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  • Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases 

    Perry, John R.B.; Voight, BF; Yengo, L; Amin, N; Dupuis, J; Ganser, M; Grallert, H; Navarro, P; Li, M; Qi, L; Steinthorsdottir, V; Scott, RA; Almgren, P; Arking, DE; Aulchenko, Yurii; Balkau, B; Benediktsson, R; Bergman, RN; Boerwinkle, E; Bonnycastle, Lori; Burtt, NP; Campbell, H; Charpentier, G; Collins, FS; Gieger, C; Green, Todd; Hadjadj, S; Hattersley, Andrew T.; Herder, C; Hofman, A; Johnson, AD; Kottgen, A; Kraft, P; Labrune, Y; Langenberg, C; Manning, AK; Mohlke, KL; Morris, AP; Oostra, B; Pankow, J; Petersen, AK; Pramstaller, PP; Prokopenko, I; Rathmann, W; Rayner, W; Roden, M; Rudan, I; Rybin, D; Scott, LJ; Sigurdsson, G; Sladek, R; Thorleifsson, G; Thorsteinsdottir, U; Tuomilehto, J; Uitterlinden, AG; Vivequin, S; Weedon, Michael N.; Wright, AF; MAGIC; DIAGRAM Consortium; GIANT Consortium; Hu, FB; Illig, T; Kao, L; Meigs, JB; Wilson, JF; Stefansson, K; van Duijn, C; Altschuler, D; Morris, AD; Boehnke, M; McCarthy, MI; Froguel, P; Palmer, CN; Wareham, NJ; Groop, Leif; Frayling, Timothy M.; Cauchi, S (Public Library of Science, 2012-05)
    Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition ...