Browsing University of Exeter Medical School by Title
Now showing items 55-74 of 1840
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Analysing and reporting UK CAMHS outcomes: an application of funnel plots
(Wiley, 2015-01-01)Child and Adolescent Mental Health published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. Background: Patient-reported outcomes measures are increasingly being used in child and ... -
Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours.
(Cancer Research UK, 2001-09-11)To understand the chemokine network in a tissue, both chemokine and chemokine receptor expression should be studied. Human epithelial ovarian tumours express a range of chemokines but little is known about the expression ... -
Analysis of cell-free fetal DNA for non-invasive prenatal diagnosis in a family with neonatal diabetes
(Wiley for Diabetes UK, 2016-06-29)AIMS: An early genetic diagnosis of neonatal diabetes guides clinical management and results in improved treatment in ~ 40% of patients. In the offspring of individuals with neonatal diabetes, a prenatal diagnosis allows ... -
Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood
(American Psychiatric Publishing, 2018-01-12)Objective: DNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become “embedded” in the genome and alter transcriptional processes to compromise health. The authors sought to ... -
Analysis of large-scale sequencing cohorts does not support the role of variants in UCP2 as a cause of hyperinsulinaemic hypoglycaemia.
(Wiley, 2017-08-01)No abstract is available for this article. -
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man
(Elsevier, 2014-01-07)Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional ... -
'And the pain just disappeared into insignificance': The healing response in Lourdes - performance, psychology and caring.
(Taylor & Francis, 2014-06-22)Three academic/practitioners from different disciplines (performance, medicine and psychology) describe the ways in which observing, and importantly, participating in the healing rituals of the French pilgrimage site of ... -
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.
(Impact Journals, 2015-10-07)Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ... -
'The Anglo-Saxon disease': a pilot study of the barriers to and facilitators of the use of randomised controlled trials of social programmes in an international context.
(BMJ Publishing Group, 2012-12-03)BACKGROUND: There appears to be considerable variation between different national jurisdictions and between different sectors of public policy in the use of evidence and particularly the use of randomised controlled trials ... -
ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity
(Public Library of Science, 2017-07-12)Recent epigenetic association studies have identified a new gene, ANK1, in the pathogenesis of Alzheimer's disease (AD). Although strong associations were observed, brain homogenates were used to generate the data, introducing ... -
Another explanation for apparent epistasis
(Nature Publishing Group, 2014-10-02)Epistasis occurs when the effect of a genetic variant on a trait is dependent on genotypes of other variants elsewhere in the genome. Hemani et al. recently reported the detection and replication of many instances of ... -
Ant Colony Optimisation for Exploring Logical Gene-Gene Associations in Genome Wide Association Studies.
(Copicentro Editorial, 2013)In this paper a search for the logical variants of gene-gene interactions in genome-wide association study (GWAS) data using ant colony optimisation is proposed. The method based on stochastic algorithms is tested on a ... -
An Ant Colony Optimization and Tabu List Approach to the Detection of Gene-Gene Interactions in Genome-Wide Association Studies [Research Frontier]
(Institute of Electrical and Electronics Engineers (IEEE), 2015-11-01)© 2015 IEEE. In this paper, a novel ant colony optimization and tabu list approach for the discovery of gene-gene interactions in genome-wide association study data is proposed. The method is tested on a number of diseases ... -
The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.
(Company of Biologists, 2015-09-01)TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression ... -
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
(American Heart Association, 2016-07-14)RATIONALE: The diabetes drug metformin is under investigation in cardiovascular disease but the molecular mechanisms underlying possible benefits are poorly understood. OBJECTIVE: Here we have studied anti-inflammatory ... -
Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12.
(BioMed Central, 2015-11-05)BACKGROUND: High risk medications are commonly prescribed to older US patients. Currently, less is known about high risk medication prescribing in other Western Countries, including the UK. We measured trends and correlates ... -
Ap39, A Mitochondria-Targeting Hydrogen Sulfide (H2 s) Donor, Protects Against Myocardial Reperfusion Injury Independently Of Salvage Kinase Signalling.
(Wiley, 2016-12-08)BACKGROUND AND PURPOSE: H2 S protects myocardium against ischaemia-reperfusion injury. This protection may involve the cytosolic reperfusion injury salvage kinase (RISK) pathway, but direct effects on mitochondrial function ... -
AP39, A Mitochondrially- Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo.
(Lippincott, Williams & Wilkins, 2015-10-28)This study evaluated the effects of AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy)decyl) triphenyl phosphonium bromide], a mitochondrially targeted donor of hydrogen sulfide (H2S) in an in vitro model of ... -
AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.
(Elsevier, 2014-04-19)The purpose of the current study was to investigate the effect of the recently synthesized mitochondrially-targeted H2S donor, AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl)phenoxy)decyl) triphenylphosphonium bromide], ... -
Application of flood risk modelling in a web-based geospatial decision support tool for coastal adaptation to climate change
(European Geosciences Union (EGU), 2015)A pressing problem facing coastal decision makers is the conversion of “high-level” but plausible climate change assessments into an effective basis for climate change adaptation at the local scale. Here, we describe a ...