Now showing items 1124-1143 of 2061

  • L-citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans 

    Bailey, Stephen J.; Blackwell, James R.; Lord, T; Vanhatalo, A; Winyard, Paul G.; Jones, Andrew M. (American Physiological Society, 2015-05-28)
    The purpose of this study was to compare the effects of L-citrulline (CIT) and L-arginine (ARG) supplementation on nitric oxide (NO) biomarkers, pulmonary O2 uptake (VO2) kinetics and exercise performance. In a randomised, ...
  • Land cover and air pollution are associated with asthma hospitalisations: A cross-sectional study. 

    Alcock, I; White, M; Cherrie, M; Wheeler, B; Taylor, J; McInnes, R; Otte Im Kampe, E; Vardoulakis, S; Sarran, C; Soyiri, I; Fleming, L (Elsevier, 2017-09-27)
    BACKGROUND: There is increasing policy interest in the potential for vegetation in urban areas to mitigate harmful effects of air pollution on respiratory health. We aimed to quantify relationships between tree and green ...
  • Large conductance Ca²⁺-activated K⁺ (BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs. 

    Duncan, PJ; Şengül, S; Tabak, J; Ruth, P; Bertram, R; Shipston, MJ (Wiley, 2015-01-23)
    Anterior pituitary corticotroph cells are a central component of the hypothalamic-pituitary-adrenal (HPA) axis essential for the neuroendocrine response to stress. Corticotrophs are excitable cells that receive input from ...
  • A large Indian family with rearrangement of chromosome 4p16 and 3p26.3 and divergent clinical presentations 

    Iype, T; Alakbarzade, V; Iype, M; Singh, R; Sreekantan-Nair, A; Chioza, BA; Mohapatra, TM; Baple, EL; Patton, MA; Warner, TT; Proukakis, C; Kulkarni, A; Crosby, AH (BioMed Central, 2015-11-10)
    BACKGROUND: The deletion of the chromosome 4p16.3 Wolf-Hirschhorn syndrome critical region (WHSCR-2) typically results in a characteristic facial appearance, varying intellectual disability, stereotypies and prenatal onset ...
  • Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair 

