Now showing items 1-3 of 3

  • Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease 

    Medici, M; Porcu, E; Pistis, G; Teumer, A; Brown, Suzanne J.; Jensen, RA; Rawal, R; Roef, GL; Plantinga, TS; Vermeulen, SH; Lahti, J; Simmonds, MJ; Husemoen, LL; Freathy, RM; Shields, BM; Pietzner, D; Nagy, R; Broer, L; Chaker, L; Korevaar, TI; Plia, MG; Sala, C; Völker, U; Richards, JB; Sweep, FC; Gieger, C; Corre, T; Kajantie, E; Thuesen, B; Taes, YE; Visser, WE; Hattersley, Andrew T.; Kratzsch, J; Hamilton, Alexander; Li, W; Homuth, G; Lobina, M; Mariotti, S; Soranzo, N; Cocca, M; Nauck, M; Spielhagen, C; Ross, A; Arnold, A; van de Bunt, M; Liyanarachchi, S; Heier, M; Grabe, HJ; Masciullo, C; Galesloot, TE; Lim, EM; Reischl, E; Leedman, PJ; Lai, S; Delitala, A; Bremner, AP; Philips, DI; Beilby, John P.; Mulas, A; Vocale, M; Abecasis, Goncalo; Forsen, T; James, A; Widen, E; Hui, J; Prokisch, H; Rietzschel, EE; Palotie, A; Feddema, P; Fletcher, SJ; Schramm, K; Rotter, JI; Kluttig, A; Radke, D; Traglia, M; Surdulescu, GL; He, H; Franklyn, JA; Tiller, D; Vaidya, B; de Meyer, T; Jørgensen, T; Eriksson, Johan G.; O'Leary, PC; Wichmann, E; Hermus, AR; Psaty, BM; Ittermann, T; Hofman, A; Bosi, E; Schlessinger, D; Wallaschofski, H; Pirastu, N; Aulchenko, Yurii; de la Chapelle, A; Netea-Maier, RT; Gough, SC; Meyer Zu Schwabedissen, H; Frayling, Timothy M.; Kaufman, JM; Linneberg, A; Räikkönen, K; Smit, JW; Kiemeney, LA; Rivadeneira, F; Uitterlinden, AG; Walsh, JP; Meisinger, C; den Heijer, M; Visser, TJ; Spector, TD; Wilson, SG; Völzke, H; Cappola, A; Toniolo, D; Sanna, S; Naitza, S; Peeters, RP (Public Library of Science, 2014-02)
    Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's ...
  • The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study 

    Winkler, TW; Justice, AE; Graff, M; Barata, L; Feitosa, MF; Chu, S; Czajkowski, J; Esko, T; Fall, T; Kilpeläinen, TO; Lu, Y; Mägi, R; Mihailov, E; Pers, TH; Rüeger, S; Teumer, A; Ehret, GB; Ferreira, T; Heard-Costa, NL; Karjalainen, J; Lagou, V; Mahajan, A; Neinast, MD; Prokopenko, I; Simino, J; Teslovich, TM; Jansen, R; Westra, H-J; White, CC; Absher, D; Ahluwalia, TS; Ahmad, S; Albrecht, E; Alves, AC; Bragg-Gresham, JL; de Craen, AJM; Bis, JC; Bonnefond, A; Boucher, G; Cadby, G; Cheng, Y-C; Chiang, CWK; Delgado, G; Demirkan, A; Dueker, N; Eklund, N; Eiriksdottir, G; Eriksson, J; Feenstra, B; Fischer, K; Frau, F; Galesloot, TE; Geller, F; Goel, A; Gorski, M; Grammer, TB; Gustafsson, S; Haitjema, S; Hottenga, JJ; Huffman, JE; Jackson, AU; Jacobs, KB; Johansson, Å; Kaakinen, M; Kleber, ME; Lahti, J; Leach, IM; Lehne, B; Liu, Y; Lo, KS; Lorentzon, M; Luan, J; Madden, PAF; Mangino, M; McKnight, B; Medina-Gomez, C; Monda, KL; Montasser, ME; Müller, G; Müller-Nurasyid, M; Nolte, IM; Panoutsopoulou, K; Pascoe, L; Paternoster, L; Rayner, NW; Renström, F; Rizzi, F; Rose, LM; Ryan, KA; Salo, P; Sanna, S; Scharnagl, H; Shi, J; Smith, AV; Southam, L; Stančáková, A; Steinthorsdottir, V; Strawbridge, RJ; Sung, YJ; Tachmazidou, I; Tanaka, T; Thorleifsson, G; Trompet, S; Pervjakova, N; Tyrer, JP; Vandenput, L; van der