Now showing items 1-3 of 3

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. 

    De Jager, PL; Srivastava, G.P.; Lunnon, Katie; Burgess, J; Schalkwyk, Leonard; Yu, L; Eaton, ML; Keenan, BT; Ernst, J; McCabe, C; Tang, A; Raj, T; Replogle, J; Brodeur, W; Gabriel, S; Chai, HS; Younkin, C; Younkin, SG; Zou, F; Szyf, M; Epstein, CB; Schneider, J.; Bernstein, BE; Meissner, A; Ertekin-Taner, N; Chibnik, LB; Kellis, M; Mill, J; Bennett, DA (Nature Publishing Group, 2014-08-17)
    We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 ...
  • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

    Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N; Rivas, MA; Mahajan, A; Locke, AE; Cingolani, P; Pers, TH; Viñuela, A; Brown, AA; Wu, Y; Flannick, J; Fuchsberger, C; Gamazon, ER; Gaulton, KJ; Im, HK; Teslovich, TM; Blackwell, TW; Bork-Jensen, J; Burtt, NP; Chen, Y; Green, T; Hartl, C; Kang, HM; Kumar, A; Ladenvall, C; Ma, C; Moutsianas, L; Pearson, RD; Perry, JRB; Rayner, NW; Robertson, NR; Scott, LJ; van de Bunt, M; Eriksson, JG; Jula, A; Koskinen, S; Lehtimäki, T; Palotie, A; Raitakari, OT; Jacobs, SB; Wessel, J; Chu, AY; Scott, RA; Goodarzi, MO; Blancher, C; Buck, G; Buck, D; Chines, PS; Gabriel, S; Gjesing, AP; Groves, CJ; Hollensted, M; Huyghe, JR; Jackson, AU; Jun, G; Justesen, JM; Mangino, M; Murphy, J; Neville, M; Onofrio, R; Small, KS; Stringham, HM; Trakalo, J; Banks, E; Carey, J; Carneiro, MO; DePristo, M; Farjoun, Y; Fennell, T; Goldstein, JI; Grant, G; Hrabé de Angelis, M; Maguire, J; Neale, BM; Poplin, R; Purcell, S; Schwarzmayr, T; Shakir, K; Smith, JD; Strom, TM; Wieland, T; Lindstrom, J; Brandslund, I; Christensen, C; Surdulescu, GL; Lakka, TA; Doney, ASF; Nilsson, P; Wareham, NJ; Langenberg, C; Varga, TV; Franks, PW; Rolandsson, O; Rosengren, AH; Farook, VS; Thameem, F; Puppala, S; Kumar, S; Lehman, DM; Jenkinson, CP; Curran, JE; Hale, DE; Fowler, SP; Arya, R; DeFronzo, RA; Abboud, HE; Syvänen, A-C; Hicks, PJ; Palmer, ND; Ng, MCY; Bowden, DW; Freedman, BI; Esko, T; Mägi, R; Milani, L; Mihailov, E; Metspalu, A; Narisu, N; Kinnunen, L; Bonnycastle, LL; Swift, A; Pasko, D; Wood, AR; Fadista, J; Pollin, TI; Barzilai, N; Atzmon, G; Glaser, B; Thorand, B; Strauch, K; Peters, A; Roden, M; Müller-Nurasyid, M; Liang, L; Kriebel, J; Illig, T; Grallert, H; Gieger, C; Meisinger, C; Lannfelt, L; Musani, SK; Griswold, M; Taylor, HA; Wilson, G; Correa, A; Oksa, H; Scott, WR; Afzal, U; Tan, S-T; Loh, M; Chambers, JC; Sehmi, J; Kooner, JS; Lehne, B; Cho, YS; Lee, J-Y; Han, B-G; Käräjämäki, A; Qi, Q; Qi, L; Huang, J; Hu, FB; Melander, O; Orho-Melander, M; Below, JE; Aguilar, D; Wong, TY; Liu, J; Khor, C-C; Chia, KS; Lim, WY; Cheng, C-Y; Chan, E; Tai, ES; Aung, T; Linneberg, A; Isomaa, B; Meitinger, T; Tuomi, T; Hakaste, L; Kravic, J; Jørgensen, ME; Lauritzen, T; Deloukas, P; Stirrups, KE; Owen, KR; Farmer, AJ; Frayling, TM; O'Rahilly, SP; Walker, M; Levy, JC; Hodgkiss, D; Hattersley, AT; Kuulasmaa, T; Stančáková, A; Barroso, I; Bharadwaj, D; Chan, J; Chandak, GR; Daly, MJ; Donnelly, PJ; Ebrahim, SB; Elliott, P; Fingerlin, T; Froguel, P; Hu, C; Jia, W; Ma, RCW; McVean, G; Park, T; Prabhakaran, D; Sandhu, M; Scott, J; Sladek, R; Tandon, N; Teo, YY; Zeggini, E; Watanabe, RM; Koistinen, HA; Kesaniemi, YA; Uusitupa, M; Spector, TD; Salomaa, V; Rauramaa, R; Palmer, CNA; Prokopenko, I; Morris, AD; Bergman, RN; Collins, FS; Lind, L; Ingelsson, E; Tuomilehto, J; Karpe, F; Groop, L; Jørgensen, T; Hansen, T; Pedersen, O; Kuusisto, J; Abecasis, G; Bell, GI; Blangero, J; Cox, NJ; Duggirala, R; Seielstad, M; Wilson, JG; Dupuis, J; Ripatti, S; Hanis, CL; Florez, JC; Mohlke, KL; Meigs, JB; Laakso, M; Morris, AP; Boehnke, M; Altshuler, D; McCarthy, MI; Gloyn, AL; Lindgren, CM (American Diabetes Association, 2017-03-24)
    To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...
  • A reference panel of 64,976 haplotypes for genotype imputation. 

