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  • Genetic studies of body mass index yield new insights for obesity biology 

    Locke, Adam E.; Kahali, Bratati; Berndt, Sonja I.; Justice, Anne E.; Pers, Tune H.; Day, Felix R.; Powell, Corey; Vedantam, S; Buchkovich, ML; Yang, J; Croteau-Chonka, DC; Esko, T; Fall, T; Ferreira, T; Gustafsson, S; Kutalik, Z; Luan, J; Mägi, R; Randall, JC; Winkler, TW; Wood, Andrew R.; Workalemahu, T; Faul, JD; Smith, JA; Hua Zhao, J; Zhao, W; Chen, J; Fehrmann, R; Hedman, ÅK; Karjalainen, J; Schmidt, EM; Absher, D; Amin, N; Anderson, D; Beekman, M; Bolton, JL; Bragg-Gresham, JL; Buyske, S; Demirkan, A; Deng, G; Ehret, GB; Feenstra, B; Feitosa, MF; Fischer, Krista; Goel, A; Gong, J; Jackson, AU; Kanoni, S; Kleber, ME; Kristiansson, K; Lim, U; Lotay, V; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Medland, SE; Nalls, MA; Palmer, CD; Pasko, Dorota; Pechlivanis, S; Peters, MJ; Prokopenko, I; Shungin, D; Stančáková, A; Strawbridge, RJ; Ju Sung, Y; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van Setten, J; Van Vliet-Ostaptchouk, JV; Wang, Z; Yengo, L; Zhang, W; Isaacs, A; Albrecht, E; Ärnlöv, J; Arscott, GM; Attwood, AP; Bandinelli, S; Barrett, Amy; Bas, IN; Bellis, C; Bennett, Amanda; Berne, C; Blagieva, R; Blüher, M; Böhringer, S; Bonnycastle, Lori; Böttcher, Y; Boyd, HA; Bruinenberg, M; Caspersen, IH; Ida Chen, YD; Clarke, R; Daw, EW; de Craen, AJ; Delgado, G; Dimitriou, M; Doney, AS; Eklund, N; Estrada, K; Eury, E; Folkersen, L; Fraser, RM; Garcia, ME; Geller, F; Giedraitis, V; Gigante, B; Go, AS; Golay, A; Goodall, AH; Gordon, SD; Gorski, M; Grabe, HJ; Grallert, H; Grammer, TB; Gräßler, J; Grönberg, H; Groves, Christopher J.; Gusto, G; Haessler, J; Hall, P; Haller, T; Hallmans, G; Hartman, CA; Hassinen, M; Hayward, C; Heard-Costa, NL; Helmer, Q; Hengstenberg, C; Holmen, O; Hottenga, JJ; James, AL; Jeff, JM; Johansson, Å; Jolley, J; Juliusdottir, T; Kinnunen, L; Koenig, W; Koskenvuo, M; Kratzer, W; Laitinen, J; Lamina, C; Leander, K; Lee, NR; Lichtner, P; Lind, L; Lindström, J; Sin Lo, K; Lobbens, S; Lorbeer, R; Lu, Y; Mach, F; Magnusson, PK; Mahajan, A; McArdle, WL; McLachlan, S; Menni, C; Merger, S; Mihailov, E; Milani, L; Moayyeri, A; Monda, KL; Morken, MA; Mulas, A; Müller, G; Müller-Nurasyid, M; Musk, AW; Nagaraja, R; Nöthen, MM; Nolte, IM; Pilz, S; Rayner, NW; Renstrom, F; Rettig, R; Ried, JS; Ripke, S; Robertson, NR; Rose, LM; Sanna, S; Scharnagl, H; Scholtens, S; Schumacher, FR; Scott, WR; Seufferlein, T; Shi, J; Vernon Smith, A; Smolonska, J; Stanton, AV; Steinthorsdottir, V; Stirrups, K; Stringham, HM; Sundström, J; Swertz, MA; Swift, AJ; Syvänen, AC; Tan, ST; Tayo, BO; Thorand, B; Thorleifsson, G; Tyrer, JP; Uh, HW; Vandenput, L; Verhulst, FC; Vermeulen, SH; Verweij, N; Vonk, JM; Waite, LL; Warren, HR; Waterworth, D; Weedon, Michael