Now showing items 833-852 of 2115

  • GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase 

    Heubl, M; Zhang, J; Pressey, JC; Al Awabdh, S; Renner, M; Gomez-Castro, F; Moutkine, I; Eugène, E; Russeau, M; Kahle, KT; Poncer, JC; Lévi, S (Springer Nature, 2017-11-24)
    The K+-Cl-co-transporter KCC2 (SLC12A5) tunes the efficacy of GABAAreceptor-mediated transmission by regulating the intraneuronal chloride concentration [Cl-]i. KCC2 undergoes activity-dependent regulation in both physiological ...
  • GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase 

    Heubl, M; Zhang, J; Pressey, JC; Al Awabdh, S; Renner, M; Gomez-Castro, F; Moutkine, I; Eugène, E; Russeau, M; Kahle, KT; Poncer, JC; Lévi, S (Springer Nature, 2017-11-24)
    The K+-Cl-co-transporter KCC2 (SLC12A5) tunes the efficacy of GABAAreceptor-mediated transmission by regulating the intraneuronal chloride concentration [Cl-]i. KCC2 undergoes activity-dependent regulation in both physiological ...
  • Galectin-9 activates and expands human T-helper cells. 

    Gooden, MJM; Wiersma, VR; Eggleton, P; Samplonius, DF; Gerssen, J; Nijman, HW; Niki, T; Helfrich, W; Bremer, E (Public Library of Science, 2013-05-31)
    Galectin-9 (Gal-9) is known for induction of apoptosis in IFN-c and IL-17 producing T-cells and amelioration of autoimmunity in murine models. On the other hand, Gal-9 induced IFN-c positive T-cells in a sarcoma mouse model ...
  • GATA4 mutations are a cause of neonatal and childhood-onset diabetes 

    Shaw-Smith, C; De Franco, E; Lango Allen, H; Batlle, M; Flanagan, SE; Borowiec, M; Taplin, CE; van Alfen-van der Velden, J; Cruz-Rojo, J; Perez de Nanclares, G; Miedzybrodzka, Z; Deja, G; Wlodarska, I; Mlynarski, W; Ferrer, J; Hattersley, AT; Ellard, S (American Diabetes Association, 2014-04-02)
    The GATA family zinc finger transcription factors GATA4 and GATA6 are known to play important roles in the development of the pancreas. In mice, both Gata4 and Gata6 are required for pancreatic development. In humans, GATA6 ...
  • Gender Differences in the Association between Common Mental Disorders and Regional Deprivation in Ireland 

    Morrissey, Karyn (Taylor & Francis (Routledge), 2015-07-24)
    This article aims to add a gender and place perspective to our understanding of depression and anxiety (common mental disorders [CMDs]) through the use of multilevel models. To date, regional variations in the prevalence ...
  • Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons 

    Pilling, LC; Joehanes, R; Kacprowski, T; Peters, M; Jansen, R; Karasik, D; Kiel, DP; Harries, LW; Teumer, A; Powell, J; Levy, D; Lin, H; Lunetta, K; Munson, P; Bandinelli, S; Henley, W; Hernandez, D; Singleton, A; Tanaka, T; van Grootheest, G; Hofman, A; Uitterlinden, AG; Biffar, R; Gläser, S; Homuth, G; Malsch, C; Völker, U; Penninx, B; van Meurs, JBJ; Ferrucci, L; Kocher, T; Murabito, J; Melzer, D (American Physiological Society, 2016-01-01)
    Lower muscle strength in midlife predicts disability and mortality in later life. Blood-borne factors, including growth differentiation factor 11 (GDF11), have been linked to muscle regeneration in animal models. We aimed ...
  • Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons 

    Pilling, Luke, C; Joehanes, R; Kacprowski, T; Peters, M; Jansen, R; Karasik, D; Kiel, D.P.; Harries, Lorna W; Teumer, A; Powell, J; Levy, D; Lin, H; Lunetta, K; Munson, P; Bandinelli, S; Henley, William E; Hernandez, D; Singleton, A; Tanaka, T; van Grootheest, G; Hofman, A; Uitterlinden, A.G.; Biffar, R; Gläser, S; Homuth, G; Malsch, C; Völker, U; Penninx, B; van Meurs, J.B.J.; Ferrucci, L; Kocher, T; Murabito, J; Melzer, David (American Physiological Society, 2015-10-20)
    Background: Lower muscle strength in midlife predicts disability and mortality in later life. Bloodborne factors, including growth differentiation factor 11 (GDF11), have been linked to muscle regeneration in animal models. ...
  • Gene-obesogenic environment interactions in the UK Biobank study 

