Now showing items 1-6 of 6

  • Defining the role of common variation in the genomic and biological architecture of adult human height. 

    Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J; Lo, KS; Locke, AE; Mägi, R; Mihailov, E; Porcu, E; Randall, JC; Scherag, A; Vinkhuyzen, AA; Westra, HJ; Winkler, TW; Workalemahu, T; Zhao, JH; Absher, D; Albrecht, E; Anderson, D; Baron, J; Beekman, M; Demirkan, A; Ehret, GB; Feenstra, B; Feitosa, MF; Fischer, K; Fraser, RM; Goel, A; Gong, J; Justice, AE; Kanoni, S; Kleber, ME; Kristiansson, K; Lim, U; Lotay, V; Lui, JC; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Nalls, MA; Nyholt, DR; Palmer, CD; Pasko, D; Pechlivanis, S; Prokopenko, I; Ried, JS; Ripke, S; Shungin, D; Stancáková, A; Strawbridge, RJ; Sung, YJ; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van Setten, J; Van Vliet-Ostaptchouk, JV; Wang, Z; Yengo, L; Zhang, W; Afzal, U; Arnlöv, J; Arscott, GM; Bandinelli, S; Barrett, A; Bellis, C; Bennett, AJ; Berne, C; Blüher, M; Bolton, JL; Böttcher, Y; Boyd, HA; Bruinenberg, M; Buckley, BM; Buyske, S; Caspersen, IH; Chines, PS; Clarke, R; Claudi-Boehm, S; Cooper, M; Daw, EW; De Jong, PA; Deelen, J; Delgado, G; Denny, JC; Dhonukshe-Rutten, R; Dimitriou, M; Doney, AS; Dörr, M; Eklund, N; Eury, E; Folkersen, L; Garcia, ME; Geller, F; Giedraitis, V; Go, AS; Grallert, H; Grammer, TB; Gräßler, J; Grönberg, H; de Groot, LC; Groves, CJ; Haessler, J; Hall, P; Haller, T; Hallmans, G; Hannemann, A; Hartman, CA; Hassinen, M; Hayward, C; Heard-Costa, NL; Helmer, Q; Hemani, G; Henders, AK; Hillege, HL; Hlatky, MA; Hoffmann, W; Hoffmann, P; Holmen, O; Houwing-Duistermaat, JJ; Illig, T; Isaacs, A; James, AL; Jeff, J; Johansen, B; Johansson, Å; Jolley, J; Juliusdottir, T; Junttila, J; Kho, AN; Kinnunen, L; Klopp, N; Kocher, T; Kratzer, W; Lichtner, P; Lind, L; Lindström, J; Lobbens, S; Lorentzon, M; Lu, Y; Lyssenko, V; Magnusson, PK; Mahajan, A; Maillard, M; McArdle, WL; McKenzie, CA; McLachlan, S; McLaren, PJ; Menni, C; Merger, S; Milani, L; Moayyeri, A; Monda, KL; Morken, MA; Müller, G; Müller-Nurasyid, M; Musk, AW; Narisu, N; Nauck, M; Nolte, IM; Nöthen, MM; Oozageer, L; Pilz, S; Rayner, NW; Renstrom, F; Robertson, NR; Rose, LM; Roussel, R; Sanna, S; Scharnagl, H; Scholtens, S; Schumacher, FR; Schunkert, H; Scott, RA; Sehmi, J; Seufferlein, T; Shi, J; Silventoinen, K; Smit, JH; Smith, AV; Smolonska, J; Stanton, AV; Stirrups, K; Stott, DJ; Stringham, HM; Sundström, J; Swertz, MA; Syvänen, AC; Tayo, BO; Thorleifsson, G; Tyrer, JP; van Dijk, S; van Schoor, NM; van der Velde, N; van Heemst, D; van Oort, FV; Vermeulen, SH; Verweij, N; Vonk, JM; Waite, LL; Waldenberger, M; Wennauer, R; Wilkens, LR; Willenborg, C; Wilsgaard, T; Wojczynski, MK; Wong, A; Wright, AF; Zhang, Q; Arveiler, D; Bakker, SJ; Beilby, J; Bergman, RN; Bergmann, S; Biffar, R; Blangero, J; Boomsma, DI; Bornstein, SR; Bovet, P; Brambilla, P; Brown, MJ; Campbell, H; Caulfield, MJ; Chakravarti, A; Collins, R; Collins, FS; Crawford, DC; Cupples, LA; Danesh, J; de Faire, U; den Ruijter, HM; Erbel, R; Erdmann, J; Eriksson, JG; Farrall, M; Ferrannini, E; Ferrières, J; Ford, I; Forouhi, NG; Forrester, T; Gansevoort, RT; Gejman, PV; Gieger, C; Golay, A; Gottesman, O; Gudnason, V; Gyllensten, U; Haas, DW; Hall, AS; Harris, TB; Hattersley, AT; Heath, AC; Hengstenberg, C; Hicks, AA; Hindorff, LA; Hingorani, AD; Hofman, A; Hovingh, GK; Humphries, SE; Hunt, SC; Hypponen, E; Jacobs, KB; Jarvelin, MR; Jousilahti, P; Jula, AM; Kaprio, J; Kastelein, JJ; Kayser, M; Kee, F; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Kooner, JS; Kooperberg, C; Koskinen, S; Kovacs, P; Kraja, AT; Kumari, M; Kuusisto, J; Lakka, TA; Langenberg, C; Le Marchand, L; Lehtimäki, T; Lupoli, S; Madden, PA; Männistö, S; Manunta, P; Marette, A; Matise, TC; McKnight, B; Meitinger, T; Moll, FL; Montgomery, GW; Morris, AD; Morris, AP; Murray, JC; Nelis, M; Ohlsson, C; Oldehinkel, AJ; Ong, KK; Ouwehand, WH; Pasterkamp, G; Peters, A; Pramstaller, PP; Price, JF; Qi, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Ritchie, M; Rudan, I; Salomaa, V; Samani, NJ; Saramies, J; Sarzynski, MA; Schwarz, PE; Sebert, S; Sever, P; Shuldiner, AR; Sinisalo, J; Steinthorsdottir, V; Stolk, RP; Tardif, JC; Tönjes, A; Tremblay, A; Tremoli, E; Virtamo, J; Vohl, MC; Electronic Medical Records and Genomics (eMEMERGEGE) Consortium; MIGen Consortium; PAGEGE Consortium; LifeLines Cohort Study; Amouyel, P; Asselbergs, FW; Assimes, TL; Bochud, M; Boehm, BO; Boerwinkle, E; Bottinger, EP; Bouchard, C; Cauchi, S; Chambers, JC; Chanock, SJ; Cooper, RS; de Bakker, PI; Dedoussis, G; Ferrucci, L; Franks, PW; Froguel, P; Groop, LC; Haiman, CA; Hamsten, A; Hayes, MG; Hui, J; Hunter, DJ; Hveem, K; Jukema, JW; Kaplan, RC; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; Martin, NG; März, W; Melbye, M; Moebus, S; Munroe, PB; Njølstad, I; Oostra, BA; Palmer, CN; Pedersen, NL; Perola, M; Pérusse, L; Peters, U; Powell, JE; Power, C; Quertermous, T; Rauramaa, R; Reinmaa, E; Ridker, PM; Rivadeneira, F; Rotter, JI; Saaristo, TE; Saleheen, D; Schlessinger, D; Slagboom, PE; Snieder, H; Spector, TD; Strauch, K; Stumvoll, M; Tuomilehto, J; Uusitupa, M; van der Harst, P; Völzke, H; Walker, M; Wareham, NJ; Watkins, H; Wichmann, HE; Wilson, JF; Zanen, P; Deloukas, P; Heid, IM; Lindgren, CM; Mohlke, KL; Speliotes, EK; Thorsteinsdottir, U; Barroso, I; Fox, CS; North, KE; Strachan, DP; Beckmann, JS; Berndt, SI; Boehnke, M; Borecki, IB; McCarthy, MI; Metspalu, A; Stefansson, K; Uitterlinden, AG; van Duijn, CM; Franke, L; Willer, CJ; Price, AL; Lettre, G; Loos, RJ; Weedon, MN; Ingelsson, E; O'Connell, JR; Abecasis, GR; Chasman, DI; Goddard, ME; Visscher, PM; Hirschhorn, JN; Frayling, TM (Nature Publishing Group, 2014-10-05)
    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in ...
  • Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees 

    Jun, G; Manning, A; Almeida, M; Zawistowski, M; Wood, AR; Teslovich, TM; Fuchsberger, C; Feng, S; Cingolani, P; Gaulton, KJ; Dyer, T; Blackwell, TW; Chen, H; Chines, PS; Choi, S; Churchhouse, C; Fontanillas, P; King, R; Lee, S; Lincoln, SE; Trubetskoy, V; DePristo, M; Fingerlin, T; Grossman, R; Grundstad, J; Heath, A; Kim, J; Kim, YJ; Laramie, J; Lee, J; Li, H; Liu, X; Livne, O; Locke, AE; Maller, J; Mazur, A; Morris, AP; Pollin, TI; Ragona, D; Reich, D; Rivas, MA; Scott, LJ; Sim, X; Tearle, RG; Teo, YY; Williams, AL; Zöllner, S; Curran, JE; Peralta, J; Akolkar, B; Bell, GI; Burtt, NP; Cox, NJ; Florez, JC; Hanis, CL; McKeon, C; Mohlke, KL; Seielstad, M; Wilson, JG; Atzmon, G; Below, JE; Dupuis, J; Nicolae, DL; Lehman, D; Park, T; Won, S; Sladek, R; Altshuler, D; McCarthy, MI; Duggirala, R; Boehnke, M; Frayling, TM; Abecasis, GR; Blangero, J (National Academy of Sciences, 2018-01-09)
    A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare ...
  • The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study 

    Winkler, TW; Justice, AE; Graff, M; Barata, L; Feitosa, MF; Chu, S; Czajkowski, J; Esko, T; Fall, T; Kilpeläinen, TO; Lu, Y; Mägi, R; Mihailov, E; Pers, TH; Rüeger, S; Teumer, A; Ehret, GB; Ferreira, T; Heard-Costa, NL; Karjalainen, J; Lagou, V; Mahajan, A; Neinast, MD; Prokopenko, I; Simino, J; Teslovich, TM; Jansen, R; Westra, H-J; White, CC; Absher, D; Ahluwalia, TS; Ahmad, S; Albrecht, E; Alves, AC; Bragg-Gresham, JL; de Craen, AJM; Bis, JC; Bonnefond, A; Boucher, G; Cadby, G; Cheng, Y-C; Chiang, CWK; Delgado, G; Demirkan, A; Dueker, N; Eklund, N; Eiriksdottir, G; Eriksson, J; Feenstra, B; Fischer, K; Frau, F; Galesloot, TE; Geller, F; Goel, A; Gorski, M; Grammer, TB; Gustafsson, S; Haitjema, S; Hottenga, JJ; Huffman, JE; Jackson, AU; Jacobs, KB; Johansson, Å; Kaakinen, M; Kleber, ME; Lahti, J; Leach, IM; Lehne, B; Liu, Y; Lo, KS; Lorentzon, M; Luan, J; Madden, PAF; Mangino, M; McKnight, B; Medina-Gomez, C; Monda, KL; Montasser, ME; Müller, G; Müller-Nurasyid, M; Nolte, IM; Panoutsopoulou, K; Pascoe, L; Paternoster, L; Rayner, NW; Renström, F; Rizzi, F; Rose, LM; Ryan, KA; Salo, P; Sanna, S; Scharnagl, H; Shi, J; Smith, AV; Southam, L; Stančáková, A; Steinthorsdottir, V; Strawbridge, RJ; Sung, YJ; Tachmazidou, I; Tanaka, T; Thorleifsson, G; Trompet, S; Pervjakova, N; Tyrer, JP; Vandenput, L; van der Laan, SW; van der Velde, N; van Setten, J; van