Browsing University of Exeter Medical School by Title
Now showing items 1-20 of 2097
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2014 consensus statement on improving pelvic floor muscle training adherence: International Continence Society 2011 State-of-the-Science Seminar
(Wiley, 2015-01-01)© 2015 Wiley Periodicals, Inc. Aims To summarize the findings and "expert-panel" consensus of the State-of-the-Science Seminar on pelvic floor muscle training (PFMT) adherence held prior to the 41st International ... -
The 2016 HIGh Heels: Health effects And psychosexual BenefITS (HIGH HABITS) study: systematic review of reviews and additional primary studies.
(BioMed Central, 2017-08-01)BACKGROUND: High-heeled shoes (high heels) are frequently worn by many women and form an important part of female gender identity. Issues of explicit and implicit compulsion to wear high heels have been noted. Previous ... -
4-dimensional functional profiling in the convulsant-treated larval zebrafish brain
(Springer Nature, 2017-07-26)Functional neuroimaging, using genetically-encoded Ca(2+) sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological ... -
5-hydroxymethylcytosine is highly dynamic across human fetal brain development
(BioMed Central, 2017-09-18)Background Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) ... -
The Aarhus statement: improving design and reporting of studies on early cancer diagnosis.
(Cancer Research UK, 2012-03-13)Early diagnosis is a key factor in improving the outcomes of cancer patients. A greater understanding of the pre-diagnostic patient pathways is vital yet, at present, research in this field lacks consistent definitions and ... -
ABCA7 p.G215S as potential protective factor for Alzheimer's disease
(Elsevier, 2016-04-20)Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over ... -
Abnormal islet sphingolipid metabolism in type 1 diabetes
(Springer Verlag (Germany), 2018-04-18)AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we ... -
Abnormal liver function is associated with food sensitisation: NHANES, 20052006
(Wiley, 2013-09)Recently, it was observed that young children with severe liver dysfunction had a high prevalence of food sensitisation. However, the relationship in adults is unclear. Therefore, we aimed to study associations of liver ... -
Abundance estimates for sperm whales in the Mediterranean Sea from acoustic line-transect surveys
(International Whaling Commission, 2017)The Mediterranean sub-population of sperm whales is believed to be isolated and is classified as Endangered on the IUCN Red List. Although there is evidence to suggest the population is declining, there is a lack of abundance ... -
The academic radiography workforce: Age profile, succession planning and academic development.
(W.B. Saunders Ltd, 2017-06-22)Introduction: Academia is one area of practice in which radiographers can specialise; they compile approximately 2% of the total radiography profession in the UK, but are highly influential and essential for the education ... -
Accelerated forgetting of real-life events in Transient Epileptic Amnesia.
(Elsevier, 2010-09)Transient Epileptic Amnesia (TEA) is a form of temporal lobe epilepsy associated with ictal and interictal memory disturbance. Some patients with TEA exhibit Accelerated Long-term Forgetting (ALF), in which memory for ... -
Accelerated Long-Term Forgetting in Epilepsy - and Beyond
(Springer, 2017-02-10)Accelerated long-term forgetting (ALF) is the excessively rapid loss of information over intervals longer than those typically used in neuropsychological assessment, most often 30 min. It has been described primarily in ... -
The acceptability and experience of a functional training programme (ReTrain) in community dwelling stroke survivors in South West England: a qualitative study.
(BMJ Publishing Group, 2018-10-22)OBJECTIVE: This article reports on the acceptability of the intervention as described by trial participants. DESIGN: A qualitative approach was undertaken. Of the 45 participants recruited into the trial, 23 were ... -
Accessibility and implementation in the UK NHS services of an effective depression relapse prevention programme: learning from mindfulness-based cognitive therapy through a mixed-methods study
(NIHR Health Technology Assessment Programme, 2017-03)Access to mindfulness-based cognitive therapy for preventing depression relapse remains variable across the UK, but can be improved by individuals who champion implementation locally, often over many years, and in challenging ... -
Accessibility and implementation in UK services of an effective depression relapse prevention programme - mindfulness-based cognitive therapy (MBCT): ASPIRE study protocol
(BioMed Central, 2014-05-24)Mindfulness-based cognitive therapy (MBCT) is a cost-effective psychosocial prevention programme that helps people with recurrent depression stay well in the long term. It was singled out in the 2009 National Institute for ... -
Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.
(Nature Publishing Group, 2014-08)Monogenic causes of autoimmunity provide key insights into the complex regulation of the immune system. We report a new monogenic cause of autoimmunity resulting from de novo germline activating STAT3 mutations in five ... -
An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.
(Elsevier (Cell Press), 2017-04-11)Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have investigated the effect of an activating mutation, STAT3K392R, on ... -
Active Governance: the value added by community involvement in governance
(Joseph Rowntree Foundation, 2006-07-12)Wider community engagement in governance is frequently argued, across the political parties, to be vital to improving public services and tackling the ‘democratic deficit’. Future Perspectives Co-operative Ltd has looked ... -
Acupressure for smoking cessation--a pilot study.
(BioMed Central, 2007-03-14)BACKGROUND: Tobacco smoking is a serious risk to health: several therapies are available to assist those who wish to stop. Smokers who approach publicly funded stop-smoking clinics in the UK are currently offered nicotine ... -
The acute effects of physical activity on cigarette cravings: exploration of potential moderators, mediators and physical activity attributes using individual participant data (IPD) meta-analyses
(Springer Verlag, 2014-02-13)RATIONALE: The effects of acute bouts of physical activity (PA) on Strength of Desire (SoD) and Desire to Smoke (DtS) using individual participant data (IPD) from 19 acute randomised controlled studies were quantified. ...