University of Exeter Medical School
The University of Exeter Medical School mission is to improve the health and wellbeing of the public, locally and across the world. This is done through swiftly turning new discoveries into treatments therapies, and through nurturing graduates, staff and researchers who are critical thinkers and problem solvers. For more information, please visit http://medicine.exeter.ac.uk
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Institute of Health Research [1244]
Recent Submissions
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A replicable, low-burden mechanism for observing, recording and analysing mother-child interaction in population research
(Wiley, 2018)Background: There is growing evidence that specific styles of parent-child interaction benefit child development, particularly child language development. Direct observational techniques help clarify the behaviours and ... -
The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice
(eLife Sciences Publications Ltd, 2018-08-14)Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. g-aminobutyric acid (GABA) neurotransmission supports inhibition in the adult ... -
Morita Therapy for depression (Morita Trial): a pilot randomised controlled trial
(BMJ Publishing Group, 2018-08-10)Objective: To address uncertainties prior to conducting a fully powered randomised controlled trial of Morita Therapy plus treatment as usual (TAU) versus TAU alone, or to determine that such a trial is not appropriate ... -
Selection of men for investigation of possible testicular cancer in primary care: a large case-control study using electronic patient records.
(Royal College of General Practitioners, 2018-08-14)BACKGROUND: Testicular cancer incidence has risen over the last two decades and is expected to continue to rise. There are no primary care studies on the clinical features of testicular cancer, with recent National Institute ... -
Cost-effectiveness of a domestic violence and abuse training and support programme in primary care in the real world: updated modelling based on a MRC phase IV observational pragmatic implementation study.
(BMJ Publishing Group, 2018)Background: Primary care clinicians often struggle to identify women who experience domestic violence and abuse (DVA) and are uncertain about how to respond when DVA is disclosed. The Identification and Referral to Improve ... -
Quantifying the risk of Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a case-control study using electronic records.
(Royal College of General Practitioners, 2015-05-01)BACKGROUND: In the UK, approximately five people are diagnosed with Hodgkin lymphoma (HL) daily. One-tenth of diagnoses are in those aged >75 years. AIM: To establish a symptom profile of HL and quantify their risk in ... -
Human With No Lysine Kinase 3 (WNK3): A Target Enabling Package (TEP)
(SGC Oxford, 2018-06-01)SUMMARY OF PROJECT Kinases WNK1-4 regulate cation-chloride cotransporters via phosphorylation of SPAK and OSR1 and thereby control salt homeostasis, cell volume and blood pressure. Gain of function mutations in WNK kinases ... -
An implementation science perspective on deprescribing
(Gerontological Society of America, 2018)Awaiting abstract. -
Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2.
(Impact Journals, 2018-07-19)Cellular senescence is a key driver of ageing, influenced by age-related changes to the regulation of alternative splicing. Hydrogen sulfide (H2S) has similarly been described to influence senescence, but the pathways by ... -
Tart cherry concentrate does not enhance muscle protein synthesis response to exercise and protein in healthy older men.
(Elsevier, 2018-06-08)BACKGROUND: Oxidative stress and inflammation may contribute to anabolic resistance in response to protein and exercise in older adults. We investigated whether consumption of montmorency cherry concentrate (MCC) increased ... -
The reliability and validity of the pupil behaviour questionnaire: a child classroom behaviour assessment tool
(Taylor & Francis, 2018-05-23)This paper assesses the reliability and validity of the teacher-completed Pupil Behaviour Questionnaire (PBQ), by comparing it to the already extensively validated teacher-completed Strengths and Difficulties Questionnaire ... -
A quantitative content analysis of person-first language use in healthcare research, healthcare practice, and by support groups for people with disabilities
(Scientific Research Publishing, 2014-10-01)This article reports the results of an original quantitative linguistic study that investigated patterns of language use referring to people with disabilities in three data source types: written by support groups run for ... -
The Politics of Women’s Fashion in the Cultural West: A Perspective
(Scientific Research Publishing, 2017-11-28)In this perspective piece, we discuss the politics of fashion in the cultural West. We cover issues of social expectation and individual freedom. We comment on where society draws the line with regard to public decency. ... -
An application of Extended Normalisation Process Theory in a randomised controlled trial of a complex social intervention: Process evaluation of the Strengthening Families Programme (10-14) in Wales, UK.
(Elsevier, 2017-01-11)Purpose: Process evaluations generate important data on the extent to which interventions are delivered as intended. However, the tendency to focus only on assessment of pre-specified structural aspects of fidelity has ... -
Improving process evaluations of health behavior interventions: learning from the social sciences.
(SAGE Publications, 2013-09-23)This article reflects on the current state of process evaluations of health behavior interventions and argues that evaluation practice in this area could be improved by drawing on the social science literature to a greater ... -
Seal or Varnish? A randomised controlled trial to determine the relative cost and effectiveness of pit and fissure sealant and fluoride varnish in preventing dental decay
(NIHR Journals Library, 2017-04)Background Fissure sealant (FS) and fluoride varnish (FV) have been shown to be effective in preventing dental caries when tested against a no-treatment control. However, the relative clinical effectiveness and ... -
Health, health behaviours and health promoting services for care leavers: perspectives of young people and LAC nurses
(CASCADE: Children's Social Care Research and Development Centre, 2015-06)This working paper reports findings from a qualitative study of care leavers’ and looked after children’s (LAC) nurses’ perspectives on the health, health behaviours and health promoting services for care leavers. Looked ... -
People-centred Public Health.
(Wiley, 2015-06-22)Book review: South J, White J and Gamsu M. (eds) People-Centred Public Health. Evidence for Public Health Practice Series. Bristol: Policy Press. 2013. 224pp £24.99 ISBN 97844730 5309. -
Policy is political; our ideas about knowledge translation must be too.
(BMJ Publishing Group, 2014-06-18)This article argues that in public health research, standard approaches to knowledge translation are based on (1) an invalid model of the relationship between research knowledge and policy and (2) an oversimplified concept ... -
Understanding intervention acceptability: changing participant views over time and the importance of context
(BMJ Publishing Group, 2017-09-02)Background Acceptability is an important aspect of the quality of health interventions and also has implications for the feasibility of future implementation. Process evaluations of complex interventions often assess the ...