Vliet-Ostaptchouk, JV; Verweij, N; Vlachopoulou, E; Waite, LL; Wang, SR; Wang, Z; Wild, SH; Willenborg, C; Wilson, JF; Wong, A; Yang, J; Yengo, L; Yerges-Armstrong, LM; Yu, L; Zhang, W; Zhao, JH; Andersson, EA; Bakker, SJL; Baldassarre, D; Banasik, K; Barcella, M; Barlassina, C; Bellis, C; Benaglio, P; Blangero, J; Blüher, M; Bonnet, F; Bonnycastle, LL; Boyd, HA; Bruinenberg, M; Buchman, AS; Campbell, H; Chen, Y-DI; Chines, PS; Claudi-Boehm, S; Cole, J; Collins, FS; de Geus, Eco; de Groot, LCPGM; Dimitriou, M; Duan, J; Enroth, S; Eury, E; Farmaki, A-E; Forouhi, NG; Friedrich, N; Gejman, PV; Gigante, B; Glorioso, N; Go, AS; Gottesman, O; Gräßler, J; Grallert, H; Grarup, N; Gu, Y-M; Broer, L; Ham, AC; Hansen, T; Harris, Tamara; Hartman, CA; Hassinen, M; Hastie, N; Hattersley, Andrew T.; Heath, AC; Henders, AK; Hernandez, Dena; Hillege, Hans; Holmen, O; Hovingh, KG; Hui, J; Husemoen, LL; Hutri-Kähönen, N; Hysi, PG; Illig, T; De Jager, PL; Jalilzadeh, S; Jørgensen, T; Jukema, JW; Juonala, M; Kanoni, S; Karaleftheri, M; Khaw, KT; Kinnunen, L; Kittner, SJ; Koenig, W; Kolcic, I; Kovacs, P; Krarup, NT; Kratzer, W; Krüger, J; Kuh, D; Kumari, M; Kyriakou, T; Langenberg, C; Lannfelt, L; Lanzani, C; Lotay, V; Launer, LJ; Leander, K; Lindström, J; Linneberg, A; Liu, Y-P; Lobbens, S; Luben, R; Lyssenko, V; Männistö, S; Magnusson, PK; McArdle, WL; Menni, C; Merger, S; Milani, L; Montgomery, GW; Morris, AP; Narisu, N; Nelis, M; Ong, KK; Palotie, A; Pérusse, L; Pichler, I; Pilia, MG; Pouta, A; Rheinberger, M; Ribel-Madsen, R; Richards, M; Rice, KM; Rice, TK; Rivolta, C; Salomaa, V; Sanders, AR; Sarzynski, MA; Scholtens, S; Scott, RA; Scott, WR; Sebert, S; Sengupta, S; Sennblad, B; Seufferlein, T; Silveira, A; Slagboom, PE; Smit, JH; Sparsø, TH; Stirrups, K; Stolk, RP; Stringham, HM; Swertz, MA; Swift, AJ; Syvänen, A-C; Tan, S-T; Thorand, B; Tönjes, A; Tremblay, A; Tsafantakis, E; van der Most, PJ; Völker, U; Vohl, M-C; Vonk, JM; Waldenberger, M; Walker, RW; Wennauer, R; Widén, E; Willemsen, G; Wilsgaard, T; Wright, AF; Zillikens, MC; van Dijk, SC; van Schoor, NM; Asselbergs, FW; de Bakker, PIW; Beckmann, JS; Beilby, J; Bennett, DA; Bergman, RN; Bergmann, S; Böger, CA; Boehm, BO; Boerwinkle, E; Boomsma, DI; Bornstein, SR; Bottinger, EP; Bouchard, C; Chambers, JC; Chanock, SJ; Chasman, DI; Cucca, F; Cusi, D; Dedoussis, G; Erdmann, J; Eriksson, JG; Evans, DA; de Faire, U; Farrall, M; Ferrucci, L; Ford, I; Franke, L; Franks, PW; Froguel, P; Gansevoort, RT; Gieger, C; Grönberg, H; Gudnason, V; Gyllensten, U; Hall, P; Hamsten, A; van der