    Tyrrell, J; Yaghootkar, H; Beaumont, R; Jones, SE; Ames, RM; Tuke, MA; Ruth, KS; Kutalik, Z; Freathy, RM; Murray, A; Wood, AR; Weedon, MN; Frayling, TM (Springer Verlag (Germany), 2016-08)
    Abstract of paper presented at: Conference: 52nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). Location: Munich, GERMANY. Date: SEP 12-16, 2016. Sponsor(s):European Association for the Study ...
  • Gene-obesogenic environment interactions in the UK Biobank study 

    Tyrrell, J; Wood, AR; Ames, RM; Yaghootkar, H; Beaumont, RN; Jones, SE; Tuke, MA; Ruth, KS; Freathy, RM; Davey Smith, G; Joost, S; Guessous, I; Murray, A; Strachan, DP; Kutalik, Z; Weedon, MN; Frayling, TM (Oxford University Press (OUP) for International Epidemiological Association, 2017-01-10)
    BACKGROUND: Previous studies have suggested that modern obesogenic environments accentuate the genetic risk of obesity. However, these studies have proven controversial as to which, if any, measures of the environment ...
  • General practitioner contributions to achieving sustained healthcare for offenders: a qualitative study. 

    Quinn, C; Denman, K; Smithson, P; Owens, C; Sheaff, R; Campbell, J; Porter, I; Annison, J; Byng, R (BioMed Central, 2018-02-02)
    BACKGROUND: Offenders frequently have substantial healthcare needs and, like many other socially marginalised groups, often receive healthcare in inverse proportion to their needs. Improved continuity of healthcare over ...
  • General practitioners' attitudes to sexual activity in under-sixteens. 

    Garside, R; Ayres, R; Owen, M R; Pearson, V H; Roizen, J (2000-11)
  • Genetic architecture of epigenetic and neuronal ageing rates in human brain regions 

    Lu, AT; Hannon, E; Levine, ME; Crimmins, EM; Lunnon, K; Mill, J; Geschwind, DH; Horvath, S (Springer Nature, 2017-05-18)
    Identifying genes regulating the pace of epigenetic ageing represents a new frontier in genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 individuals, we carry out a GWAS of two DNA ...
  • Genetic determinants of serum testosterone concentrations in men 

    Ohlsson, C; Wallaschofski, H; Lunetta, KL; Stolk, L; Perry, John R.B.; Koster, A; Petersen, A-K; Eriksson, Joel; Lehtimäki, T; Huhtaniemi, IT; Hammond, GL; Maggio, M; Coviello, AD; Emas, SG; Ferrucci, L; Heier, M; Hofman, A; Holliday, KL; Jansson, J-O; Kähönen, M; Karasik, D; Karlsson, MK; Kiel, DP; Liu, Yongmei; Ljunggren, O; Lorentzon, M; Lyytikäinen, L-P; Meitinger, T; Mellström, D; Melzer, D; Miljkovic, I; Nauck, M; Nilsson, M; Penninx, BW; Pye, SR; Vasan, RS; Reincke, M; Rivadeneira, F; Tajar, A; Teumer, A; Uitterlinden, AG; Ulloor, J; Viikari, J; Völker, U; Völzke, H; Wichmann, HE; Wu, T-S; Zhuang, WV; Ziv, E; Wu, FCW; Raitakari, O; Eriksson, A; Bidlingmaier, M; Harris, Tamara; Murray, A; de Jong, FH; Murabito, JM; Bhasin, S; Vandenput, L; Haring, R (Public Library of Science, 2011)
    Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a ...
  • Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. 

