High value","Active","Value","Alt. value","Source","Active","Value"]
["ANALYSIS CHARACTERISTICS"]
[]
["threshold",20000]
[]
[]
["Markov model characteristics"]
["cycle_length",{"$f":"1/12","v":8.3333333333333329E-2},null,null,{"$f":"CONCATENATE(\"Cycle length in years (\",cycle_length*12,\" month(s))\")","v":"Cycle length in years (1 month(s))"}]
[]
["Time preference"]
["disc_cost",{"$f":"CHOOSE(analysis_mode,C12,D12,J12,N12)","v":3.5000000000000003E-2},3.5000000000000003E-2,{"$f":"C12","v":3.5000000000000003E-2},"Discount rate for costs","NICE Methods guide",0.01,0.06,1,{"$f":"CHOOSE(I12,C12,G12,H12)","v":3.5000000000000003E-2},null,null,null,{"$f":"C12","v":3.5000000000000003E-2}]
["disc_QALYs",{"$f":"CHOOSE(analysis_mode,C13,D13,J13,N13)","v":3.5000000000000003E-2},3.5000000000000003E-2,{"$f":"C13","v":3.5000000000000003E-2},"Discount rate for QALYs","NICE Methods guide",0.01,0.06,1,{"$f":"CHOOSE(I13,C13,G13,H13)","v":3.5000000000000003E-2},null,null,null,{"$f":"C13","v":3.5000000000000003E-2}]
[]
["Population"]
[]
["Proband (endometrial cancer patient)"]
["proband_age",{"$f":"CHOOSE(analysis_mode,C18,D18,J18,N18)","v":60},60,{"$f":"C18","v":60},null,null,50,70,1,{"$f":"CHOOSE(I18,C18,G18,H18)","v":60},null,null,null,{"$f":"C18","v":60}]
["cohort_probands",1,null,null,"Number of probands in cohort"]
[]
["Relative"]
["relatives_per_proband",{"$f":"CHOOSE(analysis_mode,C22,D22,J22,N22)","v":6},6,{"$f":"_xlfn.GAMMA.INV(RAND(),$R22,$S22)","v":7.1798727227111643},"Mean number of relatives reached per proband by cascade testing",null,{"$f":"_xlfn.GAMMA.INV(0.025,$R22,$S22)","v":1.6347980604394876},{"$f":"_xlfn.GAMMA.INV(0.975,$R22,$S22)","v":13.150909604613471},1,{"$f":"CHOOSE(I22,C22,G22,H22)","v":6},null,null,null,{"$f":"C22","v":6},null,6,{"$f":"P22*0.5","v":3},{"$f":"POWER(P22/Q22,2)","v":4},{"$f":"Q22^2/P22","v":1.5},"(Gamma)"]
["p_FDR",{"$f":"CHOOSE(analysis_mode,C23,D23,J23,N23)","v":0.42369477479050832},{"$f":"1/(1+EXP(-$P23))","v":0.42369477479050832},{"$f":"_xlfn.BETA.INV(RAND(),V23,W23)","v":0.41515646058115596},"Proportion of relatives who are FDRs of the proband","meglm fdr, family(binomial relatives) link(logit) vce(cluster study) - Jenkins 2006, Hampel 2008, Cardiff",{"$f":"_xlfn.BETA.INV(0.025,$V23,$W23)","v":0.38555752832306583},{"$f":"_xlfn.BETA.INV(0.975,$V23,$W23)","v":0.46228670605202016},1,{"$f":"CHOOSE(I23,C23,G23,H23)","v":0.42369477479050832},null,null,null,{"$f":"C23","v":0.42369477479050832},null,-0.30762410000000001,8.0191200000000004E-2,"(logit)",{"$f":"1/(1+EXP(-P23))","v":0.42369477479050832},{"$f":"EXP(-P23)*POWER(1+EXP(-P23),-2)*Q23","v":1.9580887748868517E-2},"transformed MLE and delta method SE",{"$f":"S23*(S23*(1-S23)/T23^2-1)","v":269.40865662080154},{"$f":"(1-S23)*(S23*(1-S23)/T23^2-1)","v":366.44685222753861},"beta method of moments"]
["p_rel_LS",{"$f":"CHOOSE(analysis_mode,C24,D24,J24,N24)","v":0.44},0.44,{"$f":"_xlfn.BETA.INV(RAND(),$P24,$Q24)","v":0.4247329515856344},"Proportion of relatives who are found to have mutation on predictive testing",null,{"$f":"_xlfn.BETA.INV(0.025,$P24,$Q24)","v":0.40698818394053038},{"$f":"_xlfn.BETA.INV(0.975,$P24,$Q24)","v":0.47398258301177854},1,{"$f":"CHOOSE(I24,C24,G24,H24)","v":0.44},null,null,null,{"$f":"C24","v":0.44},null,370.89850000000001,471.38029999999998,"(Beta)"]
["relative_age",{"$f":"CHOOSE(analysis_mode,C25,D25,J25,N25)","v":54},{"$f":"'Relative age DT'!$D$22","v":54},{"$f":"_xlfn.NORM.INV(RAND(),54,1.173)","v":53.216367614931059},null,"Wessex data",{"$f":"C25-10","v":44},{"$f":"C25+10","v":64},1,{"$f":"CHOOSE(I25,C25,G25,H25)","v":54},null,null,null,{"$f":"C25","v":54}]
["p_rel_female",{"$f":"CHOOSE(analysis_mode,C26,D26,J26,N26)","v":0.52791878172588835},{"$f":"$P26/($P26+$Q26)","v":0.52791878172588835},{"$f":"_xlfn.BETA.INV(RAND(),$P26,$Q26)","v":0.53105610378021106},null,"Barrow 2014 PhD",{"$f":"_xlfn.BETA.INV(0.025,$P26,$Q26)","v":0.4876295559171277},{"$f":"_xlfn.BETA.INV(0.975,$P26,$Q26)","v":0.56802901681362294},1,{"$f":"CHOOSE(I26,C26,G26,H26)","v":0.52791878172588835},null,null,null,{"$f":"C26","v":0.52791878172588835},null,312,279]
[]
["Time horizon"]
["max_age",100,null,null,"Maximum age time horizon"]
[]
["NATURAL HISTORY"]
[]
["Lynch syndrome"]
[]
["Lynch syndrome prevalence"]
["Across all EC",{"$f":"CHOOSE(analysis_mode,C36,D36,J36,N36)","v":3.9064271582574646E-2},{"$f":"AB37","v":3.9064271582574646E-2},{"$f":"_xlfn.LOGNORM.INV(RAND(),$AE$37,$AF$37)","v":4.2474560853930907E-2},"Prevalence of Lynch syndrome across all endometrial cancer",null,{"$f":"_xlfn.LOGNORM.INV(0.025,$AE$37,$AF$37)","v":1.5466015925579529E-2},{"$f":"_xlfn.LOGNORM.INV(0.975,$AE$37,$AF$37)","v":8.2267894206471778E-2},1,{"$f":"CHOOSE(I36,C36,G36,H36)","v":3.9064271582574646E-2},{"$f":"EXP(-3.512697)","v":2.9816391093228176E-2},"8 low drop-out studies",false,{"$f":"IF(AND(scenario_analysis,M36),K36,C36)","v":3.9064271582574646E-2},null,"Age distribution with LS",null,null,"Age distribution without LS",null,null,"ln(prevalence)","SE","Random effects SD (ln_prevalence)",null,null,null,"Transformed MLE","SE (delta method)",null,"mu (Method of moments)","sigma (Method of Moments)"]
["At proband age",{"$f":"CHOOSE(analysis_mode,C37,D37,J37,N37)","v":3.9789360371212751E-2},{"$f":"C36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)/(C36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)+(1-C36)*_xlfn.NORM.DIST($B$18,$S$37,$T$37,FALSE))","v":3.9789360371212751E-2},{"$f":"D36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)/(D36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)+(1-D36)*_xlfn.NORM.DIST($B$18,$S$37,$T$37,FALSE))","v":4.32600998137639E-2},"Pre-test probability of Lynch syndrome for proband",null,{"$f":"G36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)/(G36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)+(1-G36)*_xlfn.NORM.DIST($B$18,$S$37,$T$37,FALSE))","v":1.5760271222931953E-2},{"$f":"H36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)/(H36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)+(1-H36)*_xlfn.NORM.DIST($B$18,$S$37,$T$37,FALSE))","v":8.3725033762323653E-2},null,{"$f":"CHOOSE(I36,C37,G37,H37)","v":3.9789360371212751E-2},null,null,null,{"$f":"N36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)/(N36*_xlfn.NORM.DIST($B$18,$P$37,$Q$37,FALSE)+(1-N36)*_xlfn.NORM.DIST($B$18,$S$37,$T$37,FALSE))","v":3.9789360371212751E-2},null,52.440105000000003,9.3729507999999999,null,65.161208999999999,12.071493,null,-3.2425470000000001,0.14227210000000001,{"$f":"EXP(-0.8598452)","v":0.42322759287847822},null,null,null,{"$f":"EXP(V37)","v":3.9064271582574646E-2},{"$f":"AB37*SQRT(SUMSQ(W37:X37))","v":1.7442227699883794E-2},null,{"$f":"LN(AB37^2/SQRT(SUMSQ(AB37:AC37)))","v":-3.3334422686690885},{"$f":"SQRT(LN(1+(AC37/AB37)^2))","v":0.42636901545278488}]
[]
["Gene distribution"]
["MLH1",{"$f":"VLOOKUP(proband_age,'Gene distribution NEW'!$A$6:$AE$1006,28,TRUE)","v":0.11051030870135591},null,null,null,null,null,null,1]
["MSH2",{"$f":"VLOOKUP(proband_age,'Gene distribution NEW'!$A$6:$AE$1006,29,TRUE)","v":0.28512157492276391},null,null,null,null,null,null,1]
["MSH6",{"$f":"VLOOKUP(proband_age,'Gene distribution NEW'!$A$6:$AE$1006,30,TRUE)","v":0.51418659665370392},null,null,null,null,null,null,1]
["PMS2",{"$f":"VLOOKUP(proband_age,'Gene distribution NEW'!$A$6:$AE$1006,31,TRUE)","v":9.0181519722176223E-2},null,null,null,null,null,null,1]
[]
[]
["wMLH1",{"$f":"CHOOSE(analysis_mode,C46,D46,IF(I46=1,J46*(1-SUMPRODUCT(($I$46:$I$49<>1)*1,$J$46:$J$49))/SUMPRODUCT(($I$46:$I$49=1)*1,$J$46:$J$49),J46),N46)","v":0.16923076923076924},{"$f":"Q46","v":0.16923076923076924},{"$f":"R46","v":9.7699917173161122E-2},"Relative abundance of MLH1 in EC overall","Multiple studies reporting gene distributions where age limit below 70 was not imposed",{"$f":"_xlfn.BETA.INV(0.025,P46,SUM($P$46:$P$49)-P46)","v":8.9048996329102875E-2},{"$f":"_xlfn.BETA.INV(0.975,P46,SUM($P$46:$P$49)-P46)","v":0.26863424426625704},1,{"$f":"CHOOSE(I46,C46,G46,H46)","v":0.16923076923076924},null,null,null,{"$f":"C46","v":0.16923076923076924},null,11,{"$f":"P46/SUM($P$46:$P$49)","v":0.16923076923076924},{"$f":"_xlfn.BETA.INV(RAND(),P46,SUM(P47:P49))","v":9.7699917173161122E-2}]
["wMSH2",{"$f":"CHOOSE(analysis_mode,C47,D47,IF(I47=1,J47*(1-SUMPRODUCT(($I$46:$I$49<>1)*1,$J$46:$J$49))/SUMPRODUCT(($I$46:$I$49=1)*1,$J$46:$J$49),J47),N47)","v":0.24615384615384617},{"$f":"Q47","v":0.24615384615384617},{"$f":"R47","v":0.26004161823994221},"…MSH2",null,{"$f":"_xlfn.BETA.INV(0.025,P47,SUM($P$46:$P$49)-P47)","v":0.15015557408527275},{"$f":"_xlfn.BETA.INV(0.975,P47,SUM($P$46:$P$49)-P47)","v":0.35693411039626599},1,{"$f":"CHOOSE(I47,C47,G47,H47)","v":0.24615384615384617},null,null,null,0.24615384615384617,null,16,{"$f":"P47/SUM($P$46:$P$49)","v":0.24615384615384617},{"$f":"(1-R46)*_xlfn.BETA.INV(RAND(),P47,SUM(P48:P49))","v":0.26004161823994221}]
["wMSH6",{"$f":"CHOOSE(analysis_mode,C48,D48,IF(I48=1,J48*(1-SUMPRODUCT(($I$46:$I$49<>1)*1,$J$46:$J$49))/SUMPRODUCT(($I$46:$I$49=1)*1,$J$46:$J$49),J48),N48)","v":0.47692307692307695},0.47692307692307695,0.54576673871668091,"…MSH6",null,0.35750199671976246,0.59769015540164883,1,0.47692307692307695,null,null,null,0.47692307692307695,null,31,0.47692307692307695,{"$f":"(1-R46-R47)*_xlfn.BETA.INV(RAND(),P48,P49)","v":0.54576673871668091}]
["wPMS2",{"$f":"CHOOSE(analysis_mode,C49,D49,IF(I49=1,J49*(1-SUMPRODUCT(($I$46:$I$49<>1)*1,$J$46:$J$49))/SUMPRODUCT(($I$46:$I$49=1)*1,$J$46:$J$49),J49),N49)","v":0.1076923076923077},0.1076923076923077,9.6491725870215705E-2,"…PMS2",null,4.512102018711487E-2,0.19296910444834392,1,0.1076923076923077,null,null,null,0.1076923076923077,null,7,0.1076923076923077,{"$f":"1-R46-R47-R48","v":9.6491725870215705E-2}]
["2.gene",{"$f":"CHOOSE(analysis_mode,C50,D50,J50,N50)","v":-1.5751554946086261},-1.5751554946086261,{"$f":"AE50","v":2.0376163333950159},null,null,{"$f":"_xlfn.NORM.INV(0.025,$C50,$AG50)","v":-7.3064181332104852},{"$f":"_xlfn.NORM.INV(0.975,$C50,$AG50)","v":4.156107143993232},1,{"$f":"CHOOSE(I50,C50,G50,H50)","v":-1.5751554946086261},null,null,null,-1.5751554946086261,null,"2.gene",2.9241673233589101,0,0,0,0,0,0,0,0,0,0,null,{"$f":"_xlfn.NORM.S.INV(RAND())","v":1.2354873810209162},{"$f":"MMULT(Q50:AA60,AC50:AC60)","v":3.612771828003642},{"$f":"C50+AD50","v":2.0376163333950159},null,2.9241673233841685]
["3.gene",-2.8963442312014416,-2.8963442312014416,{"$f":"AE51","v":-4.4385340779930802},null,null,{"$f":"_xlfn.NORM.INV(0.025,$C51,$AG51)","v":-13.343693906557876},{"$f":"_xlfn.NORM.INV(0.975,$C51,$AG51)","v":7.5510054441549936},1,-2.8963442312014416,null,null,null,-2.8963442312014416,null,"3.gene",0.92371708295314603,5.2497314760528999,0,0,0,0,0,0,0,0,0,null,{"$f":"_xlfn.NORM.S.INV(RAND())","v":-0.51115579123511368},-1.5421898467916384,{"$f":"C51+AD51","v":-4.4385340779930802},null,5.3303783935642688]
["4.gene",-3.5440091118846215,-3.5440091118846215,-8.8896177732018113,null,null,-14.16877124561511,7.0807530218458652,1,-3.5440091118846215,null,null,null,-3.5440091118846215,null,"4.gene",-0.173188875668809,-6.5994942702814502E-2,5.4177274212424402,0,0,0,0,0,0,0,0,null,-0.95342000186221643,-5.3456086613171898,-8.8896177732018113,null,5.4208966172527955]
["tspline31",0.18797152034086237,0.18797152034086237,0.20995371546877278,null,null,0.11360833584756531,0.26233470483415944,1,0.18797152034086237,null,null,null,0.18797152034086237,null,"tspline31",2.1203710370711198E-2,8.0798356453224193E-3,-2.0411785404833502E-3,3.0339405278044601E-2,0,0,0,0,0,0,0,null,-6.6934968330756531E-2,2.1982195127910407E-2,0.20995371546877278,null,3.7941097428250914E-2]
["tspline32",-0.31926037862238482,-0.31926037862238482,-0.35957387028955851,null,null,-0.4614295189648141,-0.17709123827995557,1,-0.31926037862238482,null,null,null,-0.31926037862238482,null,"tspline32",-3.4829666273341102E-2,-1.32721101236485E-2,1.0511571307141299E-2,-5.2282777702792903E-2,3.2067482977132002E-2,0,0,0,0,0,0,null,7.6601017120573434E-2,-4.0313491667173684E-2,-0.35957387028955851,null,7.2536608562117133E-2]
["2.gene#c.tspline31",3.2425619175807163E-2,3.2425619175807163E-2,-5.6510809944670601E-2,null,null,-9.7261684833474304E-2,0.1621129231850886,1,3.2425619175807163E-2,null,null,null,3.2425619175807163E-2,null,"2.gene#c.tspline31",-6.5820156207380104E-2,-2.29343979609339E-4,7.105506253805E-4,-1.3379315943011501E-3,2.5097468064199701E-3,6.1067721425070304E-3,0,0,0,0,0,null,-1.2016229572617581,-8.8936429120477764E-2,-5.6510809944670601E-2,null,6.6168207697814035E-2]
["3.gene#c.tspline31",5.6071143160083367E-2,5.6071143160083367E-2,8.3799896282625214E-2,null,null,-0.17464437443662484,0.28678666075679154,1,5.6071143160083367E-2,null,null,null,5.6071143160083367E-2,null,"3.gene#c.tspline31",-2.1203710370711198E-2,-0.115374086707379,7.3419548271298101E-4,-1.85327904786094E-3,2.4651493614806998E-3,1.35046378907274E-3,9.1636446295743704E-3,0,0,0,0,null,-0.33159295867701244,2.7728753122541853E-2,8.3799896282625214E-2,null,0.11771416179917733]
["4.gene#c.tspline31",6.0355386044356876E-2,6.0355386044356876E-2,0.15980439471720259,null,null,-0.12967894442922978,0.25038971651794351,1,6.0355386044356876E-2,null,null,null,6.0355386044356876E-2,null,"4.gene#c.tspline31",2.9031016563883698E-3,1.106249040153E-3,-9.63055793837823E-2,-2.79791875128081E-4,-2.33186404311269E-3,1.09081385643162E-3,5.5325987084845602E-4,1.0461345450027399E-2,0,0,0,null,0.59860010503747207,9.9449008672845701E-2,0.15980439471720259,null,9.6958072685290761E-2]
["2.gene#c.tspline32",2.9574460509100699E-2,2.9574460509100699E-2,0.18775958340378512,null,null,-0.19029679596956831,0.24944571698776968,1,2.9574460509100699E-2,null,null,null,2.9574460509100699E-2,null,"2.gene#c.tspline32",9.7642384113652003E-2,2.2198914034187701E-3,-8.6382630636347192E-3,1.1453407516766E-2,-3.5600799337188599E-2,-2.9429150263368599E-2,3.0700229519146699E-3,2.0097894647405998E-3,2.6323348589585901E-2,0,0,null,-6.1014532995181635E-2,0.15818512289468442,0.18775958340378512,null,0.11218127384634895]
["3.gene#c.tspline32",1.4207144712863945E-3,1.4207144712863945E-3,-1.5200647563055149E-2,null,null,-0.35015248871708532,0.35299391765965804,1,1.4207144712863945E-3,null,null,null,1.4207144712863945E-3,null,"3.gene#c.tspline32",3.4829666273341102E-2,0.15883755294408,-8.7383955248423097E-3,1.3635827489802301E-2,-3.5411935777449298E-2,-1.8321658199155701E-3,-5.22292809517221E-2,2.1047096637526099E-3,4.4807272562044599E-3,3.8232293143348299E-2,0,null,-9.6128722567912883E-2,-1.6621362034341544E-2,-1.5200647563055149E-2,null,0.17937737936081291]
["_cons",-12.21482334501297,-12.21482334501297,-12.997670578149435,null,null,-15.436030748692694,-8.9936159413332462,1,-12.21482334501297,null,null,null,-12.21482334501297,null,"_cons",-0.92371708295314603,-0.35198944347718703,5.9660846639433801E-2,-1.3003278032309,-0.112528542068093,-6.1645644549841797E-2,-3.1266619085299603E-2,-2.0468681381193701E-2,-4.3575881340213798E-2,-2.63124691788604E-2,9.5346996475071097E-2,null,0.83440662203430893,-0.78284723313646498,-12.997670578149435,null,1.643503364902722]
[]
["CRC incidence"]
["With Lynch syndrome"]
["mu.MSH2",{"$f":"CHOOSE(analysis_mode,C68,D68,J68,N68)","v":0.10043842157515942},{"$f":"R68","v":0.10043842157515942},{"$f":"R68:R74+MMULT(AB68:AH74,AJ68:AJ74)","v":0.27862075720334167},null,"Moller studies",-3.6212099999999997E-2,0.23708899999999999,1,{"$f":"CHOOSE(I68,C68,G68,H68)","v":0.10043842157515942},-0.1825232,"Weibull parameterisation",false,{"$f":"IF(AND(scenario_analysis,M$68),K68,C68)","v":0.10043842157515942},null,"mu","MSH2",0.10043842157515942,null,4.8610110164534525E-3,2.4265933829531574E-3,3.063026479940275E-3,-2.8431583818822892E-5,-1.3664222358365438E-3,-1.293855001598564E-3,1.4701306152166897E-3,null,6.9720950940158594E-2,3.4804358909027798E-2,4.39326480591034E-2,-4.0779133985712298E-4,-1.95984418108812E-2,-1.8557621239425101E-2,2.1085928693970499E-2,null,{"$f":"_xlfn.NORM.S.INV(RAND())","v":0.95226540642738977}]
["mu._cons",4.306355546459196,4.306355546459196,4.2762640411531088,null,"Moller studies",4.1881139999999997,4.4245970000000003,1,4.306355546459196,-9.131513,null,null,4.306355546459196,null,"mu","_cons",4.306355546459196,null,-1.293855001598564E-3,-7.6042750643409425E-4,-2.3640456459584358E-5,-3.0636647690469982E-3,-3.6125667353803384E-3,3.6395083826725599E-3,1.6414830723084854E-3,null,0,0,0,0,0,3.0780664335357401E-2,2.3834190514437398E-3,null,-0.96471166860626256]
["MLH1",{"$f":"SUM($B$72,$B$73)","v":4.0759147183486082}]
["Relative"]
["PMS2",{"$f":"SUM($B$73,$B$71,$B70)","v":5.0520554292844899}]
["sigma",{"$f":"EXP($B$74)","v":0.5670766788084971}]
[25,2.7000000000000002E-5,{"$f":"$P99","v":2.7000000000000002E-5},{"$f":"_xlfn.LOGNORM.INV(RAND(),$V99,$W99)","v":1.5230123967383908E-5},null,null,{"$f":"T99","v":1.1656683596526192E-5},{"$f":"U99","v":5.320076361815244E-5},1,2.7000000000000002E-5,null,null,null,2.7000000000000002E-5,null,2.7000000000000002E-5,8,{"$f":"0.5*_xlfn.CHISQ.INV(0.025,2*Q99)","v":3.453832176748501},{"$f":"0.5*_xlfn.CHISQ.INV(0.975,2*Q99+2)","v":15.763189220193315},{"$f":"R99*$P99/$Q99","v":1.1656683596526192E-5},{"$f":"S99*$P99/$Q99","v":5.320076361815244E-5},{"$f":"LN($P99)-0.5*$W99^2","v":-10.59467482433168},{"$f":"(LN(U99)-LN(T99))/(2*_xlfn.NORM.S.INV(0.975))","v":0.38730125838095447}]
[40,1.1800000000000001E-4,1.1800000000000001E-4,1.0332233742389472E-4,null,null,8.7581874420410022E-5,1.5556828932783494E-4,1,1.1800000000000001E-4,null,null,null,1.1800000000000001E-4,null,1.1800000000000001E-4,50,37.110963737461866,65.918766664336829,8.7581874420410022E-5,1.5556828932783494E-4,-9.0555660779284715,0.1465615531431263]
[75,2.356E-3,2.356E-3,2.3448910392655687E-3,null,null,2.193845904065031E-3,2.5269677216552227E-3,1,2.356E-3,null,null,null,2.356E-3,null,2.356E-3,783,729.10922872789445,839.81991768083162,2.193845904065031E-3,2.5269677216552227E-3,-6.0514402792062612,3.6062889885984342E-2]
["Male",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"lambda","n","LCL(n)","UCL(n)","LCL(lambda)","UCL(lambda)","mu","sigma"]
[0,{"$f":"CHOOSE(analysis_mode,C115,D115,J115,N115)","v":2.2999999999999997E-5},{"$f":"$P115","v":2.2999999999999997E-5},{"$f":"_xlfn.LOGNORM.INV(RAND(),$V115,$W115)","v":2.0782863104836532E-5},null,"ONS Cancer Registration Statistics 2015",{"$f":"T115","v":8.4405946383815921E-6},{"$f":"U115","v":5.0061317086321617E-5},1,{"$f":"CHOOSE(I115,C115,G115,H115)","v":2.2999999999999997E-5},null,null,null,{"$f":"C115","v":2.2999999999999997E-5},null,2.2999999999999997E-5,6,{"$f":"0.5*_xlfn.CHISQ.INV(0.025,2*Q115)","v":2.2018942534908503},{"$f":"0.5*_xlfn.CHISQ.INV(0.975,2*Q115+2)","v":13.059474022518685},{"$f":"R115*$P115/$Q115","v":8.4405946383815921E-6},{"$f":"S115*$P115/$Q115","v":5.0061317086321617E-5},{"$f":"LN($P115)-0.5*$W115^2","v":-10.783137882526702},{"$f":"(LN(U115)-LN(T115))/(2*_xlfn.NORM.S.INV(0.975))","v":0.45413993546390002}]
[45,2.32E-4,2.32E-4,2.2909021122486086E-4,null,null,1.9085308167461141E-4,2.7938784427563066E-4,1,2.32E-4,null,null,null,2.32E-4,null,2.32E-4,111,91.313327870180458,133.67263239049569,1.9085308167461141E-4,2.7938784427563066E-4,-8.3734990905779529,9.7220412259862235E-2]
[80,4.5750000000000001E-3,4.5750000000000001E-3,4.7056781456516613E-3,null,null,4.3217479858510136E-3,4.8392194741293994E-3,1,4.5750000000000001E-3,null,null,null,4.5750000000000001E-3,null,4.5750000000000001E-3,1219,1151.5214851917783,1289.4007735439864,4.3217479858510136E-3,4.8392194741293994E-3,-5.3875647678044523,2.8850911590443406E-2]
[]
["p_colon_StageI_NoLS",{"$f":"CHOOSE(analysis_mode,C135,D135,J135,N135)","v":0.4987238386932108},{"$f":"P135/(P135+Q135)","v":0.4987238386932108},{"$f":"_xlfn.BETA.INV(RAND(),$P135,$Q135)","v":0.49888714636041442},null,"Incisive Health 2014",{"$f":"_xlfn.BETA.INV(0.025,$P135,$Q135)","v":0.48594261719611703},{"$f":"_xlfn.BETA.INV(0.975,$P135,$Q135)","v":0.5115058828766964},1,{"$f":"CHOOSE(I135,C135,G135,H135)","v":0.4987238386932108},null,null,null,{"$f":"C135","v":0.4987238386932108},null,2931,2946]
[]
["Stage IV",{"$f":"CHOOSE(analysis_mode,C146,D146,J146,N146)","v":0.5436201073911423},{"$f":"-LN(P146)/5","v":0.5436201073911423},0.5546734931014905,{"$f":"CONCATENATE(\"Mortality rate for \",A146,\" CRC without Lynch syndrome\")","v":"Mortality rate for Stage IV CRC without Lynch syndrome"},null,0.53185200738655558,0.55937628296176523,1,0.5436201073911423,null,null,null,0.5436201073911423,null,6.6000000000000003E-2,6.0999999999999999E-2,7.0000000000000007E-2,null,0.5436201073911423,0.55937628296176523,0.53185200738655558,null,-0.60950460807514073,-0.58093289639271517,-0.63139000994439121,1.2871949165820221E-2]
[]
[]
[15,{"$f":"CHOOSE(analysis_mode,C161,D161,J161,N161)","v":2.6477837609149145E-2},{"$f":"T161","v":2.6477837609149145E-2},{"$f":"_xlfn.LOGNORM.INV(RAND(),X161,AA161)","v":2.0008520202059309E-2},null,null,{"$f":"V161","v":2.1294448902103351E-2},{"$f":"U161","v":3.1564817038713416E-2},1,{"$f":"CHOOSE(I161,C161,G161,H161)","v":2.6477837609149145E-2},null,null,null,{"$f":"C161","v":2.6477837609149145E-2},null,0.87599999999999989,0.85400000000000009,0.89900000000000002,null,{"$f":"-LN(P161)/5","v":2.6477837609149145E-2},{"$f":"-LN(Q161)/5","v":3.1564817038713416E-2},{"$f":"-LN(R161)/5","v":2.1294448902103351E-2},null,{"$f":"LN(T161)","v":-3.6314472125337023},{"$f":"LN(U161)","v":-3.4557121635134695},{"$f":"LN(V161)","v":-3.8493088551574539},{"$f":"(Z161-Y161)/(_xlfn.NORM.S.INV(0.025)-_xlfn.NORM.S.INV(0.975))","v":0.10040916433889219}]
["EFFECTIVENESS OF RISK REDUCTION"]
["start_colonoscopy",25,null,null,null,"Assumed based on guidelines"]
["delay_start_MSH6_PMS2",{"$f":"CHOOSE(analysis_mode,C176,D176,J176,N176)","v":0},0,0,null,null,null,null,null,null,15,"Start age 40",false,{"$f":"IF(AND(scenario_analysis,M176),K176,C176)","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Jarvinen 2000",null,null,"Arrigoni 2005"]
["Stage I",{"$f":"CHOOSE(analysis_mode,C182,D182,J182,N182)","v":0.68604651162790697},{"$f":"$Q182/SUM($Q$182:$Q$185)","v":0.68604651162790697},{"$f":"_xlfn.BETA.INV(U182,Q182,R183)","v":0.78086793412375344},null,"Mecklin 2007",{"$f":"_xlfn.BETA.INV(0.025,$Q182,SUM($Q$182:$Q$185)-$Q182)","v":0.5415994637924415},{"$f":"_xlfn.BETA.INV(0.975,$Q182,SUM($Q$182:$Q$185)-$Q182)","v":0.8141059340928245},1,{"$f":"$W182+$Y182","v":0.68604651162790697},null,null,null,{"$f":"C182","v":0.68604651162790697},null,29,{"$f":"P182+0.5","v":29.5},null,null,null,{"$f":"RAND()","v":0.91760570877248182},null,{"$f":"CHOOSE($I182,$C182,$G182,$H182)","v":0.68604651162790697},{"$f":"IF($I182=1,$C182,0)","v":0.68604651162790697},{"$f":"$X182*$W186/$X186","v":0}]
["Stage III",{"$f":"CHOOSE(analysis_mode,C190,D190,J190,N190)","v":0.29507835239467262},0.29507835239467262,{"$f":"_xlfn.BETA.INV(U190,Q190,R191,0,1-SUM(D188:D189))","v":0.29280289125930037},null,null,0.29024296916631842,{"$f":"_xlfn.BETA.INV(0.975,$Q190,SUM($Q$188:$Q$191)-$Q190)","v":0.29993656126553292},1,0.29507835239467262,null,null,null,0.29507835239467262,null,10036,{"$f":"P190+0.5","v":10036.5},{"$f":"SUM(Q190:Q191)","v":18853},null,null,{"$f":"RAND()","v":0.49504416312332833},null,0.29507835239467262,0.29507835239467262,{"$f":"$X190*$W192/$X192","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"1-SUM(W188:W191)","v":0},{"$f":"SUM(X188:X191)","v":1}]
["Stage IV",{"$f":"CHOOSE(analysis_mode,C197,D197,J197,N197)","v":0.1125},{"$f":"$Q197/SUM($Q$194:$Q$197)","v":0.1125},{"$f":"1-SUM(D194:D196)","v":8.8583137529364198E-2},null,null,3.5622990438354186E-2,0.22565899907460141,1,0.1125,null,null,null,0.1125,null,4,{"$f":"P197+0.5","v":4.5},{"$f":"Q197","v":4.5},null,null,null,null,0.1125,0.1125,{"$f":"$X197*$W198/$X198","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Z","X"]
["p_dMLH1_pathNonMLH1",{"$f":"CHOOSE(analysis_mode,C208,D208,J208,N208)","v":6.2500000000000003E-3},{"$f":"$AG208/($AG208+$AH208)","v":6.2500000000000003E-3},{"$f":"_xlfn.BETA.INV(RAND(),$AG208,$AH208)","v":1.4558949913443223E-3},"Probability tumour is dMLH1 if dMMR and actually has other LS mutation","Simple pooling of multiple studies",{"$f":"_xlfn.BETA.INV(0.025,$AG208,$AH208)","v":6.1959696330306362E-6},{"$f":"_xlfn.BETA.INV(0.975,$AG208,$AH208)","v":3.119896753289686E-2},1,{"$f":"CHOOSE(I208,C208,G208,H208)","v":6.2500000000000003E-3},null,null,null,{"$f":"C208","v":6.2500000000000003E-3},null,"Corr(logits)",0.9475922,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0.5,79.5]
["failure_IHC",{"$f":"CHOOSE(analysis_mode,C211,D211,J211,N211)","v":9.3872807381496209E-3},{"$f":"V211","v":9.3872807381496209E-3},{"$f":"_xlfn.BETA.INV(RAND(),$X211,$Y211)","v":2.0028860321064631E-3},"Test failure rate","Random effects logistic regression on 8 studies",{"$f":"_xlfn.BETA.INV(0.025,$X211,$Y211)","v":4.9053353370412503E-8},{"$f":"_xlfn.BETA.INV(0.975,$X211,$Y211)","v":6.0531268884049472E-2},1,{"$f":"CHOOSE(I211,C211,G211,H211)","v":9.3872807381496209E-3},null,null,null,{"$f":"C211","v":9.3872807381496209E-3},null,null,-4.6589679999999998,0.75126749999999998,2.8988969999999998,null,null,{"$f":"1/(1+EXP(-Q211))","v":9.3872807381496209E-3},{"$f":"EXP(-Q211)*POWER(1+EXP(-Q211),-2)*SQRT(R211^2+S211)","v":1.7305683373381883E-2},{"$f":"V211*(V211*(1-V211)/W211^2-1)","v":0.28209086976696612},{"$f":"(1-V211)*(V211*(1-V211)/W211^2-1)","v":29.768237615729102}]
["spec_MSI",{"$f":"CHOOSE(analysis_mode,C218,D218,J218,N218)","v":0.77128971559532655},{"$f":"1/(1+EXP(-Q218))","v":0.77128971559532655},{"$f":"1/(1+EXP(-$AE218))","v":0.87564302545774808},"Specificity of MSI","Meta-analysis",{"$f":"1/(1+EXP(-_xlfn.NORM.INV(0.025,$W$218,SQRT($Y$218))))","v":0.39022713679980736},{"$f":"1/(1+EXP(-_xlfn.NORM.INV(0.975,$W$218,SQRT($Y$218))))","v":0.96498330533256049},1,{"$f":"CHOOSE(I218,C218,G218,H218)","v":0.77128971559532655},null,null,null,{"$f":"C218","v":0.77128971559532655},null,"E(logitSp)",1.215608,0.3208954,0.58666430000000003,1.8445510000000001,null,null,1.43496415098991,0.45968929730991798,0.92136127142127799,null,{"$f":"X218/SQRT(X217)","v":0.69875719918632639},{"$f":"SQRT(Y218-X218^2/X217)","v":0.65810306792064011},null,{"$f":"_xlfn.NORM.S.INV(RAND())","v":0.96697918750799661},1.9518022460262376]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Coef.","Std. Err.","RE variance",null,null,"Transformed MLE",null,"Method of moments (Beta)"]
["p_methylated_dMLH1_pathMLH1",{"$f":"CHOOSE(analysis_mode,C228,D228,J228,N228)","v":0.05},{"$f":"$P$236/($P$236+$Q$236)","v":0.05},{"$f":"_xlfn.BETA.INV(RAND(),$P228,$Q228)","v":9.380606880316604E-3},"…Actually has MLH1 mutation","Assumption (no relevant data)",{"$f":"_xlfn.BETA.INV(0.025,$P228,$Q228)","v":1.3316288041794228E-3},{"$f":"_xlfn.BETA.INV(0.975,$P228,$Q228)","v":0.17646691180696539},1,{"$f":"CHOOSE(I228,C228,G228,H228)","v":0.05},null,null,null,{"$f":"C228","v":0.05},null,1,19]
["p_methylated_dMLH1_pathMSH6",{"$f":"CHOOSE(analysis_mode,C230,D230,J230,N230)","v":0.93575729703390498},{"$f":"C$232","v":0.93575729703390498},0.98304671173205627,"…Actually has MSH6 mutation","Assume equal to if sporadic",{"$f":"G232","v":0.84597976525664031},{"$f":"H232","v":0.98763071804359148},1,0.93575729703390498,null,null,null,0.93575729703390498,null,"Fixed effect","SE","Random effect",null,"X",null,"Transformed MLE",null,"Method of moments (Beta)"]
["p_methylated_MSI_pathMSH6",{"$f":"CHOOSE(analysis_mode,C238,D238,J238,N238)","v":7.1428571428571425E-2},{"$f":"C$237","v":7.1428571428571425E-2},{"$f":"D$237","v":3.2136548338845002E-2},"…Actually has MSH6 mutation","Buchanan 2012",{"$f":"G237","v":1.9456284973467482E-3},{"$f":"H237","v":0.24705263800047095},1,{"$f":"CHOOSE(I238,C238,G238,H238)","v":7.1428571428571425E-2},{"$f":"2/9","v":0.22222222222222221},"Hampel et al. 2006",null,{"$f":"IF(AND(scenario_analysis,$M$236),$K238,$C238)","v":7.1428571428571425E-2}]
["p_methylated_MSI_pathPMS2",{"$f":"CHOOSE(analysis_mode,C239,D239,J239,N239)","v":7.1428571428571425E-2},{"$f":"C$237","v":7.1428571428571425E-2},3.2136548338845002E-2,"…Actually has PMS2 mutation","Buchanan 2012",{"$f":"G237","v":1.9456284973467482E-3},{"$f":"H237","v":0.24705263800047095},1,7.1428571428571425E-2,0.22222222222222221,"Hampel et al. 2006",null,{"$f":"IF(AND(scenario_analysis,$M$236),$K239,$C239)","v":7.1428571428571425E-2},null,"x1","n1","p1","ln(p1)","Var[ln(p1)]",null,"x2","n2","p2","ln(p2)","Var[ln(p2)]",null,"ln(p1)+ln(p2)","Var[ln(p1)+ln(p2)]",null,"p1*p2","X"]
["theta_FH",{"$f":"CHOOSE(analysis_mode,C244,D244,J244,N244)","v":-1},{"$f":"$P244","v":-1},{"$f":"_xlfn.NORM.INV(RAND(),$P244,$Q244)","v":0.51436853720887155},"HSROC parameter (positivity)",null,{"$f":"_xlfn.NORM.INV(0.025,$P244,$Q244)","v":-4.9199279690801081},{"$f":"_xlfn.NORM.INV(0.975,$P244,$Q244)","v":2.9199279690801072},1,{"$f":"CHOOSE(I244,C244,G244,H244)","v":-1},null,null,null,{"$f":"C244","v":-1},null,-1,2,"(Normal)"]
[]
["acceptance_MMRdiagnostic",{"$f":"CHOOSE(analysis_mode,C254,D254,J254,N254)","v":0.9},0.9,{"$f":"_xlfn.BETA.INV(RAND(),$P254,$Q254)","v":0.91951600781149045},null,"Assumption",{"$f":"_xlfn.BETA.INV(0.025,$P254,$Q254)","v":0.66373288312005729},{"$f":"_xlfn.BETA.INV(0.975,$P254,$Q254)","v":0.99719086325340078},1,{"$f":"CHOOSE(I254,C254,G254,H254)","v":0.9},null,null,null,{"$f":"C254","v":0.9},null,9,1]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"n","x","n-x","p",null,null,"PSA"]
["COSTS"]
["c_MSI",202,202,{"$f":"_xlfn.GAMMA.INV(RAND(),R270,S270)","v":233.65048152627026},"Cost of MSI","PenTAG 2017",{"$f":"_xlfn.GAMMA.INV(0.025,$R270,$S270)","v":130.72374933046095},{"$f":"_xlfn.GAMMA.INV(0.975,$R270,$S270)","v":288.53758855752591},1,202,null,null,null,202,null,{"$f":"C270","v":202},40.400000000000006,{"$f":"POWER(P270/Q270,2)","v":24.999999999999993},{"$f":"Q270^2/P270","v":8.0800000000000018},"(Gamma)"]
["c_MMR_proband",755,755,689.23676357705961,null,"UKGTN (midpoint of Birmingham and Leeds costs for 4-gene panels)",488.5961918044456,1078.4449473313471,1,755,525,"UKGTN two-gene panels (IHC arms only)",false,755,null,{"$f":"C274","v":755},151,25,30.2,"(Gamma)"]
[]
[]
["Stage I",null,null,null,null,"Inflated from 2012/13 prices"]
["Age 60-69",4623.2215285420252,4623.2215285420252,4831.1230059305917,null,null,2991.9052088926646,6603.8276792710658,1,4623.2215285420252,{"$f":"13469*(inflate_2013_14)","v":13923.634250806022},null,null,{"$f":"IF(AND(scenario_analysis,$M$289),K293,C293)","v":4623.2215285420252},null,{"$f":"4423*(inflate_2012_13)","v":4623.2215285420252},{"$f":"P293*0.2","v":924.64430570840511},{"$f":"POWER(P293/Q293,2)","v":25},{"$f":"Q293^2/P293","v":184.92886114168104},"(Gamma)"]
["Age 70-79",3454.6116101811876,3454.6116101811876,3358.0398655316631,null,null,2235.6424859575532,4934.5807099233261,1,3454.6116101811876,{"$f":"18532*(inflate_2013_14)","v":19157.531363570954},null,null,{"$f":"IF(AND(scenario_analysis,$M$289),K300,C300)","v":3454.6116101811876},null,{"$f":"3305*(inflate_2012_13)","v":3454.6116101811876},{"$f":"P300*0.2","v":690.92232203623757},{"$f":"POWER(P300/Q300,2)","v":25},{"$f":"Q300^2/P300","v":138.18446440724753},"(Gamma)"]
["Age 80-100",1545.9517614093725,1545.9517614093725,1853.5714871661107,null,null,1000.4584679973434,2208.2435310065343,1,1545.9517614093725,{"$f":"18532*(inflate_2013_14)","v":19157.531363570954},null,null,{"$f":"IF(AND(scenario_analysis,$M$289),K301,C301)","v":1545.9517614093725},null,{"$f":"1479*(inflate_2012_13)","v":1545.9517614093725},{"$f":"P301*0.2","v":309.19035228187454},{"$f":"POWER(P301/Q301,2)","v":24.999999999999993},{"$f":"Q301^2/P301","v":61.838070456374915},"(Gamma)"]
["Age 70-79",4485.2461177874357,4485.2461177874357,3430.8211932409818,null,null,2902.6147979557813,6406.7430639276818,1,4485.2461177874357,{"$f":"25416*(inflate_2013_14)","v":26273.8947300086},null,null,{"$f":"IF(AND(scenario_analysis,$M$289),K306,C306)","v":4485.2461177874357},null,{"$f":"4291*(inflate_2012_13)","v":4485.2461177874357},{"$f":"P306*0.2","v":897.04922355748715},{"$f":"POWER(P306/Q306,2)","v":25},{"$f":"Q306^2/P306","v":179.40984471149744},"(Gamma)"]
["Age 60-69",6508.8854755214079,6508.8854755214079,5976.9046494078675,null,null,4212.2074916967258,9297.3174222972921,1,6508.8854755214079,{"$f":"27796*(inflate_2013_14)","v":28734.229537115167},null,null,{"$f":"IF(AND(scenario_analysis,$M$289),K311,C311)","v":6508.8854755214079},null,{"$f":"6227*(inflate_2012_13)","v":6508.8854755214079},{"$f":"P311*0.2","v":1301.7770951042817},{"$f":"POWER(P311/Q311,2)","v":25},{"$f":"Q311^2/P311","v":260.35541902085635},"(Gamma)"]
[]
["u_const",{"$f":"CHOOSE(analysis_mode,C321,D321,J321,N321)","v":0.95085660000000005},0.95085660000000005,{"$f":"_xlfn.NORM.INV(RAND(),$C321,$P321)","v":0.93979693470117331},null,"Ara and Brazier. Populating an economic model with health state utility values: moving toward better practice. Value in Health 2010; 13(5):509-518",{"$f":"_xlfn.NORM.INV(0.025,$C321,$P321)","v":0.93341292053759362},{"$f":"_xlfn.NORM.INV(0.975,$C321,$P321)","v":0.96830027946240649},1,{"$f":"CHOOSE($I321,$C321,$G321,$H321)","v":0.95085660000000005},null,null,null,{"$f":"C321","v":0.95085660000000005},null,8.8999999999999999E-3]
["u_baseline_relative",{"$f":"u_const+(1-p_rel_female)*u_male+relative_age*(u_age+relative_age*u_age2)","v":0.85008967005076141}]
["Utility multipliers"]
[]
[]
[]
[]
["spec_PREMM",0.85245901639344257,{"$f":"AA357","v":0.85245901639344257},{"$f":"_xlfn.BETA.INV(RAND(),W357,X357)","v":0.84644246120290767},"PREMM (>= 10%) specificity",null,{"$f":"_xlfn.BETA.INV(0.025,$W357,$X357)","v":0.8216346544922688},{"$f":"_xlfn.BETA.INV(0.975,$W357,$X357)","v":0.88085209889656535},1,0.85245901639344257,null,null,null,0.85245901639344257]
["sens_MMRpredict",0.7142857142857143,{"$f":"Z359","v":0.7142857142857143},{"$f":"_xlfn.BETA.INV(RAND(),U359,V359)","v":0.70358936773080272},"MMRpredict sensitivity",null,{"$f":"_xlfn.BETA.INV(0.025,$U359,$V359)","v":0.35876542100232517},{"$f":"_xlfn.BETA.INV(0.975,$U359,$V359)","v":0.95672813170725823},1,0.7142857142857143,null,null,null,0.7142857142857143,null,156,59,{"$f":"P359-Q359","v":97},7,{"$f":"P359-S359","v":149},5,2,{"$f":"R359-V359","v":95},{"$f":"Q359-U359","v":54},null,{"$f":"U359/(U359+V359)","v":0.7142857142857143},{"$f":"W359/(W359+X359)","v":0.63758389261744963},{"$f":"U359/(U359+X359)","v":8.4745762711864403E-2},{"$f":"W359/(W359+V359)","v":0.97938144329896903}]
["spec_MMRpredict",0.63758389261744963,{"$f":"AA359","v":0.63758389261744963},{"$f":"_xlfn.BETA.INV(RAND(),W359,X359)","v":0.61033598373121922},"MMRpredict specificity",null,{"$f":"_xlfn.BETA.INV(0.025,$W359,$X359)","v":0.55903298332112406},{"$f":"_xlfn.BETA.INV(0.975,$W359,$X359)","v":0.71263578841291775},1,0.63758389261744963,null,null,null,0.63758389261744963]
["sens_MMRpro",0.5714285714285714,{"$f":"Z361","v":0.5714285714285714},{"$f":"_xlfn.BETA.INV(RAND(),U361,V361)","v":0.6161409455626502},"MMRpro sensitivity",null,{"$f":"_xlfn.BETA.INV(0.025,$U361,$V361)","v":0.31577760291406304},{"$f":"_xlfn.BETA.INV(0.975,$U361,$V361)","v":0.80776755819871204},1,0.5714285714285714,null,null,null,0.5714285714285714,null,232,41,{"$f":"P361-Q361","v":191},14,{"$f":"P361-S361","v":218},8,6,{"$f":"R361-V361","v":185},{"$f":"Q361-U361","v":33},null,{"$f":"U361/(U361+V361)","v":0.5714285714285714},{"$f":"W361/(W361+X361)","v":0.84862385321100919},{"$f":"U361/(U361+X361)","v":0.1951219512195122},{"$f":"W361/(W361+V361)","v":0.96858638743455494}]
["spec_MMRpro",0.84862385321100919,{"$f":"AA361","v":0.84862385321100919},{"$f":"_xlfn.BETA.INV(RAND(),W361,X361)","v":0.87894384757546451},"MMRpro specificity",null,{"$f":"_xlfn.BETA.INV(0.025,$W361,$X361)","v":0.79824602676093559},{"$f":"_xlfn.BETA.INV(0.975,$W361,$X361)","v":0.89294916821978854},1,0.84862385321100919,null,null,null,0.84862385321100919]
["sens_MMRpro_TBT",0.6428571428571429,{"$f":"Z363","v":0.6428571428571429},{"$f":"_xlfn.BETA.INV(RAND(),U363,V363)","v":0.81433531508794199},"MMRpro + molecular sensitivity",null,{"$f":"_xlfn.BETA.INV(0.025,$U363,$V363)","v":0.38573833824929471},{"$f":"_xlfn.BETA.INV(0.975,$U363,$V363)","v":0.86142066110983939},1,0.6428571428571429,0.88664053621752525,"Match IHC + methylation",false,{"$f":"IF($M$363,K363,C363)","v":0.6428571428571429},null,232,33,{"$f":"P363-Q363","v":199},14,{"$f":"P363-S363","v":218},9,5,{"$f":"R363-V363","v":194},{"$f":"Q363-U363","v":24},null,{"$f":"U363/(U363+V363)","v":0.6428571428571429},{"$f":"W363/(W363+X363)","v":0.88990825688073394},{"$f":"U363/(U363+X363)","v":0.27272727272727271},{"$f":"W363/(W363+V363)","v":0.97487437185929648}]
["spec_MMRpro_TBT",0.88990825688073394,{"$f":"AA363","v":0.88990825688073394},{"$f":"_xlfn.BETA.INV(RAND(),W363,X363)","v":0.89569667492279104},"MMRpro + molecular specificity",null,{"$f":"_xlfn.BETA.INV(0.025,$W363,$X363)","v":0.84521395155333245},{"$f":"_xlfn.BETA.INV(0.975,$W363,$X363)","v":0.92783889633042627},1,0.88990825688073394,0.85942828831579865,{"$f":"SUMXMY2(Results!$C$8:$C$9,Results!$T$8:$T$9)","v":1.5406710458959931E-2},null,{"$f":"IF($M$363,K364,C364)","v":0.88990825688073394}]
[]
[]
["Prediction model cost"]
[]
["c_riskprediction",{"$f":"CHOOSE(analysis_mode,C369,D369,J369,N369)","v":116},116,{"$f":"_xlfn.GAMMA.INV(RAND(),R369,S369)","v":133.62053876637916},"Cost of taking family history and administering risk prediction tool","NHS Reference Costs 2017-18 Non-Consultant Led Outpatient Appointment, Face-to-Face, First visit, Gynecologic Oncology",{"$f":"_xlfn.GAMMA.INV(0.025,$R369,$S369)","v":75.069083773928071},{"$f":"_xlfn.GAMMA.INV(0.975,$R369,$S369)","v":165.6948528350149},1,{"$f":"CHOOSE($I369,$C369,$G369,$H369)","v":116},null,null,null,{"$f":"C369","v":116},null,{"$f":"C369","v":116},{"$f":"P369*0.2","v":23.200000000000003},{"$f":"POWER(P369/Q369,2)","v":24.999999999999993},{"$f":"Q369^2/P369","v":4.6400000000000015},"(Gamma)"]
[]
["Acceptance post-prediction models"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Mean","SD","alpha","beta"]
["acceptance_counselling_prediction",{"$f":"CHOOSE(analysis_mode,C373,D373,J373,N373)","v":0.52708596535376451},{"$f":"AVERAGE(C252:C253)","v":0.52708596535376451},{"$f":"_xlfn.BETA.INV(RAND(),$R373,$S373)","v":0.30853604044001787},null,"Assumed midpoint between acceptance with and without tumour testing",{"$f":"_xlfn.BETA.INV(0.025,$R373,$S373)","v":0.32031878653903634},{"$f":"_xlfn.BETA.INV(0.975,$R373,$S373)","v":0.72906101173461224},1,{"$f":"CHOOSE($I373,$C373,$G373,$H373)","v":0.52708596535376451},null,null,null,{"$f":"C373","v":0.52708596535376451},null,{"$f":"$C373","v":0.52708596535376451},{"$f":"P373*0.2","v":0.10541719307075291},{"$f":"P373*(P373*(1-P373)/Q373^2-1)","v":11.295764900802121},{"$f":"(1-P373)/P373*R373","v":10.134828291374296}]

{"sheet":"PSA","index":7,"n_rows":1008,"n_cols":213,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
["Iteration","Parameters",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Results",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Calculations"]
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{"sheet":"PSA Results","index":8,"n_rows":64,"n_cols":9,"rows_kept":64,"cut":false,"hidden":false,"merged":[]}
["Strategy",1,2,3,4,5,6]
["Description","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening"]
["Diagnostic Outcomes (Probands)"]
["True Positives"]
["False Positives"]
["False Negatives"]
["True Negatives"]
["Sensitivity"]
["Specificity"]
["PPV"]
["NPV"]
["Diagnostic Costs (Probands)"]
["IHC"]
["MSI"]
["Methylation"]
["Pre-test counselling"]
["Genetic testing and post-test counselling"]
["Total diagnostic costs"]
["Long-term Costs (Probands)"]
["Total long-term costs"]
["TOTAL COSTS (Probands)"]
["Total costs",{"$f":"PSA!EZ$5","v":654.34841711469494},{"$f":"PSA!FA$5","v":494.9837231412402},{"$f":"PSA!FB$5","v":625.08342132855137},{"$f":"PSA!FC$5","v":510.21395003562338},{"$f":"PSA!FD$5","v":778.77194103049533},{"$f":"PSA!FE$5","v":147.46796579763358}]
["QALYs (Probands)"]
["Short term"]
["Long term"]
["Total QALYs",{"$f":"PSA!FR$5","v":8.9614188124563974},{"$f":"PSA!FS$5","v":8.9607108429452236},{"$f":"PSA!FT$5","v":8.9606549728398885},{"$f":"PSA!FU$5","v":8.9594009569083717},{"$f":"PSA!FV$5","v":8.959630313302851},{"$f":"PSA!FW$5","v":8.9476138250871422}]
["TOTAL COSTS (Relatives)"]
["Total costs",{"$f":"PSA!FF$5","v":1337.0253784910133},{"$f":"PSA!FG$5","v":1128.2018059820584},{"$f":"PSA!FH$5","v":1299.125578270802},{"$f":"PSA!FI$5","v":1131.2935720763603},{"$f":"PSA!FJ$5","v":1057.2431963810504},{"$f":"PSA!FK$5","v":921.31991198691219}]
["QALYs (Relatives)"]
["Total QALYs",{"$f":"PSA!FX$5","v":81.777318500003446},{"$f":"PSA!FY$5","v":81.774299295233448},{"$f":"PSA!FZ$5","v":81.7756295659252},{"$f":"PSA!GA$5","v":81.771792070332154},{"$f":"PSA!GB$5","v":81.772006032173238},{"$f":"PSA!GC$5","v":81.746013356143081}]
["TOTAL COSTS"]
["Total costs",{"$f":"B22+B28","v":1991.3737956057082},{"$f":"C22+C28","v":1623.1855291232987},1924.2089995993533,1641.5075221119837,1836.0151374115458,1068.7878777845458]
["QALYs"]
["Total QALYs",{"$f":"B26+B30","v":90.738737312459847},{"$f":"C26+C30","v":90.735010138178666},90.736284538765091,90.731193027240522,90.73163634547609,90.693627181230227]
[]
[]
["QALY rank",{"$f":"_xlfn.RANK.AVG(B34,$B$34:$G$34,1)","v":6},{"$f":"_xlfn.RANK.AVG(C34,$B$34:$G$34,1)","v":4},5,2,3,1]
["Cost rank",{"$f":"_xlfn.RANK.AVG(B32,$B$32:$G$32,1)","v":6},{"$f":"_xlfn.RANK.AVG(C32,$B$32:$G$32,1)","v":2},5,3,4,1]
["ICER points",{"$f":"B37*COUNT($B$37:$G$37)+B38","v":42},{"$f":"C37*COUNT($B$37:$G$37)+C38","v":26},35,15,22,7]
["ICER rank",{"$f":"_xlfn.RANK.AVG(B39,$B$39:$G$39,1)","v":6},{"$f":"_xlfn.RANK.AVG(C39,$B$39:$G$39,1)","v":4},5,2,3,1]
[]
[]
[null,"QALYs",null,"Costs",null,"ICER","INHB @ £20k/QALY"]
[null,"Absolute","vs. No screening","Absolute","vs. No screening","vs. No screening","vs. No screening"]
[{"$f":"INDEX($B$2:$G$2,I45)","v":"No screening"},{"$f":"INDEX($B$34:$G$34,1,I45)","v":90.693627181230227},{"$f":"B45-$G$34","v":0},{"$f":"INDEX($B$32:$G$32,I45)","v":1068.7878777845458},{"$f":"D45-$G$32","v":0},{"$f":"E45/C45","v":{"$error":"#DIV/0!"}},{"$f":"C45-E45/20000","v":0},1,{"$f":"MATCH(H45,$B$40:$G$40,0)","v":6}]
[{"$f":"INDEX($B$2:$G$2,I46)","v":"MSI with methylation"},{"$f":"INDEX($B$34:$G$34,1,I46)","v":90.731193027240522},{"$f":"B46-$G$34","v":3.7565846010295445E-2},{"$f":"INDEX($B$32:$G$32,I46)","v":1641.5075221119837},{"$f":"D46-$G$32","v":572.71964432743789},{"$f":"E46/C46","v":15245.753926864207},{"$f":"C46-E46/20000","v":8.9298637939235516E-3},2,{"$f":"MATCH(H46,$B$40:$G$40,0)","v":4}]
["Direct mutation testing",90.73163634547609,3.8009164245863758E-2,1836.0151374115458,767.22725962699997,20185.323062200488,-3.5219873548623937E-4,3,5]
["IHC with methylation",90.735010138178666,4.1382956948439187E-2,1623.1855291232987,554.39765133875289,13396.762634180561,1.3663074381501543E-2,4,2]
["MSI",90.736284538765091,4.2657357534864104E-2,1924.2089995993533,855.42112181480752,20053.307828917132,-1.1369855587627098E-4,5,3]
["IHC",90.738737312459847,4.5110131229620265E-2,1991.3737956057082,922.58591782116241,20451.856216622422,-1.0191646614378588E-3,6,1]
[]
[null,{"$f":"1000*B45","v":90693.627181230229},{"$f":"1000*C45","v":0},1068787.8777845458,0]
[null,{"$f":"1000*B46","v":90731.193027240515},37.565846010295445,1641507.5221119837,572719.64432743785]
[null,{"$f":"1000*B47","v":90731.636345476087},38.009164245863758,1836015.1374115457,767227.25962699996]
[null,{"$f":"1000*B48","v":90735.010138178666},41.382956948439187,1623185.5291232986,554397.65133875294]
[null,{"$f":"1000*B49","v":90736.284538765089},42.657357534864104,1924208.9995993534,855421.12181480753]
[null,{"$f":"1000*B50","v":90738.737312459853},45.110131229620265,1991373.7956057081,922585.91782116238]
[]
[null,"IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening"]
["IHC",null,{"$f":"(HLOOKUP(C$59,$B$2:$G$34,31,FALSE)-HLOOKUP($A60,$B$2:$G$34,31,FALSE))/(HLOOKUP(C$59,$B$2:$G$34,33,FALSE)-HLOOKUP($A60,$B$2:$G$34,33,FALSE))","v":98784.82697775455},{"$f":"(HLOOKUP(D$59,$B$2:$G$34,31,FALSE)-HLOOKUP($A60,$B$2:$G$34,31,FALSE))/(HLOOKUP(D$59,$B$2:$G$34,33,FALSE)-HLOOKUP($A60,$B$2:$G$34,33,FALSE))","v":27383.201373183347},46375.006156651645,21878.52141117485,20451.856216622422]
["IHC with methylation",null,null,236207.88760033241,-4799.9634502619328,-63083.190655365637,13396.762634180561]
["MSI",null,null,null,55524.076911781012,18973.794053812846,20053.307828917132]
["MSI with methylation",null,null,null,null,438753.923691437,15245.753926864207]
["Direct mutation testing",null,null,null,null,null,{"$f":"(HLOOKUP(G$59,$B$2:$G$34,31,FALSE)-HLOOKUP($A64,$B$2:$G$34,31,FALSE))/(HLOOKUP(G$59,$B$2:$G$34,33,FALSE)-HLOOKUP($A64,$B$2:$G$34,33,FALSE))","v":20185.323062200488}]

{"sheet":"OWSA","index":9,"n_rows":161,"n_cols":45,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
["Live results",null,null,null,null,{"$f":"Results!B32","v":5519.261869609868},{"$f":"Results!C32","v":5230.5786719954576},{"$f":"Results!D32","v":5464.073297431135},{"$f":"Results!E32","v":5238.3294611194715},{"$f":"Results!F32","v":5462.1088394664575},{"$f":"Results!G32","v":4692.9979054482537},{"$f":"Results!B34","v":105.30104806640469},{"$f":"Results!C34","v":105.29881673456904},{"$f":"Results!D34","v":105.29918368612333},{"$f":"Results!E34","v":105.29536244471645},{"$f":"Results!F34","v":105.29598126993821},{"$f":"Results!G34","v":105.26087962019366},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Intervention",2]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Comparator",6]
[]
[]
[]
["Parameter","Row","Base case value","Lower","Upper","Costs.IHC.lower","Costs.IHCmeth.lower","Costs.MSI.lower","Costs.MSImeth.lower","Costs.Direct.lower","Costs.NoScreening.lower","QALYs.IHC.lower","QALYs.IHCmeth.lower","QALYs.MSI.lower","QALYs.MSImeth.lower","QALYs.Direct.lower","QALYs.NoScreening.lower","Costs.IHC.upper","Costs.IHCmeth.upper","Costs.MSI.upper","Costs.MSImeth.upper","Costs.Direct.upper","Costs.NoScreening.upper","QALYs.IHC.upper","QALYs.IHCmeth.upper","QALYs.MSI.upper","QALYs.MSImeth.upper","QALYs.Direct.upper","QALYs.NoScreening.upper","NMB.IHC.lower","NMB.IHCmeth.lower","NMB.MSI.lower","NMB.MSImeth.lower","NMB.Direct.lower","NMB.NoScreening.lower","NMB.IHC.upper","NMB.IHCmeth.upper","NMB.MSI.upper","NMB.MSImeth.upper","NMB.Direct.upper","NMB.NoScreening.upper","INMB.lower","INMB.upper","ICER.lower","ICER.upper"]
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["disc_QALYs",{"$f":"ROW(INDIRECT($A8))","v":13},{"$f":"INDIRECT(ADDRESS($B8,3,1,0,\"Parameters\"),FALSE)","v":3.5000000000000003E-2},{"$f":"INDIRECT(ADDRESS($B8,7,1,0,\"Parameters\"),FALSE)","v":0.01},{"$f":"INDIRECT(ADDRESS($B8,8,1,0,\"Parameters\"),FALSE)","v":0.06},1885.471370934365,1595.1279168104606,1830.0563337013075,1602.9834810526434,1826.1220407548587,1056.4378498072851,126.47869984280233,126.47393449172843,126.47549663462318,126.4683228661644,126.46893202527221,126.41113838741121,1885.471370934365,1595.1279168104606,1830.0563337013075,1602.9834810526434,1826.1220407548587,1056.4378498072851,71.111518912605533,71.109791491812203,71.110273566194081,71.107567535389066,71.107850617246683,71.08505548448035,2527688.5254851119,2527883.5619177581,2527679.8763587624,2527763.4738422353,2527552.5184646896,2527166.329898417,1420344.9068811764,1420600.7019194334,1420375.4149901802,1420548.3672267287,1420330.8903041787,1420644.6718397997,{"$f":"INDEX($AD8:$AI8,$AQ$1)-INDEX($AD8:$AI8,$AQ$2)","v":717.23201934108511},{"$f":"INDEX($AJ8:$AO8,$AQ$1)-INDEX($AJ8:$AO8,$AQ$2)","v":-43.969920366303995},8578.399454239694,21777.567405128069]
["proband_age",18,60,50,70,2705.48731495946,2416.3084474248021,2636.2916017219077,2397.6338244601302,2591.1667768184489,1552.4061843420941,94.204570346490527,94.200503015650938,94.199034154580531,94.189683380018835,94.192478035385108,94.080875493736258,1482.7151693426633,1210.5995485830344,1436.3111572285507,1229.92400069379,1474.8818640148834,836.35835896303797,89.442367234104651,89.440147145740283,89.44179655801068,89.43964086233045,89.439093664702696,89.432444485119476,1881385.919614851,1881593.7518655939,1881344.3914898888,1881396.0337759166,1881258.3939308836,1880065.1036903833,1787364.6295127503,1787592.3433662227,1787399.620002985,1787562.8932459152,1787306.9914300391,1787812.5313434266,1528.648175210692,-220.18797720386647,7221.6012607772327,48585.963739467246]
["relatives_per_proband",22,6,1.6347980604394876,13.150909604613471,971.54049206764137,789.23130808061251,933.85931329017592,798.05933397478668,1059.1767769941341,391.59467501407283,31.691895206216284,31.690726267008319,31.690936441096184,31.688948331791941,31.689116132048639,31.671283732640525,3382.638555896001,2915.3174245315863,3298.1725788638742,2921.57993867812,3082.5029204425327,2145.5589282857641,191.40539860781428,191.39994307579889,191.40183581603412,191.39377240316824,191.39457118395791,191.33047242619017,632866.36363225803,633025.2940320858,632884.86950863351,632980.907301864,632723.14586397866,633034.07997779653,3824725.3336003893,3825083.5440914463,3824738.5437418185,3824953.8681246866,3824808.9207587154,3824463.8895955179,-8.7859457107260823,619.65449592843652,20451.893027135873,11080.341130842477]
["p_FDR",23,0.42369477479050832,0.38555752832306583,0.46228670605202016,1867.8758240687882,1590.7744215104688,1814.0780862004883,1597.4191861101081,1826.1220407548587,1056.4378498072851,92.231297924758508,92.228676331419067,92.229375154721353,92.225222224273622,92.225744270534847,92.190374528207371,1903.2766976960847,1599.5333159130944,1846.2250791233832,1608.6141153493386,1826.1220407548587,1056.4378498072851,92.231853538782673,92.22888552005378,92.229884382107954,92.225453739687666,92.225744270534847,92.190374528207371,1842758.0826711014,1842982.7522068708,1842773.4250082267,1842907.0252993624,1842688.7633699421,1842751.0527143402,1842733.7940779573,1842978.1770851626,1842751.4625630358,1842900.460678404,1842688.7633699421,1842751.0527143402,231.69949253066443,227.12437082245015,13950.689703821288,14102.349486915711]
["p_rel_LS",24,0.44,0.40698818394053038,0.47398258301177854,1867.5653826865075,1577.2533907267646,1812.3216119866606,1585.5124579900523,1808.3283401439887,1042.4580937867968,92.238559957150827,92.235790091501471,92.236695684379086,92.232525544993479,92.232851085376666,92.199229980401313,1903.9039143286625,1613.5280728437169,1848.3125741872318,1620.9682683922931,1844.4389945088215,1070.828703633528,92.22438278282246,92.221564386035425,92.222353005557238,92.217937664716032,92.218428468069575,92.181258666821677,1842903.63376033,1843138.5484393025,1842921.5920755949,1843064.9984418794,1842848.6933673895,1842942.1415142394,1842583.7517421206,1842817.7596478646,1842598.7475369575,1842737.7850259282,1842524.1303668825,1842554.3446328,196.40692506311461,263.41501506464556,14627.835661518408,13464.574750103355]
["relative_age",25,54,44,64,1921.5452614460701,1590.3279488471803,1859.8526555202775,1598.8109928935262,1806.9653412229804,1008.3614246077569,110.17448513999629,110.17168795213975,110.17213076562379,110.16731645229146,110.16818409869677,110.12373051349591,1666.0914479752753,1429.169036337272,1618.9390515486323,1436.3206808576815,1678.9773852552853,948.41888386967537,72.251470131768755,72.249396399162109,72.250122792870471,72.247060026372395,72.247178681208837,72.22316044385515,2201568.1575384801,2201843.4310939475,2201582.7626569555,2201747.5180529361,2201556.7166327126,2201466.2488453104,1443363.3111873998,1443558.7589469049,1443383.5168058607,1443504.8798465903,1443264.5962389214,1443514.7899932333,377.18224863708019,43.968953671632335,12135.06268676097,18324.09557200631]
["p_rel_female",26,0.52791878172588835,0.4876295559171277,0.56802901681362294,1896.2461221575845,1606.0990830470685,1840.874205188768,1613.9819874305656,1837.177894118588,1067.918957166205,92.107263285877053,92.104445971817739,92.10531093737184,92.100996262324458,92.101397897794115,92.065947808590082,1874.7444881040374,1584.2054915688891,1819.2865221747577,1592.0338371322957,1815.1153046209945,1045.0077489306959,92.355332616452344,92.352562266749317,92.353393284147899,92.349125926662254,92.349538216504726,92.314248464101155,1840249.0195953834,1840482.8203533078,1840265.3445422479,1840405.9432590588,1840190.7800617637,1840251.0372146354,1845231.907840943,1845467.0398434175,1845248.5791607832,1845390.4846961126,1845175.6490254735,1845239.9615330924,231.78313867235556,227.07831032504328,13979.371501397382,14073.198308966681]
["prevalence",{"$f":"ROW(Parameters!B36)","v":36},3.9064271582574646E-2,1.5466015925579529E-2,8.2267894206471778E-2,1613.4978454851425,1316.7906834975386,1562.6360848864629,1335.5401214956678,1568.084043391616,900.4914652311794,92.24032185012959,92.237758851598116,92.239375646068297,92.236533983142891,92.236133289461193,92.222123596242554,2382.7578020357687,2104.0499862221886,2319.0173857659556,2091.986789651105,2297.9282380138548,1341.5759745601558,92.215579349902626,92.212363601669907,92.211805778496284,92.204864860068596,92.206748604923646,92.132323360513936,1843192.9391571067,1843438.386348465,1843224.8768364794,1843395.1395413622,1843154.5817458325,1843541.98045962,1841928.8291960168,1842143.2220471757,1841917.0981841597,1842005.3104117208,1841837.0438604592,1841304.8912357185,-103.59411115502007,838.33081145724282,26625.674400531276,9526.1333630447207]
["wMLH1",{"$f":"ROW(Parameters!B46)","v":46},0.16923076923076924,8.9048996329102875E-2,0.26863424426625704,1878.0452613633975,1587.8089369660033,1822.5370329405869,1595.1248037095686,1818.5420078383695,1046.8753610753884,92.236596423293051,92.233935290670587,92.234707754830907,92.230439938340012,92.230861251915684,92.196707182897114,1895.3981657120621,1604.9115067512926,1840.1077010842068,1613.4885074683361,1836.2545913792605,1069.2204329752865,92.2248605142061,92.221889419772154,92.222838283503719,92.218516378193883,92.218904185081868,92.181909400821013,1842853.8832044976,1843090.8968764455,1842871.6180636776,1843013.6739630906,1842798.6830304754,1842887.2682968669,1842601.8121184099,1842832.8768886917,1842616.6579689903,1842756.8390564094,1842541.829110258,1842568.9675834449,203.62857957859524,263.9093052467797,14530.246317704716,13398.969981246539]
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["Scenario","Switch address","Costs.IHC","Costs.IHCmeth","Costs.MSI","Costs.MSImeth","Costs.Direct","Costs.NoScreening","QALYs.IHC","QALYs.IHCmeth","QALYs.MSI","QALYs.MSImeth","QALYs.Direct","QALYs.NoScreening",null,"IHC with methylation vs. No testing",null,"IHC","IHCmeth","MSI","MSImeth","Direct","NoTesting",null,"IHC","IHCmeth","MSI","MSImeth","Direct"]
["Prevalence estimates from low drop-out studies",{"$f":"ADDRESS(ROW(Parameters!$M$36),COLUMN(Parameters!$M$36),1,1,\"Parameters\")","v":"Parameters!$M$36"},5413.7636775821265,5122.6000270458526,5360.3542664570605,5134.6049324604382,5362.0739817663198,4632.8248333600195,105.3064259117628,105.30429189429179,105.30495075796314,105.30169594812973,105.30200222477781,105.2752055774865,null,{"$f":"(D4-H4)/(J4-N4)","v":16838.680433981328},null,{"$f":"threshold*I4-C4","v":2100714.7545576738},2100963.23785879,2100738.6608928056,2100899.3140301341,2100677.9705137899,2100871.2867163699,null,{"$f":"R4-$W4","v":-156.53215869609267},{"$f":"S4-$W4","v":91.951142420060933},-132.62582356436178,28.027313764207065,-193.31620257999748]
["Weibull CRC incidence",{"$f":"ADDRESS(ROW(Parameters!$M$68),COLUMN(Parameters!$M$68),1,1,\"Parameters\")","v":"Parameters!$M$68"},5525.4597754153365,5236.783167647277,5470.3179754403927,5244.6472173864313,5468.370586327178,4700.2680495388286,105.29427371228408,105.29203638506172,105.2923706377768,105.28848922805861,105.28915209096455,105.25321821292876,null,{"$f":"(D5-H5)/(J5-N5)","v":13821.235999230856},null,2100360.0144702662,2100603.9445335874,2100377.0947800954,2100525.1373437857,2100314.6712329639,2100364.0962090367,null,{"$f":"R5-$W5","v":-4.0817387704737484},{"$f":"S5-$W5","v":239.8483245507814},{"$f":"T5-$W5","v":12.998571058735251},{"$f":"U5-$W5","v":161.04113474907354},{"$f":"V5-$W5","v":-49.42497607273981}]
["Delayed CRC surveillance for MSH6 + PMS2",{"$f":"ADDRESS(ROW(Parameters!$M$176),COLUMN(Parameters!$M$176),1,1,\"Parameters\")","v":"Parameters!$M$176"},5508.4543365559903,5219.8343466160677,5453.7372007599015,5228.7316570676112,5451.7832861155402,4692.9979054482537,105.30000438191469,105.29777915405015,105.29818552828941,105.29443558387067,105.29498413027375,105.26087962019366,null,14277.590693065973,null,2100491.6333017377,2100735.7487343866,2100509.9733650284,2100659.9800203457,2100447.8993193591,2100524.5944984253,null,-32.961196687538177,211.15423596138135,-14.621133396867663,135.38552192039788,-76.695179066155106]
["Colonoscopy effectiveness from Arrigoni",{"$f":"ADDRESS(ROW(Parameters!$M$178),COLUMN(Parameters!$M$178),1,1,\"Parameters\")","v":"Parameters!$M$178"},5436.1539239008061,5146.012833232352,5379.1405575412418,5150.0940894596888,5374.8402390472238,4569.4909339099931,105.35296089053647,105.35186436340929,105.35237275543557,105.35092803632361,105.35092088037482,105.34087886902962,null,52480.287131128607,null,2101623.0638868287,2101891.2744349535,2101668.3145511704,2101868.4666370125,2101643.5773684494,2102248.0864466825,null,-625.02255985373631,-356.81201172899455,-579.77189551200718,-379.61980966990814,-604.50907823303714]
["MLH1 post-MSI from Hampel 2006",{"$f":"ADDRESS(ROW(Parameters!$M$220),COLUMN(Parameters!$M$220),1,1,\"Parameters\")","v":"Parameters!$M$220"},5519.261869609868,5230.5786719954576,5464.073297431135,5238.3294611194715,5462.1088394664575,4692.9979054482537,105.30104806640469,105.29881673456904,105.29918368612333,105.29536244471645,105.29598126993821,105.26087962019366,null,14170.312513174586,null,{"$f":"threshold*I8-C8","v":2100501.6994584841},{"$f":"threshold*J8-D8","v":2100745.7560193855},{"$f":"threshold*K8-E8","v":2100519.6004250352},{"$f":"threshold*L8-F8","v":2100668.9194332091},{"$f":"threshold*M8-G8","v":2100457.5165592982},{"$f":"threshold*N8-H8","v":2100524.5944984253},null,{"$f":"R8-$W8","v":-22.895039941184223},{"$f":"S8-$W8","v":221.16152096027508},{"$f":"T8-$W8","v":-4.9940733900293708},{"$f":"U8-$W8","v":144.32493478385732},{"$f":"V8-$W8","v":-67.07793912710622}]
["Acceptance from Batte",{"$f":"ADDRESS(ROW(Parameters!$M$252),COLUMN(Parameters!$M$252),1,1,\"Parameters\")","v":"Parameters!$M$252"},5703.2270977409662,5320.125464468365,5633.9902741207316,5330.490578167618,5462.1088394664575,4692.9979054482537,105.31322897763714,105.31032100387023,105.31079923192958,105.30581921524595,105.29598126993821,105.26087962019366,null,12684.263917908011,null,2100561.3524550018,2100886.2946129362,2100581.9943644712,2100785.8937267512,2100457.5165592982,2100524.5944984253,null,36.757956576533616,361.70011451095343,57.399866045918316,261.29922832595184,-67.07793912710622]
["CRC costs from Murphy and Gray",{"$f":"ADDRESS(ROW(Parameters!$M$289),COLUMN(Parameters!$M$289),1,1,\"Parameters\")","v":"Parameters!$M$289"},8524.1413761745025,8242.691520214521,8473.8332211551642,8259.0660831032692,8482.1785760841012,7800.771713727725,105.30104806640469,105.29881673456904,105.29918368612333,105.29536244471645,105.29598126993821,105.26087962019366,null,11648.745925008221,null,2097496.8199519194,2097733.6431711665,2097509.8405013112,2097648.1828112253,2097437.4468226801,2097416.8206901457,null,79.999261773657054,316.8224810208194,93.019811165519059,231.36212107958272,20.6261325343512]
["Testing utilities from Kuppermann",{"$f":"ADDRESS(ROW(Parameters!$M$333),COLUMN(Parameters!$M$333),1,1,\"Parameters\")","v":"Parameters!$M$333"},5519.261869609868,5230.5786719954576,5464.073297431135,5238.3294611194715,5462.1088394664575,4692.9979054482537,105.2958467428661,105.29639251992226,105.29438646412805,105.29283815718203,105.28851965428939,105.26087962019366,null,15137.619587685869,null,{"$f":"threshold*I11-C11","v":2100397.6729877121},{"$f":"threshold*J11-D11","v":2100697.27172645},{"$f":"threshold*K11-E11","v":2100423.65598513},{"$f":"threshold*L11-F11","v":2100618.4336825209},{"$f":"threshold*M11-G11","v":2100308.2842463213},{"$f":"threshold*N11-H11","v":2100524.5944984253},null,{"$f":"R11-$W11","v":-126.92151071317494},{"$f":"S11-$W11","v":172.67722802469507},{"$f":"T11-$W11","v":-100.93851329525933},{"$f":"U11-$W11","v":93.839184095617384},{"$f":"V11-$W11","v":-216.31025210395455}]
["CRC utilities from Ness",{"$f":"ADDRESS(ROW(Parameters!$M$343),COLUMN(Parameters!$M$343),1,1,\"Parameters\")","v":"Parameters!$M$343"},5519.261869609868,5230.5786719954576,5464.073297431135,5238.3294611194715,5462.1088394664575,4692.9979054482537,105.27641454073314,105.27410299607575,105.27447968993606,105.27051594147531,105.27115829232905,105.23472236735009,null,13650.893445406871,null,2100009.028945053,2100251.4812495196,2100025.52050129,2100171.9893683866,2099961.0570071149,2100001.4494415536,null,7.5795034994371235,250.03180796606466,24.071059736423194,170.53992683300748,-40.392434438690543]
["Test only heterodimer pairs in IHC arms",{"$f":"ADDRESS(ROW(Parameters!$M$274),COLUMN(Parameters!$M$274),1,1,\"Parameters\")","v":"Parameters!$M$274"},5487.1648053589061,5220.0577327649116,5464.073297431135,5238.3294611194715,5462.1088394664575,4692.9979054482537,105.30104806640469,105.29881673456904,105.29918368612333,105.29536244471645,105.29598126993821,105.26087962019366,null,13892.986749110323,null,{"$f":"threshold*I13-C13","v":2100533.7965227352},{"$f":"threshold*J13-D13","v":2100756.276958616},{"$f":"threshold*K13-E13","v":2100519.6004250352},{"$f":"threshold*L13-F13","v":2100668.9194332091},{"$f":"threshold*M13-G13","v":2100457.5165592982},{"$f":"threshold*N13-H13","v":2100524.5944984253},null,{"$f":"R13-$W13","v":9.2020243098959327},{"$f":"S13-$W13","v":231.68246019072831},{"$f":"T13-$W13","v":-4.9940733900293708},{"$f":"U13-$W13","v":144.32493478385732},{"$f":"V13-$W13","v":-67.07793912710622}]

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["Description",null,"IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","(All)","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","(All)","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","(All)","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening"]
[null,null,"Weights",null,null,null,null,null,"Diagnostic costs (unweighted)",null,null,null,null,null,"Diagnostic costs (weighted)",null,null,null,null,null,"Long-term costs (unweighted)","Long-term costs (weighted)",null,null,null,null,null,"Total costs (weighted)",null,null,null,null,null,"Short term QALYs (unweighted)","Short term QALYs (weighted)",null,null,null,null,null,"Long term QALYs (unweighted)","Long term QALYs (weighted)",null,null,null,null,null,"Total QALYs (weighted)",null,null,null,null,null,"True Positives [including diagnosed Lynch-like if LS] (weighted)",null,null,null,null,null,"False Positives [including diagnosed Lynch-like if sporadic] (weighted)",null,null,null,null,null,"False Negatives (weighted)",null,null,null,null,null,"True Negatives (weighted)",null,null,null,null,null,"True Positives [pathogenic mutation found] (weighted)",null,null,null,null,null,"True Positives [diagnosed LL] (weighted)"]
["Cohort",null,{"$f":"cohort_probands","v":1},1,1,1,1,1,{"$f":"c_IHC*(1+failure_IHC)","v":211.97132895501142},{"$f":"c_IHC*(1+failure_IHC)","v":211.97132895501142},{"$f":"c_MSI*(1+failure_MSI)","v":203.77122708967119},{"$f":"c_MSI*(1+failure_MSI)","v":203.77122708967119},{"$f":"c_offer_counselling","v":27.300506549444513},0,{"$f":"C4*I4","v":211.97132895501142},211.97132895501142,203.77122708967119,203.77122708967119,27.300506549444513,0,null,null,null,null,null,null,null,{"$f":"O4+V4","v":211.97132895501142},211.97132895501142,203.77122708967119,203.77122708967119,27.300506549444513,0]
["Actually LS",null,{"$f":"C4*p_EC_LS","v":3.9789360371212751E-2},3.9789360371212751E-2,3.9789360371212751E-2,3.9789360371212751E-2,3.9789360371212751E-2,3.9789360371212751E-2]
["Actually LS (MLH1)",null,{"$f":"C$5*p_LS_MLH1","v":4.3971344976522185E-3},4.3971344976522185E-3,4.3971344976522185E-3,4.3971344976522185E-3,4.3971344976522185E-3,4.3971344976522185E-3]
["IHC abnormal",null,{"$f":"sens_IHC*C6","v":4.1524887740182178E-3},{"$f":"C8+C17","v":4.1524887740182178E-3},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,{"$f":"C7*I7","v":0.11336504697157918},null,null,null,null,null,null,{"$f":"C7*$U7","v":0},null,null,null,null,null,{"$f":"O7+V7","v":0.11336504697157918},null,null,null,null,null,null,{"$f":"C7*AH7","v":0},null,null,null,null,null,null,{"$f":"C7*$AO7","v":0},null,null,null,null,null,{"$f":"AI7+AP7","v":0}]
["Accept genetic counselling",null,{"$f":"C7*acceptance_counselling_tumour","v":2.3011927211390158E-3},{"$f":"C9+C14","v":2.3011927211390158E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,0.79927831022836371,null,null,null,null,null,null,{"$f":"C8*$U8","v":0},null,null,null,null,null,{"$f":"O8+V8","v":0.79927831022836371},null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["Accept mutation testing",null,{"$f":"C8*acceptance_MMRdiagnostic","v":2.0710734490251141E-3},{"$f":"C10+C11","v":2.0710734490251141E-3},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,1.839416161501999,null,null,null,null,null,null,0,null,null,null,null,null,1.839416161501999,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["MLH1 mutation found","TP",{"$f":"C9*sens_MMRdiagnostic","v":1.8639661041226028E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$3","v":4008.6314807221574},7.4719532039849001,null,null,null,null,null,7.4719532039849001,null,null,null,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$3","v":11.047317507653798},2.0591825375746872E-2,null,null,null,null,null,2.0591825375746872E-2,null,null,null,null,null,{"$f":"C10","v":1.8639661041226028E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C10","v":1.8639661041226028E-3}]
["No mutation found",null,{"$f":"C9*(1-sens_MMRdiagnostic)","v":2.0710734490251136E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",{"$f":"C11*sens_FH","v":6.0357896327413507E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},0.22076590420527561,null,null,null,null,null,0.22076590420527561,null,null,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},6.4946405427205808E-4,null,null,null,null,null,6.4946405427205808E-4,null,null,null,null,null,{"$f":"C12","v":6.0357896327413507E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C12","v":6.0357896327413507E-5}]
["FH negative","FN",{"$f":"C11*(1-sens_FH)","v":1.4674944857509783E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},0.40359517673845635,null,null,null,null,null,0.40359517673845635,null,null,null,null,null,0,0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},1.4701448107534499E-3,null,null,null,null,null,1.4701448107534499E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C13","v":1.4674944857509783E-4}]
["Decline mutation testing",null,{"$f":"C8*(1-acceptance_MMRdiagnostic)","v":2.3011927211390152E-4},null,null,null,null,null,{"$f":"0","v":0},null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",{"$f":"C14*sens_FH","v":6.7064329252681672E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},0.2452954491169729,null,null,null,null,null,0.2452954491169729,null,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},7.2162672696895341E-4,null,null,null,null,null,7.2162672696895341E-4,null,null,null,null,null,{"$f":"C15","v":6.7064329252681672E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C15","v":6.7064329252681672E-5}]
["FH negative","FN",{"$f":"C14*(1-sens_FH)","v":1.6305494286121983E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},0.44843908526495152,null,null,null,null,null,0.44843908526495152,null,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},1.6334942341705001E-3,null,null,null,null,null,1.6334942341705001E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C16","v":1.6305494286121983E-4}]
["Decline genetic counselling","FN",{"$f":"C7*(1-acceptance_counselling_tumour)","v":1.8512960528792018E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},5.0914955041526291,null,null,null,null,null,5.0914955041526291,null,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},1.8546395313478188E-2,null,null,null,null,null,1.8546395313478188E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C17","v":1.8512960528792018E-3}]
["IHC normal","FN",{"$f":"C6*(1-sens_IHC)","v":2.4464572363400091E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},0.67283274333970566,null,null,null,null,null,0.67283274333970566,null,null,null,null,null,{"$f":"0","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},2.4508755880571068E-3,null,null,null,null,null,2.4508755880571068E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C18","v":2.4464572363400091E-4}]
["IHC MLH1 abnormal",null,null,{"$f":"D$6*sens_IHC*p_dMLH1_pathMLH1","v":3.691101132460638E-3},{"$f":"D20+D31","v":3.691101132460638E-3},null,null,null,null,{"$f":"c_methylation","v":136},null,null,null,null,null,{"$f":"D19*J19","v":0.50198975401464674},null,null,null,null,null,null,{"$f":"D19*$U19","v":0},null,null,null,null,null,{"$f":"P19+W19","v":0.50198975401464674},null,null,null,null,null,null,{"$f":"D19*$AH19","v":0},null,null,null,null,null,null,{"$f":"D19*$AO19","v":0},null,null,null,null,null,{"$f":"AJ19+AQ19","v":0}]
["MLH1 unmethylated",null,null,{"$f":"D19*(1-p_methylated_dMLH1_pathMLH1)","v":3.5065460758376059E-3},{"$f":"D21+D30","v":3.5065460758376059E-3},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,9.5730484109333519E-2,null,null,null,null,null,null,0,null,null,null,null,null,9.5730484109333519E-2,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["Accept genetic counselling",null,null,{"$f":"D20*acceptance_counselling_tumour","v":1.9432294089618354E-3},{"$f":"D22+D27","v":1.9432294089618354E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,0.67494612863728487,null,null,null,null,null,null,0,null,null,null,null,null,0.67494612863728487,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["Accept mutation testing",null,null,{"$f":"D21*acceptance_MMRdiagnostic","v":1.7489064680656519E-3},{"$f":"D23+D24","v":1.7489064680656519E-3},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,1.553284758601688,null,null,null,null,null,null,0,null,null,null,null,null,1.553284758601688,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["MLH1 mutation found","TP",null,{"$f":"D22*sens_MMRdiagnostic","v":1.5740158212590868E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$3","v":4008.6314807221574},null,6.309649372253916,null,null,null,null,null,6.309649372253916,null,null,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$3","v":11.047317507653798},null,1.7388652539519579E-2,null,null,null,null,null,1.7388652539519579E-2,null,null,null,null,null,{"$f":"D23","v":1.5740158212590868E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D23","v":1.5740158212590868E-3}]