Harst, P; Hayward, C; Heliövaara, M; Hengstenberg, C; Hicks, AA; Hingorani, Aroon; Hofman, A; Hu, F; Huikuri, HV; Hveem, K; James, AL; Jordan, JM; Jula, A; Kähönen, M; Kajantie, E; Kathiresan, S; Kiemeney, LALM; Kivimaki, M; Knekt, PB; Koistinen, HA; Kooner, JS; Koskinen, S; Kuusisto, J; Maerz, W; Martin, NG; Laakso, M; Lakka, TA; Lehtimäki, T; Lettre, G; Levinson, DF; Lind, L; Lokki, M-L; Mäntyselkä, P; Melbye, M; Metspalu, A; Mitchell, BD; Moll, FL; Murray, JC; Musk, AW; Nieminen, MS; Njølstad, I; Ohlsson, C; Oldehinkel, AJ; Oostra, BA; Palmer, LJ; Pankow, JS; Pasterkamp, G; Pedersen, NL; Pedersen, O; Penninx, BW; Perola, M; Peters, A; Polašek, O; Pramstaller, PP; Psaty, BM; Qi, L; Quertermous, T; Raitakari, OT; Rankinen, T; Rauramaa, R; Ridker, PM; Rioux, JD; Rivadeneira, F; Rotter, JI; Rudan, I; den Ruijter, HM; Saltevo, J; Sattar, N; Schunkert, H; Schwarz, PEH; Shuldiner, AR; Sinisalo, J; Snieder, H; Sørensen, TIA; Spector, TD; Staessen, JA; Stefania, B; Thorsteinsdottir, U; Stumvoll, M; Tardif, J-C; Tremoli, E; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; Verbeek, ALM; Vermeulen, SH; Viikari, JS; Vitart, V; Völzke, H; Vollenweider, P; Waeber, G; Walker, M; Wallaschofski, H; Wareham, NJ; Watkins, H; Zeggini, E; Chakravarti, A; Clegg, DJ; Cupples, LA; Gordon-Larsen, P; Jaquish, CE; Rao, DC; Abecasis, GR; Assimes, TL; Barroso, I; Berndt, SI; Boehnke, M; Deloukas, P; Fox, CS; Groop, LC; Hunter, DJ; Ingelsson, E; Kaplan, RC; McCarthy, MI; Mohlke, KL; O'Connell, JR; Schlessinger, D; Strachan, DP; Stefansson, K; van Duijn, CM; Hirschhorn, JN; Lindgren, CM; Heid, IM; North, KE; Borecki, IB; Kutalik, Z; Loos, RJF (Public Library of Science, 2015-10-01)
    Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size ...
  • Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair 

    Day, FR; Ruth, KS; Thompson, DJ; Lunetta, KL; Pervjakova, N; Chasman, DI; Stolk, L; Finucane, HK; Sulem, P; Bulik-Sullivan, B; Esko, T; Johnson, AD; Elks, CE; Franceschini, N; He, C; Altmaier, E; Brody, JA; Franke, L; Huffman, JE; Keller, MF; McArdle, PF; Nutile, T; Porcu, E; Robino, A; Rose, LM; Schick, UM; Smith, JA; Teumer, A; Traglia, M; Vuckovic, D; Yao, J; Zhao, W; Albrecht, E; Amin, N; Corre, T; Hottenga, JJ; Mangino, M; Smith, AV; Tanaka, T; Abecasis, GR; Andrulis, IL; Anton-Culver, H; Antoniou, AC; Arndt, V; Arnold, AM; Barbieri, C; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bernstein, L; Bielinski, SJ; Blomqvist, C; Boerwinkle, E; Bogdanova, NV; Bojesen, SE; Bolla, MK; Borresen-Dale, AL; Boutin, TS; Brauch, H; Brenner, H; Brüning, T; Burwinkel, B; Campbell, A; Campbell, H; Chanock, SJ; Chapman, JR; Chen, YI; Chenevix-Trench, G; Couch, FJ; Coviello, AD; Cox, A; Czene, K; Darabi, H; De