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  • Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo 

    Dobson, CL; Devine, PWA; Phillips, JJ; Higazi, DR; Lloyd, C; Popovic, B; Arnold, J; Buchanan, A; Lewis, A; Goodman, J; van der Walle, CF; Thornton, P; Vinall, L; Lowne, D; Aagaard, A; Olsson, L-L; Ridderstad Wollberg, A; Welsh, F; Karamanos, TK; Pashley, CL; Iadanza, MG; Ranson, NA; Ashcroft, AE; Kippen, AD; Vaughan, TJ; Radford, SE; Lowe, DC (Nature Publishing Group, 2016-12-20)
    Uncontrolled self-association is a major challenge in the exploitation of proteins as therapeutics. Here we describe the development of a structural proteomics approach to identify the amino acids responsible for aberrant ...