Now showing items 958-977 of 2061

  • 'I'm fishing really' - inflammatory marker testing in primary care: a qualitative study 

    Watson, J; de Salis, I; Hamilton, W; Salisbury, C (Royal College of General Practitioners, 2016-03-01)
    BACKGROUND: Inflammatory markers can be helpful as part of the diagnostic workup for specific diseases or for monitoring disease activity. A third use is as a screening and/or triage tool to differentiate between the ...
  • IARC monographs: 40 years of evaluating carcinogenic hazards to humans 

    Pearce, N; Blair, A; Vineis, P; Ahrens, W; Andersen, A; Anto, JM; Armstrong, BK; Baccarelli, AA; Beland, FA; Berrington, A; Bertazzi, PA; Birnbaum, LS; Brownson, RC; Bucher, JR; Cantor, KP; Cardis, E; Cherrie, JW; Christiani, DC; Cocco, P; Coggon, D; Comba, P; Demers, PA; Dement, JM; Douwes, J; Eisen, EA; Engel, LS; Fenske, RA; Fleming, LE; Fletcher, T; Fontham, E; Forastiere, F; Frentzel-Beyme, R; Fritschi, L; Gerin, M; Goldberg, M; Grandjean, P; Grimsrud, TK; Gustavsson, P; Haines, A; Hartge, P; Hansen, J; Hauptmann, M; Heederik, D; Hemminki, K; Hemon, D; Hertz-Picciotto, I; Hoppin, JA; Huff, J; Jarvholm, B; Kang, D; Karagas, MR; Kjaerheim, K; Kjuus, H; Kogevinas, M; Kriebel, D; Kristensen, P; Kromhout, H; Laden, F; Lebailly, P; LeMasters, G; Lubin, JH; Lynch, CF; Lynge, E; 't Mannetje, A; McMichael, AJ; McLaughlin, JR; Marrett, L; Martuzzi, M; Merchant, JA; Merler, E; Merletti, F; Miller, A; Mirer, FE; Monson, R; Nordby, KC; Olshan, AF; Parent, ME; Perera, FP; Perry, MJ; Pesatori, AC; Pirastu, R; Porta, M; Pukkala, E; Rice, C; Richardson, DB; Ritter, L; Ritz, B; Ronckers, CM; Rushton, L; Rusiecki, JA; Rusyn, I; Samet, JM; Sandler, DP; de Sanjose, S; Schernhammer, E; Costantini, AS; Seixas, N; Shy, C; Siemiatycki, J; Silverman, DT; Simonato, L; Smith, AH; Smith, MT; Spinelli, JJ; Spitz, MR; Stallones, L; Stayner, LT; Steenland, K; Stenzel, M; Stewart, BW; Stewart, PA; Symanski, E; Terracini, B; Tolbert, PE; Vainio, H; Vena, J; Vermeulen, R; Victora, CG; Ward, EM; Weinberg, CR; Weisenburger, D; Wesseling, C; Weiderpass, E; Zahm, SH (National Institute of Environmental Health Sciences (NIEHS), 2015-06)
    BACKGROUND: Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used ...
  • Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene 

    Knowles, Joshua W.; Xie, Weijia; Zhang, Zhongyang; Chennemsetty, Indumathi; Assimes, Themistocles L.; Paananen, Jussi; Hansson, Ola; Pankow, James; Goodarzi, Mark O.; Carcamo-Orive, Ivan; Morris, Andrew P.; Chen, Yii-Der I.; Mäkinen, Ville-Petteri; Ganna, Andrea; Mahajan, Anubha; Guo, Xiuqing; Abbasi, Fahim; Greenawalt, Danielle M.; Lum, Pek; Molony, Cliona; Lind, Lars; Lindgren, Cecilia; Raffel, Leslie J.; Tsao, Philip S.; Schadt, Eric E.; Rotter, Jerome I.; Sinaiko, Alan; Reaven, Gerald; Yang, Xia; Hsiung, Chao A.; Groop, Leif; Cordell, Heather J.; Laakso, Markku; Hao, Ke; Ingelsson, Erik; Frayling, Timothy M.; Weedon, Michael N.; Walker, Mark; Quertermous, Thomas (American Society for Clinical Investigation, 2015-04-01)
    Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, ...
  • Identification of a SLC19A2 nonsense mutation in Persian families with thiamine-responsive megaloblastic anemia 

    Setoodeh, A; Haghighi, A; Saleh-Gohari, N; Ellard, Sian (Elsevier, 2013)
    Thiamine-responsive megaloblastic anemia (TRMA) is an autosomal recessive syndrome characterized by early-onset anemia, diabetes, and hearing loss caused by mutations in the SLC19A2 gene. We studied the genetic cause and ...
  • Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease 

