College of Medicine and Health: Recent submissions
Now showing items 1-5 of 3316
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Using SNP-chips to detect very rare pathogenic variants: retrospective population-based diagnostic evaluation
(BMJ Publishing Group, 2021)Objective: To determine whether the sensitivity and specificity of SNP-chips are adequate for detecting rare pathogenic variants in a clinically unselected population. Design: We compared genotypes from SNP-chips (index ... -
Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort
(IOS Press, 3 January 2021)Background: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimated p.C282Y ... -
Cohort Profile Update: The Harmonised Cognitive Assessment Protocol Sub-study of the English Longitudinal Study of Ageing (ELSA-HCAP)
(International Epidemiological Association / Oxford University Press (OUP), 28 December 2020) -
Internet-based Cognitive Behavioral Therapy for Depression : An Individual Patient Data Network Meta-Analysis
(American Medical Association, 2021)IMPORTANCE Personalized treatment choices would increase the effectiveness of internet40 based Cognitive Behavioral Therapy (iCBT) for depression to the extent that patients differ in interventions that better suit ... -
Electroconvulsive Therapy related Autobiographical Amnesia: ‘Somatoform’ or ‘Organic’? - A review and case report
(Taylor & Francis (Routledge), 2021)Introduction: While short-term cognitive impairment following electro-convulsive therapy (ECT) is well described and acknowledged, the relationship between ECT and persistent memory impairment, particularly of autobiographical ...