["No mutation found",null,null,{"$f":"D22*(1-sens_MMRdiagnostic)","v":1.7489064680656515E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D24*sens_FH","v":5.0968890232038074E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,0.18642454132889941,null,null,null,null,null,0.18642454132889941,null,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,5.4843631249640464E-4,null,null,null,null,null,5.4843631249640464E-4,null,null,null,null,null,{"$f":"D25","v":5.0968890232038074E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D25","v":5.0968890232038074E-5}]
["FH negative","FN",null,{"$f":"D24*(1-sens_FH)","v":1.2392175657452708E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,0.34081370480136319,null,null,null,null,null,0.34081370480136319,null,null,null,null,0,null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,1.2414556179695803E-3,null,null,null,null,null,1.2414556179695803E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D26","v":1.2392175657452708E-4}]
["Decline mutation testing",null,null,{"$f":"D21*(1-acceptance_MMRdiagnostic)","v":1.943229408961835E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D27*sens_FH","v":5.6632100257820081E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,0.20713837925433268,null,null,null,null,null,0.20713837925433268,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,6.0937368055156071E-4,null,null,null,null,null,6.0937368055156071E-4,null,null,null,null,null,{"$f":"D28","v":5.6632100257820081E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D28","v":5.6632100257820081E-5}]
["FH negative","FN",null,{"$f":"D27*(1-sens_FH)","v":1.3769084063836341E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,0.37868189422373683,null,null,null,null,null,0.37868189422373683,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,1.3793951310773112E-3,null,null,null,null,null,1.3793951310773112E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D29","v":1.3769084063836341E-4}]
["Decline genetic counselling","FN",null,{"$f":"D20*(1-acceptance_counselling_tumour)","v":1.5633166668757705E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,4.2994850923955532,null,null,null,null,null,4.2994850923955532,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,1.5661400486937139E-2,null,null,null,null,null,1.5661400486937139E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D30","v":1.5633166668757705E-3}]
["MLH1 methylated","FN",null,{"$f":"D19*p_methylated_dMLH1_pathMLH1","v":1.845550566230319E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,0.50756940771488501,null,null,null,null,null,0.50756940771488501,null,null,null,null,{"$f":"0","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,1.8488836682327451E-3,null,null,null,null,null,1.8488836682327451E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D31","v":1.845550566230319E-4}]
["IHC other abnormal",null,null,{"$f":"D$6*sens_IHC*(1-p_dMLH1_pathMLH1)","v":4.6138764155757996E-4},{"$f":"D33+D42","v":4.6138764155757991E-4},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,1.259611633017547E-2,null,null,null,null,null,null,0,null,null,null,null,null,1.259611633017547E-2,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["Accept genetic counselling",null,null,{"$f":"D32*acceptance_counselling_tumour","v":2.5568808012655742E-4},{"$f":"D34+D39","v":2.5568808012655742E-4},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,8.8808701136484897E-2,null,null,null,null,null,null,0,null,null,null,null,null,8.8808701136484897E-2,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["Accept mutation testing",null,null,{"$f":"D33*acceptance_MMRdiagnostic","v":2.3011927211390168E-4},{"$f":"D35+D36","v":2.3011927211390168E-4},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,0.20437957350022221,null,null,null,null,null,null,0,null,null,null,null,null,0.20437957350022221,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["MLH1 mutation found","TP",null,{"$f":"D34*sens_MMRdiagnostic","v":2.0710734490251152E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$3","v":4008.6314807221574},null,0.83021702266498931,null,null,null,null,null,0.83021702266498931,null,null,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$3","v":11.047317507653798},null,2.287980597305209E-3,null,null,null,null,null,2.287980597305209E-3,null,null,null,null,null,{"$f":"D35","v":2.0710734490251152E-4},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D35","v":2.0710734490251152E-4}]
["No mutation found",null,null,{"$f":"D34*(1-sens_MMRdiagnostic)","v":2.3011927211390163E-5},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D36*sens_FH","v":6.7064329252681704E-6},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,2.4529544911697301E-2,null,null,null,null,null,2.4529544911697301E-2,null,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,7.2162672696895371E-5,null,null,null,null,null,7.2162672696895371E-5,null,null,null,null,null,{"$f":"D37","v":6.7064329252681704E-6},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D37","v":6.7064329252681704E-6}]
["FH negative","FN",null,{"$f":"D36*(1-sens_FH)","v":1.6305494286121992E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,4.4843908526495176E-2,null,null,null,null,null,4.4843908526495176E-2,null,null,null,null,0,null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,1.6334942341705012E-4,null,null,null,null,null,1.6334942341705012E-4,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D38","v":1.6305494286121992E-5}]
["Decline mutation testing",null,null,{"$f":"D33*(1-acceptance_MMRdiagnostic)","v":2.5568808012655736E-5},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D39*sens_FH","v":7.4515921391868558E-6},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,2.7255049901885889E-2,null,null,null,null,null,2.7255049901885889E-2,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,8.0180747440994861E-5,null,null,null,null,null,8.0180747440994861E-5,null,null,null,null,null,{"$f":"D40","v":7.4515921391868558E-6},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D40","v":7.4515921391868558E-6}]
["FH negative","FN",null,{"$f":"D39*(1-sens_FH)","v":1.8117215873468877E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,4.9826565029439079E-2,null,null,null,null,null,4.9826565029439079E-2,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,1.8149935935227787E-4,null,null,null,null,null,1.8149935935227787E-4,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D41","v":1.8117215873468877E-5}]
["Decline genetic counselling","FN",null,{"$f":"D32*(1-acceptance_counselling_tumour)","v":2.0569956143102252E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,0.56572172268362575,null,null,null,null,null,0.56572172268362575,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,2.0607105903864666E-3,null,null,null,null,null,2.0607105903864666E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D42","v":2.0569956143102252E-4}]
["IHC normal","FN",null,{"$f":"D$6*(1-sens_IHC)","v":2.4464572363400091E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,0.67283274333970566,null,null,null,null,null,0.67283274333970566,null,null,null,null,{"$f":"0","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,2.4508755880571068E-3,null,null,null,null,null,2.4508755880571068E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D43","v":2.4464572363400091E-4}]
["MSI-H or MSI-L",null,null,null,{"$f":"E$6*sens_MSI","v":3.9713526834010068E-3},{"$f":"E45+E54","v":3.9713526834010068E-3},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,{"$f":"E44*K44","v":0.10841993994334323},null,null,null,null,null,null,{"$f":"E44*$U44","v":0},null,null,null,null,null,{"$f":"Q44+X44","v":0.10841993994334323},null,null,null,null,null,null,{"$f":"E44*$AH44","v":0},null,null,null,null,null,null,{"$f":"E44*$AO44","v":0},null,null,null,null,null,{"$f":"AK44+AR44","v":0}]
["Accept genetic counselling",null,null,null,{"$f":"E44*acceptance_counselling_tumour","v":2.200812184080862E-3},{"$f":"E46+E51","v":2.200812184080862E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,0.7644129183371775,null,null,null,null,null,null,0,null,null,null,null,null,0.7644129183371775,null,null,null,null,null,null,{"$f":"E45*$AH45","v":0},null,null,null,null,null,null,{"$f":"E45*$AO45","v":0},null,null,null,null,null,0]
["Accept mutation testing",null,null,null,{"$f":"E45*acceptance_MMRdiagnostic","v":1.9807309656727757E-3},{"$f":"E47+E48","v":1.9807309656727757E-3},null,null,null,null,{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,1.7591788217655744,null,null,null,null,null,null,0,null,null,null,null,null,1.7591788217655744,null,null,null,null,null,null,{"$f":"E46*$AH46","v":0},null,null,null,null,null,null,{"$f":"E46*$AO46","v":0},null,null,null,null,null,0]
["MLH1 mutation found","TP",null,null,{"$f":"E46*sens_MMRdiagnostic","v":1.7826578691054981E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$3","v":4008.6314807221574},null,null,7.1460184534533786,null,null,null,null,null,7.1460184534533786,null,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,null,{"$f":"E47*$AH47","v":0},null,null,null,{"$f":"'MM-Summary'!$I$3","v":11.047317507653798},null,null,{"$f":"E47*$AO47","v":1.969358748752598E-2},null,null,null,null,null,1.969358748752598E-2,null,null,null,null,null,{"$f":"E47","v":1.7826578691054981E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E47","v":1.7826578691054981E-3}]
["No mutation found",null,null,null,{"$f":"E46*(1-sens_MMRdiagnostic)","v":1.9807309656727753E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,{"$f":"E48*$AH48","v":0},null,null,null,null,null,null,{"$f":"E48*$AO48","v":0},null,null,null,null,null,0]
["FH positive","LL",null,null,{"$f":"E48*sens_FH","v":5.7725019040174718E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,null,0.2111358546119996,null,null,null,null,null,0.2111358546119996,null,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,null,{"$f":"E49*$AH49","v":0},null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,null,{"$f":"E49*$AO49","v":6.2113372367048796E-4},null,null,null,null,null,6.2113372367048796E-4,null,null,null,null,null,{"$f":"E49","v":5.7725019040174718E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E49","v":5.7725019040174718E-5}]
["FH negative","FN",null,null,{"$f":"E48*(1-sens_FH)","v":1.4034807752710281E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,0.3859899148136603,null,null,null,null,null,0.3859899148136603,null,null,null,0,null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,null,1.4060154902054325E-3,null,null,null,null,null,1.4060154902054325E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E50","v":1.4034807752710281E-4}]
["Decline mutation testing",null,null,null,{"$f":"E45*(1-acceptance_MMRdiagnostic)","v":2.2008121840808614E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,null,{"$f":"E51*sens_FH","v":6.413891004463858E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,null,0.2345953940133329,null,null,null,null,null,0.2345953940133329,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,null,6.9014858185609772E-4,null,null,null,null,null,6.9014858185609772E-4,null,null,null,null,null,6.413891004463858E-5,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E52","v":6.413891004463858E-5}]
["FH negative","FN",null,null,{"$f":"E51*(1-sens_FH)","v":1.5594230836344755E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,0.42887768312628916,null,null,null,null,null,0.42887768312628916,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,null,1.5622394335615916E-3,null,null,null,null,null,1.5622394335615916E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E53","v":1.5594230836344755E-4}]
["Decline genetic counselling","FN",null,null,{"$f":"E44*(1-acceptance_counselling_tumour)","v":1.7705404993201446E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,4.8693989155266042,null,null,null,null,null,4.8693989155266042,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},null,null,{"$f":"E54*$AH54","v":0},null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,null,{"$f":"E54*$AO54","v":1.7737381316102828E-2},null,null,null,null,null,1.7737381316102828E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E54","v":1.7705404993201446E-3}]
["MSS","FN",null,null,{"$f":"E$6*(1-sens_MSI)","v":4.25781814251212E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,1.17099919790703,null,null,null,null,null,1.17099919790703,null,null,null,{"$f":"0","v":0},null,null,{"$f":"E55*$AH55","v":0},null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,null,{"$f":"E55*$AO55","v":4.2655078490075431E-3},null,null,null,null,null,4.2655078490075431E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E55","v":4.25781814251212E-4}]
["MSI-H or MSI-L",null,null,null,null,{"$f":"F$6*sens_MSI","v":3.9713526834010068E-3},{"$f":"F57+F68","v":3.9713526834010068E-3},null,null,null,null,{"$f":"c_methylation","v":136},null,null,null,null,null,{"$f":"F56*L56","v":0.54010396494253698},null,null,null,null,null,null,{"$f":"F56*$U56","v":0},null,null,null,null,null,{"$f":"R56+Y56","v":0.54010396494253698},null,null,null,null,null,null,{"$f":"F56*$AH56","v":0},null,null,null,null,null,null,{"$f":"F56*$AO56","v":0},null,null,null,null,null,{"$f":"AL56+AS56","v":0}]
["MLH1 unmethylated",null,null,null,null,{"$f":"F56*(1-p_methylated_MSI_pathMLH1)","v":3.7727850492309564E-3},{"$f":"F58+F67","v":3.772785049230956E-3},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,0.10299894294617606,null,null,null,null,null,null,0,null,null,null,null,null,0.10299894294617606,null,null,null,null,null,null,0,null,null,null,null,null,null,{"$f":"F57*$AO57","v":0},null,null,null,null,null,0]
["Accept genetic counselling",null,null,null,null,{"$f":"F57*acceptance_counselling_tumour","v":2.0907715748768188E-3},{"$f":"F59+F64","v":2.0907715748768188E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,0.7261922724203187,null,null,null,null,null,null,0,null,null,null,null,null,0.7261922724203187,null,null,null,null,null,null,0,null,null,null,null,null,null,{"$f":"F58*$AO58","v":0},null,null,null,null,null,0]
["Accept mutation testing",null,null,null,null,{"$f":"F58*acceptance_MMRdiagnostic","v":1.8816944173891371E-3},{"$f":"F60+F61","v":1.8816944173891371E-3},null,null,null,null,{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,1.671219880677296,null,null,null,null,null,null,0,null,null,null,null,null,1.671219880677296,null,null,null,null,null,null,0,null,null,null,null,null,null,{"$f":"F59*$AO59","v":0},null,null,null,null,null,0]
["MLH1 mutation found","TP",null,null,null,{"$f":"F59*sens_MMRdiagnostic","v":1.6935249756502234E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$3","v":4008.6314807221574},null,null,null,6.7887175307807111,null,null,null,null,null,6.7887175307807111,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,null,null,0,null,null,{"$f":"'MM-Summary'!$I$3","v":11.047317507653798},null,null,null,{"$f":"F60*$AO60","v":1.8708908113149684E-2},null,null,null,null,null,1.8708908113149684E-2,null,null,null,null,null,{"$f":"F60","v":1.6935249756502234E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F60","v":1.6935249756502234E-3}]
["No mutation found",null,null,null,null,{"$f":"F59*(1-sens_MMRdiagnostic)","v":1.8816944173891367E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,{"$f":"F61*$AO61","v":0},null,null,null,null,null,0]
["FH positive","LL",null,null,null,{"$f":"F61*sens_FH","v":5.4838768088165986E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,null,null,0.20057906188139965,null,null,null,null,null,0.20057906188139965,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},null,null,null,{"$f":"F62*$AH62","v":0},null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796},null,null,null,5.9007703748696356E-4,null,null,null,null,null,5.9007703748696356E-4,null,null,null,null,null,{"$f":"F62","v":5.4838768088165986E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F62","v":5.4838768088165986E-5}]
["Decline mutation testing",null,null,null,null,{"$f":"F58*(1-acceptance_MMRdiagnostic)","v":2.0907715748768184E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["MLH1 methylated","FN",null,null,null,{"$f":"F56*p_methylated_MSI_pathMLH1","v":1.9856763417005035E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,null,0.54610726095087947,null,null,null,null,null,0.54610726095087947,null,null,{"$f":"0","v":0},null,null,null,{"$f":"F68*$AH68","v":0},null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,null,null,{"$f":"F68*$AO68","v":1.9892625137143166E-3},null,null,null,null,null,1.9892625137143166E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F68","v":1.9856763417005035E-4}]
["No mutation found","FN",null,null,null,null,{"$f":"G71*(1-sens_MMRdiagnostic)","v":1.9787105239434978E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,null,null,0.54419149876160766,null,null,null,null,null,0.54419149876160766,null,0,null,null,null,null,{"$f":"G73*$AH73","v":0},null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571},null,null,null,null,{"$f":"G73*$AO73","v":1.9822841155482237E-3},null,null,null,null,null,1.9822841155482237E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"G73","v":1.9787105239434978E-4}]
["Actually LS (MSH2)",null,{"$f":"C$5*p_LS_MSH2","v":1.1344805094209589E-2},1.1344805094209589E-2,1.1344805094209589E-2,1.1344805094209589E-2,1.1344805094209589E-2,1.1344805094209589E-2,null,null,null,null,null,null,{"$f":"C77*I77","v":0},{"$f":"D77*J77","v":0},{"$f":"E77*K77","v":0},{"$f":"F77*L77","v":0},{"$f":"G77*M77","v":0},{"$f":"H77*N77","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"AI77+AP77","v":0},{"$f":"AJ77+AQ77","v":0},{"$f":"AK77+AR77","v":0},{"$f":"AL77+AS77","v":0},{"$f":"AM77+AT77","v":0},{"$f":"AN77+AU77","v":0}]
["FH positive","LL",{"$f":"C82*sens_FH","v":1.5572609163914044E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$7","v":3530.9657796484967},0.54986350057621081,null,null,null,null,null,0.54986350057621081,null,null,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},{"$f":"C83*AH83","v":0},null,null,null,null,null,{"$f":"'MM-Summary'!$I$7","v":10.847751169286413},1.6892778926668889E-3,null,null,null,null,null,1.6892778926668889E-3,null,null,null,null,null,{"$f":"C83","v":1.5572609163914044E-4},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C83","v":1.5572609163914044E-4}]
["Decline genetic counselling","FN",{"$f":"C78*(1-acceptance_counselling_tumour)","v":4.7764272170451186E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},12.085436908572014,null,null,null,null,null,12.085436908572014,null,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},{"$f":"C88*AH88","v":0},null,null,null,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},{"$f":"C88*$AO88","v":4.8552731448212559E-2},null,null,null,null,null,4.8552731448212559E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C88","v":4.7764272170451186E-3}]
["MSH2 mutation found","TP",null,{"$f":"D93*sens_MMRdiagnostic","v":1.9309415257880055E-6},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$6","v":3918.0986432146274},null,7.5656193723167668E-3,null,null,null,null,null,7.5656193723167668E-3,null,null,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$6","v":11.111842756275266},null,2.1456318606118558E-5,null,null,null,null,null,2.1456318606118558E-5,null,null,null,null,null,{"$f":"D94","v":1.9309415257880055E-6},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D94","v":1.9309415257880055E-6}]
["FH positive","LL",null,{"$f":"D95*sens_FH","v":6.2526656557776196E-8},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$7","v":3530.9657796484967},null,2.2077948462134202E-4,null,null,null,null,null,2.2077948462134202E-4,null,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},null,{"$f":"D96*$AH96","v":0},null,null,null,null,{"$f":"'MM-Summary'!$I$7","v":10.847751169286413},null,{"$f":"D96*$AO96","v":6.7827361178618667E-7},null,null,null,null,null,6.7827361178618667E-7,null,null,null,null,null,{"$f":"D96","v":6.2526656557776196E-8},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D96","v":6.2526656557776196E-8}]
["Accept genetic counselling",null,null,{"$f":"D103*acceptance_counselling_tumour","v":5.9000735083787901E-3},{"$f":"D105+D110","v":5.9000735083787901E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,2.049285459961808,null,null,null,null,null,null,0,null,null,null,null,null,2.049285459961808,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","FN",null,{"$f":"D107*(1-sens_FH)","v":3.7625381218769519E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,0.95200690854809289,null,null,null,null,null,0.95200690854809289,null,null,null,null,0,null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,3.8246474759049609E-3,null,null,null,null,null,3.8246474759049609E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D109","v":3.7625381218769519E-4}]
["Decline genetic counselling","FN",null,{"$f":"D103*(1-acceptance_counselling_tumour)","v":4.7465745469385872E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,12.009902927893441,null,null,null,null,null,12.009902927893441,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},null,{"$f":"D113*$AH113","v":0},null,null,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,{"$f":"D113*$AO113","v":4.8249276876661237E-2},null,null,null,null,null,4.8249276876661237E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D113","v":4.7465745469385872E-3}]
["IHC normal","FN",null,{"$f":"D$77*(1-sens_IHC)","v":6.3119698822983867E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,1.5970705783833845,null,null,null,null,null,1.5970705783833845,null,null,null,null,{"$f":"0","v":0},null,{"$f":"D114*$AH114","v":0},null,null,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,{"$f":"D114*$AO114","v":6.4161634769770324E-3},null,null,null,null,null,6.4161634769770324E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D114","v":6.3119698822983867E-4}]
["No mutation found",null,null,null,{"$f":"E117*(1-sens_MMRdiagnostic)","v":5.1103751230764541E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,{"$f":"E119*$AH119","v":0},null,null,null,null,null,null,{"$f":"E119*$AO119","v":0},null,null,null,null,null,0]
["FH negative","FN",null,null,{"$f":"E122*(1-sens_FH)","v":4.0233818075590923E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,null,1.0180062373991896,null,null,null,null,null,1.0180062373991896,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,null,4.0897969871482578E-3,null,null,null,null,null,4.0897969871482578E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E124","v":4.0233818075590923E-4}]
["No mutation found",null,null,null,null,{"$f":"F130*(1-sens_MMRdiagnostic)","v":4.745348328570994E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","FN",null,null,null,{"$f":"F132*(1-sens_FH)","v":3.3623976534600988E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,null,null,0.85076235554075141,null,null,null,null,null,0.85076235554075141,null,null,0,null,null,null,0,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,null,null,3.4179017678310441E-3,null,null,null,null,null,3.4179017678310441E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F134","v":3.3623976534600988E-4}]
["MSS","FN",null,null,null,{"$f":"F$77*(1-sens_MSI)","v":1.0985362621766684E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,null,null,2.7795442252185878,null,null,null,null,null,2.7795442252185878,null,null,{"$f":"0","v":0},null,null,null,{"$f":"F140*$AH140","v":0},null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,null,null,{"$f":"F140*$AO140","v":1.1166701322957304E-2},null,null,null,null,null,1.1166701322957304E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F140","v":1.0985362621766684E-3}]
["Decline mutation testing","FN",null,null,null,null,{"$f":"G141*(1-acceptance_MMRdiagnostic)","v":5.6724025471047938E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,null,null,null,1.4352456341932491,null,null,null,null,null,1.4352456341932491,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,null,null,0,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232},null,null,null,null,5.766038610468256E-3,null,null,null,null,null,5.766038610468256E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"G145","v":5.6724025471047938E-4}]
["Accept mutation testing",null,{"$f":"C150*acceptance_MMRdiagnostic","v":9.6363698616743227E-3},{"$f":"C152+C153","v":9.6363698616743227E-3},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,8.5585059622671036,null,null,null,null,null,null,0,null,null,null,null,null,8.5585059622671036,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","FN",{"$f":"C153*(1-sens_FH)","v":6.828014545462172E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},1.0355107839002531,null,null,null,null,null,1.0355107839002531,null,null,null,null,null,0,0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},7.3894128461823548E-3,null,null,null,null,null,7.3894128461823548E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C155","v":6.828014545462172E-4}]
["IHC normal","FN",{"$f":"C$148*(1-sens_IHC)","v":1.138296992375573E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},1.7262980373547894,null,null,null,null,null,1.7262980373547894,null,null,null,null,null,{"$f":"0","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},1.231887595175217E-2,null,null,null,null,null,1.231887595175217E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C160","v":1.138296992375573E-3}]
["Accept mutation testing",null,null,{"$f":"D163*acceptance_MMRdiagnostic","v":3.8691652918435852E-6},{"$f":"D165+D166","v":3.8691652918435852E-6},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,3.4363847272967417E-3,null,null,null,null,null,null,0,null,null,null,null,null,3.4363847272967417E-3,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D169*sens_FH","v":1.2528912250185476E-7},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$10","v":2957.4324421088386},null,3.7053411553033378E-4,null,null,null,null,null,3.7053411553033378E-4,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$10","v":11.22747375577938},null,1.4066803347742021E-6,null,null,null,null,null,1.4066803347742021E-6,null,null,null,null,null,1.2528912250185476E-7,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D170","v":1.2528912250185476E-7}]
["Accept genetic counselling",null,null,{"$f":"D174*acceptance_counselling_tumour","v":1.0640158388932064E-2},{"$f":"D176+D181","v":1.0640158388932064E-2},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,3.6956695280429805,null,null,null,null,null,null,0,null,null,null,null,null,3.6956695280429805,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["Accept mutation testing",null,null,{"$f":"D175*acceptance_MMRdiagnostic","v":9.5761425500388575E-3},{"$f":"D177+D178","v":9.5761425500388575E-3},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,8.5050153000029329,null,null,null,null,null,null,0,null,null,null,null,null,8.5050153000029329,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","FN",null,{"$f":"D181*(1-sens_FH)","v":7.5392660606144813E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},null,1.1433764905565296,null,null,null,null,null,1.1433764905565296,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},null,8.1591433509930165E-3,null,null,null,null,null,8.1591433509930165E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D183","v":7.5392660606144813E-4}]
["IHC normal","FN",null,{"$f":"D$148*(1-sens_IHC)","v":1.138296992375573E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},null,1.7262980373547894,null,null,null,null,null,1.7262980373547894,null,null,null,null,{"$f":"0","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},null,1.231887595175217E-2,null,null,null,null,null,1.231887595175217E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D185","v":1.138296992375573E-3}]
["FH positive","LL",null,null,{"$f":"E190*sens_FH","v":2.6858517934511499E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$10","v":2957.4324421088386},null,null,0.79432252286486382,null,null,null,null,null,0.79432252286486382,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$10","v":11.22747375577938},null,null,3.0155330522885766E-3,null,null,null,null,null,3.0155330522885766E-3,null,null,null,null,null,{"$f":"E191","v":2.6858517934511499E-4},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E191","v":2.6858517934511499E-4}]
["Decline genetic counselling","FN",null,null,{"$f":"E186*(1-acceptance_counselling_tumour)","v":8.2380386434646215E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},null,null,12.493496896786727,null,null,null,null,null,12.493496896786727,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},null,null,8.9153689076161308E-2,null,null,null,null,null,8.9153689076161308E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E196","v":8.2380386434646215E-3}]
["MSH6 mutation found","TP",null,null,null,{"$f":"F201*sens_MMRdiagnostic","v":7.7019603195538798E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$9","v":3514.8279678890995},null,null,null,27.071065538740044,null,null,null,null,null,27.071065538740044,null,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,null,null,0,null,null,{"$f":"'MM-Summary'!$I$9","v":11.384253049172225},null,null,null,8.7681065252484744E-2,null,null,null,null,null,8.7681065252484744E-2,null,null,null,null,null,{"$f":"F202","v":7.7019603195538798E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F202","v":7.7019603195538798E-3}]
["Decline mutation testing",null,null,null,null,{"$f":"F200*(1-acceptance_MMRdiagnostic)","v":9.5085929871035525E-4},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["MSS","FN",null,null,null,{"$f":"F$148*(1-sens_MSI)","v":1.9810939319562684E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},null,null,null,3.0044519044316313,null,null,null,null,null,3.0044519044316313,null,null,{"$f":"0","v":0},null,null,null,0,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},null,null,null,2.1439791688816143E-2,null,null,null,null,null,2.1439791688816143E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F211","v":1.9810939319562684E-3}]
["No mutation found","FN",null,null,null,null,{"$f":"G213*(1-sens_MMRdiagnostic)","v":9.2066201065357366E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},null,null,null,null,1.3962410800554834,null,null,null,null,null,1.3962410800554834,null,0,null,null,null,null,0,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701},null,null,null,null,9.9635869888954724E-3,null,null,null,null,null,9.9635869888954724E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"G215","v":9.2066201065357366E-4}]
["Accept genetic counselling",null,{"$f":"C220*acceptance_counselling_tumour","v":1.8778796223141876E-3},{"$f":"C222+C227","v":1.8778796223141876E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,0.65224804404588976,null,null,null,null,null,null,0,null,null,null,null,null,0.65224804404588976,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","FN",{"$f":"C224*(1-sens_FH)","v":1.1975433284380371E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$14","v":804.48484252274875},9.6340545599264263E-2,null,null,null,null,null,9.6340545599264263E-2,null,null,null,null,null,0,0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$14","v":11.267352610670535},1.3493142948067399E-3,null,null,null,null,null,1.3493142948067399E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C226","v":1.1975433284380371E-4}]
["IHC MLH1 abnormal",null,null,{"$f":"D$219*sens_IHC*p_dMLH1_pathNonMLH1","v":2.1178892306001484E-5},{"$f":"D233+D244","v":2.1178892306001484E-5},null,null,null,null,{"$f":"c_methylation","v":136},null,null,null,null,null,{"$f":"D232*J232","v":2.8803293536162019E-3},null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"P232+W232","v":2.8803293536162019E-3},null,null,null,null,null,null,{"$f":"D232*$AH232","v":0},null,null,null,null,null,null,{"$f":"D232*$AO232","v":0},null,null,null,null,null,{"$f":"AJ232+AQ232","v":0}]
["Accept genetic counselling",null,null,{"$f":"D233*acceptance_counselling_tumour","v":7.540003923900817E-7},{"$f":"D235+D240","v":7.540003923900817E-7},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,2.6188860846160353E-4,null,null,null,null,null,null,0,null,null,null,null,null,2.6188860846160353E-4,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["No mutation found",null,null,{"$f":"D235*(1-sens_MMRdiagnostic)","v":6.7860035315107342E-8},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","FN",null,{"$f":"D240*(1-sens_FH)","v":5.3425986345745555E-8},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$14","v":804.48484252274875},null,4.2980396211979639E-5,null,null,null,null,null,4.2980396211979639E-5,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$14","v":11.267352610670535},null,6.0196942673038451E-7,null,null,null,null,null,6.0196942673038451E-7,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D242","v":5.3425986345745555E-8}]
["Accept mutation testing",null,null,{"$f":"D246*acceptance_MMRdiagnostic","v":1.6795285872072516E-3},{"$f":"D248+D249","v":1.6795285872072516E-3},null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,1.4916670524011804,null,null,null,null,null,null,0,null,null,null,null,null,1.4916670524011804,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D252*sens_FH","v":5.4385544952439093E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$13","v":2559.1494572527472},null,0.13918073784742938,null,null,null,null,null,0.13918073784742938,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$13","v":11.47791282376992},null,6.2423254383731606E-4,null,null,null,null,null,6.2423254383731606E-4,null,null,null,null,null,{"$f":"D253","v":5.4385544952439093E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D253","v":5.4385544952439093E-5}]
["MSI-H or MSI-L",null,null,null,{"$f":"E$219*sens_MSI","v":3.2408073468484584E-3},{"$f":"E258+E267","v":3.2408073468484584E-3},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,{"$f":"E257*K257","v":8.8475682198124239E-2},null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"Q257+X257","v":8.8475682198124239E-2},null,null,null,null,null,null,{"$f":"E257*$AH257","v":0},null,null,null,null,null,null,{"$f":"E257*$AO257","v":0},null,null,null,null,null,{"$f":"AK257+AR257","v":0}]
