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  • Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes 

    Macfarlane, Wendy M.; Frayling, Timothy M.; Ellard, Sian; Evans, Julie C.; Allen, Lisa I. S.; Bulman, Michael P.; Ayres, Susan; Shepherd, Maggie H.; Clark, Penny; Millward, Ann; Demaine, Andrew; Wilkin, Terence; Docherty, Kevin; Hattersley, Andrew T. (American Society for Clinical Investigation, 1999-11-01)
    The transcription factor insulin promoter factor-1 (IPF-1) plays a central role in both the development of the pancreas and the regulation of insulin gene expression in the mature pancreatic beta cell. A dominant-negative ...