Now showing items 1375-1394 of 2061

  • Pancreas and gallbladder agenesis in a newborn with semilobar holoprosencephaly, a case report 

    Hilbrands, R; Keymolen, K; Michotte, A; Marichal, M; Cools, F; Goossens, A; Veld, PI; De Schepper, J; Hattersley, A; Heimberg, H (BioMed Central, 2017-05-19)
    BACKGROUND: Pancreatic agenesis is an extremely rare cause of neonatal diabetes mellitus and has enabled the discovery of several key transcription factors essential for normal pancreas and beta cell development. CASE ...
  • Pancreatic cancer clusters and arsenic-contaminated drinking water wells in Florida 

    Liu-Mares, W; Mackinnon, JA; Sherman, R; Fleming, LE; Rocha-Lima, C; Hu, JJ; Lee, DJ (BioMed Central, 2013-03-12)
    BACKGROUND: We sought to identify high-risk areas of pancreatic cancer incidence, and determine if clusters of persons diagnosed with pancreatic cancer were more likely to be located near arsenic-contaminated drinking water ...
  • Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism. 

    Arya, VB; Senniappan, S; Demirbilek, H; Alam, S; Flanagan, SE; Ellard, S; Hussain, K (Public Library of Science, 2014-05-19)
    CONTEXT: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal. Diffuse CHI, if medically unresponsive, is managed with near-total ...
  • Pancreatic pathology in type 1 diabetes mellitus 

    Richardson, Sarah J.; Morgan, Noel G.; Foulis, Alan K. (Springer Verlag (Germany), 2014-03)
    Type 1 diabetes is a multifactorial disease resulting from a complex interplay between host genetics, the immune system and the environment, that culminates in the destruction of insulin-producing beta cells. The incidence ...
  • A panel of oxidative stress assays does not provide supplementary diagnostic information in Behcet's disease patients 

    Akcay, Yasemin D.; Sagin, Ferhan G.; Aksu, Kenan; Keser, Gokhan; Taylor, Emma; Knight, Iona; Winyard, Paul G.; Sozmen, Eser Y. (BioMed Central, 2012)
    BACKGROUND: Recent findings suggest a role of oxidative stress in the pathogenesis of Behcet's disease (BD), but the utility of oxidative stress-associated assays in offering diagnostic information or in the monitoring of ...
  • Paradigmatic Approaches to Studying Environment and Human Health: (Forgotten) Implications for Interdisciplinary Research 

    Phoenix, Cassandra; Wheeler, Benedict W.; Osborne, Nicholas J.; Redshaw, Clare; Moran, Rebecca; Stahl-Timmins, Will; Depledge, MH; Fleming, Lora E. (2012-12-14)
    Interdisciplinary research is increasingly promoted in a wide range of fields, especially so in the study of relationships between the environment and human health. However, many projects and research teams struggle to ...
  • Parathyroid hormone, cognitive function and dementia: a systematic review 

    Lourida, I; Thompson-Coon, Jo; Dickens, Chris; Soni, Maya; Kuźma, Elżbieta; Kos, Katarina; Llewellyn, DJ (Public Library of Science, 2015-05-26)
    BACKGROUND: Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium ...
  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche 