Laan, SW; van der Velde, N; van Setten, J; van Vliet-Ostaptchouk, JV; Verweij, N; Vlachopoulou, E; Waite, LL; Wang, SR; Wang, Z; Wild, SH; Willenborg, C; Wilson, JF; Wong, A; Yang, J; Yengo, L; Yerges-Armstrong, LM; Yu, L; Zhang, W; Zhao, JH; Andersson, EA; Bakker, SJL; Baldassarre, D; Banasik, K; Barcella, M; Barlassina, C; Bellis, C; Benaglio, P; Blangero, J; Blüher, M; Bonnet, F; Bonnycastle, LL; Boyd, HA; Bruinenberg, M; Buchman, AS; Campbell, H; Chen, Y-DI; Chines, PS; Claudi-Boehm, S; Cole, J; Collins, FS; de Geus, Eco; de Groot, LCPGM; Dimitriou, M; Duan, J; Enroth, S; Eury, E; Farmaki, A-E; Forouhi, NG; Friedrich, N; Gejman, PV; Gigante, B; Glorioso, N; Go, AS; Gottesman, O; Gräßler, J; Grallert, H; Grarup, N; Gu, Y-M; Broer, L; Ham, AC; Hansen, T; Harris, Tamara; Hartman, CA; Hassinen, M; Hastie, N; Hattersley, Andrew T.; Heath, AC; Henders, AK; Hernandez, Dena; Hillege, Hans; Holmen, O; Hovingh, KG; Hui, J; Husemoen, LL; Hutri-Kähönen, N; Hysi, PG; Illig, T; De Jager, PL; Jalilzadeh, S; Jørgensen, T; Jukema, JW; Juonala, M; Kanoni, S; Karaleftheri, M; Khaw, KT; Kinnunen, L; Kittner, SJ; Koenig, W; Kolcic, I; Kovacs, P; Krarup, NT; Kratzer, W; Krüger, J; Kuh, D; Kumari, M; Kyriakou, T; Langenberg, C; Lannfelt, L; Lanzani, C; Lotay, V; Launer, LJ; Leander, K; Lindström, J; Linneberg, A; Liu, Y-P; Lobbens, S; Luben, R; Lyssenko, V; Männistö, S; Magnusson, PK; McArdle, WL; Menni, C; Merger, S; Milani, L; Montgomery, GW; Morris, AP; Narisu, N; Nelis, M; Ong, KK; Palotie, A; Pérusse, L; Pichler, I; Pilia, MG; Pouta, A; Rheinberger, M; Ribel-Madsen, R; Richards, M; Rice, KM; Rice, TK; Rivolta, C; Salomaa, V; Sanders, AR; Sarzynski, MA; Scholtens, S; Scott, RA; Scott, WR; Sebert, S; Sengupta, S; Sennblad, B; Seufferlein, T; Silveira, A; Slagboom, PE; Smit, JH; Sparsø, TH; Stirrups, K; Stolk, RP; Stringham, HM; Swertz, MA; Swift, AJ; Syvänen, A-C; Tan, S-T; Thorand, B; Tönjes, A; Tremblay, A; Tsafantakis, E; van der Most, PJ; Völker, U; Vohl, M-C; Vonk, JM; Waldenberger, M; Walker, RW; Wennauer, R; Widén, E; Willemsen, G; Wilsgaard, T; Wright, AF; Zillikens, MC; van Dijk, SC; van Schoor, NM; Asselbergs, FW; de Bakker, PIW; Beckmann, JS; Beilby, J; Bennett, DA; Bergman, RN; Bergmann, S; Böger, CA; Boehm, BO; Boerwinkle, E; Boomsma, DI; Bornstein, SR; Bottinger, EP; Bouchard, C; Chambers, JC; Chanock, SJ; Chasman, DI; Cucca, F; Cusi, D; Dedoussis, G; Erdmann, J; Eriksson, JG; Evans, DA; de Faire, U; Farrall, M; Ferrucci, L; Ford, I; Franke, L; Franks, PW; Froguel, P; Gansevoort, RT; Gieger, C; Grönberg, H; Gudnason, V; Gyllensten, U; Hall, P; Hamsten, A; van der Harst, P; Hayward, C; Heliövaara, M; Hengstenberg, C; Hicks, AA; Hingorani, Aroon; Hofman, A; Hu, F; Huikuri, HV; Hveem, K; James, AL; Jordan, JM; Jula, A; Kähönen, M; Kajantie, E; Kathiresan, S; Kiemeney, LALM; Kivimaki, M; Knekt, PB; Koistinen, HA; Kooner, JS; Koskinen, S; Kuusisto, J; Maerz, W; Martin, NG; Laakso, M; Lakka, TA; Lehtimäki, T; Lettre, G; Levinson, DF; Lind, L; Lokki, M-L; Mäntyselkä, P; Melbye, M; Metspalu, A; Mitchell, BD; Moll, FL; Murray, JC; Musk, AW; Nieminen, MS; Njølstad, I; Ohlsson, C; Oldehinkel, AJ; Oostra, BA; Palmer, LJ; Pankow, JS; Pasterkamp, G; Pedersen, NL; Pedersen, O; Penninx, BW; Perola, M; Peters, A; Polašek, O; Pramstaller, PP; Psaty, BM; Qi, L; Quertermous, T; Raitakari, OT; Rankinen, T; Rauramaa, R; Ridker, PM; Rioux, JD; Rivadeneira, F; Rotter, JI; Rudan, I; den