    Yaghootkar, H; Lotta, LA; Tyrrell, J; Smit, RA; Jones, SE; Donnelly, L; Beaumont, R; Campbell, A; Tuke, MA; Hayward, C; Ruth, KS; Padmanabhan, S; Jukema, JW; Palmer, CC; Hattersley, A; Freathy, RM; Langenberg, C; Wareham, NJ; Wood, AR; Murray, A; Weedon, MN; Sattar, N; Pearson, E; Scott, RA; Frayling, TM (American Diabetes Association, 2016-04-26)
    Recent genetic studies have identified some alleles associated with higher BMI but lower risk of type 2 diabetes, hypertension and heart disease. These "favorable adiposity" alleles are collectively associated with lower ...
  • Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes 

    Yaghootkar, H; Scott, RA; White, CC; Zhang, W; Speliotes, E; Munroe, PB; Ehret, GB; Bis, JC; Fox, CS; Walker, M; Borecki, IB; Knowles, JW; Yerges-Armstrong, L; Ohlsson, C; Perry, JR; Chambers, JC; Kooner, JS; Franceschini, N; Langenberg, C; Hivert, MF; Dastani, Z; Richards, JB; Semple, RK; Frayling, Timothy M. (American Diabetes Association, 2014-12)
    The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type 2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in monogenic primary lipodystrophy-a reduction ...
  • Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight 

    Tyrrell, J; Richmond, RC; Palmer, TM; Feenstra, B; Rangarajan, J; Metrustry, S; Cavadino, A; Paternoster, L; Armstrong, LL; De Silva, NMG; Wood, AR; Horikoshi, M; Geller, F; Myhre, R; Bradfield, JP; Kreiner-Møller, E; Huikari, V; Painter, JN; Hottenga, J-J; Allard, C; Berry, DJ; Bouchard, L; Das, S; Evans, DM; Hakonarson, H; Hayes, MG; Heikkinen, J; Hofman, A; Knight, B; Lind, PA; McCarthy, MI; McMahon, G; Medland, SE; Melbye, M; Morris, AP; Nodzenski, M; Reichetzeder, C; Ring, SM; Sebert, S; Sengpiel, V; Sørensen, TIA; Willemsen, G; de Geus, EJC; Martin, NG; Spector, TD; Power, C; Järvelin, M-R; Bisgaard, H; Grant, SFA; Nohr, EA; Jaddoe, VW; Jacobsson, B; Murray, JC; Hocher, B; Hattersley, AT; Scholtens, DM; Davey Smith, G; Hivert, M-F; Felix, JF; Hyppönen, E; Lowe, WL; Frayling, Timothy M.; Lawlor, DA; Freathy, RM (American Medical Association (AMA), 2016-03-15)
    Importance Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of ...
  • Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health 

    Ruth, KS; Beaumont, RN; Tyrrell, J; Jones, SE; Tuke, MA; Yaghootkar, H; Wood, AR; Freathy, RM; Weedon, MN; Frayling, TM; Murray, A (Oxford University Press (OUP), 2016-02)
    STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: The T allele of the FSHB promoter polymorphism (rs10835638; c.-211G>T) results ...
  • Genetic influences on exercise participation in 37,051 twin pairs from seven countries. 

    Stubbe, JH; Boomsma, DI; Vink, JM; Cornes, BK; Martin, NG; Skytthe, A; Kyvik, KO; Rose, RJ; Kujala, UM; Kaprio, J; Harris, JR; Pedersen, NL; Hunkin, J; Spector, TD; de Geus, EJC (Public Library of Science, 2006-12-20)
    BACKGROUND: A sedentary lifestyle remains a major threat to health in contemporary societies. To get more insight in the relative contribution of genetic and environmental influences on individual differences in exercise ...
  • Genetic risk scores in adult-onset type 1 diabetes - Authors' reply 

    Thomas, NJ; Jones, SE; Weedon, MN; Shields, BM; Hattersley, AT; Oram, RA (Elsevier, 2018-02-20)
  • Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: a prospective study in children. 

    Bonifacio, E; Beyerlein, A; Hippich, M; Winkler, C; Vehik, K; Weedon, MN; Laimighofer, M; Hattersley, AT; Krumsiek, J; Frohnert, BI; Steck, AK; Hagopian, WA; Krischer, JP; Lernmark, Å; Rewers, MJ; She, J-X; Toppari, J; Akolkar, B; Oram, RA; Rich, SS; Ziegler, A-G; TEDDY Study Group (Public Library of Science`, 2018-04-03)
    BACKGROUND: Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early ...