    Perry, JRB; Day, F; Elks, CE; Sulem, P; Thompson, DJ; Ferreira, T; He, C; Chasman, DI; Esko, T; Thorleifsson, G; Albrecht, E; Ang, WQ; Corre, T; Cousminer, DL; Feenstra, B; Franceschini, N; Ganna, A; Johnson, AD; Kjellqvist, S; Lunetta, KL; McMahon, G; Nolte, IM; Paternoster, L; Porcu, E; Smith, AV; Stolk, L; Teumer, A; Tšernikova, N; Tikkanen, E; Ulivi, S; Wagner, EK; Amin, N; Bierut, LJ; Byrne, EM; Hottenga, J-J; Koller, DL; Mangino, M; Pers, TH; Yerges-Armstrong, LM; Hua Zhao, J; Andrulis, IL; Anton-Culver, H; Atsma, F; Bandinelli, S; Beckmann, MW; Benitez, J; Blomqvist, C; Bojesen, SE; Bolla, MK; Bonanni, B; Brauch, H; Brenner, H; Buring, JE; Chang-Claude, J; Chanock, S; Chen, J; Chenevix-Trench, G; Collée, JM; Couch, FJ; Couper, D; Coviello, AD; Cox, A; Czene, K; D'adamo, AP; Davey Smith, G; De Vivo, I; Demerath, EW; Dennis, J; Devilee, P; Dieffenbach, AK; Dunning, AM; Eiriksdottir, G; Eriksson, JG; Fasching, PA; Ferrucci, L; Flesch-Janys, D; Flyger, H; Foroud, T; Franke, L; Garcia, ME; García-Closas, M; Geller, F; de Geus, EEJ; Giles, GG; Gudbjartsson, DF; Gudnason, V; Guénel, P; Guo, S; Hall, P; Hamann, U; Haring, R; Hartman, CA; Heath, AC; Hofman, A; Hooning, MJ; Hopper, JL; Hu, FB; Hunter, DJ; Karasik, D; Kiel, DP; Knight, JA; Kosma, V-M; Kutalik, Z; Lai, S; Lambrechts, D; Lindblom, A; Mägi, R; Magnusson, PK; Mannermaa, A; Martin, NG; Masson, G; McArdle, PF; McArdle, WL; Melbye, M; Michailidou, K; Mihailov, E; Milani, L; Milne, RL; Nevanlinna, H; Neven, P; Nohr, EA; Oldehinkel, AJ; Oostra, BA; Palotie, A; Peacock, M; Pedersen, NL; Peterlongo, P; Peto, J; Pharoah, PDP; Postma, DS; Pouta, A; Pylkäs, K; Radice, P; Ring, S; Rivadeneira, F; Robino, A; Rose, LM; Rudolph, A; Salomaa, V; Sanna, S; Schlessinger, D; Schmidt, MK; Southey, MC; Sovio, U; Stampfer, MJ; Stöckl, D; Storniolo, AM; Timpson, NJ; Tyrer, J; Visser, JA; Vollenweider, P; Völzke, H; Waeber, G; Waldenberger, M; Wallaschofski, H; Wang, Q; Willemsen, G; Winqvist, R; Wolffenbuttel, BHR; Wright, MJ; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium; Boomsma, DI; Econs, MJ; Khaw, K-T; Loos, RJF; McCarthy, MI; Montgomery, GW; Rice, JP; Streeten, EA; Thorsteinsdottir, U; van Duijn, CM; Alizadeh, BZ; Bergmann, S; Boerwinkle, E; Boyd, HA; Crisponi, L; Gasparini, P; Gieger, C; Harris, TB; Ingelsson, E; Järvelin, M-R; Kraft, P; Lawlor, D; Metspalu, A; Pennell, CE; Ridker, PM; Snieder, H; Sørensen, TIA; Spector, TD; Strachan, DP; Uitterlinden, AG; Wareham, NJ; Widen, E; Zygmunt, M; Murray, A; Easton, DF; Stefansson, K; Murabito, JM; Ong, KK (Nature Publishing Group, 2014-10-02)
    Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and ...
  • Parental diabetes and birthweight in 236 030 individuals in the UK biobank study 

    Tyrrell, Jessica S.; Yaghootkar, H; Freathy, RM; Hattersley, Andrew T.; Frayling, Timothy M. (Oxford University Press, 2013-12)
    BACKGROUND: The UK Biobank study provides a unique opportunity to study the causes and consequences of disease. We aimed to use the UK Biobank data to study the well-established, but poorly understood, association between ...
  • Parents Suggest Which Indicators of Progress and Outcomes Should be Measured in Young Children with Autism Spectrum Disorder 

    McConachie, H; Livingstone, N; Morris, C; Beresford, B; Le Couteur, A; Gringras, P; Garland, D; Jones, G; Macdonald, G; Williams, K; Parr, JR (Springer Verlag, 2017-08-31)
    Evaluation of interventions for children with autism spectrum disorder (ASD) is hampered by the multitude of outcomes measured and tools used. Measurement in research with young children tends to focus on core impairments ...
  • Participation during first social encounters in schizophrenia. 

    Lavelle, M; Healey, PG; McCabe, Rose (Public Library of Science, 2014-01-20)
    BACKGROUND: Patients with a diagnosis of schizophrenia are socially excluded. The aim of this study was to investigate how patients participate in first encounters with unfamiliar healthy participants, who are unaware of ...
  • Participation in environmental enhancement and conservation activities for health and well-being in adults (intervention protocol) 

    Husk, K; Lovell, R; Cooper, Chris; Garside, R (Cochrane Collaboration / Wiley, 2013-01-28)
    This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the health and well-being impacts on adults following participation in environmental enhancement and conservation activities.
  • Participation in environmental enhancement and conservation activities for health and well-being in adults: a review of quantitative and qualitative evidence 

    Husk, K; Lovell, R; Cooper, C; Stahl-Timmins, W; Garside, R (Cochrane Collaboration / Wiley, 2016-05-21)
    BACKGROUND: There is growing research and policy interest in the potential for using the natural environment to enhance human health and well-being. This resource may be underused as a health promotion tool to address the ...
  • PARTNERS collaborative care for people with psychosis in the UK: Using tape assisted recall to explore practitioner-client interactions 

    Gwernan-Jones, RC; Baker, E; Cox, M; Gill, L; McCabe, C; Retzer, A; Planner, C; Plappert, H; Pinfold, V; Reilly, S; Gask, L; Byng, R; Britten, N; Birchwood, M (COMET, 2017-06)
    In the UK there is a need to better support people with bipolar and schizophrenia not currently in crisis. PARTNERS is testing collaborative care by placing secondary practitioners in primary care, who take a coaching ...
  • Pathogen quantitation in complex matrices: a multi-operator comparison of DNA extraction methods with a novel assessment of PCR inhibition 

    Pontiroli, A; Travis, ER; Sweeney, FP; Porter, D; Gaze, WH; Mason, S; Hibberd, V; Holden, J; Courtenay, O; Wellington, EMH (Public Library of Science, 2011-03-23)
    BACKGROUND: Mycobacterium bovis is the aetiological agent of bovine tuberculosis (bTB), an important recrudescent zoonosis, significantly increasing in British herds in recent years. Wildlife reservoirs have been identified ...
  • A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. 

    Voyle, N; Keohane, A; Newhouse, S; Lunnon, Katie; Johnston, C; Soininen, H; Kloszewska, I; Mecocci, P; Tsolaki, M; Vellas, B; Lovestone, Simon; Hodges, A; Kiddle, S; Dobson, RJ (IOS Press, 2015-10-15)
    BACKGROUND: Recent studies indicate that gene expression levels in blood may be able to differentiate subjects with Alzheimer's disease (AD) from normal elderly controls and mild cognitively impaired (MCI) subjects. However, ...
  • Pathways to the diagnosis of lung cancer in the UK: a cohort study 

    Barrett, Jacqueline; Hamilton, W (BioMed Central, 2008-05-18)
    BACKGROUND: Lung cancer is the commonest cause of cancer death in the UK. Patients generally present to their general practitioner, but the pathway of diagnosis from first symptom to diagnosis has not been mapped. We ...
  • Pathways to the diagnosis of ovarian cancer in the UK: a cohort study in primary care. 

    Barrett, J; Sharp, DJ; Stapley, S; Stabb, C; Hamilton, W (Wiley, 2010-01-29)
    OBJECTIVE: To identify the routes patients with ovarian cancer take between first symptom presentation and diagnosis. DESIGN: Cohort study. SETTING: The study took place in 39 general practices in Devon, UK. POPULATION: ...
  • Patient and public perspectives shaping scientific and medical research: panels for data, discussions, and decisions 

    Uhm, Seilin; Liabo, K; Stewart, R; Rees, Rebecca; Oliver, Sandy (Dove Medical Press, 2012-01)
    This paper explores the role of patient panels for shaping research for health, scientific research about health and illness, and applied medical research. After examining the history and purposes of involving patients in ...
  • Patient characteristics predicting failure to receive indicated care for type 2 diabetes. 

    Mounce, LT; Steel, N; Hardcastle, AC; Henley, William E.; Bachmann, MO; Campbell, John; Clark, A; Melzer, D; Richards, SH (Elsevier, 2014-12-03)
    AIMS: To determine which patient characteristics were associated with failure to receive indicated care for diabetes over time. METHODS: English Longitudinal Study of Ageing participants aged 50 or older with diabetes ...