    Medici, M; Porcu, E; Pistis, G; Teumer, A; Brown, Suzanne J.; Jensen, RA; Rawal, R; Roef, GL; Plantinga, TS; Vermeulen, SH; Lahti, J; Simmonds, MJ; Husemoen, LL; Freathy, RM; Shields, BM; Pietzner, D; Nagy, R; Broer, L; Chaker, L; Korevaar, TI; Plia, MG; Sala, C; Völker, U; Richards, JB; Sweep, FC; Gieger, C; Corre, T; Kajantie, E; Thuesen, B; Taes, YE; Visser, WE; Hattersley, Andrew T.; Kratzsch, J; Hamilton, Alexander; Li, W; Homuth, G; Lobina, M; Mariotti, S; Soranzo, N; Cocca, M; Nauck, M; Spielhagen, C; Ross, A; Arnold, A; van de Bunt, M; Liyanarachchi, S; Heier, M; Grabe, HJ; Masciullo, C; Galesloot, TE; Lim, EM; Reischl, E; Leedman, PJ; Lai, S; Delitala, A; Bremner, AP; Philips, DI; Beilby, John P.; Mulas, A; Vocale, M; Abecasis, Goncalo; Forsen, T; James, A; Widen, E; Hui, J; Prokisch, H; Rietzschel, EE; Palotie, A; Feddema, P; Fletcher, SJ; Schramm, K; Rotter, JI; Kluttig, A; Radke, D; Traglia, M; Surdulescu, GL; He, H; Franklyn, JA; Tiller, D; Vaidya, B; de Meyer, T; Jørgensen, T; Eriksson, Johan G.; O'Leary, PC; Wichmann, E; Hermus, AR; Psaty, BM; Ittermann, T; Hofman, A; Bosi, E; Schlessinger, D; Wallaschofski, H; Pirastu, N; Aulchenko, Yurii; de la Chapelle, A; Netea-Maier, RT; Gough, SC; Meyer Zu Schwabedissen, H; Frayling, Timothy M.; Kaufman, JM; Linneberg, A; Räikkönen, K; Smit, JW; Kiemeney, LA; Rivadeneira, F; Uitterlinden, AG; Walsh, JP; Meisinger, C; den Heijer, M; Visser, TJ; Spector, TD; Wilson, SG; Völzke, H; Cappola, A; Toniolo, D; Sanna, S; Naitza, S; Peeters, RP (Public Library of Science, 2014-02)
    Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's ...
  • Identification of novel L2HGDH mutation in a large consanguineous Pakistani family- a case report 

    Ullah, MI; Nasir, A; Ahmad, A; Harlalka, GV; Ahmad, W; Hassan, MJ; Baple, EL; Crosby, AH; Chioza, BA (BioMed Central, 2018-02-20)
    BACKGROUND: L-2-hydroxyglutaric aciduria (L2HGA) is a progressive neurometabolic disease of brain caused by mutations of in L-2-hydroxyglutarate dehydrogenase (L2HGDH) gene. Cardinal clinical features include cerebellar ...
  • Identifying clinical criteria to predict Type 1 diabetes, as defined by absolute insulin deficiency: a systematic review protocol. 

    Shields, BM; Peters, JL; Cooper, C; Powell, RJ; Knight, BA; Hyde, C; Hattersley, AT (BMJ Publishing Group, 2012-12-28)
    INTRODUCTION: Management of a patient's diabetes is entirely dependent upon the type of diabetes they are deemed to have. Patients with Type 1 diabetes are insulin deficient so require multiple daily insulin injections, ...
  • Identifying clinical features in primary care electronic health record studies: methods for codelist development 

    Watson, J; Nicholson, BD; Hamilton, W; Price, S (BMJ Publishing Group, 2017-11-22)
    OBJECTIVE: Analysis of routinely collected electronic health record (EHR) data from primary care is reliant on the creation of codelists to define clinical features of interest. To improve scientific rigour, transparency ...
  • Identifying enablers and barriers to individually tailored prescribing: a survey of healthcare professionals in the UK 

    Reeve, J; Britten, N; Byng, R; Fleming, J; Heaton, J; Krska, J (BioMed Central, 2018-01-15)
    Background Many people now take multiple medications on a long-term basis to manage health conditions. Optimising the benefit of such polypharmacy requires tailoring of medicines use to the needs and circumstances of ...
  • Identifying good responders to glucose lowering therapy in type 2 diabetes: implications for stratified medicine 

    Jones, AG; Shields, BM; Hyde, CJ; Henley, WE; Hattersley, AT (Public Library of Science (PLoS), 2014)
    AIMS: Defining responders to glucose lowering therapy can be important for both clinical care and for the development of a stratified approach to diabetes management. Response is commonly defined by either HbA1c change ...
  • Identifying patient and practice characteristics associated with patient-reported experiences of safety problems and harm: a cross-sectional study using a multilevel modelling approach. 