    Day, FR; Ruth, KS; Thompson, DJ; Lunetta, KL; Pervjakova, N; Chasman, DI; Stolk, L; Finucane, HK; Sulem, P; Bulik-Sullivan, B; Esko, T; Johnson, AD; Elks, CE; Franceschini, N; He, C; Altmaier, E; Brody, JA; Franke, L; Huffman, JE; Keller, MF; McArdle, PF; Nutile, T; Porcu, E; Robino, A; Rose, LM; Schick, UM; Smith, JA; Teumer, A; Traglia, M; Vuckovic, D; Yao, J; Zhao, W; Albrecht, E; Amin, N; Corre, T; Hottenga, JJ; Mangino, M; Smith, AV; Tanaka, T; Abecasis, GR; Andrulis, IL; Anton-Culver, H; Antoniou, AC; Arndt, V; Arnold, AM; Barbieri, C; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bernstein, L; Bielinski, SJ; Blomqvist, C; Boerwinkle, E; Bogdanova, NV; Bojesen, SE; Bolla, MK; Borresen-Dale, AL; Boutin, TS; Brauch, H; Brenner, H; Brüning, T; Burwinkel, B; Campbell, A; Campbell, H; Chanock, SJ; Chapman, JR; Chen, YI; Chenevix-Trench, G; Couch, FJ; Coviello, AD; Cox, A; Czene, K; Darabi, H; De Vivo, I; Demerath, EW; Dennis, J; Devilee, P; Dörk, T; Dos-Santos-Silva, I; Dunning, AM; Eicher, JD; Fasching, PA; Faul, JD; Figueroa, J; Flesch-Janys, D; Gandin, I; Garcia, ME; García-Closas, M; Giles, Graham; Girotto, GG; Goldberg, MS; González-Neira, A; Goodarzi, Mark O.; Grove, ML; Gudbjartsson, DF; Guénel, P; Guo, Xiuqing; Haiman, CA; Hall, P; Hamann, U; Henderson, BE; Hocking, LJ; Hofman, A; Homuth, G; Hooning, MJ; Hopper, JL; Hu, FB; Huang, J; Humphreys, K; Hunter, DJ; Jakubowska, A; Jones, SE; Kabisch, M; Karasik, D; Knight, JA; Kolcic, I; Kooperberg, C; Kosma, VM; Kriebel, J; Kristensen, V; Lambrechts, D; Langenberg, C; Li, J; Li, X; Lindström, S; Liu, Y; Luan, J; Lubinski, J; Mägi, R; Mannermaa, A; Manz, J; Margolin, S; Marten, J; Martin, NG; Masciullo, C; Meindl, A; Michailidou, K; Mihailov, E; Milani, L; Milne, RL; Müller-Nurasyid, M; Nalls, M; Neale, BM; Nevanlinna, H; Neven, P; Newman, AB; Nordestgaard, BG; Olson, JE; Padmanabhan, S; Peterlongo, P; Peters, U; Petersmann, A; Peto, J; Pharoah, PD; Pirastu, NN; Pirie, A; Pistis, G; Polasek, O; Porteous, D; Psaty, BM; Pylkäs, K; Radice, P; Raffel, Leslie J.; Rivadeneira, F; Rudan, I; Rudolph, A; Ruggiero, D; Sala, CF; Sanna, S; Sawyer, EJ; Schlessinger, D; Schmidt, MK; Schmidt, F; Schmutzler, RK; Schoemaker, MJ; Scott, RA; Seynaeve, CM; Simard, J; Sorice, R; Southey, MC; Stöckl, D; Strauch, K; Swerdlow, A; Taylor, KD; Thorsteinsdottir, U; Toland, AE; Tomlinson, I; Truong, T; Tryggvadottir, L; Turner, ST; Vozzi, D; Wang, Q; Wellons, M; Willemsen, G; Wilson, JF; Winqvist, R; Wolffenbuttel, BB; Wright, AF; Yannoukakos, D; Zemunik, T; Zheng, W; Zygmunt, M; Bergmann, S; Boomsma, DI; Buring, JE; Ferrucci, L; Montgomery, GW; Gudnason, V; Spector, TD; van Duijn, CM; Alizadeh, BZ; Ciullo, M; Crisponi, L; Easton, DF; Gasparini, Paolo; Gieger, C; Harris, Tamara; Hayward, C; Kardia, SL; Kraft, P; McKnight, B; Metspalu, A; Morrison, AC; Reiner, AP; Ridker, PM; Rotter, JI; Toniolo, D; Uitterlinden, AG; Ulivi, S; Völzke, H; Wareham, NJ; Weir, DR; Yerges-Armstrong, LM; PRACTICAL Consortium; kConFab Investigators; AOCS Investigators; Generation Scotland; EPIC-InterAct Consortium; LifeLines Cohort Study; Price, AL; Stefansson, K; Visser, JA; Ong, KK; Chang-Claude, J; Murabito, JM; Perry, JR; Murray, A (Nature Publishing Group, 2015-09-28)
    Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and ...
  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 

    Nalls, MA; Pankratz, N; Lill, CM; Do, CB; Hernandez, DG; Saad, M; DeStefano, AL; Kara, E; Bras, J; Sharma, M; Schulte, C; Keller, MF; Arepalli, S; Letson, C; Edsall, C; Stefansson, H; Liu, X; Pliner, H; Lee, JH; Cheng, R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group; Ikram, MA; Ioannidis, JPA; Hadjigeorgiou, GM; Bis, JC; Martinez, M; Perlmutter, JS; Goate, A; Marder, K; Fiske, B; Sutherland, M; Xiromerisiou, G; Myers, RH; Clark, LN; Stefansson, K; Hardy, JA; Heutink, P; Chen, H; Wood, NW; Houlden, H; Payami, H; Brice, A; Scott, WK; Gasser, T; Bertram, L; Eriksson, N; Foroud, T; Singleton, AB (Nature Publishing Group, 2014-09)
    We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide ...
  • Lay knowledge, social movements and the use of medicines: Personal reflections. 

    Britten, Nicky; Maguire, Kath (Sage, 2015-11-30)
    This article consists of two personal reflections about the changing status of lay knowledge over the last 20 years. The first reflection is by Nicky Britten from the perspective of a sociologist working in medical schools ...
  • Learning to Run From Narrative Foreclosure: One Woman's Story of Aging and Physical Activity. 

    Griffin, Meridith; Phoenix, Cassandra (Human Kinetics, 2014-07)
    In this article, the authors construct a story of one woman's (Justine's) experience of learning to run within the context of a beginners group. Building on existing scholarship on narrative, aging, and physical activity, ...
  • Leaving foster or residential care: a participatory study of care leavers' experiences of health and social care transitions. 