Ruijter, HM; Saltevo, J; Sattar, N; Schunkert, H; Schwarz, PEH; Shuldiner, AR; Sinisalo, J; Snieder, H; Sørensen, TIA; Spector, TD; Staessen, JA; Stefania, B; Thorsteinsdottir, U; Stumvoll, M; Tardif, J-C; Tremoli, E; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; Verbeek, ALM; Vermeulen, SH; Viikari, JS; Vitart, V; Völzke, H; Vollenweider, P; Waeber, G; Walker, M; Wallaschofski, H; Wareham, NJ; Watkins, H; Zeggini, E; Chakravarti, A; Clegg, DJ; Cupples, LA; Gordon-Larsen, P; Jaquish, CE; Rao, DC; Abecasis, GR; Assimes, TL; Barroso, I; Berndt, SI; Boehnke, M; Deloukas, P; Fox, CS; Groop, LC; Hunter, DJ; Ingelsson, E; Kaplan, RC; McCarthy, MI; Mohlke, KL; O'Connell, JR; Schlessinger, D; Strachan, DP; Stefansson, K; van Duijn, CM; Hirschhorn, JN; Lindgren, CM; Heid, IM; North, KE; Borecki, IB; Kutalik, Z; Loos, RJF (Public Library of Science, 2015-10-01)
    Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size ...
  • Rare and low-frequency coding variants alter human adult height 

    Marouli, E; Graff, M; Medina-Gomez, C; Lo, KS; Wood, AR; Kjaer, TR; Fine, RS; Lu, Y; Schurmann, C; Highland, HM; Rüeger, S; Thorleifsson, G; Justice, AE; Lamparter, D; Stirrups, KE; Turcot, V; Young, KL; Winkler, TW; Esko, T; Karaderi, T; Locke, AE; Masca, NGD; Ng, MCY; Mudgal, P; Rivas, MA; Vedantam, S; Mahajan, A; Guo, X; Abecasis, G; Aben, KK; Adair, LS; Alam, DS; Albrecht, E; Allin, KH; Allison, M; Amouyel, P; Appel, EV; Arveiler, D; Asselbergs, FW; Auer, PL; Balkau, B; Banas, B; Bang, LE; Benn, M; Bergmann, S; Bielak, LF; Blüher, M; Boeing, H; Boerwinkle, E; Böger, CA; Bonnycastle, LL; Bork-Jensen, J; Bots, ML; Bottinger, EP; Bowden, DW; Brandslund, I; Breen, G; Brilliant, MH; Broer, L; Burt, AA; Butterworth, AS; Carey, DJ; Caulfield, MJ; Chambers, JC; Chasman, DI; Chen, Y-DI; Chowdhury, R; Christensen, C; Chu, AY; Cocca, M; Collins, FS; Cook, JP; Corley, J; Galbany, JC; Cox, AJ; Cuellar-Partida, G; Danesh, J; Davies, G; de Bakker, PIW; de Borst, GJ; de Denus, S; de Groot, MCH; de Mutsert, R; Deary, IJ; Dedoussis, G; Demerath, EW; den Hollander, AI; Dennis, JG; Di Angelantonio, E; Drenos, F; Du, M; Dunning, AM; Easton, DF; Ebeling, T; Edwards, TL; Ellinor, PT; Elliott, P; Evangelou, E; Farmaki, A-E; Faul, JD; Feitosa, MF; Feng, S; Ferrannini, E; Ferrario, MM; Ferrieres, J; Florez, JC; Ford, I; Fornage, M; Franks, PW; Frikke-Schmidt, R; Galesloot, TE; Gan, W; Gandin, I; Gasparini, P; Giedraitis, V; Giri, A; Girotto, G; Gordon, SD; Gordon-Larsen, P; Gorski, M; Grarup, N; Grove, ML; Gudnason, V; Gustafsson, S; Hansen, T; Harris, KM; Harris, TB; Hattersley, AT; Hayward, C; He, L; Heid, IM; Heikkilä, K; Helgeland, Ø; Hernesniemi, J; Hewitt, AW; Hocking, LJ; Hollensted, M; Holmen, OL; Hovingh, GK; Howson, JMM; Hoyng, CB; Huang, PL; Hveem, K; Ikram, MA; Ingelsson, E; Jackson, AU; Jansson, J-H; Jarvik, GP; Jensen, GB; Jhun, MA; Jia, Y; Jiang, X; Johansson, S; Jørgensen, ME; Jørgensen, T; Jousilahti, P; Jukema, JW; Kahali, B; Kahn, RS; Kähönen, M; Kamstrup, PR; Kanoni, S; Kaprio, J; Karaleftheri, M; Kardia, SLR; Karpe, F; Kee, F; Keeman, R; Kiemeney, LA; Kitajima, H; Kluivers, KB; Kocher, T; Komulainen, P; Kontto, J; Kooner, JS; Kooperberg, C; Kovacs, P; Kriebel, J; Kuivaniemi, H; Küry, S; Kuusisto, J; La