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Now showing items 1-2 of 2

  • Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes 

    Macfarlane, Wendy M.; Frayling, Timothy M.; Ellard, Sian; Evans, Julie C.; Allen, Lisa I. S.; Bulman, Michael P.; Ayres, Susan; Shepherd, Maggie; Clark, Penny; Millward, Ann; Demaine, Andrew; Wilkin, Terence; Docherty, Kevin; Hattersley, Andrew T. (American Society for Clinical Investigation, 1999-11-01)
    The transcription factor insulin promoter factor-1 (IPF-1) plays a central role in both the development of the pancreas and the regulation of insulin gene expression in the mature pancreatic beta cell. A dominant-negative ...
  • Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom 

    Evans, Julie C.; Frayling, Timothy M.; Cassell, Paul G.; Saker, Philip J.; Hitman, Graham A.; Walker, Mark; Levy, Jonathan C.; O’Rahilly, Stephen; Rao, Pamidighantam V. Subba; Bennett, Amanda J.; Jones, Elizabeth C.; Menzel, Stephan; Prestwich, Philip; Simecek, Nikol; Wishart, Marie; Dhillon, Ranjit; Fletcher, Chris; Millward, Ann; Demaine, Andrew; Wilkin, Terence; Horikawa, Yukio; Cox, Nancy J.; Bell, Graeme I.; Ellard, Sian; McCarthy, Mark I.; Hattersley, Andrew T. (The American Society of Human Genetics, 2001-09)