University of Exeter Medical School
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Natural environments and subjective wellbeing: Different types of exposure are associated with different aspects of wellbeing.
(Elsevier, 2017-03-17)Despite growing interest in the relationships between natural environments and subjective wellbeing (SWB), previous studies have various methodological and theoretical limitations. Focusing on urban/peri-urban residents ... -
A comparison of two methods for expert elicitation in health technology assessments.
(BioMed Central, 2016-07-26)BACKGROUND: When data needed to inform parameters in decision models are lacking, formal elicitation of expert judgement can be used to characterise parameter uncertainty. Although numerous methods for eliciting expert ... -
Touching the Void
(Elsevier, 2017-08-01)Temporal lobe epilepsy (TLE) can be associated with a marked impairment of autobiographical memory. Thisis occasionally its presenting feature. We describe two individuals with severe epilepsyassociated autobiographical ... -
Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data.
(Royal College of General Practitioners, 2017-05-23)BACKGROUND: Thrombocytosis (raised platelet count) is an emerging risk marker of cancer, but the association has not been fully explored in a primary care context. AIM: To examine the incidence of cancer in a cohort of ... -
Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients
(Oxford University Press (OUP) / Gerontological Society of America, 2016-08-04)BACKGROUND: Moderate obesity in later life may improve survival, prompting calls to revise obesity control policies. However, this obesity paradox may be due to confounding from smoking, diseases causing weight-loss, plus ... -
Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants
(American Society for Nutrition, 2017-05-31)Background: For older groups, being overweight [body mass index (BMI; in kg/m(2)): 25 to <30] is reportedly associated with a lower or similar risk of mortality than being normal weight (BMI: 18.5 to <25). However, this ... -
The Relationship between Exclusion from School and Mental Health: A Secondary Analysis of The British Child and Adolescent Mental Health Surveys 2004 and 2007
(Cambridge University Press (CUP), 2017)Background Children with poor mental health often struggle at school. The relationship between childhood psychiatric disorder and exclusion from school has not been frequently studied, but both are associated with poor ... -
Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations.
(NIHR Journals Library, 2017-05)BACKGROUND: There is currently no disease-modifying treatment available to halt or delay the progression of the disease pathology in dementia. An agreed core set of the best-available and most appropriate outcomes for ... -
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
(2017-04-24)The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 ... -
Prescribing of medication for attention deficit hyperactivity disorder among young people in the Clinical Practice Research Datalink 2005-2013: analysis of time to cessation
(Springer Verlag, 2017-06-06)The aim of this study was to examine the time to cessation of ADHD medication amongst young people with ADHD aged 16 in the period 2005-2013. Previous studies of prescribing in primary care reported high rates of medication ... -
European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
(Elsevier, 2017-05-18)The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different ... -
Relationship between perceptions of ageing and frailty in English older adults
(Taylor & Francis (Routledge), 2017)Older adults’ negative beliefs about ageing are related to their health and functioning, but little is known about how perceptions of ageing (POA) relate to frailty status. This study aimed to explore the relationship ... -
Perampanel in the general population and in people with intellectual disability: Differing responses
(Elsevier, 2017-05-17)PURPOSE: There is a shortfall of suitably powered studies to provide evidence for safe prescribing of AEDs to people with Intellectual Disability (ID). We report clinically useful information on differences in response to ... -
Examining the psychological and social impact of relative age in primary school children: a cross-sectional survey.
(Wiley, 2017-05-25)BACKGROUND: A number of studies demonstrate that children who are younger within their school year have poorer academic attainment and are more likely to have special educational needs. Few, however, have considered the ... -
Splicing regulatory factors, ageing and age-related disease.
(Elsevier Masson, 2017-04-26)Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed ... -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
(Nature Publishing Group:, 2017-04-26)Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ... -
Violent injury predicts poor psychological outcomes after traumatic injury in a hard-to-reach population: an observational cohort study
(BMJ Publishing Group, 2017-05-01)Background: People who experience physical trauma face a range of psychosocial outcomes. These may be overlooked by busy clinicians. While some risk factors are understood, understanding of the psychological effects ... -
Gene-obesogenic environment interactions in the UK Biobank study
(Springer Verlag (Germany), 2016-08)Abstract of paper presented at: Conference: 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Location: Munich, GERMANY. Date: SEP 12-16, 2016. Sponsor(s):European Association for the Study ... -
Redesigning the diagnostic pathway for chest pain patients in emergency departments
(Wiley for British Society for Immunology, 2017-03-30)Patients presenting with chest pain at an emergency department in the United Kingdom receive troponin tests to assess the likelihood of an acute myocardial infarction (AMI). Until recently, serial testing with two blood ... -
MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice
(Springer Nature, 2017-03-17)MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in multiple processes that occur in higher eukaryotes. They act by binding to specific sequences in the 3' untranslated region of their ...