    Ricci-Cabello, I; Reeves, D; Bell, BG; Valderas, JM (BMJ Publishing Group, 2017-08-07)
    OBJECTIVE: To identify patient and family practice characteristics associated with patient-reported experiences of safety problems and harm. DESIGN: Cross-sectional study combining data from the individual postal administration ...
  • Identifying patient-centred recommendations for improving patient safety in General Practices in England: a qualitative content analysis of free-text responses using the Patient Reported Experiences and Outcomes of Safety in Primary Care (PREOS-PC) questionnaire. 

    Ricci-Cabello, I; Saletti-Cuesta, L; Slight, SP; Valderas, JM (Wiley Open Access, 2017-02-28)
    BACKGROUND: There is a growing interest in identifying strategies to achieve safer primary health-care provision. However, most of the research conducted so far in this area relies on information supplied by health-care ...
  • Identifying primary care pathways from quality of care to outcomes and satisfaction using structural equation modeling 

    Ricci-Cabello, I; Stevens, S; Dalton, ARH; Griffiths, RI; Campbell, JL; Valderas, JM (Wiley, 2017-02-19)
    OBJECTIVE: To study the relationships between the different domains of quality of primary health care for the evaluation of health system performance and for informing policy decision making. DATA SOURCES: A total of 137 ...
  • Identifying risk factors for exposure to culturable allergenic moulds in energy efficient homes by using highly specific monoclonal antibodies. 

    Sharpe, RA; Cocq, KL; Nikolaou, V; Osborne, NJ; Thornton, CR (Elsevier, 2015-11-05)
    The aim of this study was to determine the accuracy of monoclonal antibodies (mAbs) in identifying culturable allergenic fungi present in visible mould growth in energy efficient homes, and to identify risk factors for ...
  • IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response 

    Song, L; Li, J; Zhang, D; Liu, ZG; Ye, J; Zhan, Q; Shen, HM; Whiteman, Matthew; Huang, C (Rockefeller University Press, 2006-11-20)
    Cross talk between NF-kappaB and c-Jun N-terminal kinases (JNKs) has been implicated in the cell life and death decision under various stresses. Functional suppression of JNK activation by NF-kappaB has recently been ...
  • Image interpretation performance: A longitudinal study from novice to professional 

    Wright, C; Reeves, P (WB Saunders, 2017-08-31)
    Purpose Universities need to deliver educational programmes that create radiography graduates who are ready and able to participate in abnormality detection schemes, ultimately delivering safe and reliable performance ...
  • Imaging the uptake of gold nanoshells in live cells using plasmon resonance enhanced four wave mixing microscopy 

    Garrett, Natalie; Whiteman, Matthew; Moger, Julian (Optical Society of America, 2011)
    Gold nanoshells (GNS) are novel metal nanoparticles exhibiting attractive optical properties which make them highly suitable for biophotonics applications. We present a novel investigation using plasmon-enhanced four wave ...
  • Immediate chest X-ray for patients at risk of lung cancer presenting in primary care: randomised controlled feasibility trial. 

    Neal, RD; Barham, A; Bongard, E; Edwards, RT; Fitzgibbon, J; Griffiths, G; Hamilton, W; Hood, K; Nelson, A; Parker, D; Porter, C; Prout, H; Roberts, K; Rogers, T; Thomas-Jones, E; Tod, A; Yeo, ST; Hurt, CN (Cancer Research UK, 2017-01-10)
    BACKGROUND: Achieving earlier stage diagnosis is one option for improving lung cancer outcomes in the United Kingdom. Patients with lung cancer typically present with symptoms to general practitioners several times before ...
  • Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. 

    Willcox, A; Richardson, Sarah J.; Bone, AJ; Foulis, Alan K.; Morgan, Noel G. (Springer, 2011-09)
    AIMS/HYPOTHESIS: The enteroviral capsid protein, VP1, was recently shown to be present in some beta cells in more than 60% of patients with recent-onset type 1 diabetes but in very few age-matched controls. The rate of ...
  • Immunosuppressive agents in adult kidney transplantation in the NHS: a model-based economic evaluation 

    Snowsill, TM; Moore, J; Mujica Mota, R; Peters, JL; Jones-Hughes, T; Huxley, NJ; Coelho, H; Haasova, M; Cooper, C; Lowe, JA; Varley-Campbell, J; Crathorne, L; Allwood, M; Anderson, R (Oxford University Press (OUP) for European Renal Association - European Dialysis and Transplant Association (ERA-EDTA), 2017-06-01)
    Background Immunosuppression is required in kidney transplantation to prevent rejection and prolong graft survival. We conducted an economic evaluation to support the National Institute for Health and Care Excellence in ...