University of Exeter Medical School
The University of Exeter Medical School mission is to improve the health and wellbeing of the public, locally and across the world. This is done through swiftly turning new discoveries into treatments therapies, and through nurturing graduates, staff and researchers who are critical thinkers and problem solvers. For more information, please visit http://medicine.exeter.ac.uk
Collections in this community
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Institute of Health Research [1182]
Recent Submissions
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Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
(Wiley, 2017-08-14)Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic ... -
Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease
(Future Medicine, 2017-10-03)It is thought that both genetic and epigenetic variation play a role in Alzheimer's disease initiation and progression. With the advent of somatic cell reprogramming into induced pluripotent stem cells it is now possible ... -
Independently getting off the floor (IGO): a feasibility study of teaching people with stroke to get up after a fall
(Mark Allen Healthcare, 2018)Background: Falls are common among stroke survivors but many are not taught how to get up again. A technique from Action for Rehabilitation following Neurological Injury (ARNI) addresses this problem. We investigated the ... -
The acceptability and experience of a functional training programme (ReTrain) in community dwelling stroke survivors in South West England: a qualitative study.
(BMJ Publishing Group, 2018)OBJECTIVE: This article reports on the acceptability of the intervention as described by trial participants. DESIGN: A qualitative approach was undertaken. Of the 45 participants recruited into the trial, 23 were ... -
Psychosocial interventions for recurrent abdominal pain in childhood
(Cochrane Collaboration, 2017-01-10)BACKGROUND: This review supersedes the original Cochrane review first published in 2008 (Huertas-Ceballos 2008).Between 4% and 25% of school-aged children complain of recurrent abdominal pain (RAP) severe enough to interfere ... -
Use of near-infrared systems for investigations of hemodynamics in human in vivo bone tissue: a systematic review
(Wiley, 2018-05-04)A range of technologies using near infrared (NIR) light have shown promise at providing real time measurements of hemodynamic markers in bone tissue in vivo, an exciting prospect given existing difficulties in measuring ... -
Fragile: Please handle with care
(Elsevier, 2018-05-04) -
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
(American Society for Clinical Investigation, 2016-12-19)The current frontline symptomatic treatment for Alzheimer’s disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse ... -
Concurrent Use of Prescription Drugs and Herbal Medicinal Products in Older Adults: A Systematic Review
(Springer International Publishing / Adis, 2017-12-01)BACKGROUND: The use of herbal medicinal products (HMPs) is common among older adults; however, little is known about concurrent use with prescription drugs, as well as potential interactions associated with such combinations. ... -
Protocol for a cluster randomised controlled trial of an intervention to improve the mental health support and training available to secondary school teachers – the WISE (Wellbeing in Secondary Education) study
(BioMed Central, 2016-06-08)BACKGROUND: Teachers are reported to be at increased risk of common mental health disorders compared to other occupations. Failure to support teachers adequately may lead to serious long-term mental disorders, poor performance ... -
Adapting QOF to focus on wellbeing and health
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Impact of multi-morbidity on quality of healthcare and its implications for health policy, research and clinical practice. A scoping review
(Taylor & Francis, 2015-07-31)The simultaneous presence of multiple conditions in one patient (multi-morbidity) is a key challenge facing healthcare systems globally. It potentially threatens the coordination, continuity and safety of care. In this ... -
How do aggregated patient-reported outcome measures data stimulate health care improvement? A realist synthesis.
(SAGE Publications, 2018-01-01)Objectives Internationally, there has been considerable debate about the role of data in supporting quality improvement in health care. Our objective was to understand how, why and in what circumstances the feedback of ... -
Multimorbidity, not a health condition or complexity by another name
(Taylor & Francis, 2015-12-18) -
Time spent on health-related activities by senior Australians with chronic diseases: what is the role of multimorbidity and comorbidity?
(Wiley, 2015-04-22)OBJECTIVE: To examine the effect of various morbidity clusters of chronic diseases on health-related time use and to explore factors associated with heavy time burden (more than 30 hours/month) of health-related activities. ... -
Developing a research agenda for patient safety in primary care. Background, aims and output of the LINNEAUS collaboration on patient safety in primary care.
(Taylor & Francis, 2015-09-04)This paper is an introduction to a supplement to The European Journal of General Practice, bringing together a body of research focusing on the issue of patient safety in relation to primary care. The supplement represents ... -
Analysing indicators of performance, satisfaction, or safety using empirical logit transformation
(BMJ Publishing Group, 2016-03-10)Performance, satisfaction, and safety indicators are commonly measured on a percentage scale. Such indicators are often subject to ceiling or floor effects and performance may be inherently non-linear. For example, improving ... -
Measurement tools and process indicators of patient safety culture in primary care. A mixed methods study by the LINNEAUS collaboration on patient safety in primary care.
(Taylor & Francis, 2015-09-04)BACKGROUND: There is little guidance available to healthcare practitioners about what tools they might use to assess the patient safety culture. OBJECTIVE: To identify useful tools for assessing patient safety culture in ... -
Patient-reported outcomes: pathways to better health, better services, and better societies
(Springer Verlag (Germany), 2015-11-15)While the use of PROs in research is well established, many challenges lie ahead as their use is extended to other applications. There is consensus that health outcome evaluations that include PROs along with clinician-reported ... -
Electronic Quality of Life Assessment using computer-adaptive testing
(Journal of Medical Internet Research, 2016-09-30)BACKGROUND: Quality of life (QoL) questionnaires are desirable for clinical practice but can be time-consuming to administer and interpret, making their widespread adoption difficult. OBJECTIVE: Our aim was to assess the ...