Now showing items 1-3 of 3

  • Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. 

    Day, FR; Thompson, DJ; Helgason, H; Chasman, DI; Finucane, H; Sulem, P; Ruth, KS; Whalen, S; Sarkar, AK; Albrecht, E; Altmaier, E; Amini, M; Barbieri, CM; Boutin, T; Campbell, A; Demerath, E; Giri, A; He, C; Hottenga, JJ; Karlsson, R; Kolcic, I; Loh, P-R; Lunetta, KL; Mangino, M; Marco, B; McMahon, G; Medland, SE; Nolte, IM; Noordam, R; Nutile, T; Paternoster, L; Perjakova, N; Porcu, E; Rose, LM; Schraut, KE; Segrè, AV; Smith, AV; Stolk, L; Teumer, A; Andrulis, IL; Bandinelli, S; Beckmann, MW; Benitez, J; Bergmann, S; Bochud, M; Boerwinkle, E; Bojesen, SE; Bolla, MK; Brand, JS; Brauch, H; Brenner, H; Broer, L; Brüning, T; Buring, JE; Campbell, H; Catamo, E; Chanock, S; Chenevix-Trench, G; Corre, T; Couch, FJ; Cousminer, DL; Cox, A; Crisponi, L; Czene, K; Davey Smith, G; de Geus, EJCN; de Mutsert, R; De Vivo, I; Dennis, J; Devilee, P; Dos-Santos-Silva, I; Dunning, AM; Eriksson, JG; Fasching, PA; Fernández-Rhodes, L; Ferrucci, L; Flesch-Janys, D; Franke, L; Gabrielson, M; Gandin, I; Giles, GG; Grallert, H; Gudbjartsson, DF; Guénel, P; Hall, P; Hallberg, E; Hamann, U; Harris, TB; Hartman, CA; Heiss, G; Hooning, MJ; Hopper, JL; Hu, F; Hunter, DJ; Ikram, MA; Im, HK; Järvelin, M-R; Joshi, PK; Karasik, D; Kellis, M; Kutalik, Z; LaChance, G; Lambrechts, D; Langenberg, C; Launer, LJ; Laven, JSE; Lenarduzzi, S; Li, J; Lind, PA; Lindstrom, S; Liu, Y; Luan, J; Mägi, R; Mannermaa, A; Mbarek, H; McCarthy, MI; Meisinger, C; Meitinger, T; Menni, C; Metspalu, A; Michailidou, K; Milani, L; Milne, RL; Montgomery, GW; Mulligan, AM; Nalls, MA; Navarro, P; Nevanlinna, H; Nyholt, DR; Oldehinkel, AJ; O'Mara, TA; Padmanabhan, S; Palotie, A; Pedersen, N; Peters, A; Peto, J; Pharoah, PDP; Pouta, A; Radice, P; Rahman, I; Ring, SM; Robino, A; Rosendaal, FR; Rudan, I; Rueedi, R; Ruggiero, D; Sala, CF; Schmidt, MK; Scott, RA; Shah, M; Sorice, R; Southey, MC; Sovio, U; Stampfer, M; Steri, M; Strauch, K; Tanaka, T; Tikkanen, E; Timpson, NJ; Traglia, M; Truong, T; Tyrer, JP; Uitterlinden, AG; Edwards, DRV; Vitart, V; Völker, U; Vollenweider, P; Wang, Q; Widen, E; van Dijk, KW; Willemsen, G; Winqvist, R; Wolffenbuttel, BHR; Zhao, JH; Zoledziewska, M; Zygmunt, M; Alizadeh, BZ; Boomsma, DI; Ciullo, M; Cucca, F; Esko, T; Franceschini, N; Gieger, C; Gudnason, V; Hayward, C; Kraft, P; Lawlor, DA; Magnusson, PKE; Martin, NG; Mook-Kanamori, DO; Nohr, EA; Polasek, O; Porteous, D; Price, AL; Ridker, PM; Snieder, H; Spector, TD; Stöckl, D; Toniolo, D; Ulivi, S; Visser, JA; Völzke, H; Wareham, NJ; Wilson, JF; LifeLines Cohort Study; InterAct Consortium; kConFab/AOCS Investigators; Endometrial Cancer Association Consortium; Ovarian Cancer Association Consortium; PRACTICAL consortium; Spurdle, AB; Thorsteindottir, U; Pollard, KS; Easton, DF; Tung, JY; Chang-Claude, J; Hinds, D; Murray, A; Murabito, JM; Stefansson, K; Ong, KK; Perry, JRB (2017-04-24)
    The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 ...
  • Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair 

    Day, FR; Ruth, KS; Thompson, DJ; Lunetta, KL; Pervjakova, N; Chasman, DI; Stolk, L; Finucane, HK; Sulem, P; Bulik-Sullivan, B; Esko, T; Johnson, AD; Elks, CE; Franceschini, N; He, C; Altmaier, E; Brody, JA; Franke, L; Huffman, JE; Keller, MF; McArdle, PF; Nutile, T; Porcu, E; Robino, A; Rose, LM; Schick, UM; Smith, JA; Teumer, A; Traglia, M; Vuckovic, D; Yao, J; Zhao, W; Albrecht, E; Amin, N; Corre, T; Hottenga, JJ; Mangino, M; Smith, AV; Tanaka, T; Abecasis, GR; Andrulis, IL; Anton-Culver, H; Antoniou, AC; Arndt, V; Arnold, AM; Barbieri, C; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bernstein, L; Bielinski, SJ; Blomqvist, C; Boerwinkle, E; Bogdanova, NV; Bojesen, SE; Bolla, MK; Borresen-Dale, AL; Boutin, TS; Brauch, H; Brenner, H; Brüning, T; Burwinkel, B; Campbell, A; Campbell, H; Chanock, SJ; Chapman, JR; Chen, YI; Chenevix-Trench, G; Couch, FJ; Coviello, AD; Cox, A; Czene, K; Darabi, H; De Vivo, I; Demerath, EW; Dennis, J; Devilee, P; Dörk, T; Dos-Santos-Silva, I; Dunning, AM; Eicher, JD; Fasching, PA; Faul, JD; Figueroa, J; Flesch-Janys, D; Gandin, I; Garcia, ME; García-Closas, M; Giles, Graham; Girotto, GG; Goldberg, MS; González-Neira, A; Goodarzi, Mark O.; Grove, ML; Gudbjartsson, DF; Guénel, P; Guo, Xiuqing; Haiman, CA; Hall, P; Hamann, U; Henderson, BE; Hocking, LJ; Hofman, A; Homuth, G; Hooning, MJ; Hopper, JL; Hu, FB; Huang, J; Humphreys, K; Hunter, DJ; Jakubowska, A; Jones, SE; Kabisch, M; Karasik, D; Knight, JA; Kolcic, I; Kooperberg, C; Kosma, VM; Kriebel, J; Kristensen, V; Lambrechts, D; Langenberg, C; Li, J; Li, X; Lindström, S; Liu, Y; Luan, J; Lubinski, J; Mägi, R; Mannermaa, A; Manz, J; Margolin, S; Marten, J; Martin, NG; Masciullo, C; Meindl, A; Michailidou, K; Mihailov, E; Milani, L; Milne, RL; Müller-Nurasyid, M; Nalls, M; Neale, BM; Nevanlinna, H; Neven, P; Newman, AB; Nordestgaard, BG; Olson, JE; Padmanabhan, S; Peterlongo, P; Peters, U; Petersmann, A; Peto, J; Pharoah, PD; Pirastu, NN; Pirie, A; Pistis, G; Polasek, O; Porteous, D; Psaty, BM; Pylkäs, K; Radice, P; Raffel, Leslie J.; Rivadeneira, F; Rudan, I; Rudolph, A; Ruggiero, D; Sala, CF; Sanna, S; Sawyer, EJ; Schlessinger, D; Schmidt, MK; Schmidt, F; Schmutzler, RK; Schoemaker, MJ; Scott, RA; Seynaeve, CM; Simard, J; Sorice, R; Southey, MC; Stöckl, D; Strauch, K; Swerdlow, A; Taylor, KD; Thorsteinsdottir, U; Toland, AE; Tomlinson, I; Truong, T; Tryggvadottir, L; Turner, ST; Vozzi, D; Wang, Q; Wellons, M; Willemsen, G; Wilson, JF; Winqvist, R; Wolffenbuttel, BB; Wright, AF; Yannoukakos, D; Zemunik, T; Zheng, W; Zygmunt, M; Bergmann, S; Boomsma, DI; Buring, JE; Ferrucci, L; Montgomery, GW; Gudnason, V; Spector, TD; van