    Liabo, K; McKenna, C; Ingold, A; Roberts, H (Wiley, 2016-11-29)
    BACKGROUND: Young people in residential or foster care experience multiple transitions around their 18th birthday without the long term and consistent support from their family of origin that most of their peers can expect. ...
  • Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause 

    Ruth, KS; Bennett, CE; Schoemaker, MJ; Weedon, MN; Swerdlow, AJ; Murray, A (Oxford University Press (OUP), 2016-10)
    STUDY QUESTION: Is the length of FMR1 repeat alleles within the normal range associated with the risk of early menopause? SUMMARY ANSWER: The length of repeat alleles within the normal range does not substantially affect ...
  • Leptin-induced endothelium-dependent vasorelaxation of peripheral arteries in lean and obese rats: role of nitric oxide and hydrogen sulfide. 

    Jamroz-Wiśniewska, A; Gertler, A; Solomon, G; Wood, ME; Whiteman, M; Bełtowski, J (Public Library of Science, 2014-01-24)
    Adipose tissue hormone leptin induces endothelium-dependent vasorelaxation mediated by nitric oxide (NO) and endothelium-derived hyperpolarizing factors (EDHF). Previously it has been demonstrated that in short-term obesity ...
  • Lessons from genome-wide association studies in reproductive medicine: menopause. 

    Ruth, KS; Murray, A (Georg Thieme Verlag / Thieme Publishing, 2016-07)
    In recent years, common genetic variants have been identified by genome-wide association studies (GWASs) that have led to the detection of 44 genetic loci associated with approximately 6% of common variation in age at ...
  • Lessons learned from recruiting socioeconomically disadvantaged smokers into a pilot randomized controlled trial to explore the role of Exercise Assisted Reduction then Stop (EARS) smoking 

    Thompson, TP; Greaves, CJ; Ayres, R; Aveyard, P; Warren, FC; Byng, R; Taylor, Rod S.; Campbell, John; Ussher, M; Michie, S; West, R; Taylor, AH (BioMed Central, 2015-02-12)
    Research is needed on what influences recruitment to smoking reduction trials, and how to increase their reach. The present study aimed to i) assess the feasibility of recruiting a disadvantaged population, ii) examine the ...
  • Let's talk about psychosis 

    McCabe, Rose; Steele, A (Walsh Medical Media, 2015)
    n/a
  • Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults 

    Harries, LW; Bradley-Smith, Rachel; Llewellyn, DJ; Pilling, LC; Fellows, A; Henley, William E.; Hernandez, Dena; Guralnik, Jack; Bandinelli, S; Singleton, A; Ferrucci, L; Melzer, D (Mary Ann Liebert, 2012-08)
    Circulating inflammatory markers may play an important role in cognitive impairment at older ages. Mice deficient for the chemokine (C-C motif) receptor 2 (CCR2) develop an accelerated Alzheimer-like pathology. CCR2 is ...
  • Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition 

    Zhang, J; Deng, X; Kahle, KT (American Association for the Advancement of Science, 2016-10-18)
    The with-no-lysine (K) WNK kinases are master regulators of the Na+-(K+)-Cl- cotransporters, including the renal-specific NCC and NKCC2 cotransporters. The discovery of WNK463, an orally bioavailable pan-WNK kinase inhibitor ...
  • Likeability of Garden Birds: Importance of Species Knowledge & Richness in Connecting People to Nature. 

    Cox, DTC; Gaston, KJ (Public Library of Science, 2015-11-11)
    Interacting with nature is widely recognised as providing many health and well-being benefits. As people live increasingly urbanised lifestyles, the provision of food for garden birds may create a vital link for connecting ...
  • Linguistic indicators of severity and profess in online text-based therapy for depression 

    McCabe, Rose; Howes, Christine; Purver, Matthew (Association for Computational Linguistics, 2014-06-27)
    Mental illnesses such as depression and anxiety are highly prevalent, and therapy is increasingly being offered online. This new setting is a departure from face-to-face therapy, and offers both a challenge and an opportunity ...
  • Linking health and education data to plan and evaluate services for children 

    Downs, J; Gilbert, R; Hayes, RD; Hotopf, M; Ford, T (BMJ Publishing Group, 2017-07)
    In this leading article, we report on the first area-based linkage in England between mental health, hospital and school data, covering a total population of 1.25 million. We describe this resource, give examples of how ...