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  • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

    Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N; Rivas, MA; Mahajan, A; Locke, AE; Cingolani, P; Pers, TH; Viñuela, A; Brown, AA; Wu, Y; Flannick, J; Fuchsberger, C; Gamazon, ER; Gaulton, KJ; Im, HK; Teslovich, TM; Blackwell, TW; Bork-Jensen, J; Burtt, NP; Chen, Y; Green, T; Hartl, C; Kang, HM; Kumar, A; Ladenvall, C; Ma, C; Moutsianas, L; Pearson, RD; Perry, JRB; Rayner, NW; Robertson, NR; Scott, LJ; van de Bunt, M; Eriksson, JG; Jula, A; Koskinen, S; Lehtimäki, T; Palotie, A; Raitakari, OT; Jacobs, SB; Wessel, J; Chu, AY; Scott, RA; Goodarzi, MO; Blancher, C; Buck, G; Buck, D; Chines, PS; Gabriel, S; Gjesing, AP; Groves, CJ; Hollensted, M; Huyghe, JR; Jackson, AU; Jun, G; Justesen, JM; Mangino, M; Murphy, J; Neville, M; Onofrio, R; Small, KS; Stringham, HM; Trakalo, J; Banks, E; Carey, J; Carneiro, MO; DePristo, M; Farjoun, Y; Fennell, T; Goldstein, JI; Grant, G; Hrabé de Angelis, M; Maguire, J; Neale, BM; Poplin, R; Purcell, S; Schwarzmayr, T; Shakir, K; Smith, JD; Strom, TM; Wieland, T; Lindstrom, J; Brandslund, I; Christensen, C; Surdulescu, GL; Lakka, TA; Doney, ASF; Nilsson, P; Wareham, NJ; Langenberg, C; Varga, TV; Franks, PW; Rolandsson, O; Rosengren, AH; Farook, VS; Thameem, F; Puppala, S; Kumar, S; Lehman, DM; Jenkinson, CP; Curran, JE; Hale, DE; Fowler, SP; Arya, R; DeFronzo, RA; Abboud, HE; Syvänen, A-C; Hicks, PJ; Palmer, ND; Ng, MCY; Bowden, DW; Freedman, BI; Esko, T; Mägi, R; Milani, L; Mihailov, E; Metspalu, A; Narisu, N; Kinnunen, L; Bonnycastle, LL; Swift, A; Pasko, D; Wood, AR; Fadista, J; Pollin, TI; Barzilai, N; Atzmon, G; Glaser, B; Thorand, B; Strauch, K; Peters, A; Roden, M; Müller-Nurasyid, M; Liang, L; Kriebel, J; Illig, T; Grallert, H; Gieger, C; Meisinger, C; Lannfelt, L; Musani, SK; Griswold, M; Taylor, HA; Wilson, G; Correa, A; Oksa, H; Scott, WR; Afzal, U; Tan, S-T; Loh, M; Chambers, JC; Sehmi, J; Kooner, JS; Lehne, B; Cho, YS; Lee, J-Y; Han, B-G; Käräjämäki, A; Qi, Q; Qi, L; Huang, J; Hu, FB; Melander, O; Orho-Melander, M; Below, JE; Aguilar, D; Wong, TY; Liu, J; Khor, C-C; Chia, KS; Lim, WY; Cheng, C-Y; Chan, E; Tai, ES; Aung, T; Linneberg, A; Isomaa, B; Meitinger, T; Tuomi, T; Hakaste, L; Kravic, J; Jørgensen, ME; Lauritzen, T; Deloukas, P; Stirrups, KE; Owen, KR; Farmer, AJ; Frayling, TM; O'Rahilly, SP; Walker, M; Levy, JC; Hodgkiss, D; Hattersley, AT; Kuulasmaa, T; Stančáková, A; Barroso, I; Bharadwaj, D; Chan, J; Chandak, GR; Daly, MJ; Donnelly, PJ; Ebrahim, SB; Elliott, P; Fingerlin, T; Froguel, P; Hu, C; Jia, W; Ma, RCW; McVean, G; Park, T; Prabhakaran, D; Sandhu, M; Scott, J; Sladek, R; Tandon, N; Teo, YY; Zeggini, E; Watanabe, RM; Koistinen, HA; Kesaniemi, YA; Uusitupa, M; Spector, TD; Salomaa, V; Rauramaa, R; Palmer, CNA; Prokopenko, I; Morris, AD; Bergman, RN; Collins, FS; Lind, L; Ingelsson, E; Tuomilehto, J; Karpe, F; Groop, L; Jørgensen, T; Hansen, T; Pedersen, O; Kuusisto, J; Abecasis, G; Bell, GI; Blangero, J; Cox, NJ; Duggirala, R; Seielstad, M; Wilson, JG; Dupuis, J; Ripatti, S; Hanis, CL; Florez, JC; Mohlke, KL; Meigs, JB; Laakso, M; Morris, AP; Boehnke, M; Altshuler, D; McCarthy, MI; Gloyn, AL; Lindgren, CM (American Diabetes Association, 2017-03-24)
    To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...