["FH negative","FN",null,null,{"$f":"E261*(1-sens_FH)","v":1.1453051819521924E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$14","v":804.48484252274875},null,null,9.2138065894329768E-2,null,null,null,null,null,9.2138065894329768E-2,null,null,null,0,null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$14","v":11.267352610670535},null,null,1.2904557331883527E-3,null,null,null,null,null,1.2904557331883527E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E263","v":1.1453051819521924E-4}]
["FH negative","FN",null,null,{"$f":"E264*(1-sens_FH)","v":1.2725613132802139E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$14","v":804.48484252274875},null,null,0.10237562877147752,null,null,null,null,null,0.10237562877147752,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$14","v":11.267352610670535},null,null,1.4338397035426143E-3,null,null,null,null,null,1.4338397035426143E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E266","v":1.2725613132802139E-4}]
["Accept mutation testing",null,null,null,null,{"$f":"F271*acceptance_MMRdiagnostic","v":1.5009131595795438E-3},{"$f":"F273+F274","v":1.5009131595795436E-3},null,null,null,null,{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,1.3330304263430128,null,null,null,null,null,null,0,null,null,null,null,null,1.3330304263430128,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,null,null,{"$f":"F277*sens_FH","v":4.860172118043732E-5},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$13","v":2559.1494572527472},null,null,null,0.12437906838046552,null,null,null,null,null,0.12437906838046552,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,null,0,null,null,{"$f":"'MM-Summary'!$I$13","v":11.47791282376992},null,null,null,5.5784631879423165E-4,null,null,null,null,null,5.5784631879423165E-4,null,null,null,null,null,{"$f":"F278","v":4.860172118043732E-5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F278","v":4.860172118043732E-5}]
["Accept genetic counselling",null,null,null,null,null,{"$f":"G$219*acceptance_counselling_direct","v":1.7941324935246499E-3},{"$f":"G284+G287","v":1.7941324935246499E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,{"$f":"G283*M283","v":0.62315997029592274},null,null,null,null,null,null,{"$f":"G283*$U283","v":0},null,null,null,null,null,{"$f":"S283+Z283","v":0.62315997029592274},null,null,null,null,null,null,{"$f":"G283*$AH283","v":0},null,null,null,null,null,null,{"$f":"G283*$AO283","v":0},null,null,null,null,null,{"$f":"AM283+AT283","v":0}]
["PMS2 mutation found","TP",null,null,null,null,{"$f":"G284*sens_MMRdiagnostic","v":1.4532473197549666E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,{"$f":"'MM-Summary'!$J$12","v":3237.9351558431454},null,null,null,null,4.7055205867694312,null,null,null,null,null,4.7055205867694312,null,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},null,null,null,null,0,null,{"$f":"'MM-Summary'!$I$12","v":11.559367285291604},null,null,null,null,1.6798619525413266E-2,null,null,null,null,null,1.6798619525413266E-2,null,null,null,null,null,{"$f":"G285","v":1.4532473197549666E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"G285","v":1.4532473197549666E-3}]
["Accept mutation testing",null,{"$f":"C292*acceptance_MMRdiagnostic","v":0.12081145549422868},null,null,null,null,null,{"$f":"IF(AND(scenario_analysis,Parameters!$M$274),Parameters!$K$274,c_MMR_proband)+c_posttest_proband","v":888.14627137817843},null,null,null,null,null,107.29824373696995,null,null,null,null,null,null,0,null,null,null,null,null,107.29824373696995,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",{"$f":"C297*(1-spec_FH)","v":3.3233784945270726E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$15","v":1807.4247336343246},6.0067564902366373,null,null,null,null,null,6.0067564902366373,null,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$15","v":8.9569461379480586},2.9767322171493898E-2,null,null,null,null,null,2.9767322171493898E-2,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C298","v":3.3233784945270726E-3}]
["FH negative","TN",{"$f":"C297*spec_FH","v":1.0100116560387222E-2},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"'MM-Summary'!$J$16","v":70.707408025595356},0.71415306274137202,null,null,null,null,null,0.71415306274137202,null,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},0,null,null,null,null,null,{"$f":"'MM-Summary'!$I$16","v":8.9410115327291919},9.0305258648331249E-2,null,null,null,null,null,9.0305258648331249E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C299","v":1.0100116560387222E-2}]
["Accept genetic counselling",null,null,{"$f":"D303*acceptance_counselling_tumour","v":7.1414320462069294E-3},{"$f":"D305+D309","v":7.1414320462069285E-3},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,2.4804492409821672,null,null,null,null,null,null,0,null,null,null,null,null,2.4804492409821672,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH negative","TN",null,{"$f":"D306*spec_FH","v":4.8360256551464587E-3},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$16","v":70.707408025595356},null,0.34194283922068774,null,null,null,null,null,0.34194283922068774,null,null,null,null,0,null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$16","v":8.9410115327291919},null,4.3238961155238731E-2,null,null,null,null,null,4.3238961155238731E-2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D308","v":4.8360256551464587E-3}]
["IHC other abnormal",null,null,{"$f":"D$290*(1-spec_IHC)*(1-p_dMLH1_sporadic)","v":4.1632624907901164E-2},{"$f":"D315+D323","v":4.1632624907901164E-2},null,null,null,null,{"$f":"c_offer_counselling","v":27.300506549444513},null,null,null,null,null,1.1365917489687225,null,null,null,null,null,null,0,null,null,null,null,null,1.1365917489687225,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,{"$f":"D320*(1-spec_FH)","v":5.7120567874684072E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$15","v":1807.4247336343246},null,1.0324112717594223,null,null,null,null,null,1.0324112717594223,null,null,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$15","v":8.9569461379480586},null,5.1162584982255141E-3,null,null,null,null,null,5.1162584982255141E-3,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D321","v":5.7120567874684072E-4}]
["IHC normal","TN",null,{"$f":"D$290*spec_IHC","v":0.71798445834645319},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,null,{"$f":"'MM-Summary'!$J$16","v":70.707408025595356},null,50.766820052338737,null,null,null,null,null,50.766820052338737,null,null,null,null,{"$f":"0","v":0},null,0,null,null,null,null,{"$f":"'MM-Summary'!$I$16","v":8.9410115327291919},null,6.41950732239596,null,null,null,null,null,6.41950732239596,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"D324","v":0.71798445834645319}]
["FH positive","LL",null,null,{"$f":"E328*(1-spec_FH)","v":2.7117736719735715E-2},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$15","v":1807.4247336343246},null,null,49.013268067434069,null,null,null,null,null,49.013268067434069,null,null,null,{"$f":"u_baseline_proband*(u_LynchLike-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$15","v":8.9569461379480586},null,null,0.24289210718172907,null,null,null,null,null,0.24289210718172907,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E329","v":2.7117736719735715E-2}]
["Decline genetic counselling","TN",null,null,{"$f":"E325*(1-acceptance_counselling_tumour)","v":9.7908323910125147E-2},null,null,null,null,null,null,null,null,null,null,null,0,null,null,null,{"$f":"'MM-Summary'!$J$16","v":70.707408025595356},null,null,6.9228438078153722,null,null,null,null,null,6.9228438078153722,null,null,null,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},null,null,0,null,null,null,{"$f":"'MM-Summary'!$I$16","v":8.9410115327291919},null,null,0.87539945323061419,null,null,null,null,null,0.87539945323061419,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"E334","v":9.7908323910125147E-2}]
["No mutation found",null,null,null,null,{"$f":"F339*spec_MMRdiagnostic","v":3.6119312402505085E-2},null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,null,0,null,null,null,null,null,0]
["FH positive","LL",null,null,null,{"$f":"F343*(1-spec_FH)","v":9.9359903896965081E-4},null,null,null,null,null,null,null,null,null,null,null,0,null,null,{"$f":"'MM-Summary'!$J$15","v":1807.4247336343246},null,null,null,1.7958554783490421,null,null,null,null,null,1.7958554783490421,null,null,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},null,null,null,0,null,null,{"$f":"'MM-Summary'!$I$15","v":8.9569461379480586},null,null,null,8.899613074768116E-3,null,null,null,null,null,8.899613074768116E-3,null,null,null,null,null,null,null,null,null,null,null,{"$f":"F344","v":9.9359903896965081E-4}]
["Accept genetic counselling",null,null,null,null,null,{"$f":"G$290*acceptance_counselling_direct","v":0.48010531981439364},{"$f":"G350+G352","v":0.48010531981439364},null,null,null,null,{"$f":"c_pretest_proband","v":347.33219120941197},null,null,null,null,null,{"$f":"G349*M349","v":166.75603274242886},null,null,null,null,null,null,0,null,null,null,null,null,{"$f":"S349+Z349","v":166.75603274242886},null,null,null,null,null,null,{"$f":"G349*$AH349","v":0},null,null,null,null,null,null,{"$f":"G349*$AO349","v":0},null,null,null,null,null,{"$f":"AM349+AT349","v":0}]
["GRAND TOTAL",null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(O$4:O$354)","v":397.40978240391041},300.56641294289454,373.13454724564463,308.69327956363293,600.63242427433079,0,null,{"$f":"SUM(V$4:V$354)","v":231.85732830957949},186.85108878745319,225.092836290722,187.91644161814909,171.31809216666238,142.60634693736495,629.26711071349018,487.41750173034779,598.22738353636669,496.60972118178211,771.95051644099317,142.60634693736495,null,{"$f":"SUM(AI$3:AI$354)","v":0},0,0,0,0,0,null,{"$f":"SUM(AP$3:AP$354)","v":9.0193703192010624},9.0188098938634766,9.0187812151177553,9.0176555405373335,9.0177337683938816,9.0064692241702051,9.0193703192010624,9.0188098938634766,9.0187812151177553,9.0176555405373335,9.0177337683938816,9.0064692241702051,1.8019932738440214E-2,1.783768391925775E-2,1.723388361294971E-2,1.6043703107700237E-2,1.6114690950341164E-2,0,3.3233784945270739E-2,7.4801269946237169E-3,3.0130818577484127E-2,9.9359903896965134E-3,0,0,2.1769427632772533E-2,2.1951676451954998E-2,2.2555476758263041E-2,2.374565726351251E-2,2.3674669420871583E-2,3.9789360371212744E-2,0.92697685468351643,0.95273051263416353,0.93007982105130316,0.95027464923909077,0.96021063962878728,0.96021063962878728,1.6866897993741036E-2,1.6696310662076202E-2,1.6131145501755581E-2,1.5017120634539588E-2,1.6114690950341164E-2,0,1.1530347446991772E-3,1.1413732571815514E-3,1.1027381111941286E-3,1.0265824731606511E-3,0,0]
[null,null,{"$f":"SUMIF($B$4:$B$354,\"TP\",C$4:C$354)+SUMIF($B$4:$B$354,\"LL\",C$4:C$354)+SUMIF($B$4:$B$354,\"FN\",C$4:C$354)+SUMIF($B$4:$B$354,\"TN\",C$4:C$354)","v":0.99999999999999989},1,1,1,1,1]
["Subtotals"]
["Diagnostic testing",null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(O359:O363)","v":397.40978240391041},300.56641294289454,373.13454724564463,308.69327956363298,600.63242427433079,0]
["IHC",null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"O4","v":211.97132895501142},{"$f":"P4","v":211.97132895501142},0,0,0,0]
["MSI",null,null,null,null,null,null,null,null,null,null,null,null,null,0,0,{"$f":"Q4","v":203.77122708967119},{"$f":"R4","v":203.77122708967119},0,0]
["Methylation",null,null,null,null,null,null,null,null,null,null,null,null,null,0,{"$f":"P19+P90+P161+P232+P302","v":27.811123047161153},0,{"$f":"R56+R127+R198+R269+R336","v":34.754329331270867},0,0]
["Pre-test genetic counselling (incl. offer)",null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"O7+O8+O78+O79+O149+O150+O220+O221+O291+O292","v":61.495462419865547},{"$f":"P20+P21+P32+P33+P91+P92+P103+P104+P162+P163+P174+P175+P233+P234+P245+P246+P303+P304+P314+P315","v":20.157295945044119},{"$f":"Q44+Q45+Q115+Q116+Q186+Q187+Q257+Q258+Q325+Q326","v":56.164595294283913},{"$f":"R57+R58+R128+R129+R199+R200+R270+R271+R337+R338","v":23.269157509437242},{"$f":"S4+S70+S141+S212+S283+S349","v":200.96660215415051},0]
["Mutation testing + post-test genetic counselling",null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"O9+O80+O151+O222+O293","v":123.94299102903349},{"$f":"P22+P34+P93+P105+P164+P176+P235+P247+P305+P316","v":40.626664995677878},{"$f":"Q46+Q117+Q188+Q259+Q327","v":113.19872486168951},{"$f":"R59+R130+R201+R272+R339","v":46.898565633253646},{"$f":"S71+S142+S213+S284+S350","v":399.66582212018034},0]
[]
["By underlying genetic status"]
["path_MLH1",null,{"$f":"SUM(C10,C12:C13,C15:C18)","v":4.3971344976522176E-3},{"$f":"SUM(D23,D25:D26,D28:D31,D35,D37:D38,D40:D43)","v":4.3971344976522194E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(V7:V18)","v":14.554377066802891},{"$f":"SUM(W19:W43)","v":14.444988949030526},{"$f":"SUM(X44:X55)","v":14.447015413452295},{"$f":"SUM(Y56:Y69)","v":14.329321863625912},{"$f":"SUM(Z70:Z75)","v":14.334150095834675},{"$f":"AA76","v":12.093144416924616},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AP$7:AP$76)","v":4.6063826103447128E-2},{"$f":"SUM(AQ$7:AQ$76)","v":4.5974356415440322E-2},4.5976013881929956E-2,4.5879751093998153E-2,4.5883700155725696E-2,4.4050758123293871E-2]
["path_MSH2",null,{"$f":"SUM(C81,C83:C84,C86:C89)","v":1.1344805094209589E-2},{"$f":"SUM(D94,D96:D97,D99:D102,D106,D108:D109,D111:D114)","v":1.1344805094209591E-2},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(V78:V89)","v":35.708355910862608},{"$f":"SUM(W90:W114)","v":35.667396391462454},{"$f":"SUM(X115:X126)","v":35.402858076663669},{"$f":"SUM(Y127:Y140)","v":34.924433405749483},{"$f":"SUM(Z141:Z146)","v":35.081699552998252},{"$f":"SUM(AA147)","v":28.70491268386499},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AP$78:AP$147)","v":0.12009833208678507},{"$f":"SUM(AQ$78:AQ$147)","v":0.12007039060855187},0.11988992971269555,0.11956356131960051,0.11967084403908851,0.11532077220936514]
["path_MSH6",null,{"$f":"SUM(C152,C154:C155,C157:C160)","v":2.0459155792301641E-2},{"$f":"SUM(D165,D167:D168,D170:D173,D177,D179:D180,D182:D185)","v":2.0459155792301641E-2},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(V149:V160)","v":49.2122619876287},{"$f":"SUM(W161:W185)","v":49.105909179635553},{"$f":"SUM(X186:X197)","v":48.419026300816597},{"$f":"SUM(Y198:Y211)","v":47.176780104814604},{"$f":"SUM(Z212:Z217)","v":47.585127092452908},{"$f":"SUM(AA218)","v":31.027579556788524},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AP$149:AP$218)","v":0.22652787115666556},{"$f":"SUM(AQ$149:AQ$218)","v":0.2264979571776034},0.22630475682452539,0.22595534877975054,0.22607020501597774,0.22141304419767721]
["path_PMS2",null,{"$f":"SUM(C223,C225:C226,C228:C231)","v":3.5882649870492994E-3},{"$f":"SUM(D236,D238:D239,D241:D244,D248,D250:D251,D253:D256)","v":3.5882649870493002E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(V220:V231)","v":6.7706377475284896},{"$f":"SUM(W232:W256)","v":6.7479226312575111},{"$f":"SUM(X257:X268)","v":6.6012163547488285},{"$f":"SUM(Y269:Y282)","v":6.3358941003407878},{"$f":"SUM(Z283:Z288)","v":6.4231099386259984},{"$f":"SUM(AA289)","v":2.8867047930362491},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AP$220:AP$289)","v":4.0896319840873059E-2},{"$f":"SUM(AQ$220:AQ$289)","v":4.0893594020974235E-2},4.0875989229388787E-2,4.0844150489404416E-2,4.0854616412829788E-2,4.0430246869607604E-2]
["Sporadic",null,{"$f":"SUM(C295:C296,C298:C301)","v":0.96021063962878728},{"$f":"SUM(D307:D308,D310:D313,D318:D319,D321:D324)","v":0.96021063962878728},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(V291:V301)","v":125.61169559675682},{"$f":"SUM(W302:W324)","v":80.884871636067118},{"$f":"SUM(X325:X335)","v":120.2227201450406},{"$f":"SUM(Y336:Y348)","v":85.150012143618326},{"$f":"SUM(Z349:Z353)","v":67.894005486750558},{"$f":"SUM(AA354)","v":67.894005486750558},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AP$291:AP$354)","v":8.5857839700132921},{"$f":"SUM(AQ$291:AQ$354)","v":8.5853735956409061},8.5857345254692135,8.5854127288545783,8.5852544027702606,8.5852544027702606]

{"sheet":"Decision tree - Relatives","index":12,"n_rows":134,"n_cols":65,"rows_kept":134,"cut":false,"hidden":false,"merged":[]}
["Strategy",null,1,2,3,4,5,6,"1 to 6",1,2,3,4,5,6,"1 to 6",1,2,3,4,5,6,"1 to 6",1,2,3,4,5,6,1,2,3,4,5,6,1,2,3,4,5,6,1,2,3,4,5,6,1,2,3,4,5,6,1,2,3,4,5,6,1,2,3,4,5,6]
["Description",null,"IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","(All)","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","(All)","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","(All)","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening","IHC","IHC with methylation","MSI","MSI with methylation","Direct mutation testing","No screening"]
[null,null,"Weights",null,null,null,null,null,"Costs (unweighted)","Costs (weighted)",null,null,null,null,null,"Short term QALYs (unweighted)","Short term QALYs (weighted)",null,null,null,null,null,"Long term QALYs (unweighted)","Long term QALYs (weighted)",null,null,null,null,null,"Total QALYs (weighted)",null,null,null,null,null,"True Positives [pathogenic variant found]",null,null,null,null,null,"True Positives [diagnosed LL]",null,null,null,null,null,"False Negatives",null,null,null,null,null,"False Positives",null,null,null,null,null,"True Negatives"]
["Cohort",null,{"$f":"cohort_probands*relatives_per_proband","v":6},6,6,6,6,6,null,{"$f":"C4*$I4","v":0},{"$f":"D4*$I4","v":0},{"$f":"E4*$I4","v":0},{"$f":"F4*$I4","v":0},{"$f":"G4*$I4","v":0},{"$f":"H4*$I4","v":0},null,{"$f":"C4*$P4","v":0},{"$f":"D4*$P4","v":0},{"$f":"E4*$P4","v":0},{"$f":"F4*$P4","v":0},{"$f":"G4*$P4","v":0},{"$f":"H4*$P4","v":0},null,{"$f":"C4*$W4","v":0},{"$f":"D4*$W4","v":0},{"$f":"E4*$W4","v":0},{"$f":"F4*$W4","v":0},{"$f":"G4*$W4","v":0},{"$f":"H4*$W4","v":0},{"$f":"Q4+X4","v":0},{"$f":"R4+Y4","v":0},{"$f":"S4+Z4","v":0},{"$f":"T4+AA4","v":0},{"$f":"U4+AB4","v":0},{"$f":"V4+AC4","v":0}]
["Proband has LS",null,{"$f":"'Decision tree - Probands'!C5*relatives_per_proband","v":0.2387361622272765},{"$f":"'Decision tree - Probands'!D5*relatives_per_proband","v":0.2387361622272765},{"$f":"'Decision tree - Probands'!E5*relatives_per_proband","v":0.2387361622272765},{"$f":"'Decision tree - Probands'!F5*relatives_per_proband","v":0.2387361622272765},{"$f":"'Decision tree - Probands'!G5*relatives_per_proband","v":0.2387361622272765},{"$f":"'Decision tree - Probands'!H5*relatives_per_proband","v":0.2387361622272765},null,{"$f":"C5*$I5","v":0},0,0,0,0,0,null,{"$f":"C5*$P5","v":0},0,0,0,0,0,null,{"$f":"C5*$W5","v":0},0,0,0,0,0,{"$f":"Q5+X5","v":0},0,0,0,0,0]
["MLH1 mutation",null,{"$f":"'Decision tree - Probands'!C6*relatives_per_proband","v":2.6382806985913311E-2},{"$f":"'Decision tree - Probands'!D6*relatives_per_proband","v":2.6382806985913311E-2},{"$f":"'Decision tree - Probands'!E6*relatives_per_proband","v":2.6382806985913311E-2},{"$f":"'Decision tree - Probands'!F6*relatives_per_proband","v":2.6382806985913311E-2},{"$f":"'Decision tree - Probands'!G6*relatives_per_proband","v":2.6382806985913311E-2},{"$f":"'Decision tree - Probands'!H6*relatives_per_proband","v":2.6382806985913311E-2},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Proband TP",null,{"$f":"'Decision tree - Probands'!C10*relatives_per_proband","v":1.1183796624735617E-2},{"$f":"('Decision tree - Probands'!D23+'Decision tree - Probands'!D35)*relatives_per_proband","v":1.068673899696959E-2},{"$f":"'Decision tree - Probands'!E47*relatives_per_proband","v":1.0695947214632989E-2},{"$f":"'Decision tree - Probands'!F60*relatives_per_proband","v":1.016114985390134E-2},{"$f":"'Decision tree - Probands'!G72*relatives_per_proband","v":1.0685036829294892E-2},{"$f":"0","v":0},{"$f":"c_GP","v":36.400675399259349},0.40709775066833348,0.38900451730529645,0.38933970264746759,0.36987271751509421,0.38894255725229465,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C7*p_rel_LS","v":4.9208705148836712E-3},4.7021651586666192E-3,4.7062167744385151E-3,4.4709059357165891E-3,4.7014162048897527E-3,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C8*acceptance_counselling_relative","v":3.8245255859049466E-3},3.6545466709758381E-3,3.6576956073554896E-3,3.4748108269877149E-3,3.6539645802921624E-3,0,{"$f":"c_pretest_relative","v":171.72712297629874},0.65677477561669972,0.62758478558929098,0.6281255433742039,0.59671926620549365,0.62748482483087198,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C9*acceptance_MMRpredictive","v":2.7393678500790661E-3},2.6176181678533301E-3,2.6198736358549438E-3,2.4888799540621963E-3,2.6172012375782214E-3,0,{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},0.82035534533282206,0.78389510776247451,0.7845705501756931,0.74534202266690841,0.78377025013161394,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation found","TP",{"$f":"C10","v":2.7393678500790661E-3},{"$f":"D10","v":2.6176181678533301E-3},2.6198736358549438E-3,2.4888799540621963E-3,2.6172012375782214E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$17+(1-p_rel_female)*'MM-Summary'!$N$31","v":5377.8344016907286},14.731866663040773,14.077117033572295,14.089246566983284,13.384784238634118,14.074874851595709,0,{"$f":"u_baseline_relative*(u_pathMMR-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$17+(1-p_rel_female)*'MM-Summary'!$M$31","v":15.227667507951699},4.1714182802976493E-2,3.9860219122844209E-2,3.9894564639647606E-2,3.789983640766522E-2,3.9853870247240859E-2,0,4.1714182802976493E-2,3.9860219122844209E-2,3.9894564639647606E-2,3.789983640766522E-2,3.9853870247240859E-2,0,{"$f":"C11","v":2.7393678500790661E-3},{"$f":"D11","v":2.6176181678533301E-3},{"$f":"E11","v":2.6198736358549438E-3},{"$f":"F11","v":2.4888799540621963E-3},{"$f":"G11","v":2.6172012375782214E-3},{"$f":"H11","v":0}]
["Decline mutation testing","LL",{"$f":"C9*(1-acceptance_MMRpredictive)","v":1.0851577358258805E-3},1.0369285031225082E-3,1.037821971500546E-3,9.8593087292551864E-4,1.0367633427139412E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$18+(1-p_rel_female)*'MM-Summary'!$N$32","v":4920.6616052774325},5.3396940063482008,5.1023742727327264,5.1067707282760662,4.8514321918622629,5.101561574251579,0,{"$f":"u_baseline_relative*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$18+(1-p_rel_female)*'MM-Summary'!$M$32","v":14.860965644555044},1.6126491831031549E-2,1.5409758860763482E-2,1.5423036663633998E-2,1.4651884830452298E-2,1.5407304417605927E-2,0,1.6126491831031549E-2,1.5409758860763482E-2,1.5423036663633998E-2,1.4651884830452298E-2,1.5407304417605927E-2,0,null,null,null,null,null,null,{"$f":"C12","v":1.0851577358258805E-3},1.0369285031225082E-3,1.037821971500546E-3,9.8593087292551864E-4,1.0367633427139412E-3,0]
["Decline genetic counselling","FN",{"$f":"C8*(1-acceptance_counselling_relative)","v":1.0963449289787246E-3},1.0476184876907814E-3,1.0485211670830255E-3,9.9609510872887422E-4,1.04745162459759E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$19+(1-p_rel_female)*'MM-Summary'!$N$33","v":3738.8675127539327},4.099088437731071,3.9169067293874682,3.9202817280415623,3.724267641639484,3.9162828503892575,0,0,0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$19+(1-p_rel_female)*'MM-Summary'!$M$33","v":13.913039391550811},1.5253490183607972E-2,1.4575557286558729E-2,1.4588116300500964E-2,1.3858710485475914E-2,1.4573235713770163E-2,0,1.5253490183607972E-2,1.4575557286558729E-2,1.4588116300500964E-2,1.3858710485475914E-2,1.4573235713770163E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C13","v":1.0963449289787246E-3},1.0476184876907814E-3,1.0485211670830255E-3,9.9609510872887422E-4,1.04745162459759E-3,0]
["Mutation not present",null,{"$f":"C7*(1-p_rel_LS)","v":6.2629261098519464E-3},5.9845738383029704E-3,5.9897304401944742E-3,5.6902439181847507E-3,5.9836206244051398E-3,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C14*acceptance_counselling_relative","v":4.8675780184244781E-3},{"$f":"D14*acceptance_counselling_relative","v":4.6512412176056119E-3},{"$f":"E14*acceptance_counselling_relative","v":4.6552489548160776E-3},{"$f":"F14*acceptance_counselling_relative","v":4.4224865070752739E-3},{"$f":"G14*acceptance_counselling_relative","v":4.6505003749172978E-3},{"$f":"H14*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},0.8358951689667089,0.79874427256818847,0.79943250974898672,0.75946088426153746,0.79861704978474624,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C15*acceptance_MMRpredictive","v":3.4864681728279025E-3},{"$f":"D15*acceptance_MMRpredictive","v":3.3315140318133287E-3},{"$f":"E15*acceptance_MMRpredictive","v":3.3343846274517465E-3},{"$f":"F15*acceptance_MMRpredictive","v":3.1676653960791591E-3},{"$f":"G15*acceptance_MMRpredictive","v":3.3309833932813728E-3},{"$f":"H15*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},1.0440886213326828,0.99768468260678556,0.99854433658724573,0.94861711975788343,0.99752577289478139,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation not found","TN",{"$f":"C16","v":3.4864681728279025E-3},{"$f":"D16","v":3.3315140318133287E-3},3.3343846274517465E-3,3.1676653960791591E-3,3.3309833932813728E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},2.5381284766614929,2.4253227665876484,2.4274125434545741,2.3060419162818455,2.4249364648341238,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},5.6004543136297914E-2,5.3515452330240222E-2,5.3561563864689778E-2,5.0883485671455293E-2,5.350692846968004E-2,0,5.6004543136297914E-2,5.3515452330240222E-2,5.3561563864689778E-2,5.0883485671455293E-2,5.350692846968004E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C17","v":3.4864681728279025E-3},3.3315140318133287E-3,3.3343846274517465E-3,3.1676653960791591E-3,3.3309833932813728E-3,0]
["Decline mutation testing","LL",{"$f":"C15*(1-acceptance_MMRpredictive)","v":1.3811098455965756E-3},1.319727185792283E-3,1.3208643273643311E-3,1.2548211109961146E-3,1.3195169816359253E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},4.6504921542639126,4.4438036140744037,4.4476326128871762,4.2252509822428177,4.4430958117348203,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},2.2221619800928908E-2,2.1233992254220953E-2,2.1252288501803614E-2,2.0189674076713432E-2,2.1230610135949877E-2,0,2.2221619800928908E-2,2.1233992254220953E-2,2.1252288501803614E-2,2.0189674076713432E-2,2.1230610135949877E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C18","v":1.3811098455965756E-3},1.319727185792283E-3,1.3208643273643311E-3,1.2548211109961146E-3,1.3195169816359253E-3,0]
["Decline genetic counselling","TN",{"$f":"C14*(1-acceptance_counselling_relative)","v":1.3953480914274678E-3},1.3333326206973581E-3,1.3344814853783963E-3,1.2677574111094765E-3,1.333120249487842E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},1.0158052648548122,0.97065836419459817,0.97149473097560013,0.92291999442682016,0.97050375919384213,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},2.241403864963892E-2,2.1417859154099411E-2,2.1436313830407207E-2,2.0364498138886848E-2,2.141444774978574E-2,0,2.241403864963892E-2,2.1417859154099411E-2,2.1436313830407207E-2,2.0364498138886848E-2,2.141444774978574E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C19","v":1.3953480914274678E-3},1.3333326206973581E-3,1.3344814853783963E-3,1.2677574111094765E-3,1.333120249487842E-3,0]
["Proband LL",null,{"$f":"('Decision tree - Probands'!C12+'Decision tree - Probands'!C15)*relatives_per_proband","v":7.6453335348057117E-4},{"$f":"('Decision tree - Probands'!D25+'Decision tree - Probands'!D28+'Decision tree - Probands'!D37+'Decision tree - Probands'!D40)*relatives_per_proband","v":7.3055409332587905E-4},{"$f":"('Decision tree - Probands'!E49+'Decision tree - Probands'!E52)*relatives_per_proband","v":7.3118357450887976E-4},{"$f":"('Decision tree - Probands'!F62+'Decision tree - Probands'!F65)*relatives_per_proband","v":6.9462439578343578E-4},{"$f":"0","v":0},{"$f":"0","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C20*p_rel_LS","v":3.3639467553145131E-4},3.2144380106338677E-4,3.2172077278390707E-4,3.0563473414471176E-4,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C21*p_FDR","v":1.4252866629002438E-4},1.3619405889935663E-4,1.3631141037010581E-4,1.2949583985160054E-4,0,0,{"$f":"c_GP","v":36.400675399259349},5.1881397167125353E-3,4.9575557293030899E-3,4.9618274020974563E-3,4.7137360319925844E-3,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C22*acceptance_counselling_relative","v":1.1077400417311982E-4},1.0585071509875895E-4,1.0594192125853623E-4,1.0064482519560944E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},1.9022901037214379E-2,1.8177438768893741E-2,1.8193101340310009E-2,1.7283446273294513E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C23","v":1.1077400417311982E-4},{"$f":"D23","v":1.0585071509875895E-4},1.0594192125853623E-4,1.0064482519560944E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$18+(1-p_rel_female)*'MM-Summary'!$N$32","v":4920.6616052774325},0.54508138919751281,0.52085554967762338,0.52130434432620421,0.49523912710989415,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$18+(1-p_rel_female)*'MM-Summary'!$M$32","v":14.860965644555044},1.6462086703265307E-3,1.5730438405342406E-3,1.5743992521412627E-3,1.4956792895341998E-3,0,0,1.6462086703265307E-3,1.5730438405342406E-3,1.5743992521412627E-3,1.4956792895341998E-3,0,0,null,null,null,null,null,null,{"$f":"C24","v":1.1077400417311982E-4},1.0585071509875895E-4,1.0594192125853623E-4,1.0064482519560944E-4,0,0]
["Decline genetic counselling","FN",{"$f":"C22*(1-acceptance_counselling_relative)","v":3.1754662116904552E-5},3.0343343800597685E-5,3.0369489111569578E-5,2.8851014655991104E-5,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$19+(1-p_rel_female)*'MM-Summary'!$N$33","v":3738.8675127539327},0.11872647456737245,0.11344974236437813,0.11354749621818179,0.10787012140727271,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$19+(1-p_rel_female)*'MM-Summary'!$M$33","v":13.913039391550811},4.4180386489787928E-4,4.2216813756908471E-4,4.2253189831054099E-4,4.01405303395014E-4,0,0,4.4180386489787928E-4,4.2216813756908471E-4,4.2253189831054099E-4,4.01405303395014E-4,0,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C25","v":3.1754662116904552E-5},3.0343343800597685E-5,3.0369489111569578E-5,2.8851014655991104E-5,0,0]
["Relative not FDR of proband","FN",{"$f":"C21*(1-p_FDR)","v":1.9386600924142694E-4},1.8524974216403014E-4,1.8540936241380127E-4,1.7613889429311122E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$19+(1-p_rel_female)*'MM-Summary'!$N$33","v":3738.8675127539327},0.72483932378002491,0.69262424272313472,0.69322104168938159,0.65855998960491258,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$19+(1-p_rel_female)*'MM-Summary'!$M$33","v":13.913039391550811},2.6972654232587266E-3,2.5773869600027827E-3,2.5796077628255374E-3,2.4506273746842605E-3,0,0,2.6972654232587266E-3,2.5773869600027827E-3,2.5796077628255374E-3,2.4506273746842605E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,1.9386600924142694E-4,1.8524974216403014E-4,1.8540936241380127E-4,1.7613889429311122E-4,0,0]
["Mutation not present",null,{"$f":"C20*(1-p_rel_LS)","v":4.2813867794911991E-4},4.0911029226249233E-4,4.0946280172497268E-4,3.8898966163872407E-4,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C27*p_FDR","v":1.8140012073275834E-4},1.7333789314463572E-4,1.7348724956195286E-4,1.6481288708385523E-4,0,0,{"$f":"c_GP","v":36.400675399259349},6.6030869121795925E-3,6.3096163827493874E-3,6.3150530572149447E-3,5.9993004043541976E-3,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C28*acceptance_counselling_relative","v":1.4098509622033435E-4},1.3471909194387504E-4,1.348351725108643E-4,1.2809341388532111E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},2.4210964956454667E-2,2.3134922069501126E-2,2.3154856251303649E-2,2.1997113438738471E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C29","v":1.4098509622033435E-4},{"$f":"D29","v":1.3471909194387504E-4},{"$f":"E29","v":1.348351725108643E-4},{"$f":"F29","v":1.2809341388532111E-4},{"$f":"G29","v":0},{"$f":"H29","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},0.47472696392052521,0.4536279877462796,0.45401885583527862,0.4313179130435148,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},2.2684055260299547E-3,2.1675875026508453E-3,2.169455202192729E-3,2.0609824420830931E-3,0,0,2.2684055260299547E-3,2.1675875026508453E-3,2.169455202192729E-3,2.0609824420830931E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C30","v":1.4098509622033435E-4},1.3471909194387504E-4,1.348351725108643E-4,1.2809341388532111E-4,0,0]
["Decline genetic counselling","TN",{"$f":"C28*(1-acceptance_counselling_relative)","v":4.0415024512423983E-5},3.8618801200760693E-5,3.8652077051088554E-5,3.6719473198534134E-5,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},2.942190191191486E-2,2.8114261826940865E-2,2.8138486451723187E-2,2.6731562129137035E-2,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},6.4920282402139472E-4,6.2034936517599943E-4,6.2088388856835607E-4,5.8983969413993844E-4,0,0,6.4920282402139472E-4,6.2034936517599943E-4,6.2088388856835607E-4,5.8983969413993844E-4,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C31","v":4.0415024512423983E-5},3.8618801200760693E-5,3.8652077051088554E-5,3.6719473198534134E-5,0,0]
["Relative not FDR of proband","TN",{"$f":"C27*(1-p_FDR)","v":2.4673855721636157E-4},2.3577239911785661E-4,2.3597555216301982E-4,2.2417677455486884E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},0.17962422925354243,0.17164093017560722,0.17178882440652773,0.16319938318620136,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},3.9634608681378986E-3,3.7873070517762146E-3,3.7905703810014128E-3,3.6010418619513425E-3,0,0,3.9634608681378986E-3,3.7873070517762146E-3,3.7905703810014128E-3,3.6010418619513425E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,2.4673855721636157E-4,2.3577239911785661E-4,2.3597555216301982E-4,2.2417677455486884E-4,0,0]