    McCarthy, S; Das, S; Kretzschmar, W; Delaneau, O; Wood, AR; Teumer, A; Kang, HM; Fuchsberger, C; Danecek, P; Sharp, K; Luo, Y; Sidore, C; Kwong, A; Timpson, N; Koskinen, S; Vrieze, S; Scott, LJ; Zhang, H; Mahajan, A; Veldink, J; Peters, U; Pato, C; van Duijn, CM; Gillies, CE; Gandin, I; Mezzavilla, M; Gilly, A; Cocca, M; Traglia, M; Angius, A; Barrett, JC; Boomsma, D; Branham, K; Breen, G; Brummett, CM; Busonero, F; Campbell, H; Chan, A; Chen, S; Chew, E; Collins, FS; Corbin, LJ; Smith, GD; Dedoussis, G; Dorr, M; Farmaki, AE; Ferrucci, L; Forer, L; Fraser, RM; Gabriel, S; Levy, S; Groop, L; Harrison, T; Hattersley, A; Holmen, OL; Hveem, K; Kretzler, M; Lee, JC; McGue, M; Meitinger, T; Melzer, D; Min, JL; Mohlke, KL; Vincent, JB; Nauck, M; Nickerson, D; Palotie, A; Pato, M; Pirastu, N; McInnis, M; Richards, JB; Sala, C; Salomaa, V; Schlessinger, D; Schoenherr, S; Slagboom, PE; Small, K; Spector, T; Stambolian, D; Tuke, M; Tuomilehto, J; Van den Berg, LH; Van Rheenen, W; Volker, U; Wijmenga, C; Toniolo, D; Zeggini, E; Gasparini, P; Sampson, MG; Wilson, JF; Frayling, T; de Bakker, PI; Swertz, MA; McCarroll, S; Kooperberg, C; Dekker, A; Altshuler, D; Willer, C; Iacono, W; Ripatti, S; Soranzo, N; Walter, K; Swaroop, A; Cucca, F; Anderson, CA; Myers, RM; Boehnke, M; McCarthy, MI; Durbin, R; Abecasis, G; Marchini, J; Haplotype Reference Consortium (Nature Publishing Group, 2016-08-22)
    We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype ...