University of Exeter Medical School
The University of Exeter Medical School mission is to improve the health and wellbeing of the public, locally and across the world. This is done through swiftly turning new discoveries into treatments therapies, and through nurturing graduates, staff and researchers who are critical thinkers and problem solvers. For more information, please visit http://medicine.exeter.ac.uk
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Institute of Health Research [1289]
Recent Submissions
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Working with Patients and Members of the Public: Informing Health Economics in Child Health Research
(Springer, 2018-10-15)This paper considers patient and public involvement (PPI) in health economics research and how this might be facilitated. PPI refers to research carried out 'with' or 'by' members of the public and is now an important ... -
How much evidence is there that political factors are related to population health outcomes? An internationally comparative systematic review
(BMJ Publishing Group, 2018-10-18)Objectives To provide a 7-year update of the most recent systematic review about the relationships between political features and population health outcomes. Setting Internationally comparative scholarly literature. Data ... -
Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years
(Public Library of Science, 2018-09-13)Higher Red Blood Cell Distribution Width (RDW or anisocytosis) predicts incident coronary artery disease (CAD) plus all-cause and cardiovascular mortality, but its predictive value for other common diseases in healthy ... -
Human longevity: 25 genetic loci associated in 389,166 UK biobank participants
(Impact Journals, 2017-12-06)We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10-8), including 8 ... -
Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers
(Springer Verlag, 2018-10-18)Letter to the Editor -
Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study
(Wiley, 2018-09-03)Produced as a tissue defence response to hypoxia and inflammation, growth differentiation factor-15 (GDF-15) is elevated in people receiving metformin treatment. To gain insight into the relationship of GDF-15 with metformin ... -
Is teachers’ mental health and wellbeing associated with students’ mental health and wellbeing? A cross sectional study
(Elsevier for International Society for Affective Disorders, 2018)Background: Factors within the school environment may impact young people’s mental health and wellbeing. The aim of this study was to understand the association between teacher and student mental health and wellbeing. ... -
Vitamin D and cognitive function: A Mendelian randomisation study
(Springer Nature, 2017-10-16)The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D ... -
Social isolation, cognitive reserve, and cognition in healthy older people
(Public Library of Science, 2018-08-17)There is evidence to suggest that social isolation is associated with poor cognitive health, although findings are contradictory. One reason for inconsistency in reported findings may be a lack of consideration of underlying ... -
Case-finding in clinical practice: An appropriate strategy for dementia identification?
(Elsevier, 2018-07-10)Earlier diagnosis of dementia is increasingly being recognized as a public health priority. As screening is not generally recommended, case-finding in clinical practice is encouraged as an alternative dementia identification ... -
Individual and Area-Based Socioeconomic Factors Associated With Dementia Incidence in England: Evidence From a 12-Year Follow-up in the English Longitudinal Study of Ageing
(American Medical Association (AMA), 2018-05-16)Importance: Lower educational attainment is associated with a higher risk of dementia. However, less clear is the extent to which other socioeconomic markers contribute to dementia risk. Objective: To examine the relationship ... -
A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex
(Springer Nature, 2018)We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer’s disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel ... -
Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
(Springer Nature, 2018-05-14)Coffee's long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee ... -
Experiences of the ‘Nearest Relative’ provisions in the compulsory detention of people under the Mental Health Act: rapid systematic review
(NIHR Journals Library, 2018)Background Service users detained for assessment and/or treatment under the Mental Health Act 1983 are allocated a ‘Nearest Relative’. The Nearest Relative has access to confidential information about the service user, ... -
Homozygosity mapping provides supporting evidence of pathogenicity in recessive Mendelian disease
(Springer Nature for American College of Medical Genetics, 2018-10-03)PURPOSE: One of the greatest challenges currently facing those studying Mendelian disease is identifying the pathogenic variant from the long list produced by a next-generation sequencing test. We investigate the predictive ... -
Assessment of Kidney Function in Mouse Models of Glomerular Disease
(Journal of Visualized Experiments (JoVE), 2018-06-30)The use of murine models to mimic human kidney disease is becoming increasingly common. Our research is focused on the assessment of glomerular function in diabetic nephropathy and podocyte-specific VEGF-A knock-out mice; ... -
Psychological distress amongst primary school teachers: a comparison with clinical and population samples
(Elsevier, 2018)Objectives: This analysis explored the level of psychological distress among primary school teachers in the South West of England as compared to clinical and general population samples. Study design: Secondary analysis ... -
Supporting Supportive Care in Cancer: The ethical importance of promoting a holistic conception of quality of life
(Elsevier, 2018-09-10)Advances in anticancer therapies and increasing attention towards patient quality of life make Supportive Care in Cancer (SCC) a key aspect of excellence in oncological care. SCC promotes a holistic conception of quality ... -
Health State Values Derived from People with Multiple Sclerosis for a Condition-Specific Preference-Based Measure: Multiple Sclerosis Impact Scale–Eight Dimensions–Patient Version (MSIS-8D-P)
(Elsevier for International Society for Pharmacoeconomics and Outcomes Research, 2018-06-19)Objective: In economic evaluation, health outcomes are commonly quantified using quality-adjusted life-years (QALYs) derived from the preferences of a sample of the general population. It can be argued that this approach ... -
Review of 99 self-report measures for assessing well-being in adults: exploring dimensions of well-being and developments over time
(BMJ Publishing Group, 2016-07-07)OBJECTIVE: Investigators within many disciplines are using measures of well-being, but it is not always clear what they are measuring, or which instruments may best meet their objectives. The aims of this review were to: ...