["Proband FN",null,{"$f":"('Decision tree - Probands'!C13+'Decision tree - Probands'!C16+'Decision tree - Probands'!C17+'Decision tree - Probands'!C18)*relatives_per_proband","v":1.443447700769712E-2},{"$f":"('Decision tree - Probands'!D26+'Decision tree - Probands'!D29+'Decision tree - Probands'!D30+'Decision tree - Probands'!D31+'Decision tree - Probands'!D38+'Decision tree - Probands'!D41+'Decision tree - Probands'!D42+'Decision tree - Probands'!D43)*relatives_per_proband","v":1.4965513895617844E-2},{"$f":"('Decision tree - Probands'!E50+'Decision tree - Probands'!E53+'Decision tree - Probands'!E54+'Decision tree - Probands'!E55)*relatives_per_proband","v":1.4955676196771444E-2},{"$f":"('Decision tree - Probands'!F63+'Decision tree - Probands'!F66+'Decision tree - Probands'!F67+'Decision tree - Probands'!F68+'Decision tree - Probands'!F69)*relatives_per_proband","v":1.5527032736228536E-2},{"$f":"('Decision tree - Probands'!G73+'Decision tree - Probands'!G74+'Decision tree - Probands'!G75)*relatives_per_proband","v":1.5697770156618419E-2},{"$f":"'Decision tree - Probands'!H76*relatives_per_proband","v":2.6382806985913311E-2},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present","FN",{"$f":"C33*p_rel_LS","v":6.3511698833867329E-3},6.5848261140718511E-3,6.5804975265794357E-3,6.8318944039405562E-3,6.9070188689121046E-3,1.1608435073801857E-2,{"$f":"p_rel_female*'MM-Summary'!$N$19+(1-p_rel_female)*'MM-Summary'!$N$33","v":3738.8675127539327},23.74618274497584,24.619792435036967,24.603608419885461,25.543548037458738,25.824428458953882,43.402400771351068,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$19+(1-p_rel_female)*'MM-Summary'!$M$33","v":13.913039391550811},8.8364076769990779E-2,9.1614945111594112E-2,9.1554721303302361E-2,9.5052415960940509E-2,9.6097625601358844E-2,0.16150861445606529,8.8364076769990779E-2,9.1614945111594112E-2,9.1554721303302361E-2,9.5052415960940509E-2,9.6097625601358844E-2,0.16150861445606529,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C34","v":6.3511698833867329E-3},6.5848261140718511E-3,6.5804975265794357E-3,6.8318944039405562E-3,6.9070188689121046E-3,1.1608435073801857E-2]
["Mutation not present","TN",{"$f":"C33*(1-p_rel_LS)","v":8.083307124310388E-3},8.3806877815459924E-3,8.37517867019201E-3,8.6951383322879817E-3,8.7907512877063165E-3,1.4774371912111455E-2,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},5.8846003981077049,6.1010917805389351,6.0970811796340945,6.3300099457929075,6.3996156191721667,10.755656502810362,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.12984541951524403,0.13462236484228063,0.13453386976669918,0.13967351074704254,0.14120938017727219,0.23732668937356671,0.12984541951524403,0.13462236484228063,0.13453386976669918,0.13967351074704254,0.14120938017727219,0.23732668937356671,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C35","v":8.083307124310388E-3},8.3806877815459924E-3,8.37517867019201E-3,8.6951383322879817E-3,8.7907512877063165E-3,1.4774371912111455E-2]
["MSH2 mutation",null,{"$f":"'Decision tree - Probands'!C77*relatives_per_proband","v":6.8068830565257532E-2},{"$f":"'Decision tree - Probands'!D77*relatives_per_proband","v":6.8068830565257532E-2},{"$f":"'Decision tree - Probands'!E77*relatives_per_proband","v":6.8068830565257532E-2},{"$f":"'Decision tree - Probands'!F77*relatives_per_proband","v":6.8068830565257532E-2},{"$f":"'Decision tree - Probands'!G77*relatives_per_proband","v":6.8068830565257532E-2},{"$f":"'Decision tree - Probands'!H77*relatives_per_proband","v":6.8068830565257532E-2},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Proband TP",null,{"$f":"'Decision tree - Probands'!C81*relatives_per_proband","v":2.8854699120222312E-2},{"$f":"('Decision tree - Probands'!D94+'Decision tree - Probands'!D106)*relatives_per_proband","v":2.8685942899875652E-2},{"$f":"'Decision tree - Probands'!E118*relatives_per_proband","v":2.7596025664612861E-2},{"$f":"'Decision tree - Probands'!F131*relatives_per_proband","v":2.5624880974283372E-2},{"$f":"'Decision tree - Probands'!G143*relatives_per_proband","v":2.7567876378929303E-2},{"$f":"0","v":0},{"$f":"c_GP","v":36.400675399259349},1.0503305364185067,1.044187696020062,1.004513972527203,0.9327629744895457,1.0034893195163148,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C37*p_rel_LS","v":1.2696067612897818E-2},1.2621814875945287E-2,1.2142251292429658E-2,1.1274947628684683E-2,1.2129865606728893E-2,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C38*acceptance_counselling_relative","v":9.867448305953791E-3},{"$f":"D38*acceptance_counselling_relative","v":9.8097387012325357E-3},{"$f":"E38*acceptance_counselling_relative","v":9.4370194456300238E-3},{"$f":"F38*acceptance_counselling_relative","v":8.7629466280850221E-3},{"$f":"G38*acceptance_counselling_relative","v":9.4273932277244149E-3},{"$f":"H38*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},1.6945085086987974,1.6845982043119168,1.6205921988694296,1.5048356132358991,1.6189391161633566,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C39*acceptance_MMRpredictive","v":7.0676924613255199E-3},{"$f":"D39*acceptance_MMRpredictive","v":7.0263571813637907E-3},{"$f":"E39*acceptance_MMRpredictive","v":6.7593920054303857E-3},{"$f":"F39*acceptance_MMRpredictive","v":6.2765782907567864E-3},{"$f":"G39*acceptance_MMRpredictive","v":6.7524970974852895E-3},{"$f":"H39*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},2.1165537478471657,2.1041751190089633,2.0242273642419777,1.8796396953675505,2.0221625540748529,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation found","TP",{"$f":"C40","v":7.0676924613255199E-3},{"$f":"D40","v":7.0263571813637907E-3},6.7593920054303857E-3,6.2765782907567864E-3,6.7524970974852895E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N20+(1-p_rel_female)*'MM-Summary'!$N34","v":5248.1004524113523},37.091960003786767,36.875028302319066,35.473968241724883,32.940113367315966,35.437783072218892,0,{"$f":"u_baseline_relative*(u_pathMMR-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M20+(1-p_rel_female)*'MM-Summary'!$M34","v":15.362751150235965},0.10857920048974269,0.10794417686996531,0.10384285730632145,9.6425510355869909E-2,0.10373693255135714,0,0.10857920048974269,0.10794417686996531,0.10384285730632145,9.6425510355869909E-2,0.10373693255135714,0,7.0676924613255199E-3,7.0263571813637907E-3,6.7593920054303857E-3,6.2765782907567864E-3,6.7524970974852895E-3,0]
["Decline mutation testing","LL",{"$f":"C39*(1-acceptance_MMRpredictive)","v":2.7997558446282711E-3},2.783381519868745E-3,2.6776274401996382E-3,2.4863683373282353E-3,2.6748961302391254E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N21+(1-p_rel_female)*'MM-Summary'!$N35","v":4724.9056860011124},13.228582309698965,13.151215169538251,12.651537117191873,11.747855894535311,12.638631935229215,0,{"$f":"u_baseline_relative*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M21+(1-p_rel_female)*'MM-Summary'!$M35","v":15.038207171108791},4.2103308420042618E-2,4.1857067932021846E-2,4.0266716172767877E-2,3.7390522160427313E-2,4.0225642167733174E-2,0,4.2103308420042618E-2,4.1857067932021846E-2,4.0266716172767877E-2,3.7390522160427313E-2,4.0225642167733174E-2,0,null,null,null,null,null,null,{"$f":"C42","v":2.7997558446282711E-3},2.783381519868745E-3,2.6776274401996382E-3,2.4863683373282353E-3,2.6748961302391254E-3,0]
["Decline genetic counselling","FN",{"$f":"C38*(1-acceptance_counselling_relative)","v":2.8286193069440263E-3},2.8120761747127522E-3,2.7052318467996341E-3,2.5120010005996603E-3,2.7024723790044771E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N22+(1-p_rel_female)*'MM-Summary'!$N36","v":3372.4444524506762},9.5393614897982584,9.4835706952787397,9.1232441343323227,8.4715838390228715,9.1139379824748303,0,0,0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M22+(1-p_rel_female)*'MM-Summary'!$M36","v":14.199259271527669},4.0164298919747134E-2,3.9929398696032112E-2,3.8412288382301624E-2,3.5668553497851509E-2,3.8373105983626761E-2,0,4.0164298919747134E-2,3.9929398696032112E-2,3.8412288382301624E-2,3.5668553497851509E-2,3.8373105983626761E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C43","v":2.8286193069440263E-3},2.8120761747127522E-3,2.7052318467996341E-3,2.5120010005996603E-3,2.7024723790044771E-3,0]
["Mutation not present",null,{"$f":"C37*(1-p_rel_LS)","v":1.6158631507324498E-2},1.6064128023930365E-2,1.5453774372183204E-2,1.4349933345598689E-2,1.5438010772200412E-2,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C44*acceptance_counselling_relative","v":1.2558570571213918E-2},{"$f":"D44*acceptance_counselling_relative","v":1.2485121983386862E-2},{"$f":"E44*acceptance_counselling_relative","v":1.2010752021710942E-2},{"$f":"F44*acceptance_counselling_relative","v":1.1152841163017303E-2},{"$f":"G44*acceptance_counselling_relative","v":1.1998500471649258E-2},{"$f":"H44*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},2.1566471928893787,2.1440340782151663,2.0625718894701834,1.9152453259365991,2.0604679660260907,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C45*acceptance_MMRpredictive","v":8.9952449507779367E-3},{"$f":"D45*acceptance_MMRpredictive","v":8.9426364126448232E-3},{"$f":"E45*acceptance_MMRpredictive","v":8.6028625523659474E-3},{"$f":"F45*acceptance_MMRpredictive","v":7.9883723700540938E-3},{"$f":"G45*acceptance_MMRpredictive","v":8.5940872149812796E-3},{"$f":"H45*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},2.6937956790782116,2.6780410605568621,2.5762893726716083,2.3922687031950649,2.5736614324589047,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation not found","TN",{"$f":"C46","v":8.9952449507779367E-3},{"$f":"D46","v":8.9426364126448232E-3},8.6028625523659474E-3,7.9883723700540938E-3,8.5940872149812796E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},6.5484858121038032,6.510187103458807,6.2628337166933319,5.8154884512152369,6.2564453223055896,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.14449424428813681,0.14364917214143663,0.13819124771152846,0.12832044430356213,0.13805028593108673,0,0.14449424428813681,0.14364917214143663,0.13819124771152846,0.12832044430356213,0.13805028593108673,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C47","v":8.9952449507779367E-3},8.9426364126448232E-3,8.6028625523659474E-3,7.9883723700540938E-3,8.5940872149812796E-3,0]
["Decline mutation testing","LL",{"$f":"C45*(1-acceptance_MMRpredictive)","v":3.5633256204359817E-3},3.5424855707420384E-3,3.4078894693449946E-3,3.1644687929632091E-3,3.4044132566679788E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},11.998479261993184,11.928306358726182,11.475092506448497,10.655443041702176,11.463387355093188,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},5.7332780167122892E-2,5.6997470370868969E-2,5.4831861747146188E-2,5.0915300193778601E-2,5.4775930586636323E-2,0,5.7332780167122892E-2,5.6997470370868969E-2,5.4831861747146188E-2,5.0915300193778601E-2,5.4775930586636323E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C48","v":3.5633256204359817E-3},3.5424855707420384E-3,3.4078894693449946E-3,3.1644687929632091E-3,3.4044132566679788E-3,0]
["Decline genetic counselling","TN",{"$f":"C44*(1-acceptance_counselling_relative)","v":3.6000609361105792E-3},3.5790060405435026E-3,3.4430223504722623E-3,3.1970921825813861E-3,3.4395103005511536E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},2.6208233452042267,2.6054955041447787,2.5065001716127808,2.3274644450690105,2.5039434197727108,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},5.7829229465235749E-2,5.7491016193648603E-2,5.5306655385257635E-2,5.1356180000596365E-2,5.5250239912190503E-2,0,5.7829229465235749E-2,5.7491016193648603E-2,5.5306655385257635E-2,5.1356180000596365E-2,5.5250239912190503E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C49","v":3.6000609361105792E-3},3.5790060405435026E-3,3.4430223504722623E-3,3.1970921825813861E-3,3.4395103005511536E-3,0]
["Proband LL",null,{"$f":"('Decision tree - Probands'!C83+'Decision tree - Probands'!C86)*relatives_per_proband","v":1.9725304940957787E-3},{"$f":"('Decision tree - Probands'!D96+'Decision tree - Probands'!D99+'Decision tree - Probands'!D108+'Decision tree - Probands'!D111)*relatives_per_proband","v":1.9609941828240786E-3},{"$f":"('Decision tree - Probands'!E120+'Decision tree - Probands'!E123)*relatives_per_proband","v":1.8864865619461432E-3},{"$f":"('Decision tree - Probands'!F133+'Decision tree - Probands'!F136)*relatives_per_proband","v":1.7517375218071335E-3},{"$f":"0","v":0},{"$f":"0","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C50*p_rel_LS","v":8.6791341740214269E-4},{"$f":"D50*p_rel_LS","v":8.6283744044259459E-4},{"$f":"E50*p_rel_LS","v":8.3005408725630298E-4},{"$f":"F50*p_rel_LS","v":7.7076450959513872E-4},{"$f":"G50*p_rel_LS","v":0},{"$f":"H50*p_rel_LS","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C51*p_FDR","v":3.6773037992386128E-4},3.6557971500914373E-4,3.5168957956400023E-4,3.2656889530942887E-4,0,0,{"$f":"c_GP","v":36.400675399259349},1.3385634194054792E-2,1.3307348538601582E-2,1.2801738227011167E-2,1.1887328353653229E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C52*acceptance_counselling_relative","v":2.858019211193573E-4},2.8413041341189636E-4,2.7333492951510206E-4,2.5381100597830916E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},4.9079941654926303E-2,4.8792898445291326E-2,4.6939021054557883E-2,4.3586233836375193E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C53","v":2.858019211193573E-4},{"$f":"D53","v":2.8413041341189636E-4},{"$f":"E53","v":2.7333492951510206E-4},{"$f":"F53","v":2.5381100597830916E-4},{"$f":"G53","v":0},{"$f":"H53","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$21+(1-p_rel_female)*'MM-Summary'!$N$35","v":4724.9056860011124},1.3503871221668926,1.3424894058957157,1.291481762648619,1.1992330653165753,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$21+(1-p_rel_female)*'MM-Summary'!$M$35","v":15.038207171108791},4.2979484996937883E-3,4.2728120205008848E-3,4.1104672971485241E-3,3.8168624902093448E-3,0,0,4.2979484996937883E-3,4.2728120205008848E-3,4.1104672971485241E-3,3.8168624902093448E-3,0,0,null,null,null,null,null,null,{"$f":"C54","v":2.858019211193573E-4},2.8413041341189636E-4,2.7333492951510206E-4,2.5381100597830916E-4,0,0]
["Decline genetic counselling","FN",{"$f":"C52*(1-acceptance_counselling_relative)","v":8.192845880450397E-5},8.1449301597247365E-5,7.8354650048898149E-5,7.2757889331119741E-5,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$22+(1-p_rel_female)*'MM-Summary'!$N$36","v":3372.4444524506762},0.27629917639308316,0.2746832453276189,0.26424670488112068,0.24537194024675502,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$22+(1-p_rel_female)*'MM-Summary'!$M$36","v":14.199259271527669},1.1633234282818258E-3,1.1565197508641681E-3,1.112577991174123E-3,1.0331081346616861E-3,0,0,1.1633234282818258E-3,1.1565197508641681E-3,1.112577991174123E-3,1.0331081346616861E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C55","v":8.192845880450397E-5},8.1449301597247365E-5,7.8354650048898149E-5,7.2757889331119741E-5,0,0]
["Relative not FDR of proband","FN",{"$f":"C51*(1-p_FDR)","v":5.001830374782814E-4},4.972577254334508E-4,4.7836450769230275E-4,4.4419561428570985E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$22+(1-p_rel_female)*'MM-Summary'!$N$36","v":3372.4444524506762},1.6868395099535587,1.6769740575762826,1.6132577302162052,1.4980250352007625,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$22+(1-p_rel_female)*'MM-Summary'!$M$36","v":14.199259271527669},7.102228632374359E-3,7.060691368199686E-3,6.7924216710196989E-3,6.3072486945182941E-3,0,0,7.102228632374359E-3,7.060691368199686E-3,6.7924216710196989E-3,6.3072486945182941E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,5.001830374782814E-4,4.972577254334508E-4,4.7836450769230275E-4,4.4419561428570985E-4,0,0]
["Mutation not present",null,{"$f":"C50*(1-p_rel_LS)","v":1.1046170766936363E-3},1.0981567423814841E-3,1.0564324746898403E-3,9.8097301221199487E-4,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C57*p_FDR","v":4.6802048353945986E-4},4.6528327364800116E-4,4.4760491944509129E-4,4.1563313948472775E-4,0,0,{"$f":"c_GP","v":36.400675399259349},1.703626170152428E-2,1.6936625412765652E-2,1.6293121379832395E-2,1.5129326995558658E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C58*acceptance_counselling_relative","v":3.637478996064548E-4},3.616205261605954E-4,3.4788081938285726E-4,3.2303218942693898E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},6.2465380288088034E-2,6.2100052566734426E-2,5.9740572251255501E-2,5.5473388519022983E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C59","v":3.637478996064548E-4},{"$f":"D59","v":3.616205261605954E-4},{"$f":"E59","v":3.4788081938285726E-4},{"$f":"F59","v":3.2303218942693898E-4},{"$f":"G59","v":0},{"$f":"H59","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},1.2248169532953401,1.217653632035484,1.1713891015381594,1.0877184514282914,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},5.8525884484949033E-3,5.8183596838248053E-3,5.597292155297225E-3,5.1974855727759967E-3,0,0,5.8525884484949033E-3,5.8183596838248053E-3,5.597292155297225E-3,5.1974855727759967E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C60","v":3.637478996064548E-4},3.616205261605954E-4,3.4788081938285726E-4,3.2303218942693898E-4,0,0]
["Decline genetic counselling","TN",{"$f":"C58*(1-acceptance_counselling_relative)","v":1.0427258393300507E-4},1.0366274748740575E-4,9.9724100062234034E-5,9.2600950057788775E-5,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},7.5909832385124054E-2,7.54658750128053E-2,7.2598562680150525E-2,6.7412951060139795E-2,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},1.6749725324675968E-3,1.6651764839076724E-3,1.6019084032348515E-3,1.4874863744323626E-3,0,0,1.6749725324675968E-3,1.6651764839076724E-3,1.6019084032348515E-3,1.4874863744323626E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C61","v":1.0427258393300507E-4},1.0366274748740575E-4,9.9724100062234034E-5,9.2600950057788775E-5,0,0]
["Relative not FDR of proband","TN",{"$f":"C57*(1-p_FDR)","v":6.365965931541764E-4},6.3287346873348296E-4,6.0882755524474909E-4,5.6533987272726718E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},0.46343860351943111,0.4607281906758654,0.4432229060302893,0.41156412702812589,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},1.0225907593128979E-2,1.0166101545322322E-2,9.7798423476256526E-3,9.0812821799381074E-3,0,0,1.0225907593128979E-2,1.0166101545322322E-2,9.7798423476256526E-3,9.0812821799381074E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,6.365965931541764E-4,6.3287346873348296E-4,6.0882755524474909E-4,5.6533987272726718E-4,0,0]
["Proband FN",null,{"$f":"('Decision tree - Probands'!C84+'Decision tree - Probands'!C87+'Decision tree - Probands'!C88+'Decision tree - Probands'!C89)*(relatives_per_proband)","v":3.7241600950939445E-2},{"$f":"('Decision tree - Probands'!D97+'Decision tree - Probands'!D100+'Decision tree - Probands'!D101+'Decision tree - Probands'!D102+'Decision tree - Probands'!D109+'Decision tree - Probands'!D112+'Decision tree - Probands'!D113+'Decision tree - Probands'!D114)*(relatives_per_proband)","v":3.7421893482557811E-2},{"$f":"('Decision tree - Probands'!E121+'Decision tree - Probands'!E124+'Decision tree - Probands'!E125+'Decision tree - Probands'!E126)*(relatives_per_proband)","v":3.8586318338698529E-2},{"$f":"('Decision tree - Probands'!F134+'Decision tree - Probands'!F137+'Decision tree - Probands'!F138+'Decision tree - Probands'!F139+'Decision tree - Probands'!F140)*(relatives_per_proband)","v":4.0692212069167025E-2},{"$f":"('Decision tree - Probands'!G144+'Decision tree - Probands'!G145+'Decision tree - Probands'!G146)*(relatives_per_proband)","v":4.0500954186328229E-2},{"$f":"('Decision tree - Probands'!H147)*(relatives_per_proband)","v":6.8068830565257532E-2},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present","FN",{"$f":"C63*p_rel_LS","v":1.6386304418413357E-2},{"$f":"D63*p_rel_LS","v":1.6465633132325436E-2},{"$f":"E63*p_rel_LS","v":1.6977980069027353E-2},{"$f":"F63*p_rel_LS","v":1.7904573310433491E-2},{"$f":"G63*p_rel_LS","v":1.782041984198442E-2},{"$f":"H63*p_rel_LS","v":2.9950285448713313E-2},{"$f":"p_rel_female*'MM-Summary'!$N$22+(1-p_rel_female)*'MM-Summary'!$N$36","v":3372.4444524506762},55.26190143204613,55.529433113198969,57.257294697609446,60.38217893426787,60.098376036442311,101.00567401082742,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$22+(1-p_rel_female)*'MM-Summary'!$M$36","v":14.199259271527669},0.23267338493923068,0.23379979391574512,0.24107474090694864,0.25423167858091961,0.25303676166381295,0.42527186834254277,0.23267338493923068,0.23379979391574512,0.24107474090694864,0.25423167858091961,0.25303676166381295,0.42527186834254277,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C64","v":1.6386304418413357E-2},1.6465633132325436E-2,1.6977980069027353E-2,1.7904573310433491E-2,1.782041984198442E-2,2.9950285448713313E-2]
["Mutation not present","TN",{"$f":"C63*(1-p_rel_LS)","v":2.0855296532526092E-2},2.0956260350232375E-2,2.1608338269671179E-2,2.2787638758733537E-2,2.2680534344343809E-2,3.8118545116544222E-2,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},15.182534127506299,15.256035197394146,15.73074411607255,16.589267987639168,16.51129659921309,27.750078318005198,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.33500703186651337,0.33662885435381018,0.34710344472926646,0.36604702368549696,0.36432656231931387,0.61231355011649402,0.33500703186651337,0.33662885435381018,0.34710344472926646,0.36604702368549696,0.36432656231931387,0.61231355011649402,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C65","v":2.0855296532526092E-2},2.0956260350232375E-2,2.1608338269671179E-2,2.2787638758733537E-2,2.2680534344343809E-2,3.8118545116544222E-2]
["MSH6 mutation",null,{"$f":"'Decision tree - Probands'!C148*relatives_per_proband","v":0.12275493475380984},{"$f":"'Decision tree - Probands'!D148*relatives_per_proband","v":0.12275493475380984},{"$f":"'Decision tree - Probands'!E148*relatives_per_proband","v":0.12275493475380984},{"$f":"'Decision tree - Probands'!F148*relatives_per_proband","v":0.12275493475380984},{"$f":"'Decision tree - Probands'!G148*relatives_per_proband","v":0.12275493475380984},{"$f":"'Decision tree - Probands'!H148*relatives_per_proband","v":0.12275493475380984},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Proband TP",null,{"$f":"('Decision tree - Probands'!C152)*(relatives_per_proband)","v":5.2036397253041336E-2},{"$f":"('Decision tree - Probands'!D165+'Decision tree - Probands'!D177)*(relatives_per_proband)","v":5.1732063262785788E-2},{"$f":"('Decision tree - Probands'!E189)*(relatives_per_proband)","v":4.9766512834040447E-2},{"$f":"('Decision tree - Probands'!F202)*(relatives_per_proband)","v":4.6211761917323277E-2},{"$f":"('Decision tree - Probands'!G214)*(relatives_per_proband)","v":4.9715748575292984E-2},{"$f":"0","v":0},{"$f":"c_GP","v":36.400675399259349},1.8941600053548686,1.8830820425626149,1.8115346794249807,1.6821393451803395,1.8096868261204304,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C67*p_rel_LS","v":2.2896014791338189E-2},{"$f":"D67*p_rel_LS","v":2.2762107835625746E-2},{"$f":"E67*p_rel_LS","v":2.1897265646977797E-2},{"$f":"F67*p_rel_LS","v":2.0333175243622242E-2},{"$f":"G67*p_rel_LS","v":2.1874929373128914E-2},{"$f":"H67*p_rel_LS","v":0},null,0,{"$f":"D68*$I68","v":0},{"$f":"E68*$I68","v":0},{"$f":"F68*$I68","v":0},{"$f":"G68*$I68","v":0},{"$f":"H68*$I68","v":0},null,0,{"$f":"D68*$P68","v":0},{"$f":"E68*$P68","v":0},{"$f":"F68*$P68","v":0},{"$f":"G68*$P68","v":0},{"$f":"H68*$P68","v":0},null,0,{"$f":"D68*$W68","v":0},{"$f":"E68*$W68","v":0},{"$f":"F68*$W68","v":0},{"$f":"G68*$W68","v":0},{"$f":"H68*$W68","v":0},0,{"$f":"R68+Y68","v":0},{"$f":"S68+Z68","v":0},{"$f":"T68+AA68","v":0},{"$f":"U68+AB68","v":0},{"$f":"V68+AC68","v":0}]
["Accept genetic counselling",null,{"$f":"C68*acceptance_counselling_relative","v":1.7794899117925901E-2},{"$f":"D68*acceptance_counselling_relative","v":1.7690825951053517E-2},{"$f":"E68*acceptance_counselling_relative","v":1.7018666204470081E-2},{"$f":"F68*acceptance_counselling_relative","v":1.5803047189865076E-2},{"$f":"G68*acceptance_counselling_relative","v":1.7001306338858813E-2},{"$f":"H68*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},{"$f":"C69*$I69","v":3.0558668291748914},3.0379946436488647,2.9225665841876132,2.7138118281742121,2.9195854244109349,0,null,{"$f":"C69*$P69","v":0},0,0,0,0,0,null,{"$f":"C69*$W69","v":0},0,0,0,0,0,{"$f":"Q69+X69","v":0},0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C69*acceptance_MMRpredictive","v":1.2745835645262717E-2},{"$f":"D69*acceptance_MMRpredictive","v":1.2671291840813658E-2},{"$f":"E69*acceptance_MMRpredictive","v":1.2189848388926729E-2},{"$f":"F69*acceptance_MMRpredictive","v":1.1319144932574819E-2},{"$f":"G69*acceptance_MMRpredictive","v":1.2177414151877182E-2},{"$f":"H69*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},3.816980768764989,3.7946572212211769,3.6504799033704445,3.3897313388439843,3.6467562366754307,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation found","TP",{"$f":"C70","v":1.2745835645262717E-2},{"$f":"D70","v":1.2671291840813658E-2},1.2189848388926729E-2,1.1319144932574819E-2,1.2177414151877182E-2,0,{"$f":"p_rel_female*'MM-Summary'!$N23+(1-p_rel_female)*'MM-Summary'!$N37","v":4768.8528972315198},60.783015244547883,60.427526806730327,58.131593806346203,53.979337105892903,58.07229675896761,0,{"$f":"u_baseline_relative*(u_pathMMR-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M23+(1-p_rel_female)*'MM-Summary'!$M37","v":15.811652571455916},0.20153272495577271,0.20035406421846963,0.19274164762443108,0.17897438707982885,0.1925450417882125,0,0.20153272495577271,0.20035406421846963,0.19274164762443108,0.17897438707982885,0.1925450417882125,0,{"$f":"C71","v":1.2745835645262717E-2},{"$f":"D71","v":1.2671291840813658E-2},{"$f":"E71","v":1.2189848388926729E-2},{"$f":"F71","v":1.1319144932574819E-2},{"$f":"G71","v":1.2177414151877182E-2},{"$f":"H71","v":0}]
["Decline mutation testing","LL",{"$f":"C69*(1-acceptance_MMRpredictive)","v":5.049063472663185E-3},5.0195341102398598E-3,4.8288178155433533E-3,4.4839022572902565E-3,4.8238921869816322E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N24+(1-p_rel_female)*'MM-Summary'!$N38","v":3972.9592425871961},20.059723390126607,19.942404436759148,19.184696371032679,17.814360915958915,19.165127049512837,0,{"$f":"u_baseline_relative*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M24+(1-p_rel_female)*'MM-Summary'!$M38","v":15.66172181502824},7.9077027535271252E-2,7.8614546875621985E-2,7.5627601322492355E-2,7.0225629799457179E-2,7.5550457498194515E-2,0,7.9077027535271252E-2,7.8614546875621985E-2,7.5627601322492355E-2,7.0225629799457179E-2,7.5550457498194515E-2,0,null,null,null,null,null,null,{"$f":"C72","v":5.049063472663185E-3},5.0195341102398598E-3,4.8288178155433533E-3,4.4839022572902565E-3,4.8238921869816322E-3,0]
["Decline genetic counselling","FN",{"$f":"C68*(1-acceptance_counselling_relative)","v":5.1011156734122884E-3},5.0712818845722292E-3,4.8785994425077162E-3,4.5301280537571658E-3,4.8736230342701021E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N25+(1-p_rel_female)*'MM-Summary'!$N39","v":1915.5699431475955},9.7715438605076859,9.7143951513154558,9.3452984567243966,8.6777771383869418,9.3357657986795921,0,0,0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M25+(1-p_rel_female)*'MM-Summary'!$M39","v":15.274150018053664},7.791520605514414E-2,7.7459520288794131E-2,7.4516459762855827E-2,6.9193855494080428E-2,7.4440449356883431E-2,0,7.791520605514414E-2,7.7459520288794131E-2,7.4516459762855827E-2,6.9193855494080428E-2,7.4440449356883431E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C73","v":5.1011156734122884E-3},5.0712818845722292E-3,4.8785994425077162E-3,4.5301280537571658E-3,4.8736230342701021E-3,0]
["Mutation not present",null,{"$f":"C67*(1-p_rel_LS)","v":2.9140382461703151E-2},2.8969955427160046E-2,2.7869247187062653E-2,2.5878586673701038E-2,2.7840819202164073E-2,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C74*acceptance_counselling_relative","v":2.2648053422814785E-2},{"$f":"D74*acceptance_counselling_relative","v":2.2515596664977208E-2},{"$f":"E74*acceptance_counselling_relative","v":2.1660120623871012E-2},{"$f":"F74*acceptance_counselling_relative","v":2.0112969150737372E-2},{"$f":"G74*acceptance_counselling_relative","v":2.1638026249456672E-2},{"$f":"H74*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},3.8892850553134983,3.8665386373712827,3.7196301980569619,3.4539423267671796,3.7158359947048263,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C75*acceptance_MMRpredictive","v":1.6221972639425278E-2},{"$f":"D75*acceptance_MMRpredictive","v":1.6127098706490112E-2},{"$f":"E75*acceptance_MMRpredictive","v":1.5514352494997654E-2},{"$f":"F75*acceptance_MMRpredictive","v":1.440618445964068E-2},{"$f":"G75*acceptance_MMRpredictive","v":1.549852710238914E-2},{"$f":"H75*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},4.8579755238827138,4.829563736099681,4.6460653315623839,4.3142035221650712,4.6413261194050932,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation not found","TN",{"$f":"C76","v":1.6221972639425278E-2},{"$f":"D76","v":1.6127098706490112E-2},1.5514352494997654E-2,1.440618445964068E-2,1.549852710238914E-2,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},11.809501381552202,11.740433712226455,11.294358047324002,10.487618186800859,11.282837253889813,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.2605800831687049,0.25905608495441229,0.2492132956524529,0.23141234596299198,0.24895908599412309,0,0.2605800831687049,0.25905608495441229,0.2492132956524529,0.23141234596299198,0.24895908599412309,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C77","v":1.6221972639425278E-2},1.6127098706490112E-2,1.5514352494997654E-2,1.440618445964068E-2,1.549852710238914E-2,0]
["Decline mutation testing","LL",{"$f":"C75*(1-acceptance_MMRpredictive)","v":6.4260807833895076E-3},6.3884979584870952E-3,6.1457681288733584E-3,5.7067846910966906E-3,6.1394991470675323E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},21.637988000085763,21.511438592809437,20.694115356845607,19.215964259928064,20.673006354693339,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},0.10339360365420822,0.10278890790992037,9.8883461862150857E-2,9.1820357443425801E-2,9.8782595931267689E-2,0,0.10339360365420822,0.10278890790992037,9.8883461862150857E-2,9.1820357443425801E-2,9.8782595931267689E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C78","v":6.4260807833895076E-3},6.3884979584870952E-3,6.1457681288733584E-3,5.7067846910966906E-3,6.1394991470675323E-3,0]
["Decline genetic counselling","TN",{"$f":"C74*(1-acceptance_counselling_relative)","v":6.492329038888368E-3},6.454358762182838E-3,6.2091265631916397E-3,5.7656175229636661E-3,6.2027929527074021E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},4.7263776396654071,4.698735499885065,4.5202078906256871,4.1973358984381388,4.5155970591672467,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.10428889744275059,0.10367896558786514,9.9739701958886734E-2,9.2615437533251979E-2,9.9637962621543147E-2,0,0.10428889744275059,0.10367896558786514,9.9739701958886734E-2,9.2615437533251979E-2,9.9637962621543147E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C79","v":6.492329038888368E-3},6.454358762182838E-3,6.2091265631916397E-3,5.7656175229636661E-3,6.2027929527074021E-3,0]
["Proband LL",null,{"$f":"('Decision tree - Probands'!C154+'Decision tree - Probands'!C157)*(relatives_per_proband)","v":3.5572500672020535E-3},{"$f":"('Decision tree - Probands'!D167+'Decision tree - Probands'!D170+'Decision tree - Probands'!D179+'Decision tree - Probands'!D182)*(relatives_per_proband)","v":3.5364455502785623E-3},{"$f":"SUM('Decision tree - Probands'!E191,'Decision tree - Probands'!E194)*relatives_per_proband","v":3.4020789383714567E-3},{"$f":"SUM('Decision tree - Probands'!F204,'Decision tree - Probands'!F207)*relatives_per_proband","v":3.1590732999163531E-3},{"$f":"0","v":0},{"$f":"0","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C80*p_rel_LS","v":1.5651900295689035E-3},{"$f":"D80*p_rel_LS","v":1.5560360421225674E-3},{"$f":"E80*p_rel_LS","v":1.496914732883441E-3},{"$f":"F80*p_rel_LS","v":1.3899922519631954E-3},{"$f":"G80*p_rel_LS","v":0},{"$f":"H80*p_rel_LS","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C81*p_FDR","v":6.6316283708254566E-4},6.5928434043303506E-4,6.3423495062964348E-4,5.8893245415609751E-4,0,0,{"$f":"c_GP","v":36.400675399259349},2.4139575169493655E-2,2.3998395271917706E-2,2.3086580564734931E-2,2.1437539095825294E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C82*acceptance_counselling_relative","v":5.1541352904374625E-4},5.1239914172629202E-4,4.9293062859947535E-4,4.5772129798522711E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},8.851048248574353E-2,8.7992830424180879E-2,8.4649558676286346E-2,7.8603161627980173E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C83","v":5.1541352904374625E-4},{"$f":"D83","v":5.1239914172629202E-4},{"$f":"E83","v":4.9293062859947535E-4},{"$f":"F83","v":4.5772129798522711E-4},{"$f":"G83","v":0},{"$f":"H83","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$24+(1-p_rel_female)*'MM-Summary'!$N$38","v":3972.9592425871961},2.0477169439688359,2.0357409060152185,1.958393296848602,1.8185080613594162,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$24+(1-p_rel_female)*'MM-Summary'!$M$38","v":15.66172181502824},8.0722633115851324E-3,8.0250528159764144E-3,7.7201423792319862E-3,7.1687036378582734E-3,0,0,8.0722633115851324E-3,8.0250528159764144E-3,7.7201423792319862E-3,7.1687036378582734E-3,0,0,null,null,null,null,null,null,{"$f":"C84","v":5.1541352904374625E-4},5.1239914172629202E-4,4.9293062859947535E-4,4.5772129798522711E-4,0,0]
["Decline genetic counselling","FN",{"$f":"C82*(1-acceptance_counselling_relative)","v":1.4774930803879941E-4},1.4688519870674306E-4,1.413043220301681E-4,1.3121115617087037E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$25+(1-p_rel_female)*'MM-Summary'!$N$39","v":1915.5699431475955},0.28302413359997958,0.28136887173589908,0.27067831211783866,0.25134414696656443,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$25+(1-p_rel_female)*'MM-Summary'!$M$39","v":15.274150018053664},2.2567450960482445E-3,2.2435465604784158E-3,2.1583034128881528E-3,2.0041388833961418E-3,0,0,2.2567450960482445E-3,2.2435465604784158E-3,2.1583034128881528E-3,2.0041388833961418E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C85","v":1.4774930803879941E-4},1.4688519870674306E-4,1.413043220301681E-4,1.3121115617087037E-4,0,0]
["Relative not FDR of proband","FN",{"$f":"C81*(1-p_FDR)","v":9.0202719248635781E-4},8.9675170168953232E-4,8.6267978225379753E-4,8.0105979780709785E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$25+(1-p_rel_female)*'MM-Summary'!$N$39","v":1915.5699431475955},1.7278961778286777,1.7177906062229269,1.652523461446487,1.5344860713431667,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$25+(1-p_rel_female)*'MM-Summary'!$M$39","v":15.274150018053664},1.3777698658400398E-2,1.3697120020550823E-2,1.3176700411686372E-2,1.2235507525137348E-2,0,0,1.3777698658400398E-2,1.3697120020550823E-2,1.3176700411686372E-2,1.2235507525137348E-2,0,0,null,null,null,null,null,null,null,null,null,null,null,null,9.0202719248635781E-4,8.9675170168953232E-4,8.6267978225379753E-4,8.0105979780709785E-4,0,0]