Vivo, I; Demerath, EW; Dennis, J; Devilee, P; Dörk, T; Dos-Santos-Silva, I; Dunning, AM; Eicher, JD; Fasching, PA; Faul, JD; Figueroa, J; Flesch-Janys, D; Gandin, I; Garcia, ME; García-Closas, M; Giles, Graham; Girotto, GG; Goldberg, MS; González-Neira, A; Goodarzi, Mark O.; Grove, ML; Gudbjartsson, DF; Guénel, P; Guo, Xiuqing; Haiman, CA; Hall, P; Hamann, U; Henderson, BE; Hocking, LJ; Hofman, A; Homuth, G; Hooning, MJ; Hopper, JL; Hu, FB; Huang, J; Humphreys, K; Hunter, DJ; Jakubowska, A; Jones, SE; Kabisch, M; Karasik, D; Knight, JA; Kolcic, I; Kooperberg, C; Kosma, VM; Kriebel, J; Kristensen, V; Lambrechts, D; Langenberg, C; Li, J; Li, X; Lindström, S; Liu, Y; Luan, J; Lubinski, J; Mägi, R; Mannermaa, A; Manz, J; Margolin, S; Marten, J; Martin, NG; Masciullo, C; Meindl, A; Michailidou, K; Mihailov, E; Milani, L; Milne, RL; Müller-Nurasyid, M; Nalls, M; Neale, BM; Nevanlinna, H; Neven, P; Newman, AB; Nordestgaard, BG; Olson, JE; Padmanabhan, S; Peterlongo, P; Peters, U; Petersmann, A; Peto, J; Pharoah, PD; Pirastu, NN; Pirie, A; Pistis, G; Polasek, O; Porteous, D; Psaty, BM; Pylkäs, K; Radice, P; Raffel, Leslie J.; Rivadeneira, F; Rudan, I; Rudolph, A; Ruggiero, D; Sala, CF; Sanna, S; Sawyer, EJ; Schlessinger, D; Schmidt, MK; Schmidt, F; Schmutzler, RK; Schoemaker, MJ; Scott, RA; Seynaeve, CM; Simard, J; Sorice, R; Southey, MC; Stöckl, D; Strauch, K; Swerdlow, A; Taylor, KD; Thorsteinsdottir, U; Toland, AE; Tomlinson, I; Truong, T; Tryggvadottir, L; Turner, ST; Vozzi, D; Wang, Q; Wellons, M; Willemsen, G; Wilson, JF; Winqvist, R; Wolffenbuttel, BB; Wright, AF; Yannoukakos, D; Zemunik, T; Zheng, W; Zygmunt, M; Bergmann, S; Boomsma, DI; Buring, JE; Ferrucci, L; Montgomery, GW; Gudnason, V; Spector, TD; van Duijn, CM; Alizadeh, BZ; Ciullo, M; Crisponi, L; Easton, DF; Gasparini, Paolo; Gieger, C; Harris, Tamara; Hayward, C; Kardia, SL; Kraft, P; McKnight, B; Metspalu, A; Morrison, AC; Reiner, AP; Ridker, PM; Rotter, JI; Toniolo, D; Uitterlinden, AG; Ulivi, S; Völzke, H; Wareham, NJ; Weir, DR; Yerges-Armstrong, LM; PRACTICAL Consortium; kConFab Investigators; AOCS Investigators; Generation Scotland; EPIC-InterAct Consortium; LifeLines Cohort Study; Price, AL; Stefansson, K; Visser, JA; Ong, KK; Chang-Claude, J; Murabito, JM; Perry, JR; Murray, A (Nature Publishing Group, 2015-09-28)
    Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and ...
