Now showing items 1-3 of 3

  • Defining the role of common variation in the genomic and biological architecture of adult human height. 

    Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J; Lo, KS; Locke, AE; Mägi, R; Mihailov, E; Porcu, E; Randall, JC; Scherag, A; Vinkhuyzen, AA; Westra, HJ; Winkler, TW; Workalemahu, T; Zhao, JH; Absher, D; Albrecht, E; Anderson, D; Baron, J; Beekman, M; Demirkan, A; Ehret, GB; Feenstra, B; Feitosa, MF; Fischer, K; Fraser, RM; Goel, A; Gong, J; Justice, AE; Kanoni, S; Kleber, ME; Kristiansson, K; Lim, U; Lotay, V; Lui, JC; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Nalls, MA; Nyholt, DR; Palmer, CD; Pasko, D; Pechlivanis, S; Prokopenko, I; Ried, JS; Ripke, S; Shungin, D; Stancáková, A; Strawbridge, RJ; Sung, YJ; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van Setten, J; Van Vliet-Ostaptchouk, JV; Wang, Z; Yengo, L; Zhang, W; Afzal, U; Arnlöv, J; Arscott, GM; Bandinelli, S; Barrett, A; Bellis, C; Bennett, AJ; Berne, C; Blüher, M; Bolton, JL; Böttcher, Y; Boyd, HA; Bruinenberg, M; Buckley, BM; Buyske, S; Caspersen, IH; Chines, PS; Clarke, R; Claudi-Boehm, S; Cooper, M; Daw, EW; De Jong, PA; Deelen, J; Delgado, G; Denny, JC; Dhonukshe-Rutten, R; Dimitriou, M; Doney, AS; Dörr, M; Eklund, N; Eury, E; Folkersen, L; Garcia, ME; Geller, F; Giedraitis, V; Go, AS; Grallert, H; Grammer, TB; Gräßler, J; Grönberg, H; de Groot, LC; Groves, CJ; Haessler, J; Hall, P; Haller, T; Hallmans, G; Hannemann, A; Hartman, CA; Hassinen, M; Hayward, C; Heard-Costa, NL; Helmer, Q; Hemani, G; Henders, AK; Hillege, HL; Hlatky, MA; Hoffmann, W; Hoffmann, P; Holmen, O; Houwing-Duistermaat, JJ; Illig, T; Isaacs, A; James, AL; Jeff, J; Johansen, B; Johansson, Å; Jolley, J; Juliusdottir, T; Junttila, J; Kho, AN; Kinnunen, L; Klopp, N; Kocher, T; Kratzer, W; Lichtner, P; Lind, L; Lindström, J; Lobbens, S; Lorentzon, M; Lu, Y; Lyssenko, V; Magnusson, PK; Mahajan, A; Maillard, M; McArdle, WL; McKenzie, CA; McLachlan, S; McLaren, PJ; Menni, C; Merger, S; Milani, L; Moayyeri, A; Monda, KL; Morken, MA; Müller, G; Müller-Nurasyid, M; Musk, AW; Narisu, N; Nauck, M; Nolte, IM; Nöthen, MM; Oozageer, L; Pilz, S; Rayner, NW; Renstrom, F; Robertson, NR; Rose, LM; Roussel, R; Sanna, S; Scharnagl, H; Scholtens, S; Schumacher, FR; Schunkert, H; Scott, RA; Sehmi, J; Seufferlein, T; Shi, J; Silventoinen, K; Smit, JH; Smith, AV; Smolonska, J; Stanton, AV; Stirrups, K; Stott, DJ; Stringham, HM; Sundström, J; Swertz, MA; Syvänen, AC; Tayo, BO; Thorleifsson, G; Tyrer, JP; van Dijk, S; van Schoor, NM; van der Velde, N; van Heemst, D; van Oort, FV; Vermeulen, SH; Verweij, N; Vonk, JM; Waite, LL; Waldenberger, M; Wennauer, R; Wilkens, LR; Willenborg, C; Wilsgaard, T; Wojczynski, MK; Wong, A; Wright, AF; Zhang, Q; Arveiler, D; Bakker, SJ; Beilby, J; Bergman, RN; Bergmann, S; Biffar, R; Blangero, J; Boomsma, DI; Bornstein, SR; Bovet, P; Brambilla, P; Brown, MJ; Campbell, H; Caulfield, MJ; Chakravarti, A; Collins, R; Collins, FS; Crawford, DC; Cupples, LA; Danesh, J; de Faire, U; den Ruijter, HM; Erbel, R; Erdmann, J; Eriksson, JG; Farrall, M; Ferrannini, E; Ferrières, J; Ford, I; Forouhi, NG; Forrester, T; Gansevoort, RT; Gejman, PV; Gieger, C; Golay, A; Gottesman, O; Gudnason, V; Gyllensten, U; Haas, DW; Hall, AS; Harris, TB; Hattersley, AT; Heath, AC; Hengstenberg, C; Hicks, AA; Hindorff, LA; Hingorani, AD; Hofman, A; Hovingh, GK; Humphries, SE; Hunt, SC; Hypponen, E; Jacobs, KB; Jarvelin, MR; Jousilahti, P; Jula, AM; Kaprio, J; Kastelein, JJ; Kayser, M; Kee, F; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Kooner, JS; Kooperberg, C; Koskinen, S; Kovacs, P; Kraja, AT; Kumari, M; Kuusisto, J; Lakka, TA; Langenberg, C; Le Marchand, L; Lehtimäki, T; Lupoli, S; Madden, PA; Männistö, S; Manunta, P; Marette, A; Matise, TC; McKnight, B; Meitinger, T; Moll, FL; Montgomery, GW; Morris, AD; Morris, AP; Murray, JC; Nelis, M; Ohlsson, C; Oldehinkel, AJ; Ong, KK; Ouwehand, WH; Pasterkamp, G; Peters, A; Pramstaller, PP; Price, JF; Qi, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Ritchie, M; Rudan, I; Salomaa, V; Samani, NJ; Saramies, J; Sarzynski, MA; Schwarz, PE; Sebert, S; Sever, P; Shuldiner, AR; Sinisalo, J; Steinthorsdottir, V; Stolk, RP; Tardif, JC; Tönjes, A; Tremblay, A; Tremoli, E; Virtamo, J; Vohl, MC; Electronic Medical Records and Genomics (eMEMERGEGE) Consortium; MIGen Consortium; PAGEGE Consortium; LifeLines Cohort Study; Amouyel, P; Asselbergs, FW; Assimes, TL; Bochud, M; Boehm, BO; Boerwinkle, E; Bottinger, EP; Bouchard, C; Cauchi, S; Chambers, JC; Chanock, SJ; Cooper, RS; de Bakker, PI; Dedoussis, G; Ferrucci, L; Franks, PW; Froguel, P; Groop, LC; Haiman, CA; Hamsten, A; Hayes, MG; Hui, J; Hunter, DJ; Hveem, K; Jukema, JW; Kaplan, RC; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; Martin, NG; März, W; Melbye, M; Moebus, S; Munroe, PB; Njølstad, I; Oostra, BA; Palmer, CN; Pedersen, NL; Perola, M; Pérusse, L; Peters, U; Powell, JE; Power, C; Quertermous, T; Rauramaa, R; Reinmaa, E; Ridker, PM; Rivadeneira, F; Rotter, JI; Saaristo, TE; Saleheen, D; Schlessinger, D; Slagboom, PE; Snieder, H; Spector, TD; Strauch, K; Stumvoll, M; Tuomilehto, J; Uusitupa, M; van der Harst, P; Völzke, H; Walker, M; Wareham, NJ; Watkins, H; Wichmann, HE; Wilson, JF; Zanen, P; Deloukas, P; Heid, IM; Lindgren, CM; Mohlke, KL; Speliotes, EK; Thorsteinsdottir, U; Barroso, I; Fox, CS; North, KE; Strachan, DP; Beckmann, JS; Berndt, SI; Boehnke, M; Borecki, IB; McCarthy, MI; Metspalu, A; Stefansson, K; Uitterlinden, AG; van Duijn, CM; Franke, L; Willer, CJ; Price, AL; Lettre, G; Loos, RJ; Weedon, MN; Ingelsson, E; O'Connell, JR; Abecasis, GR; Chasman, DI; Goddard, ME; Visscher, PM; Hirschhorn, JN; Frayling, TM (Nature Publishing Group, 2014-10-05)
    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in ...
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

    Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L; Deng, X; Czajkowski, J; Hadley, D; Ngwa, JS; Ahluwalia, TS; Chu, AY; Heard-Costa, NL; Lim, E; Perez, J; Eicher, JD; Kutalik, Z; Xue, L; Mahajan, A; Renström, F; Wu, J; Qi, Q; Ahmad, S; Alfred, T; Amin, N; Bielak, LF; Bonnefond, A; Bragg, J; Cadby, G; Chittani, M; Coggeshall, S; Corre, T; Direk, N; Eriksson, J; Fischer, K; Gorski, M; Neergaard Harder, M; Horikoshi, M; Huang, T; Huffman, JE; Jackson, AU; Justesen, JM; Kanoni, S; Kinnunen, L; Kleber, ME; Komulainen, P; Kumari, M; Lim, U; Luan, J; Lyytikäinen, L-P; Mangino, M; Manichaikul, A; Marten, J; Middelberg, RPS; Müller-Nurasyid, M; Navarro, P; Pérusse, L; Pervjakova, N; Sarti, C; Smith, AV; Smith, JA; Stančáková, A; Strawbridge, RJ; Stringham, HM; Sung, YJ; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van der Most, PJ; Van Vliet-Ostaptchouk, JV; Vedantam, SL; Verweij, N; Vink, JM; Vitart, V; Wu, Y; Yengo, L; Zhang, W; Hua Zhao, J; Zimmermann, ME; Zubair, N; Abecasis, GR; Adair, LS; Afaq, S; Afzal, U; Bakker, SJL; Bartz, TM; Beilby, J; Bergman, RN; Bergmann, S; Biffar, R; Blangero, J; Boerwinkle, E; Bonnycastle, LL; Bottinger, E; Braga, D; Buckley, BM; Buyske, S; Campbell, H; Chambers, JC; Collins, FS; Curran, JE; de Borst, GJ; de Craen, AJM; de Geus, EJC; Dedoussis, G; Delgado, GE; den Ruijter, HM; Eiriksdottir, G; Eriksson, AL; Esko, T; Faul, JD; Ford, I; Forrester, T; Gertow, K; Gigante, B; Glorioso, N; Gong, J; Grallert, H; Grammer, TB; Grarup, N; Haitjema, S; Hallmans, G; Hamsten, A; Hansen, T; Harris, TB; Hartman, CA; Hassinen, M; Hastie, ND; Heath, AC; Hernandez, D; Hindorff, L; Hocking, LJ; Hollensted, M; Holmen, OL; Homuth, G; Jan Hottenga, J; Huang, J; Hung, J; Hutri-Kähönen, N; Ingelsson, E; James, AL; Jansson, J-O; Jarvelin, M-R; Jhun, MA; Jørgensen, ME; Juonala, M; Kähönen, M; Karlsson, M; Koistinen, HA; Kolcic, I; Kolovou, G; Kooperberg, C; Krämer, BK; Kuusisto, J; Kvaløy, K; Lakka, TA; Langenberg, C; Launer, LJ; Leander, K; Lee, NR; Lind, L; Lindgren, CM; Linneberg, A; Lobbens, S; Loh, M; Lorentzon, M; Luben, R; Lubke, G; Ludolph-Donislawski, A; Lupoli, S; Madden, PAF; Männikkö, R; Marques-Vidal, P; Martin, NG; McKenzie, CA; McKnight, B; Mellström, D; Menni, C; Montgomery, GW; Musk, AB; Narisu, N; Nauck, M; Nolte, IM; Oldehinkel, AJ; Olden, M; Ong, KK; Padmanabhan, S; Peyser, PA; Pisinger, C; Porteous, DJ; Raitakari, OT; Rankinen, T; Rao, DC; Rasmussen-Torvik, LJ; Rawal, R; Rice, T; Ridker, PM; Rose, LM; Bien, SA; Rudan, I; Sanna, S; Sarzynski, MA; Sattar, N; Savonen, K; Schlessinger, D; Scholtens, S; Schurmann, C; Scott, RA; Sennblad, B; Siemelink, MA; Silbernagel, G; Slagboom, PE; Snieder, H; Staessen, JA; Stott, DJ; Swertz, MA; Swift, AJ; Taylor, KD; Tayo, BO; Thorand, B; Thuillier, D; Tuomilehto, J; Uitterlinden, AG; Vandenput, L; Vohl, M-C; Völzke, H; Vonk, JM; Waeber, G; Waldenberger, M; Westendorp, RGJ; Wild, S; Willemsen, G; Wolffenbuttel, BHR; Wong, A; Wright, AF; Zhao, W; Zillikens, MC; Baldassarre, D; Balkau, B; Bandinelli, S; Böger, CA; Boomsma, DI; Bouchard, C; Bruinenberg, M; Chasman, DI; Chen, Y-D; Chines, PS; Cooper, RS; Cucca, F; Cusi, D; Faire, UD; Ferrucci, L; Franks, PW; Froguel, P; Gordon-Larsen, P; Grabe, H-J; Gudnason, V; Haiman, CA; Hayward, C; Hveem, K; Johnson, AD; Wouter Jukema, J; Kardia, SLR; Kivimaki, M; Kooner, JS; Kuh, D; Laakso, M; Lehtimäki, T; Marchand, LL; März, W; McCarthy, MI; Metspalu, A; Morris, AP; Ohlsson, C; Palmer, LJ; Pasterkamp, G; Pedersen, O; Peters, A; Peters, U; Polasek, O; Psaty, BM; Qi, L; Rauramaa, R; Smith, BH; Sørensen, TIA; Strauch, K; Tiemeier, H; Tremoli, E; van der Harst, P; Vestergaard, H; Vollenweider, P; Wareham, NJ; Weir, DR; Whitfield, JB; Wilson, JF; Tyrrell, J; Frayling, TM; Barroso, I; Boehnke, M; Deloukas, P; Fox, CS; Hirschhorn, JN; Hunter, DJ; Spector, TD; Strachan, DP; van Duijn, CM; Heid, IM; Mohlke, KL; Marchini, J; Loos, RJF; Kilpeläinen, TO; Liu, C-T; Borecki, IB; North, KE; Cupples, LA (Nature Publishing Group:, 2017-04-26)
    Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
  • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

    Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N; Rivas, MA; Mahajan, A; Locke, AE; Cingolani, P; Pers, TH; Viñuela, A; Brown, AA; Wu, Y; Flannick, J; Fuchsberger, C; Gamazon, ER; Gaulton, KJ; Im, HK; Teslovich, TM; Blackwell, TW; Bork-Jensen, J; Burtt, NP; Chen, Y; Green, T; Hartl, C; Kang, HM; Kumar, A; Ladenvall, C; Ma, C; Moutsianas, L; Pearson, RD; Perry, JRB; Rayner, NW; Robertson, NR; Scott, LJ; van de Bunt, M; Eriksson, JG; Jula, A; Koskinen, S; Lehtimäki, T; Palotie, A; Raitakari, OT; Jacobs, SB; Wessel, J; Chu, AY; Scott, RA; Goodarzi, MO; Blancher, C; Buck, G; Buck, D; Chines, PS; Gabriel, S; Gjesing, AP; Groves, CJ; Hollensted, M; Huyghe, JR; Jackson, AU; Jun, G; Justesen, JM; Mangino, M; Murphy, J; Neville, M; Onofrio, R; Small, KS; Stringham, HM; Trakalo, J; Banks, E; Carey, J; Carneiro, MO; DePristo, M; Farjoun, Y; Fennell, T; Goldstein, JI; Grant, G; Hrabé