["Mutation not present",null,{"$f":"C80*(1-p_rel_LS)","v":1.99206003763315E-3},1.980409508155995E-3,1.9051642054880159E-3,1.769081047953158E-3,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C87*p_FDR","v":8.4402542901414906E-4},8.3908916055113565E-4,8.0720811898318259E-4,7.4955039619866977E-4,0,0,{"$f":"c_GP","v":36.400675399259349},3.0723095670264655E-2,3.0543412164258901E-2,2.9382920718753546E-2,2.7284140667414018E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C88*acceptance_counselling_relative","v":6.5598085514658616E-4},6.5214436219709904E-4,6.2736625458115051E-4,5.8255437925392557E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},0.11264970498185542,0.11199087508532114,0.10773580195163718,0.10004038752652025,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C89","v":6.5598085514658616E-4},{"$f":"D89","v":6.5214436219709904E-4},{"$f":"E89","v":6.2736625458115051E-4},{"$f":"F89","v":5.8255437925392557E-4},{"$f":"G89","v":0},{"$f":"H89","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},2.2088277988408649,2.1959095067742611,2.1124763204619144,1.9615851547146352,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},1.0554524106993883E-2,1.0492796151057387E-2,1.0094124250640754E-2,9.373115375594987E-3,0,0,1.0554524106993883E-2,1.0492796151057387E-2,1.0094124250640754E-2,9.373115375594987E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C90","v":6.5598085514658616E-4},6.5214436219709904E-4,6.2736625458115051E-4,5.8255437925392557E-4,0,0]
["Decline genetic counselling","TN",{"$f":"C88*(1-acceptance_counselling_relative)","v":1.880445738675629E-4},1.8694479835403667E-4,1.7984186440203213E-4,1.6699601694474415E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},0.13689535201688369,0.1360947218632598,0.13092382741140951,0.1215721254534517,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},3.0206357628013631E-3,3.0029696255718451E-3,2.8888723353657922E-3,2.682524311411093E-3,0,0,3.0206357628013631E-3,3.0029696255718451E-3,2.8888723353657922E-3,2.682524311411093E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C91","v":1.880445738675629E-4},1.8694479835403667E-4,1.7984186440203213E-4,1.6699601694474415E-4,0,0]
["Relative not FDR of proband","TN",{"$f":"C87*(1-p_FDR)","v":1.1480346086190009E-3},1.1413203476048593E-3,1.0979560865048332E-3,1.0195306517544883E-3,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},0.83576249312649342,0.8308745503044288,0.7993056213736689,0.74221236270412128,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},1.8441342520048136E-2,1.8333488639859161E-2,1.7636911040133003E-2,1.6377131680123509E-2,0,0,1.8441342520048136E-2,1.8333488639859161E-2,1.7636911040133003E-2,1.6377131680123509E-2,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1.1480346086190009E-3,1.1413203476048593E-3,1.0979560865048332E-3,1.0195306517544883E-3,0,0]
["Proband FN",null,{"$f":"('Decision tree - Probands'!C155+'Decision tree - Probands'!C158+'Decision tree - Probands'!C159+'Decision tree - Probands'!C160)*(relatives_per_proband)","v":6.7161287433566447E-2},{"$f":"SUM('Decision tree - Probands'!D168,'Decision tree - Probands'!D171:D173,'Decision tree - Probands'!D180,'Decision tree - Probands'!D183:D185)*(relatives_per_proband)","v":6.7486425940745484E-2},{"$f":"SUM('Decision tree - Probands'!E192,'Decision tree - Probands'!E195:E197)*relatives_per_proband","v":6.9586342981397931E-2},{"$f":"SUM('Decision tree - Probands'!F205,'Decision tree - Probands'!F208:F211)*relatives_per_proband","v":7.3384099536570213E-2},{"$f":"('Decision tree - Probands'!G215+'Decision tree - Probands'!G216+'Decision tree - Probands'!G217)*(relatives_per_proband)","v":7.303918617851686E-2},{"$f":"('Decision tree - Probands'!H218)*(relatives_per_proband)","v":0.12275493475380984},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present","FN",{"$f":"C93*p_rel_LS","v":2.9550966470769238E-2},{"$f":"D93*p_rel_LS","v":2.9694027413928015E-2},{"$f":"E93*p_rel_LS","v":3.061799091181509E-2},{"$f":"F93*p_rel_LS","v":3.2289003796090891E-2},{"$f":"G93*p_rel_LS","v":3.2137241918547416E-2},{"$f":"H93*p_rel_LS","v":5.4012171291676334E-2},{"$f":"p_rel_female*'MM-Summary'!$N$25+(1-p_rel_female)*'MM-Summary'!$N$39","v":1915.5699431475955},56.606943162367926,56.880986405121227,58.650903110239227,61.851845165970325,61.561134674832395,103.46409189047462,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$25+(1-p_rel_female)*'MM-Summary'!$M$39","v":15.274150018053664},0.45136589505300317,0.4535510293605346,0.4676637864384674,0.49318708791499649,0.49086905423037597,0.82499000710987569,0.45136589505300317,0.4535510293605346,0.4676637864384674,0.49318708791499649,0.49086905423037597,0.82499000710987569,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C94","v":2.9550966470769238E-2},2.9694027413928015E-2,3.061799091181509E-2,3.2289003796090891E-2,3.2137241918547416E-2,5.4012171291676334E-2]
["Mutation not present","TN",{"$f":"C93*(1-p_rel_LS)","v":3.7610320962797213E-2},3.7792398526817476E-2,3.8968352069582844E-2,4.1095095740479322E-2,4.0901944259969444E-2,6.8742763462133524E-2,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},27.380094100966957,27.512645504648965,28.368732818850035,29.916989795847943,29.776376645608337,50.044330496820741,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.6041497407453772,0.60707452602458822,0.62596434163379455,0.6601270821930928,0.65702441213106233,1.1042427094639704,0.6041497407453772,0.60707452602458822,0.62596434163379455,0.6601270821930928,0.65702441213106233,1.1042427094639704,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C95","v":3.7610320962797213E-2},3.7792398526817476E-2,3.8968352069582844E-2,4.1095095740479322E-2,4.0901944259969444E-2,6.8742763462133524E-2]
["PMS2 mutation",null,{"$f":"'Decision tree - Probands'!C219*relatives_per_proband","v":2.1529589922295797E-2},{"$f":"'Decision tree - Probands'!D219*relatives_per_proband","v":2.1529589922295797E-2},{"$f":"'Decision tree - Probands'!E219*relatives_per_proband","v":2.1529589922295797E-2},{"$f":"'Decision tree - Probands'!F219*relatives_per_proband","v":2.1529589922295797E-2},{"$f":"'Decision tree - Probands'!G219*relatives_per_proband","v":2.1529589922295797E-2},{"$f":"'Decision tree - Probands'!H219*relatives_per_proband","v":2.1529589922295797E-2},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Proband TP",null,{"$f":"('Decision tree - Probands'!C223)*(relatives_per_proband)","v":9.1264949644469517E-3},{"$f":"('Decision tree - Probands'!D236+'Decision tree - Probands'!D248)*(relatives_per_proband)","v":9.073118812826176E-3},{"$f":"('Decision tree - Probands'!E260)*(relatives_per_proband)","v":8.7283872972471928E-3},{"$f":"('Decision tree - Probands'!F273)*(relatives_per_proband)","v":8.1049310617295357E-3},{"$f":"('Decision tree - Probands'!G285)*(relatives_per_proband)","v":8.7194839185297992E-3},{"$f":"0","v":0},{"$f":"c_GP","v":36.400675399259349},0.33221058073380849,0.33026765276459896,0.31771919276611371,0.29502496471139128,0.31739510376746516,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C97*p_rel_LS","v":4.0156577843566592E-3},{"$f":"D97*p_rel_LS","v":3.9921722776435171E-3},{"$f":"E97*p_rel_LS","v":3.8404904107887648E-3},{"$f":"F97*p_rel_LS","v":3.5661696671609958E-3},{"$f":"G97*p_rel_LS","v":3.8365729241531116E-3},{"$f":"H97*p_rel_LS","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C98*acceptance_counselling_relative","v":3.1209896488961918E-3},{"$f":"D98*acceptance_counselling_relative","v":3.10273659365918E-3},{"$f":"E98*acceptance_counselling_relative","v":2.9848486754647826E-3},{"$f":"F98*acceptance_counselling_relative","v":2.7716451986458698E-3},{"$f":"G98*acceptance_counselling_relative","v":2.9818039849318413E-3},{"$f":"H98*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},0.53595857324375173,0.53282402858237232,0.5125794755571832,0.47596665587452724,0.51205661961160798,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C99*acceptance_MMRpredictive","v":2.2354507801240963E-3},{"$f":"D99*acceptance_MMRpredictive","v":2.2223767840012136E-3},{"$f":"E99*acceptance_MMRpredictive","v":2.1379379782563513E-3},{"$f":"F99*acceptance_MMRpredictive","v":1.985228122666612E-3},{"$f":"G99*acceptance_MMRpredictive","v":2.1357571777434413E-3},{"$f":"H99*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},0.66944787887844226,0.66553262426816506,0.64024583204552932,0.59451398689942014,0.63959275021943629,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation found","TP",{"$f":"C100","v":2.2354507801240963E-3},{"$f":"D100","v":2.2223767840012136E-3},2.1379379782563513E-3,1.985228122666612E-3,2.1357571777434413E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N26+(1-p_rel_female)*'MM-Summary'!$N40","v":4530.0791181167315},10.126768898617925,10.067542661791316,9.6850281911277989,8.9932404631900997,9.6751489922634875,0,{"$f":"u_baseline_relative*(u_pathMMR-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M26+(1-p_rel_female)*'MM-Summary'!$M40","v":16.003427966355048},3.5774875532048174E-2,3.5565646776863212E-2,3.4214336431560265E-2,3.1770455257877389E-2,3.4179436147642919E-2,0,3.5774875532048174E-2,3.5565646776863212E-2,3.4214336431560265E-2,3.1770455257877389E-2,3.4179436147642919E-2,0,2.2354507801240963E-3,2.2223767840012136E-3,2.1379379782563513E-3,1.985228122666612E-3,2.1357571777434413E-3,0]
["Decline mutation testing","LL",{"$f":"C99*(1-acceptance_MMRpredictive)","v":8.8553886877209534E-4},8.8035980965796637E-4,8.4691069720843116E-4,7.8641707597925758E-4,8.4604680718840003E-4,0,{"$f":"p_rel_female*'MM-Summary'!$N27+(1-p_rel_female)*'MM-Summary'!$N41","v":3591.122089793088},3.1800781930178541,3.1614795594287615,3.0413597128272625,2.8241197333396011,3.038257378293177,0,{"$f":"u_baseline_relative*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M27+(1-p_rel_female)*'MM-Summary'!$M41","v":15.944068082517887},1.411909201341816E-2,1.4036516742299105E-2,1.3503201816103918E-2,1.2538687400667926E-2,1.3489427894808734E-2,0,1.411909201341816E-2,1.4036516742299105E-2,1.3503201816103918E-2,1.2538687400667926E-2,1.3489427894808734E-2,0,null,null,null,null,null,null,{"$f":"C102","v":8.8553886877209534E-4},8.8035980965796637E-4,8.4691069720843116E-4,7.8641707597925758E-4,8.4604680718840003E-4,0]
["Decline genetic counselling","FN",{"$f":"C98*(1-acceptance_counselling_relative)","v":8.9466813546046733E-4},8.894356839843371E-4,8.5564173532398202E-4,7.9452446851512612E-4,8.5476893922127009E-4,0,{"$f":"p_rel_female*'MM-Summary'!$N28+(1-p_rel_female)*'MM-Summary'!$N42","v":1163.9132140419929},1.0413160650447495,1.035225945629848,0.99589272222940406,0.92475752778444664,0.9948768633122933,0,0,0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M28+(1-p_rel_female)*'MM-Summary'!$M42","v":15.790622469388676},1.4127366762448128E-2,1.4044743096599159E-2,1.351111561155359E-2,1.2546035925014047E-2,1.3497333617802912E-2,0,1.4127366762448128E-2,1.4044743096599159E-2,1.351111561155359E-2,1.2546035925014047E-2,1.3497333617802912E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C103","v":8.9466813546046733E-4},8.894356839843371E-4,8.5564173532398202E-4,7.9452446851512612E-4,8.5476893922127009E-4,0]
["Mutation not present",null,{"$f":"C97*(1-p_rel_LS)","v":5.1108371800902934E-3},5.0809465351826589E-3,4.8878968864584284E-3,4.5387613945685407E-3,4.8829109943766876E-3,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C104*acceptance_counselling_relative","v":3.9721686440496989E-3},{"$f":"D104*acceptance_counselling_relative","v":3.9489374828389568E-3},{"$f":"E104*acceptance_counselling_relative","v":3.7988983142279056E-3},{"$f":"F104*acceptance_counselling_relative","v":3.5275484346401981E-3},{"$f":"G104*acceptance_counselling_relative","v":3.7950232535496164E-3},{"$f":"H104*acceptance_counselling_relative","v":0},{"$f":"c_pretest_relative","v":171.72712297629874},0.68212909321932047,0.67813967274120113,0.65237387798186952,0.60577574384030741,0.65170842496022841,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept mutation testing",null,{"$f":"C105*acceptance_MMRpredictive","v":2.8451191747033955E-3},{"$f":"D105*acceptance_MMRpredictive","v":2.8284795432742724E-3},{"$f":"E105*acceptance_MMRpredictive","v":2.7210119723262657E-3},{"$f":"F105*acceptance_MMRpredictive","v":2.526653974302961E-3},{"$f":"G105*acceptance_MMRpredictive","v":2.7182364080371073E-3},{"$f":"H105*acceptance_MMRpredictive","v":0},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},0.8520245731180176,0.84704152179584657,0.81485833169431021,0.75665416514471662,0.81402713664291892,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation not found","TN",{"$f":"C106","v":2.8451191747033955E-3},{"$f":"D106","v":2.8284795432742724E-3},2.7210119723262657E-3,2.526653974302961E-3,2.7182364080371073E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},2.0712301500670507,2.0591165955247894,1.9808808312443049,1.8393893432982833,1.97886023664487,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},4.5702295747143733E-2,4.5435006642540049E-2,4.3708711746226966E-2,4.0586660907210755E-2,4.3664126738633548E-2,0,4.5702295747143733E-2,4.5435006642540049E-2,4.3708711746226966E-2,4.0586660907210755E-2,4.3664126738633548E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C107","v":2.8451191747033955E-3},2.8284795432742724E-3,2.7210119723262657E-3,2.526653974302961E-3,2.7182364080371073E-3,0]
["Decline mutation testing","LL",{"$f":"C105*(1-acceptance_MMRpredictive)","v":1.1270494693463031E-3},1.1204579395646846E-3,1.0778863419016399E-3,1.0008944603372371E-3,1.0767868455125091E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},3.7950165451164923,3.7728214549636356,3.6294737831200892,3.3702256557543686,3.625771543687363,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},1.8133868847943813E-2,1.802781322233182E-2,1.7342849705054408E-2,1.610407472612195E-2,1.7325159156536738E-2,0,1.8133868847943813E-2,1.802781322233182E-2,1.7342849705054408E-2,1.610407472612195E-2,1.7325159156536738E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C108","v":1.1270494693463031E-3},1.1204579395646846E-3,1.0778863419016399E-3,1.0008944603372371E-3,1.0767868455125091E-3,0]
["Decline genetic counselling","TN",{"$f":"C104*(1-acceptance_counselling_relative)","v":1.1386685360405947E-3},1.1320090523437019E-3,1.0889985722305226E-3,1.0112129599283424E-3,1.087887740827071E-3,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},0.8289440469662781,0.82409598171139387,0.79278460327377065,0.73615713161135843,0.79197592449682275,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},1.8290891522152009E-2,1.8183917552082578E-2,1.7493022878904578E-2,1.624352124469711E-2,1.7475179146460205E-2,0,1.8290891522152009E-2,1.8183917552082578E-2,1.7493022878904578E-2,1.624352124469711E-2,1.7475179146460205E-2,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C109","v":1.1386685360405947E-3},1.1320090523437019E-3,1.0889985722305226E-3,1.0112129599283424E-3,1.087887740827071E-3,0]
["Proband LL",null,{"$f":"SUM('Decision tree - Probands'!C225,'Decision tree - Probands'!C228)*relatives_per_proband","v":6.2389455341665978E-4},{"$f":"SUM('Decision tree - Probands'!D238,'Decision tree - Probands'!D241,'Decision tree - Probands'!D250,'Decision tree - Probands'!D253)*relatives_per_proband","v":6.2024571666078883E-4},{"$f":"SUM('Decision tree - Probands'!E262,'Decision tree - Probands'!E265)*relatives_per_proband","v":5.9667959233829205E-4},{"$f":"SUM('Decision tree - Probands'!F275,'Decision tree - Probands'!F278)*relatives_per_proband","v":5.5405962145698546E-4},{"$f":"0","v":0},{"$f":"0","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present",null,{"$f":"C110*p_rel_LS","v":2.7451360350333031E-4},{"$f":"D110*p_rel_LS","v":2.7290811533074711E-4},{"$f":"E110*p_rel_LS","v":2.6253902062884851E-4},{"$f":"F110*p_rel_LS","v":2.4378623344107361E-4},{"$f":"G110*p_rel_LS","v":0},{"$f":"H110*p_rel_LS","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C111*p_FDR","v":1.1630997941327443E-4},1.1562974246356296E-4,1.1123641121906058E-4,1.0329095327484198E-4,0,0,{"$f":"c_GP","v":36.400675399259349},4.2337618063171397E-3,4.2090007219161103E-3,4.0490804973635549E-3,3.7598604618375871E-3,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C112*acceptance_counselling_relative","v":9.0396707415224767E-5},8.986802379902704E-5,8.64535044165043E-5,8.0278254101039708E-5,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},1.55235664909468E-2,1.5432777174572459E-2,1.484641158466502E-2,1.3785953614331804E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C113","v":9.0396707415224767E-5},{"$f":"D113","v":8.986802379902704E-5},{"$f":"E113","v":8.64535044165043E-5},{"$f":"F113","v":8.0278254101039708E-5},{"$f":"G113","v":0},{"$f":"H113","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$27+(1-p_rel_female)*'MM-Summary'!$N$41","v":3591.122089793088},0.32462561284337632,0.32272704543073694,0.3104650894501329,0.28828901163226628,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$27+(1-p_rel_female)*'MM-Summary'!$M$41","v":15.944068082517887},1.4412912574637933E-3,1.4328618898930248E-3,1.3784205603890054E-3,1.279961948932648E-3,0,0,1.4412912574637933E-3,1.4328618898930248E-3,1.3784205603890054E-3,1.279961948932648E-3,0,0,null,null,null,null,null,null,{"$f":"C114","v":9.0396707415224767E-5},8.986802379902704E-5,8.64535044165043E-5,8.0278254101039708E-5,0,0]
["Decline genetic counselling","FN",{"$f":"C112*(1-acceptance_counselling_relative)","v":2.5913271998049664E-5},2.5761718664535918E-5,2.4782906802556283E-5,2.3012699173802265E-5,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$28+(1-p_rel_female)*'MM-Summary'!$N$42","v":1163.9132140419929},3.0160799697594359E-2,2.9984404770085599E-2,2.8845152709866453E-2,2.6784784659161707E-2,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$28+(1-p_rel_female)*'MM-Summary'!$M$42","v":15.790622469388676},4.0918669506778341E-4,4.0679357359429052E-4,3.9133752501321071E-4,3.6338484465512429E-4,0,0,4.0918669506778341E-4,4.0679357359429052E-4,3.9133752501321071E-4,3.6338484465512429E-4,0,0,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C115","v":2.5913271998049664E-5},2.5761718664535918E-5,2.4782906802556283E-5,2.3012699173802265E-5,0,0]
["Relative not FDR of proband","FN",{"$f":"C111*(1-p_FDR)","v":1.5820362409005588E-4},1.5727837286718413E-4,1.5130260940978793E-4,1.4049528016623163E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$28+(1-p_rel_female)*'MM-Summary'!$N$42","v":1163.9132140419929},0.18413528858774819,0.18305837646313924,0.17610310641108654,0.16352431309600893,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$28+(1-p_rel_female)*'MM-Summary'!$M$42","v":15.790622469388676},2.4981337012951561E-3,2.483523408545448E-3,2.3891623838233358E-3,2.2185079278359545E-3,0,0,2.4981337012951561E-3,2.483523408545448E-3,2.3891623838233358E-3,2.2185079278359545E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,1.5820362409005588E-4,1.5727837286718413E-4,1.5130260940978793E-4,1.4049528016623163E-4,0,0]
["Mutation not present",null,{"$f":"C110*(1-p_rel_LS)","v":3.4938094991332952E-4},3.4733760133004178E-4,3.3414057170944359E-4,3.102733880159119E-4,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C117*p_FDR","v":1.4803088288962201E-4},1.4716512677180743E-4,1.415736142788044E-4,1.314612132588898E-4,0,0,{"$f":"c_GP","v":36.400675399259349},5.3884241171309058E-3,5.3569100097114143E-3,5.1533751784627073E-3,4.785276951429657E-3,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C118*acceptance_counselling_relative","v":1.1505035489210425E-4},1.1437748483512534E-4,1.1003173289373277E-4,1.0217232340132328E-4,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},1.97572664430232E-2,1.9641716404001315E-2,1.8895432925937303E-2,1.754575914551321E-2,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C119","v":1.1505035489210425E-4},{"$f":"D119","v":1.1437748483512534E-4},{"$f":"E119","v":1.1003173289373277E-4},{"$f":"F119","v":1.0217232340132328E-4},{"$f":"G119","v":0},{"$f":"H119","v":0},{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},0.38739914459149821,0.38513344723889709,0.37050037125854768,0.34403605902579426,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},1.8511237556705323E-3,1.8402974896575231E-3,1.7703757179036907E-3,1.6439203094819985E-3,0,0,1.8511237556705323E-3,1.8402974896575231E-3,1.7703757179036907E-3,1.6439203094819985E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C120","v":1.1505035489210425E-4},1.1437748483512534E-4,1.1003173289373277E-4,1.0217232340132328E-4,0,0]
["Decline genetic counselling","TN",{"$f":"C118*(1-acceptance_counselling_relative)","v":3.2980527997517757E-5},3.2787641936682084E-5,3.1541881385071639E-5,2.9288889857566524E-5,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},2.4009631849854104E-2,2.3869211923587867E-2,2.2962305514464001E-2,2.1322140834859431E-2,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},5.2977951076395443E-4,5.2668110424510179E-4,5.0666995052400657E-4,4.704792397722918E-4,0,0,5.2977951076395443E-4,5.2668110424510179E-4,5.0666995052400657E-4,4.704792397722918E-4,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C121","v":3.2980527997517757E-5},3.2787641936682084E-5,3.1541881385071639E-5,2.9288889857566524E-5,0,0]
["Relative not FDR of proband","TN",{"$f":"C117*(1-p_FDR)","v":2.0135006702370751E-4},2.0017247455823435E-4,1.9256695743063919E-4,1.7881217475702209E-4,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},0.14658167336030878,0.14572439291994407,0.14018762085022271,0.13017421936092108,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},3.2343672608315332E-3,3.2154511185464659E-3,3.0932806322744601E-3,2.8723320156834272E-3,0,0,3.2343672608315332E-3,3.2154511185464659E-3,3.0932806322744601E-3,2.8723320156834272E-3,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,2.0135006702370751E-4,2.0017247455823435E-4,1.9256695743063919E-4,1.7881217475702209E-4,0,0]
["Proband FN",null,{"$f":"SUM('Decision tree - Probands'!C226,'Decision tree - Probands'!C229:C231)*relatives_per_proband","v":1.1779200404432186E-2},{"$f":"SUM('Decision tree - Probands'!D239,'Decision tree - Probands'!D242:D244,'Decision tree - Probands'!D251,'Decision tree - Probands'!D254:D256)*relatives_per_proband","v":1.1836225392808835E-2},{"$f":"SUM('Decision tree - Probands'!E263,'Decision tree - Probands'!E266:E268)*relatives_per_proband","v":1.2204523032710315E-2},{"$f":"SUM('Decision tree - Probands'!F276,'Decision tree - Probands'!F279:F282)*relatives_per_proband","v":1.2870599239109277E-2},{"$f":"('Decision tree - Probands'!G286+'Decision tree - Probands'!G287+'Decision tree - Probands'!G288)*(relatives_per_proband)","v":1.2810106003766E-2},{"$f":"('Decision tree - Probands'!H289)*(relatives_per_proband)","v":2.1529589922295797E-2},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Mutation present","FN",{"$f":"C123*p_rel_LS","v":5.1828481779501619E-3},{"$f":"D123*p_rel_LS","v":5.2079391728358871E-3},{"$f":"E123*p_rel_LS","v":5.3699901343925386E-3},{"$f":"F123*p_rel_LS","v":5.6630636652080825E-3},{"$f":"G123*p_rel_LS","v":5.6364466416570398E-3},{"$f":"H123*p_rel_LS","v":9.4730195658101514E-3},{"$f":"p_rel_female*'MM-Summary'!$N$28+(1-p_rel_female)*'MM-Summary'!$N$42","v":1163.9132140419929},6.0323854806896593,6.0615892211906148,6.2502024766946125,6.5913146318967675,6.560334726467242,11.025772649524777,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$28+(1-p_rel_female)*'MM-Summary'!$M$42","v":15.790622469388676},8.1840398894169983E-2,8.2236601321791836E-2,8.4795486876534334E-2,8.9423300357413346E-2,8.9003000987259995E-2,0.14958487560884035,8.1840398894169983E-2,8.2236601321791836E-2,8.4795486876534334E-2,8.9423300357413346E-2,8.9003000987259995E-2,0.14958487560884035,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C124","v":5.1828481779501619E-3},5.2079391728358871E-3,5.3699901343925386E-3,5.6630636652080825E-3,5.6364466416570398E-3,9.4730195658101514E-3]
["Mutation not present","TN",{"$f":"C123*(1-p_rel_LS)","v":6.5963522264820247E-3},6.6282862199729484E-3,6.8345328983177777E-3,7.2075355739011958E-3,7.1736593621089606E-3,1.2056570356485647E-2,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},4.8021059129714008,4.8253536738098699,4.9755000516267236,5.2470438219521247,5.222382137528502,8.777112836182356,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.10595986382132472,0.10647283242660702,0.10978585592818463,0.11577754820791714,0.11523338096744187,0.1936695478444401,0.10595986382132472,0.10647283242660702,0.10978585592818463,0.11577754820791714,0.11523338096744187,0.1936695478444401,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C125","v":6.5963522264820247E-3},6.6282862199729484E-3,6.8345328983177777E-3,7.2075355739011958E-3,7.1736593621089606E-3,1.2056570356485647E-2]
["Proband sporadic",null,{"$f":"'Decision tree - Probands'!C290*relatives_per_proband","v":5.7612638377727237},{"$f":"'Decision tree - Probands'!D290*relatives_per_proband","v":5.7612638377727237},{"$f":"'Decision tree - Probands'!E290*relatives_per_proband","v":5.7612638377727237},{"$f":"'Decision tree - Probands'!F290*relatives_per_proband","v":5.7612638377727237},{"$f":"'Decision tree - Probands'!G290*relatives_per_proband","v":5.7612638377727237},{"$f":"'Decision tree - Probands'!H290*relatives_per_proband","v":5.7612638377727237},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Proband LL",null,{"$f":"('Decision tree - Probands'!C295+'Decision tree - Probands'!C298)*relatives_per_proband","v":0.19940270967162443},{"$f":"('Decision tree - Probands'!D307+'Decision tree - Probands'!D310+'Decision tree - Probands'!D318+'Decision tree - Probands'!D321)*relatives_per_proband","v":4.4880761967742301E-2},{"$f":"('Decision tree - Probands'!E329+'Decision tree - Probands'!E332)*relatives_per_proband","v":0.18078491146490477},{"$f":"('Decision tree - Probands'!F341+'Decision tree - Probands'!F344)*relatives_per_proband","v":5.961594233817908E-2},{"$f":"(0)*(relatives_per_proband)","v":0},{"$f":"(0)*(relatives_per_proband)","v":0},null,0,0,0,0,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Relative is FDR of proband",null,{"$f":"C127*p_FDR","v":8.4485886166936031E-2},1.9015744334348987E-2,7.6597622348644812E-2,2.5258963262898716E-2,0,0,{"$f":"c_GP","v":36.400675399259349},3.0753433181814143,0.69218593698994246,2.7882051874680731,0.91944332265459294,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Accept genetic counselling",null,{"$f":"C128*acceptance_counselling_relative","v":6.5662860324407074E-2},1.4779133188279791E-2,5.9532061574435052E-2,1.9631394685188729E-2,0,0,{"$f":"c_pretest_relative","v":171.72712297629874},11.276094089904982,2.5379780225068216,10.223269659025597,3.3712429292996622,0,0,null,0,0,0,0,0,0,null,0,0,0,0,0,0,0,0,0,0,0,0]
["Diagnosed LL","LL",{"$f":"C129","v":6.5662860324407074E-2},{"$f":"D129","v":1.4779133188279791E-2},5.9532061574435052E-2,1.9631394685188729E-2,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},221.10089051843582,49.764501468185742,200.45718026105195,66.103103422083677,0,0,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083},1.0564946168638705,0.23779157012336202,0.95785200756508537,0.31586292013420869,0,0,1.0564946168638705,0.23779157012336202,0.95785200756508537,0.31586292013420869,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C130","v":6.5662860324407074E-2},1.4779133188279791E-2,5.9532061574435052E-2,1.9631394685188729E-2,0,0]
["Decline genetic counselling","TN",{"$f":"C128*(1-acceptance_counselling_relative)","v":1.8823025842528953E-2},4.2366111460691962E-3,1.7065560774209759E-2,5.6275685777099852E-3,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},13.703052929092717,3.0842281820280646,12.423628619011982,4.0968370721897838,0,0,{"$f":"0","v":0},0,0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},0.30236184886739215,6.8054391986404297E-2,0.27413097930250957,9.0397901698668626E-2,0,0,0.30236184886739215,6.8054391986404297E-2,0.27413097930250957,9.0397901698668626E-2,0,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C131","v":1.8823025842528953E-2},4.2366111460691962E-3,1.7065560774209759E-2,5.6275685777099852E-3,0,0]
["Relative not FDR of proband","TN",{"$f":"C127*(1-p_FDR)","v":0.1149168235046884},2.5865017633393314E-2,0.10418728911625996,3.4356979075280368E-2,0,0,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},83.658776654815568,{"$f":"D132*$I132","v":18.829581843398557},{"$f":"E132*$I132","v":75.847738256464112},{"$f":"F132*$I132","v":25.011680199077094},{"$f":"G132*$I132","v":0},{"$f":"H132*$I132","v":0},{"$f":"0","v":0},0,{"$f":"D132*$P132","v":0},{"$f":"E132*$P132","v":0},{"$f":"F132*$P132","v":0},{"$f":"G132*$P132","v":0},{"$f":"H132*$P132","v":0},{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},1.8459552418155232,{"$f":"D132*$W132","v":0.4154802005823402},{"$f":"E132*$W132","v":1.6736024074565805},{"$f":"F132*$W132","v":0.55188999906852243},{"$f":"G132*$W132","v":0},{"$f":"H132*$W132","v":0},1.8459552418155232,{"$f":"R132+Y132","v":0.4154802005823402},{"$f":"S132+Z132","v":1.6736024074565805},{"$f":"T132+AA132","v":0.55188999906852243},{"$f":"U132+AB132","v":0},{"$f":"V132+AC132","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,0.1149168235046884,2.5865017633393314E-2,0.10418728911625996,3.4356979075280368E-2,0,0]
["Proband TN","TN",{"$f":"('Decision tree - Probands'!C296+'Decision tree - Probands'!C299+'Decision tree - Probands'!C300+'Decision tree - Probands'!C301)*relatives_per_proband","v":5.5618611281010981},{"$f":"('Decision tree - Probands'!D308+'Decision tree - Probands'!D311+'Decision tree - Probands'!D312+'Decision tree - Probands'!D313+'Decision tree - Probands'!D319+'Decision tree - Probands'!D322+'Decision tree - Probands'!D323+'Decision tree - Probands'!D324)*relatives_per_proband","v":5.7163830758049814},{"$f":"('Decision tree - Probands'!E330+'Decision tree - Probands'!E333+'Decision tree - Probands'!E334+'Decision tree - Probands'!E335)*relatives_per_proband","v":5.5804789263078192},{"$f":"('Decision tree - Probands'!F342+'Decision tree - Probands'!F345+'Decision tree - Probands'!F346+'Decision tree - Probands'!F347+'Decision tree - Probands'!F348)*relatives_per_proband","v":5.7016478954345446},{"$f":"('Decision tree - Probands'!G351+'Decision tree - Probands'!G352+'Decision tree - Probands'!G353)*(relatives_per_proband)","v":5.7612638377727237},{"$f":"('Decision tree - Probands'!H354)*(relatives_per_proband)","v":5.7612638377727237},{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},{"$f":"C133*$I133","v":4049.0024324586984},4161.4935083254004,4062.5560808669925,4150.766383036138,4194.1664410348922,4194.1664410348922,{"$f":"0","v":0},{"$f":"C133*$P133","v":0},0,0,0,0,0,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678},{"$f":"C133*$W133","v":89.342416458712393},91.824564769467699,89.641481653369098,91.58786762962032,92.545502533707662,92.545502533707662,{"$f":"Q133+X133","v":89.342416458712393},91.824564769467699,89.641481653369098,91.58786762962032,92.545502533707662,92.545502533707662,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,5.5618611281010981,5.7163830758049814,5.5804789263078192,5.7016478954345446,5.7612638377727237,5.7612638377727237]
["GRAND TOTAL",null,{"$f":"SUMPRODUCT((LEN($B$4:$B$133)=2)*C$4:C$133)","v":5.9999999999999991},{"$f":"SUMPRODUCT((LEN($B$4:$B$133)=2)*D$4:D$133)","v":6},6,6,6,6,null,{"$f":"SUM(J4:J133)","v":4889.9947588963778},{"$f":"SUM(K4:K133)","v":4743.1611702651098},4865.8459138947683,4741.7197399376892,4690.1583230254646,4550.3915585108889,null,{"$f":"SUM(Q4:Q133)","v":0},0,0,0,0,0,null,{"$f":"SUM(X4:X133)","v":96.281677747203631},96.280006840705568,96.280402471005573,96.277706904179112,96.278247501544328,96.254410396023459,96.281677747203631,96.280006840705568,96.280402471005573,96.277706904179112,96.278247501544328,96.254410396023459,{"$f":"SUM(AJ4:AJ133)","v":2.4788346736791401E-2},2.4537643974031992E-2,2.3707052008468409E-2,2.2069831300060412E-2,2.3682869664684133E-2,0,{"$f":"SUM(AP4:AP133)","v":1.082190208364088E-2},1.0712452236925053E-2,1.0349838908241584E-2,9.635073926783453E-3,9.3815984671231003E-3,0,{"$f":"SUM(AV4:AV133)","v":6.943366255956937E-2},6.9793815169044607E-2,7.0987020463291667E-2,7.3339006153157763E-2,7.1979443248194414E-2,0.10504391138000166,7.9436190249040917E-2,2.8413163308002587E-2,7.2704583821287985E-2,3.1894216046549489E-2,1.1940216230883946E-2,0,5.8155198983709564,5.8665429253119958,5.8222515047987109,5.8630618725734491,5.8830158723891142,5.8949560886199981]

{"sheet":"Supplementary decision trees","index":13,"n_rows":122,"n_cols":61,"rows_kept":122,"cut":false,"hidden":false,"merged":[]}
["Strategy",null,"S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4"]
["Description",null,"PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC"]
[null,null,"Weights",null,null,null,"Diagnostic costs (unweighted)",null,null,null,"Diagnostic costs (weighted)",null,null,null,"Long-term costs (unweighted)","Long-term costs (weighted)",null,null,null,"Total costs (weighted)",null,null,null,"Short-term QALYs (unweighted)","Short-term QALYs (weighted)",null,null,null,"Long-term QALYs (unweighted)","Long-term QALYs (weighted)",null,null,null,"Total QALYs (weighted)",null,null,null,"True Positives [including diagnosed Lynch-like if LS] (weighted)",null,null,null,"False Positives [including diagnosed Lynch-like if sporadic] (weighted)",null,null,null,"False Negatives (weighted)",null,null,null,"True Negatives (weighted)",null,null,null,"True Positives [pathogenic variant detected] (weighted)",null,null,null,"True Positives [diagnosed LL] (weighted)"]
["Cohort (probands)",null,{"$f":"cohort_probands","v":1},{"$f":"cohort_probands","v":1},{"$f":"cohort_probands","v":1},{"$f":"cohort_probands","v":1},{"$f":"c_riskprediction","v":116},{"$f":"c_riskprediction","v":116},{"$f":"c_riskprediction","v":116},{"$f":"c_riskprediction+c_IHC","v":326},{"$f":"C4*G4","v":116},{"$f":"D4*H4","v":116},116,326,null,null,null,null,null,{"$f":"K4+P4","v":116},{"$f":"L4+Q4","v":116},{"$f":"M4+R4","v":116},{"$f":"N4+S4","v":326}]
["Actually LS",null,{"$f":"C$4*p_EC_LS","v":3.9789360371212751E-2},{"$f":"D$4*p_EC_LS","v":3.9789360371212751E-2},{"$f":"E$4*p_EC_LS","v":3.9789360371212751E-2},{"$f":"F$4*p_EC_LS","v":3.9789360371212751E-2}]
["Meets criteria",null,{"$f":"C$5*sens_PREMM","v":2.5578874524351057E-2},{"$f":"D$5*sens_MMRpredict","v":2.8420971693723394E-2},{"$f":"E$5*sens_MMRpro","v":2.2736777354978713E-2},{"$f":"F$5*sens_MMRpro_TBT","v":2.5578874524351057E-2},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"C6*G6","v":0.69831623147946542},{"$f":"D6*H6","v":0.77590692386607263},{"$f":"E6*I6","v":0.6207255390928581},{"$f":"F6*J6","v":0.69831623147946542},null,null,null,null,null,{"$f":"K6+P6","v":0.69831623147946542},0.77590692386607263,0.6207255390928581,0.69831623147946542]
["Accept genetic counselling",null,{"$f":"C$6*acceptance_counselling_prediction","v":1.348226577133039E-2},{"$f":"D$6*acceptance_counselling_prediction","v":1.4980295301478212E-2},{"$f":"E$6*acceptance_counselling_prediction","v":1.1984236241182568E-2},{"$f":"F$6*MAX(acceptance_counselling_prediction,acceptance_counselling_tumour)","v":1.4175094280485254E-2},{"$f":"c_pretest_proband","v":347.33219120941197},{"$f":"c_pretest_proband","v":347.33219120941197},{"$f":"c_pretest_proband","v":347.33219120941197},{"$f":"c_pretest_proband","v":347.33219120941197},4.6828249128238371,5.2031387920264862,4.1625110336211879,4.9234665570409462,null,null,null,null,null,4.6828249128238371,5.2031387920264862,4.1625110336211879,4.9234665570409462]