Bianca, M; Laakso, M; Lakka, TA; Lange, EM; Lange, LA; Langefeld, CD; Langenberg, C; Larson, EB; Lee, I-T; Lehtimäki, T; Lewis, CE; Li, H; Li, J; Li-Gao, R; Lin, H; Lin, L-A; Lin, X; Lind, L; Lindström, J; Linneberg, A; Liu, Y; Liu, Y; Lophatananon, A; Luan, J; Lubitz, SA; Lyytikäinen, L-P; Mackey, DA; Madden, PAF; Manning, AK; Männistö, S; Marenne, G; Marten, J; Martin, NG; Mazul, AL; Meidtner, K; Metspalu, A; Mitchell, P; Mohlke, KL; Mook-Kanamori, DO; Morgan, A; Morris, AD; Morris, AP; Müller-Nurasyid, M; Munroe, PB; Nalls, MA; Nauck, M; Nelson, CP; Neville, M; Nielsen, SF; Nikus, K; Njølstad, PR; Nordestgaard, BG; Ntalla, I; O'Connel, JR; Oksa, H; Loohuis, LMO; Ophoff, RA; Owen, KR; Packard, CJ; Padmanabhan, S; Palmer, CNA; Pasterkamp, G; Patel, AP; Pattie, A; Pedersen, O; Peissig, PL; Peloso, GM; Pennell, CE; Perola, M; Perry, JA; Perry, JRB; Person, TN; Pirie, A; Polasek, O; Posthuma, D; Raitakari, OT; Rasheed, A; Rauramaa, R; Reilly, DF; Reiner, AP; Renström, F; Ridker, PM; Rioux, JD; Robertson, N; Robino, A; Rolandsson, O; Rudan, I; Ruth, KS; Saleheen, D; Salomaa, V; Samani, NJ; Sandow, K; Sapkota, Y; Sattar, N; Schmidt, MK; Schreiner, PJ; Schulze, MB; Scott, RA; Segura-Lepe, MP; Shah, S; Sim, X; Sivapalaratnam, S; Small, KS; Smith, AV; Smith, JA; Southam, L; Spector, TD; Speliotes, EK; Starr, JM; Steinthorsdottir, V; Stringham, HM; Stumvoll, M; Surendran, P; 't Hart, LM; Tansey, KE; Tardif, J-C; Taylor, KD; Teumer, A; Thompson, DJ; Thorsteinsdottir, U; Thuesen, BH; Tönjes, A; Tromp, G; Trompet, S; Tsafantakis, E; Tuomilehto, J; Tybjaerg-Hansen, A; Tyrer, JP; Uher, R; Uitterlinden, AG; Ulivi, S; van der Laan, SW; Van Der Leij, AR; van Duijn, CM; van Schoor, NM; van Setten, J; Varbo, A; Varga, TV; Varma, R; Edwards, DRV; Vermeulen, SH; Vestergaard, H; Vitart, V; Vogt, TF; Vozzi, D; Walker, M; Wang, F; Wang, CA; Wang, S; Wang, Y; Wareham, NJ; Warren, HR; Wessel, J; Willems, SM; Wilson, JG; Witte, DR; Woods, MO; Wu, Y; Yaghootkar, H; Yao, J; Yao, P; Yerges-Armstrong, LM; Young, R; Zeggini, E; Zhan, X; Zhang, W; Zhao, JH; Zhao, W; Zhao, W; Zheng, H; Zhou, W; EPIC-InterAct Consortium; CHD Exome+ Consortium; ExomeBP Consortium; T2D-Genes Consortium; GoT2D Genes Consortium; Global Lipids Genetics Consortium; ReproGen Consortium; MAGIC Investigators; Rotter, JI; Boehnke, M; Kathiresan, S; McCarthy, MI; Willer, CJ; Stefansson, K; Borecki, IB; Liu, DJ; North, KE; Heard-Costa, NL; Pers, TH; Lindgren, CM; Oxvig, C; Kutalik, Z; Rivadeneira, F; Loos, RJF; Frayling, TM; Hirschhorn, JN; Deloukas, P; Lettre, G (Nature Publishing Group, 2017-02-01)
    Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with ...