de Angelis, M; Maguire, J; Neale, BM; Poplin, R; Purcell, S; Schwarzmayr, T; Shakir, K; Smith, JD; Strom, TM; Wieland, T; Lindstrom, J; Brandslund, I; Christensen, C; Surdulescu, GL; Lakka, TA; Doney, ASF; Nilsson, P; Wareham, NJ; Langenberg, C; Varga, TV; Franks, PW; Rolandsson, O; Rosengren, AH; Farook, VS; Thameem, F; Puppala, S; Kumar, S; Lehman, DM; Jenkinson, CP; Curran, JE; Hale, DE; Fowler, SP; Arya, R; DeFronzo, RA; Abboud, HE; Syvänen, A-C; Hicks, PJ; Palmer, ND; Ng, MCY; Bowden, DW; Freedman, BI; Esko, T; Mägi, R; Milani, L; Mihailov, E; Metspalu, A; Narisu, N; Kinnunen, L; Bonnycastle, LL; Swift, A; Pasko, D; Wood, AR; Fadista, J; Pollin, TI; Barzilai, N; Atzmon, G; Glaser, B; Thorand, B; Strauch, K; Peters, A; Roden, M; Müller-Nurasyid, M; Liang, L; Kriebel, J; Illig, T; Grallert, H; Gieger, C; Meisinger, C; Lannfelt, L; Musani, SK; Griswold, M; Taylor, HA; Wilson, G; Correa, A; Oksa, H; Scott, WR; Afzal, U; Tan, S-T; Loh, M; Chambers, JC; Sehmi, J; Kooner, JS; Lehne, B; Cho, YS; Lee, J-Y; Han, B-G; Käräjämäki, A; Qi, Q; Qi, L; Huang, J; Hu, FB; Melander, O; Orho-Melander, M; Below, JE; Aguilar, D; Wong, TY; Liu, J; Khor, C-C; Chia, KS; Lim, WY; Cheng, C-Y; Chan, E; Tai, ES; Aung, T; Linneberg, A; Isomaa, B; Meitinger, T; Tuomi, T; Hakaste, L; Kravic, J; Jørgensen, ME; Lauritzen, T; Deloukas, P; Stirrups, KE; Owen, KR; Farmer, AJ; Frayling, TM; O'Rahilly, SP; Walker, M; Levy, JC; Hodgkiss, D; Hattersley, AT; Kuulasmaa, T; Stančáková, A; Barroso, I; Bharadwaj, D; Chan, J; Chandak, GR; Daly, MJ; Donnelly, PJ; Ebrahim, SB; Elliott, P; Fingerlin, T; Froguel, P; Hu, C; Jia, W; Ma, RCW; McVean, G; Park, T; Prabhakaran, D; Sandhu, M; Scott, J; Sladek, R; Tandon, N; Teo, YY; Zeggini, E; Watanabe, RM; Koistinen, HA; Kesaniemi, YA; Uusitupa, M; Spector, TD; Salomaa, V; Rauramaa, R; Palmer, CNA; Prokopenko, I; Morris, AD; Bergman, RN; Collins, FS; Lind, L; Ingelsson, E; Tuomilehto, J; Karpe, F; Groop, L; Jørgensen, T; Hansen, T; Pedersen, O; Kuusisto, J; Abecasis, G; Bell, GI; Blangero, J; Cox, NJ; Duggirala, R; Seielstad, M; Wilson, JG; Dupuis, J; Ripatti, S; Hanis, CL; Florez, JC; Mohlke, KL; Meigs, JB; Laakso, M; Morris, AP; Boehnke, M; Altshuler, D; McCarthy, MI; Gloyn, AL; Lindgren, CM (American Diabetes Association, 2017-03-24)
    To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...