  • New genetic loci link adipose and insulin biology to body fat distribution 

    Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, Krista; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, Felix R.; Esko, T; Fall, T; Kutalik, Z; Luan, J; Randall, JC; Scherag, A; Vedantam, S; Wood, Andrew R.; Chen, J; Fehrmann, R; Karjalainen, J; Kahali, B; Liu, CT; Schmidt, EM; Absher, D; Amin, N; Anderson, D; Beekman, M; Bragg-Gresham, JL; Buyske, S; Demirkan, A; Ehret, GB; Feitosa, MF; Goel, A; Jackson, AU; Johnson, T; Kleber, ME; Kristiansson, K; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Palmer, CD; Pasko, Dorota; Pechlivanis, S; Peters, MJ; Prokopenko, I; Stančáková, A; Ju Sung, Y; Tanaka, T; Teumer, A; Van Vliet-Ostaptchouk, JV; Yengo, L; Zhang, W; Albrecht, E; Ärnlöv, J; Arscott, GM; Bandinelli, S; Barrett, A; Bellis, C; Bennett, AJ; Berne, C; Blüher, M; Böhringer, S; Bonnet, F; Böttcher, Y; Bruinenberg, M; Carba, DB; Caspersen, IH; Clarke, R; Daw, EW; Deelen, J; Deelman, E; Delgado, G; Doney, AS; Eklund, N; Erdos, MR; Estrada, K; Eury, E; Friedrich, N; Garcia, ME; Giedraitis, V; Gigante, B; Go, AS; Golay, A; Grallert, H; Grammer, TB; Gräßler, J; Grewal, J; Groves, Christopher J.; Haller, T; Hallmans, G; Hartman, CA; Hassinen, M; Hayward, C; Heikkilä, K; Herzig, KH; Helmer, Q; Hillege, Hans; Holmen, O; Hunt, SC; Isaacs, A; Ittermann, T; James, AL; Johansson, I; Juliusdottir, T; Kalafati, IP; Kinnunen, L; Koenig, W; Kooner, IK; Kratzer, W; Lamina, C; Leander, K; Lee, NR; Lichtner, P; Lind, L; Lindström, J; Lobbens, S; Lorentzon, M; Mach, F; Magnusson, PK; Mahajan, A; McArdle, WL; Menni, C; Merger, S; Mihailov, E; Milani, L; Mills, R; Moayyeri, A; Monda, KL; Mooijaart, SP; Mühleisen, TW; Mulas, A; Müller, G; Müller-Nurasyid, M; Nagaraja, R; Nalls, MA; Narisu, N; Glorioso, N; Nolte, IM; Olden, M; Rayner, NW; Renstrom, F; Ried, JS; Robertson, NR; Rose, LM; Sanna, S; Scharnagl, H; Scholtens, S; Sennblad, B; Seufferlein, T; Sitlani, CM; 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    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and ...
  • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape 

    Ried, JS; Jeff M, J; Chu, AY; Bragg-Gresham, JL; van Dongen, J; Huffman, JE; Ahluwalia, TS; Cadby, G; Eklund, N; Eriksson, J; Esko, T; Feitosa, MF; Goel, A; Gorski, M; Hayward, C; Heard-Costa, NL; Jackson, AU; Jokinen, E; Kanoni, S; Kristiansson, K; Kutalik, Z; Lahti, J; Luan, J; Mägi, R; Mahajan, A; Mangino, M; Medina-Gomez, C; Monda, KL; Nolte, IM; Pérusse, L; Prokopenko, I; Qi, L; Rose, LM; Salvi, E; Smith, MT; Snieder, H; Stančáková, A; Ju Sung, Y; Tachmazidou, I; Teumer, A; Thorleifsson, G; van der Harst, P; Walker, RW; Wang, SR; Wild, SH; Willems, SM; Wong, A; Zhang, W; Albrecht, E; Couto