N.; Wilkens, LR; Willenborg, C; Wilsgaard, T; Wojczynski, MK; Wong, A; Wright, AF; Zhang, Q; LifeLines Cohort Study; Brennan, EP; Choi, M; Dastani, Z; Drong, AW; Eriksson, P; Franco-Cereceda, A; Gådin, JR; Gharavi, AG; Goddard, ME; Handsaker, RE; Huang, J; Karpe, F; Kathiresan, S; Keildson, S; Kiryluk, K; Kubo, M; Lee, JY; Liang, L; Lifton, RP; Ma, B; McCarroll, SA; McKnight, AJ; Min, JL; Moffatt, MF; Montgomery, GW; Murabito, JM; Nicholson, G; Nyholt, DR; Okada, Y; Perry, John R.B.; Dorajoo, R; Reinmaa, E; Salem, RM; Sandholm, N; Scott, RA; Stolk, L; Takahashi, A; Tanaka, T; Van't Hooft, FM; Vinkhuyzen, AA; Westra, HJ; Zheng, W; Zondervan, KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath, AC; Arveiler, D; Bakker, SJ; Beilby, John P.; Bergman, RN; Blangero, J; Bovet, P; Campbell, H; Caulfield, MJ; Cesana, G; Chakravarti, A; Chasman, DI; Chines, PS; Collins, FS; Crawford, DC; Cupples, LA; Cusi, D; Danesh, J; de Faire, U; den Ruijter, HM; Dominiczak, AF; Erbel, R; Erdmann, J; Eriksson, Johan G.; Farrall, M; Felix, SB; Ferrannini, E; Ferrières, J; Ford, I; Forouhi, NG; Forrester, T; Franco, OH; Gansevoort, RT; Gejman, PV; Gieger, C; Gottesman, O; Gudnason, V; Gyllensten, U; Hall, AS; Harris, Tamara; Hattersley, Andrew T.; Hicks, AA; Hindorff, LA; Hingorani, Aroon; Hofman, A; Homuth, G; Hovingh, GK; Humphries, SE; Hunt, SC; Hyppönen, E; Illig, T; Jacobs, KB; Jarvelin, MR; Jöckel, KH; Johansen, B; Jousilahti, P; Jukema, JW; Jula, AM; Kaprio, J; Kastelein, JJ; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Knekt, P; Kooner, JS; Kooperberg, C; Kovacs, P; Kraja, AT; Kumari, M; Kuusisto, J; Lakka, TA; Langenberg, C; Le Marchand, L; Lehtimäki, T; Lyssenko, V; Männistö, S; Marette, A; Matise, TC; McKenzie, CA; McKnight, B; Moll, FL; Morris, AD; Morris, AP; Murray, JC; Nelis, M; Ohlsson, C; Oldehinkel, AJ; Ong, KK; Madden, PA; Pasterkamp, G; Peden, JF; Peters, A; Postma, DS; Pramstaller, PP; Price, JF; Qi, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Ridker, PM; Rioux, JD; Ritchie, MD; Rudan, I; Salomaa, V; Samani, NJ; Saramies, J; Sarzynski, MA; Schunkert, H; Schwarz, PE; Sever, P; Shuldiner, AR; Sinisalo, J; Stolk, RP; Strauch, K; Tönjes, A; Trégouët, DA; Tremblay, A; Tremoli, E; Virtamo, J; Vohl, MC; Völker, U; Waeber, G; Willemsen, G; Witteman, JC; Zillikens, MC; Adair, LS; Amouyel, P; Asselbergs, FW; Assimes, TL; Bochud, M; Boehm, BO; Boerwinkle, E; Bornstein, SR; Bottinger, EP; Bouchard, C; Cauchi, S; Chambers, JC; Chanock, SJ; Cooper, RS; de Bakker, PI; Dedoussis, George