Browsing University of Exeter Medical School by Title
Now showing items 55-74 of 1533
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The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.
(Company of Biologists, 2015-09-01)TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression ... -
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
(American Heart Association, 2016-07-14)RATIONALE: The diabetes drug metformin is under investigation in cardiovascular disease but the molecular mechanisms underlying possible benefits are poorly understood. OBJECTIVE: Here we have studied anti-inflammatory ... -
Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12.
(BioMed Central, 2015-11-05)BACKGROUND: High risk medications are commonly prescribed to older US patients. Currently, less is known about high risk medication prescribing in other Western Countries, including the UK. We measured trends and correlates ... -
Ap39, A Mitochondria-Targeting Hydrogen Sulfide (H2 s) Donor, Protects Against Myocardial Reperfusion Injury Independently Of Salvage Kinase Signalling.
(Wiley, 2016-12-08)BACKGROUND AND PURPOSE: H2 S protects myocardium against ischaemia-reperfusion injury. This protection may involve the cytosolic reperfusion injury salvage kinase (RISK) pathway, but direct effects on mitochondrial function ... -
AP39, A Mitochondrially- Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo.
(Lippincott, Williams & Wilkins, 2015-10-28)This study evaluated the effects of AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy)decyl) triphenyl phosphonium bromide], a mitochondrially targeted donor of hydrogen sulfide (H2S) in an in vitro model of ... -
AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.
(Elsevier, 2014-04-19)The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H2S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], ... -
Application of flood risk modelling in a web-based geospatial decision support tool for coastal adaptation to climate change
(European Geosciences Union (EGU), 2015)A pressing problem facing coastal decision makers is the conversion of “high-level” but plausible climate change assessments into an effective basis for climate change adaptation at the local scale. Here, we describe a ... -
Are facial injuries really different? An observational cohort study comparing appearance concern and psychological distress in facial trauma and non-facial trauma patients
(Elsevier for British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS), 2017-08-16)Facial injuries are widely assumed to lead to stigma and significant psychosocial burden. Experimental studies of face perception support this idea, but there is very little empirical evidence to guide treatment. This study ... -
Are rheumatoid factor, anti-citrullinated, and anti-carbamylated protein antibodies linked by post-translational modification of IgG?
(Wiley, 2016-08-02)No abstract is available. -
Are stem cell-derived neural cells physiologically credible?
(Wiley / Physiological Society, 2016-11-15)The fast emerging technological advances that are enabling biologists to convert stem cells from various sources into an ever-increasing variety of cell types unquestionably will have far-reaching implications for the ... -
Are we missing hypoglycaemia? Elderly patients with insulin-treated diabetes present to primary care frequently with non-specific symptoms associated with hypoglycaemia
(Elsevier, 2017-09-11)Introduction We assessed if patients with known hypoglycaemia present on other occasions with non-specific symptoms associated with (but not diagnosed as) hypoglycaemia, potentially representing missed hypoglycaemia. ... -
Asking more of qualitative synthesis: a response to Sally Thorne
(SAGE Publications, 2017-05-25)We continue the conversation initiated by Sally Thorne’s observations about ‘metasynthetic madness’. We note that the variety of labels used to describe qualitative syntheses often reflect authors’ disciplines and geographical ... -
Assessing communication quality of consultations in primary care: initial reliability of the Global Consultation Rating Scale, based on the Calgary-Cambridge Guide to the Medical Interview.
(BMJ Publishing Group, 2014-03-06)OBJECTIVES: To investigate initial reliability of the Global Consultation Rating Scale (GCRS: an instrument to assess the effectiveness of communication across an entire doctor-patient consultation, based on the Calgary-Cambridge ... -
Assessing newborn body composition using principal components analysis: differences in the determinants of fat and skeletal size
(BioMed Central, 2006-08-17)BACKGROUND: Birth weight is a composite of skeletal size and soft tissue. These components are likely to have different growth patterns. The aim of this paper is to investigate the association between established determinants ... -
Assessing the accuracy of quantitative molecular microbial profiling
(MDPI, 2014-11-21)The application of high-throughput sequencing in profiling microbial communities is providing an unprecedented ability to investigate microbiomes. Such studies typically apply one of two methods: amplicon sequencing using ... -
Assessing the diagnostic accuracy of the identification of hyperkinetic disorders following the introduction of government guidelines in England
(BioMed Central, 2008-11-04)BACKGROUND: Previous studies have suggested that both underdiagnosis and overdiagnosis routinely occur in ADHD and hyperkinesis (hyperkinetic disorders). England has introduced governmental guidelines for these disorders' ... -
Assessing the effectiveness and cost effectiveness of subcutaneous nerve stimulation in patients with predominant back pain due to failed back surgery syndrome (SubQStim study): study protocol for a multicenter randomized controlled trial
(BioMed Central, 2013-06-25)Chronic radicular pain can be effectively treated with spinal cord stimulation, but this therapy is not always sufficient for chronic back pain. Subcutaneous nerve stimulation (SQS) refers to the placement of percutaneous ... -
Assessing the effectiveness of enhanced psychological care for patients with depressive symptoms attending cardiac rehabilitation compared with treatment as usual (CADENCE): study protocol for a pilot cluster randomised controlled trial
(BioMed Central, 2016-02-02)BACKGROUND: Around 17 % of people eligible for UK cardiac rehabilitation programmes following an acute coronary syndrome report moderate or severe depressive symptoms. While maximising psychological health is a core goal ... -
Assessing the impact of upper limb disability following stroke: a qualitative enquiry using internet-based personal accounts of stroke survivors
(Informa Healthcare, 2015)Purpose Upper limb disability following stroke may have multiple effects on the individual. Existing assessment instruments tend to focus on impairment and function and may miss other changes that are personally important. ... -
Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin
(BioMed Central, 2012-06-08)BACKGROUND: In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed. ...