Alves, A; Bakker, SJL; Barlassina, C; Bartz, TM; Beilby, J; Bellis, C; Bergman, RN; Bergmann, S; Blangero, J; Blüher, M; Boerwinkle, E; Bonnycastle, LL; Bornstein, SR; Bruinenberg, M; Campbell, H; Chen, Y-DI; Chiang, CWK; Chines, PS; Collins, FS; Cucca, F; Cupples, LA; D'Avila, F; de Geus, EJC; Dedoussis, G; Dimitriou, M; Döring, A; Eriksson, JG; Farmaki, A-E; Farrall, M; Ferreira, T; Fischer, K; Forouhi, NG; Friedrich, N; Gjesing, AP; Glorioso, N; Graff, M; Grallert, H; Grarup, N; Gräßler, J; Grewal, J; Hamsten, A; Harder, MN; Hartman, CA; Hassinen, M; Hastie, N; Hattersley, AT; Havulinna, AS; Heliövaara, M; Hillege, H; Hofman, A; Holmen, O; Homuth, G; Hottenga, J-J; Hui, J; Husemoen, LL; Hysi, PG; Isaacs, A; Ittermann, T; Jalilzadeh, S; James, AL; Jørgensen, T; Jousilahti, P; Jula, A; Marie Justesen, J; Justice, AE; Kähönen, M; Karaleftheri, M; Tee Khaw, K; Keinanen-Kiukaanniemi, SM; Kinnunen, L; Knekt, PB; Koistinen, HA; Kolcic, I; Kooner, IK; Koskinen, S; Kovacs, P; Kyriakou, T; Laitinen, T; Langenberg, C; Lewin, AM; Lichtner, P; Lindgren, CM; Lindström, J; Linneberg, A; Lorbeer, R; Lorentzon, M; Luben, R; Lyssenko, V; Männistö, S; Manunta, P; Leach, IM; McArdle, WL; Mcknight, B; Mohlke, KL; Mihailov, E; Milani, L; Mills, R; Montasser, ME; Morris, AP; Müller, G; Musk, AW; Narisu, N; Ong, KK; Oostra, BA; Osmond, C; Palotie, A; Pankow, JS; Paternoster, L; Penninx, BW; Pichler, I; Pilia, MG; Polašek, O; Pramstaller, PP; Raitakari, OT; Rankinen, T; Rao, DC; Rayner, NW; Ribel-Madsen, R; Rice, TK; Richards, M; Ridker, PM; Rivadeneira, F; Ryan, KA; Sanna, S; Sarzynski, MA; Scholtens, S; Scott, RA; Sebert, S; Southam, L; Sparsø, TH; Steinthorsdottir, V; Stirrups, K; Stolk, RP; Strauch, K; Stringham, HM; Swertz, MA; Swift, AJ; Tönjes, A; Tsafantakis, E; van der Most, PJ; Van Vliet-Ostaptchouk, JV; Vandenput, L; Vartiainen, E; Venturini, C; Verweij, N; Viikari, JS; Vitart, V; Vohl, M-C; Vonk, JM; Waeber, G; Widén, E; Willemsen, G; Wilsgaard, T; Winkler, TW; Wright, AF; Yerges-Armstrong, LM; Hua Zhao, J; Carola Zillikens, M; Boomsma, DI; Bouchard, C; Chambers, JC; Chasman, DI; Cusi, D; Gansevoort, RT; Gieger, C; Hansen, T; Hicks, AA; Hu, F; Hveem, K; Jarvelin, M-R; Kajantie, E; Kooner, JS; Kuh, D; Kuusisto, J; Laakso, M; Lakka, TA; Lehtimäki, T; Metspalu, A; Njølstad, I; Ohlsson, C; Oldehinkel, AJ; Palmer, LJ; Pedersen, O; Perola, M; Peters, A; Psaty, BM; Puolijoki, H; Rauramaa, R; Rudan, I; Salomaa, V; Schwarz, PEH; Shudiner, AR; Smit, JH; Sørensen, TIA; Spector, TD; Stefansson, K; Stumvoll, M; Tremblay, A; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; Völker, U; Vollenweider, P; Wareham, NJ; Watkins, H; Wilson, JF; Zeggini, E; Abecasis, GR; Boehnke, M; Borecki, IB; Deloukas, P; van Duijn, CM; Fox, C; Groop, LC; Heid, IM; Hunter, DJ; Kaplan, RC; McCarthy, MI; North, KE; O'Connell, JR; Schlessinger, D; Thorsteinsdottir, U; Strachan, DP; Frayling, T; Hirschhorn, JN; Müller-Nurasyid, M; Loos, RJF (Nature Publishing Group, 2016-11-23)
    Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...