V.; Ferrucci, L; Franks, PW; Froguel, P; Groop, Leif; Haiman, CA; Hamsten, A; Hui, J; Hunter, DJ; Hveem, K; Kaplan, RC; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; Martin, NG; März, W; Melbye, M; Metspalu, A; Moebus, S; Munroe, PB; Njølstad, I; Oostra, BA; Palmer, CN; Pedersen, NL; Perola, M; Pérusse, L; Peters, U; Power, C; Quertermous, T; Rauramaa, R; Rivadeneira, F; Saaristo, TE; Saleheen, D; Sattar, N; Schadt, EE; Schlessinger, D; Slagboom, PE; Snieder, H; Spector, TD; Thorsteinsdottir, U; Stumvoll, M; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; van der Harst, P; Walker, M; Wallaschofski, H; Wareham, NJ; Watkins, H; Weir, DR; Wichmann, HE; Wilson, JF; Zanen, P; Borecki, IB; Deloukas, P; Fox, CS; Heid, IM; O'Connell, JR; Strachan, DP; Stefansson, K; van Duijn, CM; Abecasis, Goncalo; Franke, L; Frayling, Timothy M.; McCarthy, MI; Visscher, PM; Scherag, A; Willer, CJ; Boehnke, M; Mohlke, KL; Lindgren, CM; Beckmann, JS; Barroso, I; North, KE; Ingelsson, E; Hirschhorn, JN; Loos, RJ; Speliotes, EK (Nature Publishing Group, 2015-02-12)
    Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
  • Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease 

    Medici, M; Porcu, E; Pistis, G; Teumer, A; Brown, Suzanne J.; Jensen, RA; Rawal, R; Roef, GL; Plantinga, TS; Vermeulen, SH; Lahti, J; Simmonds, MJ; Husemoen, LL; Freathy, RM; Shields, BM; Pietzner, D; Nagy, R; Broer, L; Chaker, L; Korevaar, TI; Plia, MG; Sala, C; Völker, U; Richards, JB; Sweep, FC; Gieger, C; Corre, T; Kajantie, E; Thuesen, B; Taes, YE; Visser, WE; Hattersley, Andrew T.; Kratzsch, J; Hamilton, Alexander; Li, W; Homuth, G; Lobina, M; Mariotti, S; Soranzo, N; Cocca, M; Nauck, M; Spielhagen, C; Ross, A; Arnold, A; van de Bunt, M; Liyanarachchi, S; Heier, M; Grabe, HJ; Masciullo, C; Galesloot, TE; Lim, EM; Reischl, E; Leedman, PJ; Lai, S; Delitala, A; Bremner, AP; Philips, DI; Beilby, John P.; Mulas, A; Vocale, M; Abecasis, Goncalo; Forsen, T; James, A; Widen, E; Hui, J; Prokisch, H; Rietzschel, EE; Palotie, A; Feddema, P; Fletcher, SJ; Schramm, K; Rotter, JI; Kluttig, A; Radke, D; Traglia, M; Surdulescu, GL; He, H; Franklyn, JA; Tiller, D; Vaidya, B; de Meyer, T; Jørgensen, T; Eriksson, Johan G.; O'Leary, PC; Wichmann, E; Hermus, AR; Psaty, BM; Ittermann, T; Hofman, A; Bosi, E; Schlessinger, D; Wallaschofski, H; Pirastu, N; Aulchenko, Yurii; de la Chapelle, A; Netea-Maier, RT; Gough, SC; Meyer Zu Schwabedissen, H; Frayling, Timothy M.; Kaufman, JM; Linneberg, A; Räikkönen, K; Smit, JW; Kiemeney, LA; Rivadeneira, F; Uitterlinden, AG; Walsh, JP; Meisinger, C; den Heijer, M; Visser, TJ; Spector, TD; Wilson, SG; Völzke, H; Cappola, A; Toniolo, D; Sanna, S; Naitza, S; Peeters, RP (Public Library of Science, 2014-02)
    Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's ...