["Accept mutation testing",null,{"$f":"C$7*acceptance_MMRdiagnostic","v":1.2134039194197352E-2},{"$f":"D$7*acceptance_MMRdiagnostic","v":1.348226577133039E-2},{"$f":"E$7*acceptance_MMRdiagnostic","v":1.0785812617064312E-2},{"$f":"F$7*acceptance_MMRdiagnostic","v":1.2757584852436729E-2},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},10.776801667083054,11.974224074536727,9.5793792596293805,11.330601418482409,null,null,null,null,null,10.776801667083054,11.974224074536727,9.5793792596293805,11.330601418482409]
["Mutation found","TP",{"$f":"C$8*sens_MMRdiagnostic","v":1.0920635274777617E-2},{"$f":"D$8*sens_MMRdiagnostic","v":1.2134039194197352E-2},{"$f":"E$8*sens_MMRdiagnostic","v":9.7072313553578805E-3},{"$f":"F$8*sens_MMRdiagnostic","v":1.1481826367193056E-2},null,null,null,null,null,null,null,null,{"$f":"$O$24","v":3659.4089020086244},{"$f":"C9*$O9","v":39.963069940110614},{"$f":"D9*$O9","v":44.403411044567342},{"$f":"E9*$O9","v":35.522728835653872},{"$f":"F9*$O9","v":42.016697619423617},39.963069940110614,44.403411044567342,35.522728835653872,42.016697619423617,{"$f":"u_baseline_proband*(u_pathMMR-1)*t_disutility_psychological","v":0},{"$f":"C9*$X9","v":0},{"$f":"D9*$X9","v":0},{"$f":"E9*$X9","v":0},{"$f":"F9*$X9","v":0},{"$f":"$AC$24","v":11.285140214668846},{"$f":"C9*$AC9","v":0.12324090030912406},{"$f":"D9*$AC9","v":0.13693433367680449},{"$f":"E9*$AC9","v":0.10954746694144359},{"$f":"F9*$AC9","v":0.12957402047425545},{"$f":"Y9+AD9","v":0.12324090030912406},{"$f":"Z9+AE9","v":0.13693433367680449},{"$f":"AA9+AF9","v":0.10954746694144359},{"$f":"AB9+AG9","v":0.12957402047425545},{"$f":"C9","v":1.0920635274777617E-2},{"$f":"D9","v":1.2134039194197352E-2},9.7072313553578805E-3,1.1481826367193056E-2,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C9","v":1.0920635274777617E-2},{"$f":"D9","v":1.2134039194197352E-2},9.7072313553578805E-3,1.1481826367193056E-2]
["No mutation found","FN",{"$f":"C$8*(1-sens_MMRdiagnostic)","v":1.2134039194197348E-3},{"$f":"D$8*(1-sens_MMRdiagnostic)","v":1.3482265771330387E-3},{"$f":"E$8*(1-sens_MMRdiagnostic)","v":1.0785812617064309E-3},{"$f":"F$8*(1-sens_MMRdiagnostic)","v":1.2757584852436726E-3},null,null,null,null,null,null,null,null,{"$f":"$O$34","v":1877.6964684425561},2.2784042542887919,2.5315602825431025,2.0252482260344817,2.395487202327669,2.2784042542887919,2.5315602825431025,2.0252482260344817,2.395487202327669,0,{"$f":"C10*$X10","v":0},0,0,0,{"$f":"$AC$34","v":10.586116928501545},{"$f":"C10*$AC10","v":1.2845235772479379E-2},1.4272484191643755E-2,1.1417987353315003E-2,1.3505328497317531E-2,{"$f":"Y10+AD10","v":1.2845235772479379E-2},1.4272484191643755E-2,1.1417987353315003E-2,1.3505328497317531E-2,null,null,null,null,null,null,null,null,{"$f":"C10","v":1.2134039194197348E-3},{"$f":"D10","v":1.3482265771330387E-3},1.0785812617064309E-3,1.2757584852436726E-3]
["Decline mutation testing","LL",{"$f":"C$7*(1-acceptance_MMRdiagnostic)","v":1.3482265771330387E-3},{"$f":"D$7*(1-acceptance_MMRdiagnostic)","v":1.4980295301478207E-3},{"$f":"E$7*(1-acceptance_MMRdiagnostic)","v":1.1984236241182565E-3},{"$f":"F$7*(1-acceptance_MMRdiagnostic)","v":1.4175094280485252E-3},null,null,null,null,null,null,null,null,{"$f":"$O$29","v":3162.4187180359982},4.2636569636791259,4.7373966263101401,3.7899173010481118,4.4827583482531583,4.2636569636791259,4.7373966263101401,3.7899173010481118,4.4827583482531583,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$AC$29","v":11.090154926892579},1.4952041616959486E-2,1.6613379574399428E-2,1.3290703659519542E-2,1.5720399167389033E-2,1.4952041616959486E-2,1.6613379574399428E-2,1.3290703659519542E-2,1.5720399167389033E-2,{"$f":"C11","v":1.3482265771330387E-3},{"$f":"D11","v":1.4980295301478207E-3},{"$f":"E11","v":1.1984236241182565E-3},{"$f":"F11","v":1.4175094280485252E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C11","v":1.3482265771330387E-3},{"$f":"D11","v":1.4980295301478207E-3},1.1984236241182565E-3,1.4175094280485252E-3]
["Decline genetic counselling","FN",{"$f":"C$6*(1-acceptance_counselling_prediction)","v":1.2096608753020667E-2},{"$f":"D$6*(1-acceptance_counselling_prediction)","v":1.3440676392245183E-2},{"$f":"E$6*(1-acceptance_counselling_prediction)","v":1.0752541113796145E-2},{"$f":"F$6*(1-MAX(acceptance_counselling_prediction,acceptance_counselling_tumour))","v":1.1403780243865803E-2},null,null,null,null,null,null,null,null,{"$f":"$O$34","v":1877.6964684425561},22.713759535678218,25.237510595198017,20.190008476158411,21.412837890801811,22.713759535678218,25.237510595198017,20.190008476158411,21.412837890801811,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$AC$34","v":10.586116928501545},0.12805611469781203,0.14228457188645779,0.11382765750916622,0.12072175108849925,0.12805611469781203,0.14228457188645779,0.11382765750916622,0.12072175108849925,null,null,null,null,null,null,null,null,{"$f":"C12","v":1.2096608753020667E-2},{"$f":"D12","v":1.3440676392245183E-2},{"$f":"E12","v":1.0752541113796145E-2},{"$f":"F12","v":1.1403780243865803E-2}]
["Does not meet criteria","FN",{"$f":"C$5*(1-sens_PREMM)","v":1.4210485846861695E-2},{"$f":"D$5*(1-sens_MMRpredict)","v":1.1368388677489356E-2},{"$f":"E$5*(1-sens_MMRpro)","v":1.7052583016234038E-2},{"$f":"F$5*(1-sens_MMRpro_TBT)","v":1.4210485846861695E-2},null,null,null,null,null,null,null,null,{"$f":"$O$34","v":1877.6964684425561},26.682979089505132,21.346383271604104,32.019574907406167,26.682979089505132,26.682979089505132,21.346383271604104,32.019574907406167,26.682979089505132,0,0,0,0,0,{"$f":"$AC$34","v":10.586116928501545},0.1504338647856942,0.12034709182855537,0.18052063774283308,0.1504338647856942,0.1504338647856942,0.12034709182855537,0.18052063774283308,0.1504338647856942,null,null,null,null,null,null,null,null,{"$f":"C13","v":1.4210485846861695E-2},1.1368388677489356E-2,1.7052583016234038E-2,1.4210485846861695E-2]
["Actually sporadic",null,{"$f":"C$4*(1-p_EC_LS)","v":0.96021063962878728},{"$f":"D$4*(1-p_EC_LS)","v":0.96021063962878728},{"$f":"E$4*(1-p_EC_LS)","v":0.96021063962878728},{"$f":"F$4*(1-p_EC_LS)","v":0.96021063962878728}]
["Meets criteria",null,{"$f":"C$14*(1-spec_PREMM)","v":0.14167042224031293},{"$f":"D$14*(1-spec_MMRpredict)","v":0.34799580228157395},{"$f":"E$14*(1-spec_MMRpro)","v":0.14535298673279806},{"$f":"F$14*(1-spec_MMRpro_TBT)","v":0.10571126307839861},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"c_offer_counselling","v":27.300506549444513},{"$f":"C15*G15","v":3.8676742902342327},{"$f":"D15*H15","v":9.5004616793673069},{"$f":"E15*I15","v":3.9682101662800751},{"$f":"F15*J15","v":2.8859710300218731},null,null,null,null,null,3.8676742902342327,9.5004616793673069,3.9682101662800751,2.8859710300218731]
["Accept genetic counselling",null,{"$f":"C$15*acceptance_counselling_prediction","v":7.4672491268610766E-2},{"$f":"D$15*acceptance_counselling_prediction","v":0.18342370338464117},{"$f":"E$15*acceptance_counselling_prediction","v":7.6613519329109786E-2},{"$f":"F$15*MAX(acceptance_counselling_prediction,acceptance_counselling_tumour)","v":5.8582214757687684E-2},{"$f":"c_pretest_proband","v":347.33219120941197},{"$f":"c_pretest_proband","v":347.33219120941197},{"$f":"c_pretest_proband","v":347.33219120941197},{"$f":"c_pretest_proband","v":347.33219120941197},25.936160015392261,63.708956816332652,26.610341544844342,20.347489017688016,null,null,null,null,null,25.936160015392261,63.708956816332652,26.610341544844342,20.347489017688016]
["Accept mutation testing",null,{"$f":"C$16*acceptance_MMRdiagnostic","v":6.7205242141749694E-2},{"$f":"D$16*acceptance_MMRdiagnostic","v":0.16508133304617706},{"$f":"E$16*acceptance_MMRdiagnostic","v":6.8952167396198805E-2},{"$f":"F$16*acceptance_MMRdiagnostic","v":5.2723993281918916E-2},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},{"$f":"c_MMR_proband+c_posttest_proband","v":888.14627137817843},59.688085225262618,146.61637041910143,61.239610376377968,46.826618045504411,null,null,null,null,null,59.688085225262618,146.61637041910143,61.239610376377968,46.826618045504411]
["No mutation found","TN",{"$f":"C$17","v":6.7205242141749694E-2},{"$f":"D$17","v":0.16508133304617706},6.8952167396198805E-2,5.2723993281918916E-2,null,null,null,null,null,null,null,null,{"$f":"$O$43","v":70.707408025595356},4.7519084775756317,11.67247317310524,4.875429034332182,3.7279769057233891,4.7519084775756317,11.67247317310524,4.875429034332182,3.7279769057233891,0,{"$f":"C18*$X18","v":0},{"$f":"D18*$X18","v":0},{"$f":"E18*$X18","v":0},{"$f":"F18*$X18","v":0},{"$f":"$AC$43","v":8.9410115327291919},{"$f":"C18*$AC18","v":0.60088284504924194},{"$f":"D18*$AC18","v":1.4759941026041778},{"$f":"E18*$AC18","v":0.61650212389608727},{"$f":"F18*$AC18","v":0.47140583198517344},{"$f":"Y18+AD18","v":0.60088284504924194},{"$f":"Z18+AE18","v":1.4759941026041778},{"$f":"AA18+AF18","v":0.61650212389608727},{"$f":"AB18+AG18","v":0.47140583198517344},null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C18","v":6.7205242141749694E-2},{"$f":"D18","v":0.16508133304617706},6.8952167396198805E-2,5.2723993281918916E-2]
["Decline mutation testing","LL",{"$f":"C$16*(1-acceptance_MMRdiagnostic)","v":7.4672491268610751E-3},{"$f":"D$16*(1-acceptance_MMRdiagnostic)","v":1.8342370338464115E-2},{"$f":"E$16*(1-acceptance_MMRdiagnostic)","v":7.661351932910977E-3},{"$f":"F$16*(1-acceptance_MMRdiagnostic)","v":5.8582214757687675E-3},null,null,null,null,null,null,null,null,{"$f":"$O$41","v":1807.4247336343246},13.496490764098022,33.15245382322064,13.847316976620441,10.588294390412244,13.496490764098022,33.15245382322064,13.847316976620441,10.588294390412244,{"$f":"u_baseline_proband*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$AC$41","v":8.9569461379480586},6.6883748227934317E-2,0.16429162316391918,6.862231660694787E-2,5.247177422263144E-2,6.6883748227934317E-2,0.16429162316391918,6.862231660694787E-2,5.247177422263144E-2,null,null,null,null,{"$f":"C19","v":7.4672491268610751E-3},{"$f":"D19","v":1.8342370338464115E-2},{"$f":"E19","v":7.661351932910977E-3},{"$f":"F19","v":5.8582214757687675E-3}]
["Decline genetic counselling","TN",{"$f":"C$15*(1-acceptance_counselling_prediction)","v":6.699793097170216E-2},{"$f":"D$15*(1-acceptance_counselling_prediction)","v":0.16457209889693278},{"$f":"E$15*(1-acceptance_counselling_prediction)","v":6.8739467403688276E-2},{"$f":"F$15*(1-MAX(acceptance_counselling_prediction,acceptance_counselling_tumour))","v":4.7129048320710923E-2},null,null,null,null,null,null,null,null,{"$f":"$O$43","v":70.707408025595356},4.7372500420868171,11.636466546334058,4.860389569174699,3.3323728494705067,4.7372500420868171,11.636466546334058,4.860389569174699,3.3323728494705067,{"$f":"u_baseline_proband*(u_decline_counselling-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$AC$43","v":8.9410115327291919},0.59902927348698332,1.4714410342029252,0.61460037081003926,0.42138136456202774,0.59902927348698332,1.4714410342029252,0.61460037081003926,0.42138136456202774,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C20","v":6.699793097170216E-2},{"$f":"D20","v":0.16457209889693278},{"$f":"E20","v":6.8739467403688276E-2},{"$f":"F20","v":4.7129048320710923E-2}]
["Does not meet criteria","TN",{"$f":"C$14*spec_PREMM","v":0.81854021738847438},{"$f":"D$14*spec_MMRpredict","v":0.61221483734721338},{"$f":"E$14*spec_MMRpro","v":0.81485765289598922},{"$f":"F$14*spec_MMRpro_TBT","v":0.85449937655038866},null,null,null,null,null,null,null,null,{"$f":"$O$43","v":70.707408025595356},57.876857136246379,43.288124303632912,57.616472546095665,60.419436075365176,57.876857136246379,43.288124303632912,57.616472546095665,60.419436075365176,0,0,0,0,0,{"$f":"$AC$43","v":8.9410115327291919},7.3185775236730093,5.473819921229361,7.2856516720756801,7.6400887804469297,7.3185775236730093,5.473819921229361,7.2856516720756801,7.6400887804469297,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C21","v":0.81854021738847438},0.61221483734721338,0.81485765289598922,0.85449937655038866]
[]
["PROBAND HELPERS"]
["TP",null,{"$f":"p_LS_MLH1*$C25+p_LS_MSH2*$C26+p_LS_MSH6*$C27+p_LS_PMS2*$C28","v":1},null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*O25+p_LS_MSH2*O26+p_LS_MSH6*O27+p_LS_PMS2*O28","v":3659.4089020086244},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*AC25+p_LS_MSH2*AC26+p_LS_MSH6*AC27+p_LS_PMS2*AC28","v":11.285140214668846}]
["MLH1","TP",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$3","v":4008.6314807221574},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$3","v":11.047317507653798}]
["MSH2","TP",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$6","v":3918.0986432146274},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$6","v":11.111842756275266}]
["MSH6","TP",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$9","v":3514.8279678890995},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$9","v":11.384253049172225}]
["PMS2","TP",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$12","v":3237.9351558431454},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$12","v":11.559367285291604}]
["LL (actually LS)",null,{"$f":"p_LS_MLH1*$C30+p_LS_MSH2*$C31+p_LS_MSH6*$C32+p_LS_PMS2*$C33","v":1},null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*O30+p_LS_MSH2*O31+p_LS_MSH6*O32+p_LS_PMS2*O33","v":3162.4187180359982},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*AC30+p_LS_MSH2*AC31+p_LS_MSH6*AC32+p_LS_PMS2*AC33","v":11.090154926892579}]
["MLH1","LL",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$4","v":3657.6142913882104},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$4","v":10.76021686953796}]
["MSH2","LL",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$7","v":3530.9657796484967},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$7","v":10.847751169286413}]
["MSH6","LL",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$10","v":2957.4324421088386},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$10","v":11.22747375577938}]
["PMS2","LL",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$13","v":2559.1494572527472},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$13","v":11.47791282376992}]
["FN",null,{"$f":"p_LS_MLH1*$C35+p_LS_MSH2*$C36+p_LS_MSH6*$C37+p_LS_PMS2*$C38","v":1},null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*O35+p_LS_MSH2*O36+p_LS_MSH6*O37+p_LS_PMS2*O38","v":1877.6964684425561},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*AC35+p_LS_MSH2*AC36+p_LS_MSH6*AC37+p_LS_PMS2*AC38","v":10.586116928501545}]
["MLH1","FN",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$5","v":2750.2330036485268},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$5","v":10.01806020416571}]
["MSH2","FN",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$8","v":2530.225283333958},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$8","v":10.165073022561232}]
["MSH6","FN",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$11","v":1516.5620650126514},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$11","v":10.822198454590701}]
["PMS2","FN",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$14","v":804.48484252274875},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$14","v":11.267352610670535}]
[]
["LL (actually sporadic)"]
["Sporadic","LL",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$15","v":1807.4247336343246},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$15","v":8.9569461379480586}]
["TN"]
["Sporadic","TN",1,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$J$16","v":70.707408025595356},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"'MM-Summary'!$I$16","v":8.9410115327291919}]
[]
["GRAND TOTAL",null,{"$f":"SUM(C$9:C$13,C$18:C$21)","v":1},{"$f":"SUM(D$9:D$13,D$18:D$21)","v":1},1,1,null,null,null,null,{"$f":"SUM(K$4:K$21)","v":221.64986234227547},{"$f":"SUM(L$4:L$21)","v":353.77905870523068},222.18077791984581,413.01246230021712,null,{"$f":"SUM(P$4:P$21)","v":176.76437620326871},{"$f":"SUM(Q$4:Q$21)","v":198.00577966651556},174.74708587252402,175.05884037128271,{"$f":"SUM(T$4:T$21)","v":398.41423854554421},{"$f":"SUM(U$4:U$21)","v":551.78483837174622},396.92786379236986,588.07130267149989,null,{"$f":"SUM(Y$4:Y$21)","v":0},{"$f":"SUM(Z$4:Z$21)","v":0},0,0,null,{"$f":"SUM(AD$4:AD$21)","v":9.0149015476192389},{"$f":"SUM(AE$4:AE$21)","v":9.0159985423582434},9.0139809365950327,9.0153031152299175,{"$f":"SUM(AH$4:AH$21)","v":9.0149015476192389},{"$f":"SUM(AI$4:AI$21)","v":9.0159985423582434},9.0139809365950327,9.0153031152299175,{"$f":"SUM(AL$4:AL$21)","v":1.2268861851910656E-2},{"$f":"SUM(AM$4:AM$21)","v":1.3632068724345173E-2},1.0905654979476136E-2,1.2899335795241581E-2,{"$f":"SUM(AP$4:AP$21)","v":7.4672491268610751E-3},1.8342370338464115E-2,7.661351932910977E-3,5.8582214757687675E-3,{"$f":"SUM(AT$4:AT$21)","v":2.7520498519302099E-2},2.615729164686758E-2,2.8883705391736614E-2,2.6890024575971172E-2,{"$f":"SUM(AX$4:AX$21)","v":0.95274339050192625},0.94186826929032319,0.95254928769587632,0.95435241815301852,{"$f":"SUM(BB$4:BB$21)","v":1.0920635274777617E-2},1.2134039194197352E-2,9.7072313553578805E-3,1.1481826367193056E-2,{"$f":"SUM(BF$4:BF$21)","v":1.3482265771330387E-3},1.4980295301478207E-3,1.1984236241182565E-3,1.4175094280485252E-3]
[]
["By underlying genetic status",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Approx",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Approx"]
["path_MLH1",null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(P$9:P$13)*p_LS_MLH1","v":10.598145234785505},{"$f":"SUM(Q$9:Q$13)*p_LS_MLH1","v":10.858329825594062},{"$f":"SUM(R$9:R$13)*p_LS_MLH1","v":10.337960643976951},{"$f":"SUM(S$9:S$13)*p_LS_MLH1","v":10.718478845390081},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AH$9:AH$13)*p_LS_MLH1","v":4.7467289246114985E-2},{"$f":"SUM(AI$9:AI$13)*p_LS_MLH1","v":4.7569368057628389E-2},{"$f":"SUM(AJ$9:AJ$13)*p_LS_MLH1","v":4.7365210434601575E-2},{"$f":"SUM(AK$9:AK$13)*p_LS_MLH1","v":4.751450000489766E-2}]
["path_MSH2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(P$9:P$13)*p_LS_MSH2","v":27.343692150641449},{"$f":"SUM(Q$9:Q$13)*p_LS_MSH2","v":28.014980116205336},{"$f":"SUM(R$9:R$13)*p_LS_MSH2","v":26.672404185077561},{"$f":"SUM(S$9:S$13)*p_LS_MSH2","v":27.654158287012834},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AH$9:AH$13)*p_LS_MSH2","v":0.12246774464942405},{"$f":"SUM(AI$9:AI$13)*p_LS_MSH2","v":0.12273111258176418},{"$f":"SUM(AJ$9:AJ$13)*p_LS_MSH2","v":0.12220437671708391},{"$f":"SUM(AK$9:AK$13)*p_LS_MSH2","v":0.12258955053392113}]
["path_MSH6",null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(P$9:P$13)*p_LS_MSH6","v":49.311456036582108},{"$f":"SUM(Q$9:Q$13)*p_LS_MSH6","v":50.522052865255581},{"$f":"SUM(R$9:R$13)*p_LS_MSH6","v":48.100859207908634},{"$f":"SUM(S$9:S$13)*p_LS_MSH6","v":49.871348868544302},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AH$9:AH$13)*p_LS_MSH6","v":0.22085762130838532},{"$f":"SUM(AI$9:AI$13)*p_LS_MSH6","v":0.22133257751201316},{"$f":"SUM(AJ$9:AJ$13)*p_LS_MSH6","v":0.22038266510475751},{"$f":"SUM(AK$9:AK$13)*p_LS_MSH6","v":0.22107728533492882}]
["path_PMS2",null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(P$9:P$13)*p_LS_PMS2","v":8.6485763612528057},{"$f":"SUM(Q$9:Q$13)*p_LS_PMS2","v":8.8608990131677245},{"$f":"SUM(R$9:R$13)*p_LS_PMS2","v":8.4362537093378887},{"$f":"SUM(S$9:S$13)*p_LS_PMS2","v":8.7467741493641693},null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AH$9:AH$13)*p_LS_PMS2","v":3.8735501978144779E-2},{"$f":"SUM(AI$9:AI$13)*p_LS_PMS2","v":3.8818803006455085E-2},{"$f":"SUM(AJ$9:AJ$13)*p_LS_PMS2","v":3.8652200949834473E-2},{"$f":"SUM(AK$9:AK$13)*p_LS_PMS2","v":3.8774028139407841E-2}]
["Sporadic",null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(P$18:P$21)","v":80.862506420006852},{"$f":"SUM(Q$18:Q$21)","v":99.749517846292846},81.199608126222984,78.068080220971325,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"SUM(AH$18:AH$21)","v":8.5853733904371694},{"$f":"SUM(AI$18:AI$21)","v":8.585546681200384},8.5853764833887549,8.5853477512167622]
[]
["Strategy",null,"S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1-S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4","S1","S2","S3","S4"]
["Description",null,"PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","(All)","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC","PREMM","MMRpredict","MMRpro","MMRpro + IHC"]
[null,null,"Weights",null,null,null,"Diagnostic costs (unweighted)","Diagnostic costs (weighted)",null,null,null,"Long-term costs (unweighted)","Long-term costs (weighted)",null,null,null,"Total costs (weighted)",null,null,null,"Short-term QALYs (unweighted)","Short-term QALYs (weighted)",null,null,null,"Long-term QALYs (unweighted)","Long-term QALYs (weighted)",null,null,null,"Total QALYs (weighted)",null,null,null,"True Positives [including diagnosed Lynch-like if LS] (weighted)",null,null,null,"False Positives [including diagnosed Lynch-like if sporadic] (weighted)",null,null,null,"False Negatives (weighted)",null,null,null,"True Negatives (weighted)",null,null,null,"True Positives [pathogenic mutation found] (weighted)",null,null,null,"True Positives [diagnosed LL] (weighted)"]
["Cohort (relatives)",null,{"$f":"cohort_probands*relatives_per_proband","v":6},{"$f":"cohort_probands*relatives_per_proband","v":6},{"$f":"cohort_probands*relatives_per_proband","v":6},{"$f":"cohort_probands*relatives_per_proband","v":6}]
["Proband has LS",null,{"$f":"C$57*p_EC_LS","v":0.2387361622272765},{"$f":"D$57*p_EC_LS","v":0.2387361622272765},{"$f":"E$57*p_EC_LS","v":0.2387361622272765},{"$f":"F$57*p_EC_LS","v":0.2387361622272765}]
["Proband TP",null,{"$f":"C$9*relatives_per_proband","v":6.5523811648665706E-2},{"$f":"D$9*relatives_per_proband","v":7.2804235165184111E-2},{"$f":"E$9*relatives_per_proband","v":5.8243388132147286E-2},{"$f":"F$9*relatives_per_proband","v":6.889095820315834E-2},{"$f":"c_GP","v":36.400675399259349},{"$f":"C59*$G59","v":2.3851109987452888},{"$f":"D59*$G59","v":2.6501233319392097},2.1200986655513678,2.50767740749711,null,null,null,null,null,{"$f":"H59+M59","v":2.3851109987452888},{"$f":"I59+N59","v":2.6501233319392097},{"$f":"J59+O59","v":2.1200986655513678},{"$f":"K59+P59","v":2.50767740749711}]
["Relative has mutation",null,{"$f":"C$59*p_rel_LS","v":2.8830477125412909E-2},{"$f":"D$59*p_rel_LS","v":3.2033863472681008E-2},{"$f":"E$59*p_rel_LS","v":2.5627090778144807E-2},{"$f":"F$59*p_rel_LS","v":3.0312021609389669E-2}]
["Accept genetic counselling",null,{"$f":"C$60*acceptance_counselling_relative","v":2.2407193419637372E-2},{"$f":"D$60*acceptance_counselling_relative","v":2.4896881577374855E-2},{"$f":"E$60*acceptance_counselling_relative","v":1.9917505261899886E-2},{"$f":"F$60*acceptance_counselling_relative","v":2.3558657325970095E-2},{"$f":"c_pretest_relative","v":171.72712297629874},{"$f":"C61*$G61","v":3.8479228599277788},{"$f":"D61*$G61","v":4.2754698443641983},{"$f":"E61*$G61","v":3.4203758754913589},{"$f":"F61*$G61","v":4.0456604437733477},null,null,null,null,null,{"$f":"H61+M61","v":3.8479228599277788},4.2754698443641983,3.4203758754913589,4.0456604437733477]
["Accept mutation testing",null,{"$f":"C$61*acceptance_MMRpredictive","v":1.6049453425145258E-2},{"$f":"D$61*acceptance_MMRpredictive","v":1.7832726027939175E-2},{"$f":"E$61*acceptance_MMRpredictive","v":1.4266180822351341E-2},{"$f":"F$61*acceptance_MMRpredictive","v":1.6874204922993574E-2},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},4.8063113928303078,5.3403459920336758,4.2722767936269408,5.0532987770954731,null,null,null,null,null,4.8063113928303078,5.3403459920336758,4.2722767936269408,5.0532987770954731]
["Mutation found","TP",{"$f":"C$62","v":1.6049453425145258E-2},{"$f":"D$62","v":1.7832726027939175E-2},1.4266180822351341E-2,1.6874204922993574E-2,null,null,null,null,null,{"$f":"$L$101","v":4951.262466723103},{"$f":"C63*$L63","v":79.465056355342256},{"$f":"D63*$L63","v":88.294507061491402},{"$f":"E63*$L63","v":70.635605649193124},{"$f":"F63*$L63","v":83.548617491012294},79.465056355342256,88.294507061491402,70.635605649193124,83.548617491012294,{"$f":"u_baseline_relative*(u_pathMMR-1)*t_disutility_psychological","v":0},{"$f":"C63*$U63","v":0},{"$f":"D63*$U63","v":0},{"$f":"E63*$U63","v":0},{"$f":"F63*$U63","v":0},{"$f":"$Z$101","v":15.636419318165109},{"$f":"C63*$Z63","v":0.25095598358293247},{"$f":"D63*$Z63","v":0.27883998175881386},{"$f":"E63*$Z63","v":0.22307198540705112},{"$f":"F63*$Z63","v":0.26385214383657352},{"$f":"V63+AA63","v":0.25095598358293247},{"$f":"W63+AB63","v":0.27883998175881386},{"$f":"X63+AC63","v":0.22307198540705112},{"$f":"Y63+AD63","v":0.26385214383657352},{"$f":"C63","v":1.6049453425145258E-2},{"$f":"D63","v":1.7832726027939175E-2},1.4266180822351341E-2,1.6874204922993574E-2,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C63","v":1.6049453425145258E-2},{"$f":"D63","v":1.7832726027939175E-2},{"$f":"E63","v":1.4266180822351341E-2},{"$f":"F63","v":1.6874204922993574E-2}]
["Decline mutation testing","LL",{"$f":"C$61*(1-acceptance_MMRpredictive)","v":6.3577399944921131E-3},{"$f":"D$61*(1-acceptance_MMRpredictive)","v":7.0641555494356809E-3},{"$f":"E$61*(1-acceptance_MMRpredictive)","v":5.6513244395485452E-3},{"$f":"F$61*(1-acceptance_MMRpredictive)","v":6.6844524029765198E-3},null,null,null,null,null,{"$f":"$L$106","v":4257.6516227234843},{"$f":"C64*$L64","v":27.06904200440334},30.076713338225932,24.06137067058075,28.460069620550872,27.06904200440334,30.076713338225932,24.06137067058075,28.460069620550872,{"$f":"u_baseline_relative*(u_decline_testing-1)*t_disutility_psychological","v":0},{"$f":"C64*$U64","v":0},0,0,0,{"$f":"$Z$106","v":15.420914941663112},{"$f":"C64*$Z64","v":9.8042167676272579E-2},0.10893574186252508,8.7148593490020076E-2,0.1030803719378965,{"$f":"V64+AA64","v":9.8042167676272579E-2},0.10893574186252508,8.7148593490020076E-2,0.1030803719378965,{"$f":"C64","v":6.3577399944921131E-3},7.0641555494356809E-3,5.6513244395485452E-3,6.6844524029765198E-3,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C64","v":6.3577399944921131E-3},{"$f":"D64","v":7.0641555494356809E-3},{"$f":"E64","v":5.6513244395485452E-3},{"$f":"F64","v":6.6844524029765198E-3}]
["Decline genetic counselling","FN",{"$f":"C$60*(1-acceptance_counselling_relative)","v":6.4232837057755362E-3},{"$f":"D$60*(1-acceptance_counselling_relative)","v":7.136981895306151E-3},{"$f":"E$60*(1-acceptance_counselling_relative)","v":5.7095855162449215E-3},{"$f":"F$60*(1-acceptance_counselling_relative)","v":6.7533642834195756E-3},null,null,null,null,null,{"$f":"$L$111","v":2464.6639288364036},15.831235654307587,17.590261838119538,14.072209470495634,16.644773347636335,15.831235654307587,17.590261838119538,14.072209470495634,16.644773347636335,0,0,0,0,0,{"$f":"$Z$111","v":14.863834990578768},9.5474629100320868E-2,0.10608292122257874,8.4866336978063006E-2,0.10038089234001679,9.5474629100320868E-2,0.10608292122257874,8.4866336978063006E-2,0.10038089234001679,null,null,null,null,null,null,null,null,{"$f":"C65","v":6.4232837057755362E-3},{"$f":"D65","v":7.136981895306151E-3},5.7095855162449215E-3,6.7533642834195756E-3]
["Relative does not have mutation",null,{"$f":"C$59*(1-p_rel_LS)","v":3.6693334523252796E-2},{"$f":"D$59*(1-p_rel_LS)","v":4.0770371692503103E-2},{"$f":"E$59*(1-p_rel_LS)","v":3.2616297354002483E-2},{"$f":"F$59*(1-p_rel_LS)","v":3.8578936593768674E-2}]
["Accept genetic counselling",null,{"$f":"C$66*acceptance_counselling_relative","v":2.8518246170447566E-2},{"$f":"D$66*acceptance_counselling_relative","v":3.1686940189386184E-2},{"$f":"E$66*acceptance_counselling_relative","v":2.5349552151508945E-2},{"$f":"F$66*acceptance_counselling_relative","v":2.9983745687598304E-2},{"$f":"c_pretest_relative","v":171.72712297629874},{"$f":"C67*$G67","v":4.8973563671808096},{"$f":"D67*$G67","v":5.4415070746453447},{"$f":"E67*$G67","v":4.3532056597162754},{"$f":"F67*$G67","v":5.1490223829842607},null,null,null,null,null,4.8973563671808096,5.4415070746453447,4.3532056597162754,5.1490223829842607]
["Accept mutation testing",null,{"$f":"C$67*acceptance_MMRpredictive","v":2.0426577086548513E-2},{"$f":"D$67*acceptance_MMRpredictive","v":2.2696196762831682E-2},{"$f":"E$67*acceptance_MMRpredictive","v":1.8156957410265344E-2},{"$f":"F$67*acceptance_MMRpredictive","v":2.1476260811082733E-2},{"$f":"c_MMR_relative+c_posttest_relative","v":299.46885202333971},6.1171235908749377,6.7968039898610426,5.4374431918888337,6.4314711708487842,null,null,null,null,null,6.1171235908749377,6.7968039898610426,5.4374431918888337,6.4314711708487842]
["Mutation not found","TN",{"$f":"C$68","v":2.0426577086548513E-2},{"$f":"D$68","v":2.2696196762831682E-2},1.8156957410265344E-2,2.1476260811082733E-2,null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},{"$f":"C69*$L69","v":14.870428873594967},{"$f":"D69*$L69","v":16.522698748438852},{"$f":"E69*$L69","v":13.218158998751081},{"$f":"F69*$L69","v":15.634592497256394},14.870428873594967,16.522698748438852,13.218158998751081,15.634592497256394,0,0,0,0,0,{"$f":"$Z$120","v":16.063402951093678},0.32812033865280588,0.36457815405867322,0.29166252324693853,0.34498183129120391,0.32812033865280588,0.36457815405867322,0.29166252324693853,0.34498183129120391,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C69","v":2.0426577086548513E-2},{"$f":"D69","v":2.2696196762831682E-2},1.8156957410265344E-2,2.1476260811082733E-2]
["Decline mutation testing","LL",{"$f":"C$67*(1-acceptance_MMRpredictive)","v":8.0916690838990536E-3},{"$f":"D$67*(1-acceptance_MMRpredictive)","v":8.9907434265545042E-3},{"$f":"E$67*(1-acceptance_MMRpredictive)","v":7.1925947412436022E-3},{"$f":"F$67*(1-acceptance_MMRpredictive)","v":8.5074848765155711E-3},null,null,null,null,null,{"$f":"$L$118","v":3367.2138165484694},27.246379938242988,30.273755486936654,24.219004389549319,28.646520620280381,27.246379938242988,30.273755486936654,24.219004389549319,28.646520620280381,{"$f":"u_baseline_relative*(u_decline_testing-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$Z$118","v":16.089683142712083},0.13019239165561514,0.14465821295068348,0.11572657036054676,0.13688273600455056,0.13019239165561514,0.14465821295068348,0.11572657036054676,0.13688273600455056,null,null,null,null,{"$f":"C70","v":8.0916690838990536E-3},{"$f":"D70","v":8.9907434265545042E-3},7.1925947412436022E-3,8.5074848765155711E-3]
["Decline genetic counselling","TN",{"$f":"C$66*(1-acceptance_counselling_relative)","v":8.1750883528052282E-3},{"$f":"D$66*(1-acceptance_counselling_relative)","v":9.0834315031169208E-3},{"$f":"E$66*(1-acceptance_counselling_relative)","v":7.2667452024935365E-3},{"$f":"F$66*(1-acceptance_counselling_relative)","v":8.5951909061703705E-3},null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},5.9514165966553536,6.6126851073948378,5.2901480859158703,6.2572488030481654,5.9514165966553536,6.6126851073948378,5.2901480859158703,6.2572488030481654,0,0,0,0,0,{"$f":"$Z$120","v":16.063402951093678},0.13131973837190306,0.14591082041322564,0.11672865633058051,0.13806801496739068,0.13131973837190306,0.14591082041322564,0.11672865633058051,0.13806801496739068,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C71","v":8.1750883528052282E-3},9.0834315031169208E-3,7.2667452024935365E-3,8.5951909061703705E-3]
["Proband LL",null,{"$f":"C$11*relatives_per_proband","v":8.0893594627982329E-3},{"$f":"D$11*relatives_per_proband","v":8.9881771808869235E-3},{"$f":"E$11*relatives_per_proband","v":7.1905417447095388E-3},{"$f":"F$11*relatives_per_proband","v":8.5050565682911507E-3},{"$f":"c_GP","v":36.400675399259349},{"$f":"C72*$G72","v":0.29445814799324543},0.3271757199924949,0.26174057599399592,0.30958980339470482,null,null,null,null,null,0.29445814799324543,0.3271757199924949,0.26174057599399592,0.30958980339470482]
["Relative has mutation",null,{"$f":"C$72*p_rel_LS","v":3.5593181636312224E-3},{"$f":"D$72*p_rel_LS","v":3.9547979595902462E-3},{"$f":"E$72*p_rel_LS","v":3.1638383676721969E-3},{"$f":"F$72*p_rel_LS","v":3.7422248900481061E-3}]
["Relative is FDR of proband",null,{"$f":"C$73*p_FDR","v":1.5080645077474963E-3},{"$f":"D$73*p_FDR","v":1.6756272308305511E-3},{"$f":"E$73*p_FDR","v":1.3405017846644409E-3},{"$f":"F$73*p_FDR","v":1.5855611320043672E-3}]
["Accept genetic counselling",null,{"$f":"C$74*acceptance_counselling_relative","v":1.1720754036568658E-3},{"$f":"D$74*acceptance_counselling_relative","v":1.3023060040631841E-3},{"$f":"E$74*acceptance_counselling_relative","v":1.0418448032505471E-3},{"$f":"F$74*acceptance_counselling_relative","v":1.2323061740856364E-3},{"$f":"c_pretest_relative","v":171.72712297629874},{"$f":"C75*$G75","v":0.20127713698127758},0.22364126331253062,0.17891301065002449,0.2116203939016563,null,null,null,null,null,0.20127713698127758,0.22364126331253062,0.17891301065002449,0.2116203939016563]
["Diagnosed LL","LL",{"$f":"C$75","v":1.1720754036568658E-3},{"$f":"D$75","v":1.3023060040631841E-3},1.0418448032505471E-3,1.2323061740856364E-3,null,null,null,null,null,{"$f":"$L$106","v":4257.6516227234843},{"$f":"C76*$L76","v":4.9902887443339372},{"$f":"D76*$L76","v":5.5447652714821523},{"$f":"E76*$L76","v":4.4358122171857213},{"$f":"F76*$L76","v":5.2467303817878781},4.9902887443339372,5.5447652714821523,4.4358122171857213,5.2467303817878781,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$Z$106","v":15.420914941663112},1.8074475105007985E-2,2.0082750116675537E-2,1.6066200093340428E-2,1.9003288692660894E-2,1.8074475105007985E-2,2.0082750116675537E-2,1.6066200093340428E-2,1.9003288692660894E-2,{"$f":"C76","v":1.1720754036568658E-3},{"$f":"D76","v":1.3023060040631841E-3},{"$f":"E76","v":1.0418448032505471E-3},{"$f":"F76","v":1.2323061740856364E-3},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C76","v":1.1720754036568658E-3},{"$f":"D76","v":1.3023060040631841E-3},{"$f":"E76","v":1.0418448032505471E-3},{"$f":"F76","v":1.2323061740856364E-3}]
["Decline genetic counselling","FN",{"$f":"C$74*(1-acceptance_counselling_relative)","v":3.3598910409063045E-4},{"$f":"D$74*(1-acceptance_counselling_relative)","v":3.7332122676736712E-4},{"$f":"E$74*(1-acceptance_counselling_relative)","v":2.9865698141389368E-4},{"$f":"F$74*(1-acceptance_counselling_relative)","v":3.5325495791873072E-4},null,null,null,null,null,{"$f":"$L$111","v":2464.6639288364036},0.82810022533423655,0.92011136148248496,0.73608908918598792,0.8706547524649173,0.82810022533423655,0.92011136148248496,0.73608908918598792,0.8706547524649173,0,0,0,0,0,{"$f":"$Z$111","v":14.863834990578768},4.994086601835525E-3,5.548985113150582E-3,4.4391880905204654E-3,5.2507234041078597E-3,4.994086601835525E-3,5.548985113150582E-3,4.4391880905204654E-3,5.2507234041078597E-3,null,null,null,null,null,null,null,null,{"$f":"C77","v":3.3598910409063045E-4},{"$f":"D77","v":3.7332122676736712E-4},{"$f":"E77","v":2.9865698141389368E-4},{"$f":"F77","v":3.5325495791873072E-4}]
["Relative is not FDR of proband","FN",{"$f":"C$73*(1-p_FDR)","v":2.0512536558837261E-3},{"$f":"D$73*(1-p_FDR)","v":2.279170728759695E-3},{"$f":"E$73*(1-p_FDR)","v":1.8233365830077561E-3},{"$f":"F$73*(1-p_FDR)","v":2.156663758043739E-3},null,null,null,null,null,{"$f":"$L$111","v":2464.6639288364036},5.0556508945504204,5.6173898828337991,4.493911906267039,5.3154513710791642,5.0556508945504204,5.6173898828337991,4.493911906267039,5.3154513710791642,0,0,0,0,0,{"$f":"$Z$111","v":14.863834990578768},3.0489495864877147E-2,3.3877217627641266E-2,2.7101774102113015E-2,3.2056294229723628E-2,3.0489495864877147E-2,3.3877217627641266E-2,2.7101774102113015E-2,3.2056294229723628E-2,null,null,null,null,null,null,null,null,2.0512536558837261E-3,2.279170728759695E-3,1.8233365830077561E-3,2.156663758043739E-3]
["Relative does not have mutation",null,{"$f":"C$72*(1-p_rel_LS)","v":4.5300412991670109E-3},{"$f":"D$72*(1-p_rel_LS)","v":5.0333792212966773E-3},{"$f":"E$72*(1-p_rel_LS)","v":4.0267033770373419E-3},{"$f":"F$72*(1-p_rel_LS)","v":4.7628316782430445E-3}]
["Relative is FDR of proband",null,{"$f":"C$79*p_FDR","v":1.9193548280422685E-3},{"$f":"D$79*p_FDR","v":2.13261647560252E-3},{"$f":"E$79*p_FDR","v":1.7060931804820159E-3},{"$f":"F$79*p_FDR","v":2.0179868952782854E-3}]
["Accept genetic counselling",null,{"$f":"C$80*acceptance_counselling_relative","v":1.4917323319269206E-3},{"$f":"D$80*acceptance_counselling_relative","v":1.6574803688076891E-3},{"$f":"E$80*acceptance_counselling_relative","v":1.3259842950461512E-3},{"$f":"F$80*acceptance_counselling_relative","v":1.5683896761089918E-3},{"$f":"c_pretest_relative","v":171.72712297629874},{"$f":"C81*$G81","v":0.2561709016125352},{"$f":"D81*$G81","v":0.284634335125039},{"$f":"E81*$G81","v":0.2277074681000312},{"$f":"F81*$G81","v":0.26933504678392617},null,null,null,null,null,0.2561709016125352,0.284634335125039,0.2277074681000312,0.26933504678392617]
["Diagnosed LL","LL",{"$f":"C$81","v":1.4917323319269206E-3},{"$f":"D$81","v":1.6574803688076891E-3},1.3259842950461512E-3,1.5683896761089918E-3,null,null,null,null,null,{"$f":"$L$118","v":3367.2138165484694},{"$f":"C82*$L82","v":5.0229817186563945},{"$f":"D82*$L82","v":5.5810907985071037},{"$f":"E82*$L82","v":4.4648726388056827},{"$f":"F82*$L82","v":5.2811033871261763},5.0229817186563945,5.5810907985071037,4.4648726388056827,5.2811033871261763,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$Z$118","v":16.089683142712083},2.400150055444316E-2,2.6668333949381281E-2,2.1334667159505025E-2,2.523489293289451E-2,2.400150055444316E-2,2.6668333949381281E-2,2.1334667159505025E-2,2.523489293289451E-2,null,null,null,null,{"$f":"C82","v":1.4917323319269206E-3},{"$f":"D82","v":1.6574803688076891E-3},1.3259842950461512E-3,1.5683896761089918E-3]
["Decline genetic counselling","TN",{"$f":"C$80*(1-acceptance_counselling_relative)","v":4.2762249611534797E-4},{"$f":"D$80*(1-acceptance_counselling_relative)","v":4.7513610679483093E-4},{"$f":"E$80*(1-acceptance_counselling_relative)","v":3.8010888543586475E-4},{"$f":"F$80*(1-acceptance_counselling_relative)","v":4.4959721916929365E-4},null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},0.31130668081535601,0.34589631201706211,0.27671704961364968,0.32730415091551468,0.31130668081535601,0.34589631201706211,0.27671704961364968,0.32730415091551468,0,0,0,0,0,{"$f":"$Z$120","v":16.063402951093678},6.8690724660533256E-3,7.6323027400592479E-3,6.105842192047399E-3,7.2220612972075425E-3,6.8690724660533256E-3,7.6323027400592479E-3,6.105842192047399E-3,7.2220612972075425E-3,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C83","v":4.2762249611534797E-4},{"$f":"D83","v":4.7513610679483093E-4},{"$f":"E83","v":3.8010888543586475E-4},{"$f":"F83","v":4.4959721916929365E-4}]
["Relative is not FDR of proband","TN",{"$f":"C$79*(1-p_FDR)","v":2.6106864711247426E-3},{"$f":"D$79*(1-p_FDR)","v":2.9007627456941573E-3},{"$f":"E$79*(1-p_FDR)","v":2.3206101965553261E-3},{"$f":"F$79*(1-p_FDR)","v":2.7448447829647592E-3},null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},1.9005645104231657,2.1117383449146274,1.6893906759317023,1.9982309782589489,1.9005645104231657,2.1117383449146274,1.6893906759317023,1.9982309782589489,0,0,0,0,0,{"$f":"$Z$120","v":16.063402951093678},4.1936508764645532E-2,4.6596120849606126E-2,3.7276896679684909E-2,4.4091547786970199E-2,4.1936508764645532E-2,4.6596120849606126E-2,3.7276896679684909E-2,4.4091547786970199E-2,null,null,null,null,null,null,null,null,null,null,null,null,2.6106864711247426E-3,2.9007627456941573E-3,2.3206101965553261E-3,2.7448447829647592E-3]
["Proband FN",null,{"$f":"(C$10+C$12+C$13)*relatives_per_proband","v":0.16512299111581258},{"$f":"(D$10+D$12+D$13)*relatives_per_proband","v":0.15694374988120546},{"$f":"(E$10+E$12+E$13)*relatives_per_proband","v":0.17330223235041969},{"$f":"(F$10+F$12+F$13)*relatives_per_proband","v":0.16134014745582703}]
["Relative has mutation","FN",{"$f":"C$85*p_rel_LS","v":7.2654116090957538E-2},{"$f":"D$85*p_rel_LS","v":6.9055249947730407E-2},{"$f":"E$85*p_rel_LS","v":7.6252982234184669E-2},{"$f":"F$85*p_rel_LS","v":7.0989664880563894E-2},null,null,null,null,null,{"$f":"$L$111","v":2464.6639288364036},{"$f":"C86*$L86","v":179.06797921087556},{"$f":"D86*$L86","v":170.19798364295309},{"$f":"E86*$L86","v":187.93797477879806},{"$f":"F86*$L86","v":174.96566635131026},179.06797921087556,170.19798364295309,187.93797477879806,174.96566635131026,0,0,0,0,0,{"$f":"$Z$111","v":14.863834990578768},1.0799187929623466,1.0264258404562379,1.1334117454684554,1.0551786648211863,1.0799187929623466,1.0264258404562379,1.1334117454684554,1.0551786648211863,null,null,null,null,null,null,null,null,{"$f":"C86","v":7.2654116090957538E-2},6.9055249947730407E-2,7.6252982234184669E-2,7.0989664880563894E-2]
["Relative does not have mutation","TN",{"$f":"C$85*(1-p_rel_LS)","v":9.2468875024855055E-2},{"$f":"D$85*(1-p_rel_LS)","v":8.788849993347507E-2},{"$f":"E$85*(1-p_rel_LS)","v":9.7049250116235039E-2},{"$f":"F$85*(1-p_rel_LS)","v":9.0350482575263152E-2},null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},67.316801207186117,63.982314879782493,70.651287534589741,65.774623870545526,67.316801207186117,63.982314879782493,70.651287534589741,65.774623870545526,0,0,0,0,0,{"$f":"$Z$120","v":16.063402951093678},1.4853647999585693,1.4117883891985801,1.5589412107185585,1.4513362084322201,1.4853647999585693,1.4117883891985801,1.5589412107185585,1.4513362084322201,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C87","v":9.2468875024855055E-2},8.788849993347507E-2,9.7049250116235039E-2,9.0350482575263152E-2]
["Proband sporadic",null,{"$f":"C$57*(1-p_EC_LS)","v":5.7612638377727237},{"$f":"D$57*(1-p_EC_LS)","v":5.7612638377727237},{"$f":"E$57*(1-p_EC_LS)","v":5.7612638377727237},{"$f":"F$57*(1-p_EC_LS)","v":5.7612638377727237}]
["Proband LL",null,{"$f":"C$19*relatives_per_proband","v":4.4803494761166449E-2},{"$f":"D$19*relatives_per_proband","v":0.11005422203078469},{"$f":"E$19*relatives_per_proband","v":4.5968111597465861E-2},{"$f":"F$19*relatives_per_proband","v":3.5149328854612603E-2},{"$f":"c_GP","v":36.400675399259349},{"$f":"C89*$G89","v":1.6308774695536365},4.0060480124606102,1.6732703089762839,1.2794593101385738,null,null,null,null,null,1.6308774695536365,4.0060480124606102,1.6732703089762839,1.2794593101385738]
["Relative is FDR of proband",null,{"$f":"C$89*p_FDR","v":1.8983006622660139E-2},{"$f":"D$89*p_FDR","v":4.662939881807792E-2},{"$f":"E$89*p_FDR","v":1.9476448690833252E-2},{"$f":"F$89*p_FDR","v":1.4892586973092602E-2}]
["Accept genetic counselling",null,{"$f":"C$90*acceptance_counselling_relative","v":1.475368927228987E-2},{"$f":"D$90*acceptance_counselling_relative","v":3.6240605863477125E-2},{"$f":"E$90*acceptance_counselling_relative","v":1.5137194956737765E-2},{"$f":"F$90*acceptance_counselling_relative","v":1.157459432160121E-2},{"$f":"c_pretest_relative","v":171.72712297629874},{"$f":"C91*$G91","v":2.5336086120166219},6.2234949798529096,2.5994669398519155,1.9876717824663801,null,null,null,null,null,2.5336086120166219,6.2234949798529096,2.5994669398519155,1.9876717824663801]
["Diagnosed LL","LL",{"$f":"C$91","v":1.475368927228987E-2},{"$f":"D$91","v":3.6240605863477125E-2},1.5137194956737765E-2,1.157459432160121E-2,null,null,null,null,null,{"$f":"$L$118","v":3367.2138165484694},{"$f":"C92*$L92","v":49.678826362717381},{"$f":"D92*$L92","v":122.02986878358764},{"$f":"E92*$L92","v":50.970172002115213},{"$f":"F92*$L92","v":38.974133920639048},49.678826362717381,122.02986878358764,50.970172002115213,38.974133920639048,{"$f":"u_baseline_relative*(u_LynchLike-1)*t_disutility_psychological","v":0},0,0,0,0,{"$f":"$Z$118","v":16.089683142712083},0.23738218557717441,0.58309986524326063,0.24355267052336999,0.18623155513999798,{"$f":"V92+AA92","v":0.23738218557717441},{"$f":"W92+AB92","v":0.58309986524326063},{"$f":"X92+AC92","v":0.24355267052336999},{"$f":"Y92+AD92","v":0.18623155513999798},null,null,null,null,{"$f":"C92","v":1.475368927228987E-2},{"$f":"D92","v":3.6240605863477125E-2},1.5137194956737765E-2,1.157459432160121E-2]
["Decline genetic counselling","TN",{"$f":"C$90*(1-acceptance_counselling_relative)","v":4.2293173503702691E-3},{"$f":"D$90*(1-acceptance_counselling_relative)","v":1.0388792954600793E-2},{"$f":"E$90*(1-acceptance_counselling_relative)","v":4.3392537340954879E-3},{"$f":"F$90*(1-acceptance_counselling_relative)","v":3.317992651491393E-3},null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},3.0789183413386594,7.562980623690934,3.158951386908623,2.4154792806478245,3.0789183413386594,7.562980623690934,3.158951386908623,2.4154792806478245,0,0,0,0,0,{"$f":"$Z$120","v":16.063402951093678},6.7937228807049471E-2,0.1668793674052356,6.970318123781373E-2,5.3298252949673983E-2,6.7937228807049471E-2,0.1668793674052356,6.970318123781373E-2,5.3298252949673983E-2,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"C93","v":4.2293173503702691E-3},{"$f":"D93","v":1.0388792954600793E-2},{"$f":"E93","v":4.3392537340954879E-3},{"$f":"F93","v":3.317992651491393E-3}]
["Relative is not FDR of proband","TN",{"$f":"C$89*(1-p_FDR)","v":2.582048813850631E-2},{"$f":"D$89*(1-p_FDR)","v":6.3424823212706774E-2},{"$f":"E$89*(1-p_FDR)","v":2.6491662906632608E-2},{"$f":"F$89*(1-p_FDR)","v":2.0256741881520001E-2},null,null,null,null,null,{"$f":"$L$120","v":727.99416224207096},18.79716463107323,46.172901040085925,19.285775944113354,14.746789835791025,18.79716463107323,46.172901040085925,19.285775944113354,14.746789835791025,0,0,0,0,0,16.063402951093678,0.41476490536276156,1.0188184923675889,0.42554625611378116,0.32539220731915131,0.41476490536276156,1.0188184923675889,0.42554625611378116,0.32539220731915131,null,null,null,null,null,null,null,null,null,null,null,null,2.582048813850631E-2,6.3424823212706774E-2,2.6491662906632608E-2,2.0256741881520001E-2]
["Proband TN","TN",{"$f":"(C$18+C$20+C$21)*relatives_per_proband","v":5.7164603430115575},{"$f":"(D$18+D$20+D$21)*relatives_per_proband","v":5.6512096157419389},{"$f":"(E$18+E$20+E$21)*relatives_per_proband","v":5.7152957261752579},{"$f":"(F$18+F$20+F$21)*relatives_per_proband","v":5.7261145089181111},null,null,null,null,null,727.99416224207096,4161.5497584007207,4114.0476098663885,4160.7019241426451,4168.5779348220076,4161.5497584007207,4114.0476098663885,4160.7019241426451,4168.5779348220076,0,0,0,0,0,16.063402951093678,91.825805943741827,90.777657218758037,91.807098234216724,91.980884700855512,91.825805943741827,90.777657218758037,91.807098234216724,91.980884700855512,null,null,null,null,null,null,null,null,null,null,null,null,5.7164603430115575,5.6512096157419389,5.7152957261752579,5.7261145089181111]
[]
[]
[]
[]
["RELATIVE HELPERS"]
["TP",null,{"$f":"p_LS_MLH1*$C102+p_LS_MSH2*$C103+p_LS_MSH6*$C104+p_LS_PMS2*$C105","v":1},null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*L102+p_LS_MSH2*L103+p_LS_MSH6*L104+p_LS_PMS2*L105","v":4951.262466723103},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*Z102+p_LS_MSH2*Z103+p_LS_MSH6*Z104+p_LS_PMS2*Z105","v":15.636419318165109}]
["MLH1","TP",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$17)+((1-p_rel_female)*'MM-Summary'!$N$31)","v":5377.8344016907286},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$17)+((1-p_rel_female)*'MM-Summary'!$M$31)","v":15.227667507951699}]
["MSH2","TP",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$20)+((1-p_rel_female)*'MM-Summary'!$N$34)","v":5248.1004524113523},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$20)+((1-p_rel_female)*'MM-Summary'!$M$34)","v":15.362751150235965}]
["MSH6","TP",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$23)+((1-p_rel_female)*'MM-Summary'!$N$37)","v":4768.8528972315198},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$23)+((1-p_rel_female)*'MM-Summary'!$M$37)","v":15.811652571455916}]
["PMS2","TP",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$26)+((1-p_rel_female)*'MM-Summary'!$N$40)","v":4530.0791181167315},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$26)+((1-p_rel_female)*'MM-Summary'!$M$40)","v":16.003427966355048}]
["LL (actually LS)",null,{"$f":"p_LS_MLH1*$C107+p_LS_MSH2*$C108+p_LS_MSH6*$C109+p_LS_PMS2*$C110","v":1},null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*L107+p_LS_MSH2*L108+p_LS_MSH6*L109+p_LS_PMS2*L110","v":4257.6516227234843},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*Z107+p_LS_MSH2*Z108+p_LS_MSH6*Z109+p_LS_PMS2*Z110","v":15.420914941663112}]
["MLH1","LL",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$18)+((1-p_rel_female)*'MM-Summary'!$N$32)","v":4920.6616052774325},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$18)+((1-p_rel_female)*'MM-Summary'!$M$32)","v":14.860965644555044}]
["MSH2","LL",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$21)+((1-p_rel_female)*'MM-Summary'!$N$35)","v":4724.9056860011124},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$21)+((1-p_rel_female)*'MM-Summary'!$M$35)","v":15.038207171108791}]
["MSH6","LL",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$24)+((1-p_rel_female)*'MM-Summary'!$N$38)","v":3972.9592425871961},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$24)+((1-p_rel_female)*'MM-Summary'!$M$38)","v":15.66172181502824}]
["PMS2","LL",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$27)+((1-p_rel_female)*'MM-Summary'!$N$41)","v":3591.122089793088},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$27)+((1-p_rel_female)*'MM-Summary'!$M$41)","v":15.944068082517887}]
["FN",null,{"$f":"p_LS_MLH1*$C112+p_LS_MSH2*$C113+p_LS_MSH6*$C114+p_LS_PMS2*$C115","v":1},null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*L112+p_LS_MSH2*L113+p_LS_MSH6*L114+p_LS_PMS2*L115","v":2464.6639288364036},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_LS_MLH1*Z112+p_LS_MSH2*Z113+p_LS_MSH6*Z114+p_LS_PMS2*Z115","v":14.863834990578768}]
["MLH1","FN",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$19)+((1-p_rel_female)*'MM-Summary'!$N$33)","v":3738.8675127539327},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$19)+((1-p_rel_female)*'MM-Summary'!$M$33)","v":13.913039391550811}]
["MSH2","FN",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$22)+((1-p_rel_female)*'MM-Summary'!$N$36)","v":3372.4444524506762},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$22)+((1-p_rel_female)*'MM-Summary'!$M$36)","v":14.199259271527669}]
["MSH6","FN",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$25)+((1-p_rel_female)*'MM-Summary'!$N$39)","v":1915.5699431475955},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$25)+((1-p_rel_female)*'MM-Summary'!$M$39)","v":15.274150018053664}]
["PMS2","FN",1,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$N$28)+((1-p_rel_female)*'MM-Summary'!$N$42)","v":1163.9132140419929},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"(p_rel_female*'MM-Summary'!$M$28)+((1-p_rel_female)*'MM-Summary'!$M$42)","v":15.790622469388676}]
[]
["LL (actually sporadic)"]
["Sporadic","LL",1,null,null,null,null,null,null,null,null,{"$f":"p_rel_female*'MM-Summary'!$N$29+(1-p_rel_female)*'MM-Summary'!$N$43","v":3367.2138165484694},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_rel_female*'MM-Summary'!$M$29+(1-p_rel_female)*'MM-Summary'!$M$43","v":16.089683142712083}]
["TN"]
["Sporadic","TN",1,null,null,null,null,null,null,null,null,{"$f":"p_rel_female*'MM-Summary'!$N$30+(1-p_rel_female)*'MM-Summary'!$N$44","v":727.99416224207096},null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"p_rel_female*'MM-Summary'!$M$30+(1-p_rel_female)*'MM-Summary'!$M$44","v":16.063402951093678}]
[]
["GRAND TOTAL",null,{"$f":"SUMIF($B$57:$B$95,\"TP\",C$57:C$95)+SUMIF($B$57:$B$95,\"LL\",C$57:C$95)+SUMIF($B$57:$B$95,\"FN\",C$57:C$95)+SUMIF($B$57:$B$95,\"TN\",C$57:C$95)","v":6.0000000000000009},{"$f":"SUMIF($B$57:$B$95,\"TP\",D$57:D$95)+SUMIF($B$57:$B$95,\"LL\",D$57:D$95)+SUMIF($B$57:$B$95,\"FN\",D$57:D$95)+SUMIF($B$57:$B$95,\"TN\",D$57:D$95)","v":6.0000000000000009},6.0000000000000009,6.0000000000000009,null,{"$f":"SUM(H$57:H$95)","v":26.970217477716439},{"$f":"SUM(I$57:I$95)","v":35.569244543587054},24.54449848984703,27.244806518884214,null,{"$f":"SUM(M$57:M$95)","v":4668.031900350572},{"$f":"SUM(N$57:N$95)","v":4733.4852723883332},4660.2993766306454,4663.6859254823585,{"$f":"SUM(Q$57:Q$95)","v":4695.0021178282877},{"$f":"SUM(R$57:R$95)","v":4769.0545169319203},4684.8438751204922,4690.9307320012431,null,0,0,0,0,null,96.271644244806438,96.274080716091959,96.26978253240911,96.272426388238941,96.271644244806438,96.274080716091959,96.26978253240911,96.272426388238941,2.3579268823294239E-2,2.6199187581438039E-2,2.0959350065150432E-2,2.4790963500055732E-2,2.4337090688115844E-2,4.6888829658839316E-2,2.3655773993027519E-2,2.1650468874225774E-2,8.1464642556707434E-2,7.8844723798563623E-2,8.4084561314851244E-2,8.0252947879945941E-2,5.8706189979318832,5.8480672589611595,5.8713003146269713,5.8733056197457731,1.6049453425145258E-2,1.7832726027939175E-2,1.4266180822351341E-2,1.6874204922993574E-2,7.5298153981489787E-3,8.3664615534988652E-3,6.6931692427990921E-3,7.9167585770621562E-3]

{"sheet":"MM-Summary","index":14,"n_rows":44,"n_cols":14,"rows_kept":44,"cut":false,"hidden":false,"merged":[]}
["Proband/Relative","Sex","Gene","Diagnosis","Sheet","Undiscounted",null,null,"Discounted",null,"Across relative age range",null,"Live"]
[null,null,null,null,null,"QALYs","LYs","Costs","QALYs","Costs","Disc QALYs","Disc Costs","Disc QALYs","Disc Costs"]
["Pro","F","MLH1","TP",{"$f":"CONCATENATE(\"'MM-\",$A3,\"-\",$B3,\"-\",$C3,\"-\",$D3,\"'\")","v":"'MM-Pro-F-MLH1-TP'"},{"$f":"INDIRECT(CONCATENATE($E3,\"!QALY_undisc\"),FALSE)","v":16.261773986910349},{"$f":"INDIRECT(CONCATENATE($E3,\"!LY_undisc\"),FALSE)","v":21.624142138400835},{"$f":"INDIRECT(CONCATENATE($E3,\"!cost_undisc\"),FALSE)","v":5240.7623390032095},{"$f":"INDIRECT(CONCATENATE($E3,\"!QALY_disc\"),FALSE)","v":11.047317507653798},{"$f":"INDIRECT(CONCATENATE($E3,\"!cost_disc\"),FALSE)","v":4008.6314807221574},null,null,{"$f":"I3","v":11.047317507653798},{"$f":"J3","v":4008.6314807221574}]
["Pro","F","MLH1","LL",{"$f":"CONCATENATE(\"'MM-\",$A4,\"-\",$B4,\"-\",$C4,\"-\",$D4,\"'\")","v":"'MM-Pro-F-MLH1-LL'"},{"$f":"INDIRECT(CONCATENATE($E4,\"!QALY_undisc\"),FALSE)","v":15.735931796084621},{"$f":"INDIRECT(CONCATENATE($E4,\"!LY_undisc\"),FALSE)","v":20.897972906994287},{"$f":"INDIRECT(CONCATENATE($E4,\"!cost_undisc\"),FALSE)","v":4744.9603475388139},{"$f":"INDIRECT(CONCATENATE($E4,\"!QALY_disc\"),FALSE)","v":10.76021686953796},{"$f":"INDIRECT(CONCATENATE($E4,\"!cost_disc\"),FALSE)","v":3657.6142913882104},null,null,{"$f":"I4","v":10.76021686953796},{"$f":"J4","v":3657.6142913882104}]
["Pro","F","MLH1","FN","'MM-Pro-F-MLH1-FN'",14.37662695644225,19.020821609757625,3463.3095818525944,10.01806020416571,2750.2330036485268,null,null,10.01806020416571,2750.2330036485268]
["Pro","F","MSH2","TP","'MM-Pro-F-MSH2-TP'",16.387669051905203,21.800169331859276,5132.5639352021253,11.111842756275266,3918.0986432146274,null,null,11.111842756275266,3918.0986432146274]
["Pro","F","MSH2","LL","'MM-Pro-F-MSH2-LL'",15.901320658766,21.127820204339603,4598.8905205647998,10.847751169286413,3530.9657796484967,null,null,10.847751169286413,3530.9657796484967]
["Pro","F","MSH2","FN","'MM-Pro-F-MSH2-FN'",14.644107494663762,19.389794159811618,3219.3419260218629,10.165073022561232,2530.225283333958,null,null,10.165073022561232,2530.225283333958]
["Pro","F","MSH6","TP","'MM-Pro-F-MSH6-TP'",16.936473588577112,22.572481947683389,4608.3384104127999,11.384253049172225,3514.8279678890995,null,null,11.384253049172225,3514.8279678890995]
["Pro","F","MSH6","LL","'MM-Pro-F-MSH6-LL'",16.640731342687271,22.161695568981603,3887.270919897051,11.22747375577938,2957.4324421088386,null,null,11.22747375577938,2957.4324421088386]
["Pro","F","MSH6","FN","'MM-Pro-F-MSH6-FN'",15.876236075592903,21.099810611154862,2023.3076497993213,10.822198454590701,1516.5620650126514,null,null,10.822198454590701,1516.5620650126514]
["Pro","F","PMS2","TP","'MM-Pro-F-PMS2-TP'",17.304962355410453,23.095460490044083,4210.5731257386105,11.559367285291604,3237.9351558431454,null,null,11.559367285291604,3237.9351558431454]
["Pro","F","PMS2","LL","'MM-Pro-F-PMS2-LL'",17.148667017938021,22.877636259181866,3347.0593716789449,11.47791282376992,2559.1494572527472,null,null,11.47791282376992,2559.1494572527472]
["Pro","F","PMS2","FN","'MM-Pro-F-PMS2-FN'",16.74464274535876,22.314559472327723,1114.8717582279655,11.267352610670535,804.48484252274875,null,null,11.267352610670535,804.48484252274875]
["Pro","F","Sporadic","LL","'MM-Pro-F-Sporadic-LL'",12.657052296430336,16.66359362771167,2265.4878798528794,8.9569461379480586,1807.4247336343246,null,null,8.9569461379480586,1807.4247336343246]
["Pro","F","Sporadic","TN","'MM-Pro-F-Sporadic-TN'",12.627453528667651,16.622733555220375,101.70843376995178,8.9410115327291919,70.707408025595356,null,null,8.9410115327291919,70.707408025595356]
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{"sheet":"MM-Rel-F-MSH2-LL","index":33,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-F-MSH6-LL","index":36,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-F-PMS2-LL","index":39,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-F-Sporadic-LL","index":41,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-F-Sporadic-TN","index":42,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-M-MSH6-LL","index":50,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-M-Sporadic-LL","index":55,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"MM-Rel-M-Sporadic-TN","index":56,"n_rows":844,"n_cols":93,"rows_kept":139,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":62,"rows_last":15,"rows_between":62,"halvings":5}}
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{"sheet":"Inflation","index":57,"n_rows":13,"n_cols":7,"rows_kept":13,"cut":false,"hidden":false,"merged":[]}
["Year","HCHS Pay & Prices index"]
["2005/06",240.9,null,null,null,{"$f":"CONCATENATE(\"inflate_\",REPLACE(A2,5,1,\"_\"))","v":"inflate_2005_06"},{"$f":"$B$13/$B2","v":1.2465984725773749}]
["2006/07",249.8,{"$f":"B3/B2","v":1.036944790369448},{"$f":"LN(C3)","v":3.6278688070651689E-2},null,"inflate_2006_07",{"$f":"$B$13/$B3","v":1.2021840354038815}]
["2007/08",257,{"$f":"B4/B3","v":1.0288230584467573},{"$f":"LN(C4)","v":2.8415487203742349E-2},null,"inflate_2007_08",1.1685041713770026]
["2008/09",267,1.038910505836576,3.8172573505029811E-2,null,"inflate_2008_09",1.1247399702018339]
["2009/10",268.60000000000002,1.005992509363296,5.9746256888877731E-3,null,"inflate_2009_10",1.1180401044076307]
["2010/11",276.7,1.0301563663440059,2.9710602703742938E-2,null,"inflate_2010_11",1.0853110662952283]
["2011/12",282.5,1.0209613299602458,2.0744663793615458E-2,null,"inflate_2011_12",1.0630285736066889]
["2012/13",287.3,1.016991150442478,1.6848415398748366E-2,null,"inflate_2012_13",1.0452682632923411]
["2013/14",290.5,1.0111381830838844,1.1076610306721978E-2,null,"inflate_2013_14",1.0337541206330108]
["2014/15",293.10000000000002,1.0089500860585199,8.9102714248809143E-3,null,"inflate_2014_15",1.0245840056086306]
["2015/16",297,1.0133060388945752,1.3218291085852797E-2,null,{"$f":"CONCATENATE(\"inflate_\",REPLACE(A12,5,1,\"_\"))","v":"inflate_2015_16"},1.0111298722016486]
["2016/17",{"$f":"B12*C13","v":300.30557204388964},{"$f":"EXP(D13)","v":1.0111298722016486},{"$f":"AVERAGE($D$10:$D$12)","v":1.1068390939151898E-2},"(projected)",null,1]

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{"sheet":"Life table 2010-2012","index":59,"n_rows":108,"n_cols":12,"rows_kept":108,"cut":false,"hidden":false,"merged":[[0,10,0,11],[5,1,5,5],[5,7,5,11]]}
["Interim Life Tables, England & Wales",null,null,null,null,null,null,null,null,null,"Back to contents"]
[]
["Period expectation of life",null,null,null,null,null,null,null,null,null,null,"Office for National Statistics"]
["Based on data for the years 2010-2012"]
[]
["Age","Males",null,null,null,null,null,"Females"]
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[56,5.718E-3,5.7019999999999996E-3,93357.3,532.29999999999995,25.73,null,3.692E-3,3.6849999999999999E-3,95705.9,352.7,28.7]
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[59,7.2680000000000002E-3,7.2420000000000002E-3,91643.5,663.7,23.18,null,4.9750000000000003E-3,4.9630000000000004E-3,94549.6,469.2,26.03]
[60,8.1069999999999996E-3,8.0750000000000006E-3,90979.9,734.6,22.34,null,5.3220000000000003E-3,5.3070000000000001E-3,94080.4,499.3,25.16]
[61,8.7919999999999995E-3,8.7530000000000004E-3,90245.2,789.9,21.52,null,5.7819999999999998E-3,5.7650000000000002E-3,93581.1,539.5,24.29]
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[65,1.2246999999999999E-2,1.2172000000000001E-2,86713,1055.5,18.309999999999999,null,7.9850000000000008E-3,7.953E-3,91184.9,725.2,20.88]
[66,1.3968E-2,1.3871E-2,85657.5,1188.0999999999999,17.53,null,8.9890000000000005E-3,8.9490000000000004E-3,90459.7,809.5,20.04]
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[68,1.6423E-2,1.6289000000000001E-2,83193.5,1355.1,16.02,null,1.0631E-2,1.0574999999999999E-2,88776.8,938.8,18.399999999999999]
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[70,2.0975000000000001E-2,2.0757999999999999E-2,80323.8,1667.3,14.56,null,1.3629E-2,1.3537E-2,86787,1174.8,16.8]
[71,2.3224000000000002E-2,2.2957000000000002E-2,78656.5,1805.7,13.86,null,1.4656000000000001E-2,1.4548999999999999E-2,85612.1,1245.5999999999999,16.02]
[72,2.5457E-2,2.5137E-2,76850.7,1931.8,13.17,null,1.6546000000000002E-2,1.6410000000000001E-2,84366.5,1384.5,15.25]
[73,2.7588000000000001E-2,2.7212E-2,74918.899999999994,2038.7,12.5,null,1.7989999999999999E-2,1.7829999999999999E-2,82982.100000000006,1479.5,14.5]
[74,3.0835999999999999E-2,3.0367999999999999E-2,72880.2,2213.1999999999998,11.83,null,2.0197E-2,1.9994999999999999E-2,81502.5,1629.6,13.75]
[75,3.3839000000000001E-2,3.3276E-2,70667,2351.5,11.19,null,2.2463E-2,2.2213E-2,79872.899999999994,1774.2,13.02]
[76,3.7870000000000001E-2,3.7165999999999998E-2,68315.5,2539,10.56,null,2.537E-2,2.5052000000000001E-2,78098.7,1956.5,12.31]
[77,4.1888000000000002E-2,4.1029000000000003E-2,65776.5,2698.7,9.94,null,2.8767000000000001E-2,2.8358999999999999E-2,76142.100000000006,2159.3000000000002,11.61]
[78,4.7175000000000002E-2,4.6087999999999997E-2,63077.8,2907.1,9.35,null,3.2492E-2,3.1973000000000001E-2,73982.8,2365.5,10.93]
[79,5.2245E-2,5.0915000000000002E-2,60170.7,3063.6,8.7799999999999994,null,3.6584999999999999E-2,3.5927000000000001E-2,71617.399999999994,2573,10.28]
[80,5.8743999999999998E-2,5.7068000000000001E-2,57107.1,3259,8.2200000000000006,null,4.1758999999999998E-2,4.0904999999999997E-2,69044.3,2824.3,9.64]
[81,6.7028000000000004E-2,6.4853999999999995E-2,53848.1,3492.3,7.69,null,4.6972E-2,4.5893999999999997E-2,66220.100000000006,3039.1,9.0299999999999994]
[82,7.5162999999999994E-2,7.2440000000000004E-2,50355.8,3647.8,7.19,null,5.3502000000000001E-2,5.2108000000000002E-2,63181,3292.2,8.44]
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[91,0.20161899999999999,0.18315500000000001,16486.599999999999,3019.6,3.8,null,0.161547,0.149474,27163.8,4060.3,4.38]
[92,0.21829899999999999,0.19681599999999999,13467,2650.5,3.55,null,0.18092,0.165912,23103.5,3833.1,4.07]
[93,0.23667299999999999,0.21162900000000001,10816.5,2289.1,3.29,null,0.19356300000000001,0.176483,19270.400000000001,3400.9,3.77]
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[95,0.29783399999999999,0.25923000000000002,6518.5,1689.8,2.82,null,0.250338,0.22248899999999999,12692,2823.8,3.22]
[96,0.32814599999999999,0.28189399999999998,4828.7,1361.2,2.64,null,0.277256,0.24349999999999999,9868.2000000000007,2402.9,3]
[97,0.35762100000000002,0.30337500000000001,3467.5,1052,2.48,null,0.30094500000000002,0.26158399999999998,7465.3,1952.8,2.81]
[98,0.38501099999999999,0.32285900000000001,2415.6,779.9,2.34,null,0.32536999999999999,0.27984399999999998,5512.5,1542.6,2.62]
[99,0.41642499999999999,0.34466200000000002,1635.7,563.79999999999995,2.21,null,0.355159,0.30160100000000001,3969.8,1197.3,2.4500000000000002]
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[null,null,"Total"]
["Currency ","Currency Description","Activity ","Unit Cost ","Total Cost"]
["FZ51Z","Diagnostic Colonoscopy, 19 years and over",170286,520.65618189398992,88660458.589999974]
["FZ52Z","Diagnostic Colonoscopy with Biopsy, 19 years and over",158859,605.9905299038777,96267049.590000108]
["FZ53Z","Therapeutic Colonoscopy, 19 years and over",126284,616.21749619904347,77818410.290000007]

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["Centre","Type","MLH1","MSH2","MSH6","PMS2","Cost",null,null,"S+CNA",null,null,null,null,null,null,"Predictive"]
["Cardiff","Sequencing + copy number analysis","Y","Y","Y","N",500,null,null,"M126P2","M126","M26","M1","M2","M6","P2","M1","M2","M6","P2"]
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["Cambridge","Sequencing + copy number analysis","Y","N","N","N",475,null,"Edinburgh",null,null,525,null,350,350]
["Cambridge","Sequencing + copy number analysis","N","Y","N","N",415,null,"Leeds",{"$f":"AVERAGEIFS($G$2:$G$23,$A$2:$A$23,$I7,$C$2:$C$23,\"Y\",$D$2:$D$23,\"Y\",$E$2:$E$23,\"Y\",$F$2:$F$23,\"Y\")","v":860},null,null,null,null,null,null,{"$f":"$G$41","v":170},{"$f":"$G$41","v":170},170,170]
["Cambridge","Sequencing + copy number analysis","N","N","Y","N",475,null,"London NW",null,{"$f":"AVERAGEIFS($G$2:$G$23,$A$2:$A$23,$I8,$C$2:$C$23,\"Y\",$D$2:$D$23,\"Y\",$E$2:$E$23,\"Y\",$F$2:$F$23,\"N\")","v":500},null,null,null,null,{"$f":"AVERAGEIFS($G$2:$G$23,$A$2:$A$23,$I8,$C$2:$C$23,\"N\",$D$2:$D$23,\"N\",$E$2:$E$23,\"N\",$F$2:$F$23,\"Y\")","v":500},{"$f":"$G$45","v":156},{"$f":"$G$45","v":156},156,156]
["Birmingham","Sequencing + copy number analysis","N","Y","Y","N",525,null,"Newcastle",null,null,null,null,null,null,null,{"$f":"$G$27","v":155},{"$f":"$G$28","v":155}]
["Birmingham","Sequencing + copy number analysis","Y","N","N","N",450,null,"Oxford",null,800,null,null,null,null,null,{"$f":"$G$29","v":170},{"$f":"$G$30","v":170},{"$f":"$G$31","v":170}]
["Birmingham","Sequencing + copy number analysis","N","Y","N","N",450,null,"Salisbury",null,500,null,null,null,null,null,{"$f":"$G$40","v":180},{"$f":"$G$40","v":180},180,180]
["Birmingham","Sequencing + copy number analysis","N","N","Y","N",450,null,"Sheffield",null,525,null,null,null,null,null,{"$f":"$G$32","v":155},{"$f":"$G$32","v":155},155,155]
["Birmingham","Sequencing + copy number analysis","N","N","N","Y",450]
["Birmingham","Sequencing + copy number analysis","Y","Y","Y","N",550]
["Birmingham","Sequencing + copy number analysis","Y","Y","Y","Y",650]
["Edinburgh","Sequencing + copy number analysis","N","Y","Y","N",525]
["Edinburgh","Sequencing + copy number analysis","N","Y","N","N",350]
["Edinburgh","Sequencing + copy number analysis","N","N","Y","N",350]
["Salisbury","Sequencing + copy number analysis","Y","Y","Y","N",500]
["Leeds","Sequencing + copy number analysis","Y","Y","Y","Y",860]
["Manchester","Sequencing + copy number analysis","Y","Y","Y","N",640]
["London NW","Sequencing + copy number analysis","Y","Y","Y","N",500]
["London NW","Sequencing + copy number analysis","N","N","N","Y",500]
["Cardiff","Predictive","Y","N","N","N",160]
["Cardiff","Predictive","N","Y","N","N",160]
["Cardiff","Predictive","N","N","Y","N",160]
["Newcastle","Predictive","Y","N","N","N",155]
["Newcastle","Predictive","N","Y","N","N",155]
["Oxford","Predictive","Y","N","N","N",170]
["Oxford","Predictive","N","Y","N","N",170]
["Oxford","Predictive","N","N","Y","N",170]
["Sheffield","Predictive","U","U","U","U",155]
["Cambridge","Predictive","Y","N","N","N",160]
["Cambridge","Predictive","N","Y","N","N",160]
["Cambridge","Predictive","N","N","Y","N",160]
["Birmingham","Predictive","Y","N","N","N",183]
["Birmingham","Predictive","N","Y","N","N",183]
["Birmingham","Predictive","N","N","Y","N",183]
["Birmingham","Predictive","N","N","N","Y",183]
["Salisbury","Predictive","U","U","U","U",180]
["Leeds","Predictive","U","U","U","U",170]
["Manchester","Predictive","Y","N","N","N",138]
["Manchester","Predictive","N","Y","N","N",138]
["Manchester","Predictive","N","N","Y","N",138]
["London NW","Predictive","U","U","U","U",156]

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["analysis"]
["Deterministic",1]
["Probabilistic sensitivity analysis",2]
["One-way sensitivity analysis",3]
["Scenario analysis",4]
[]
[]
[]
[null,"CRC stage",null,null,null,"Surveillance"]
["Age at diagnosis","I","II","III","IV","Not in surveillance (LS)","Not in surveillance (sporadic)","In surveillance"]
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[50,{"$f":"Parameters!B292","v":5712.3910588926447},{"$f":"Parameters!B298","v":7015.8405832181934},{"$f":"Parameters!B304","v":9691.7273372465861},{"$f":"Parameters!B310","v":8443.6770308755313},{"$f":"SUMPRODUCT(Parameters!$B$194:$B$197,TRANSPOSE($B12:$E12))","v":7500.7013329996371},{"$f":"SUMPRODUCT(Parameters!$B$188:$B$191,TRANSPOSE($B12:$E12))","v":7946.0157080713088},{"$f":"SUMPRODUCT(Parameters!$B$182:$B$185,TRANSPOSE($B12:$E12))","v":6580.0974145287328}]
[60,{"$f":"Parameters!B293","v":4623.2215285420252},{"$f":"Parameters!B299","v":5351.7735080567863},{"$f":"Parameters!B305","v":7259.3880885653089},{"$f":"Parameters!B311","v":6508.8854755214079},{"$f":"SUMPRODUCT(Parameters!$B$194:$B$197,TRANSPOSE($B13:$E13))","v":5750.7132065956002},{"$f":"SUMPRODUCT(Parameters!$B$188:$B$191,TRANSPOSE($B13:$E13))","v":6086.3099887295275},{"$f":"SUMPRODUCT(Parameters!$B$182:$B$185,TRANSPOSE($B13:$E13))","v":5190.1337099925449}]
[70,{"$f":"Parameters!B294","v":3177.6155204087172},{"$f":"Parameters!B300","v":3454.6116101811876},{"$f":"Parameters!B306","v":4485.2461177874357},{"$f":"Parameters!B312","v":4365.0402675088162},{"$f":"SUMPRODUCT(Parameters!$B$194:$B$197,TRANSPOSE($B14:$E14))","v":3724.1079001645353},{"$f":"SUMPRODUCT(Parameters!$B$188:$B$191,TRANSPOSE($B14:$E14))","v":3945.9440246470367},{"$f":"SUMPRODUCT(Parameters!$B$182:$B$185,TRANSPOSE($B14:$E14))","v":3470.5094112089364}]
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