Duijn, CM; Alizadeh, BZ; Ciullo, M; Crisponi, L; Easton, DF; Gasparini, Paolo; Gieger, C; Harris, Tamara; Hayward, C; Kardia, SL; Kraft, P; McKnight, B; Metspalu, A; Morrison, AC; Reiner, AP; Ridker, PM; Rotter, JI; Toniolo, D; Uitterlinden, AG; Ulivi, S; Völzke, H; Wareham, NJ; Weir, DR; Yerges-Armstrong, LM; PRACTICAL Consortium; kConFab Investigators; AOCS Investigators; Generation Scotland; EPIC-InterAct Consortium; LifeLines Cohort Study; Price, AL; Stefansson, K; Visser, JA; Ong, KK; Chang-Claude, J; Murabito, JM; Perry, JR; Murray, A (Nature Publishing Group, 2015-09-28)
    Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and ...
  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche 

    Perry, JRB; Day, F; Elks, CE; Sulem, P; Thompson, DJ; Ferreira, T; He, C; Chasman, DI; Esko, T; Thorleifsson, G; Albrecht, E; Ang, WQ; Corre, T; Cousminer, DL; Feenstra, B; Franceschini, N; Ganna, A; Johnson, AD; Kjellqvist, S; Lunetta, KL; McMahon, G; Nolte, IM; Paternoster, L; Porcu, E; Smith, AV; Stolk, L; Teumer, A; Tšernikova, N; Tikkanen, E; Ulivi, S; Wagner, EK; Amin, N; Bierut, LJ; Byrne, EM; Hottenga, J-J; Koller, DL; Mangino, M; Pers, TH; Yerges-Armstrong, LM; Hua Zhao, J; Andrulis, IL; Anton-Culver, H; Atsma, F; Bandinelli, S; Beckmann, MW; Benitez, J; Blomqvist, C; Bojesen, SE; Bolla, MK; Bonanni, B; Brauch, H; Brenner, H; Buring, JE; Chang-Claude, J; Chanock, S; Chen, J; Chenevix-Trench, G; Collée, JM; Couch, FJ; Couper, D; Coviello, AD; Cox, A; Czene, K; D'adamo, AP; Davey Smith, G; De Vivo, I; Demerath, EW; Dennis, J; Devilee, P; Dieffenbach, AK; Dunning, AM; Eiriksdottir, G; Eriksson, JG; Fasching, PA; Ferrucci, L; Flesch-Janys, D; Flyger, H; Foroud, T; Franke, L; Garcia, ME; García-Closas, M; Geller, F; de Geus, EEJ; Giles, GG; Gudbjartsson, DF; Gudnason, V; Guénel, P; Guo, S; Hall, P; Hamann, U; Haring, R; Hartman, CA; Heath, AC; Hofman, A; Hooning, MJ; Hopper, JL; Hu, FB; Hunter, DJ; Karasik, D; Kiel, DP; Knight, JA; Kosma, V-M; Kutalik, Z; Lai, S; Lambrechts, D; Lindblom, A; Mägi, R; Magnusson, PK; Mannermaa, A; Martin, NG; Masson, G; McArdle, PF; McArdle, WL; Melbye, M; Michailidou, K; Mihailov, E; Milani, L; Milne, RL; Nevanlinna, H; Neven, P; Nohr, EA; Oldehinkel, AJ; Oostra, BA; Palotie, A; Peacock, M; Pedersen, NL; Peterlongo, P; Peto, J; Pharoah, PDP; Postma, DS; Pouta, A; Pylkäs, K; Radice, P; Ring, S; Rivadeneira, F; Robino, A; Rose, LM; Rudolph, A; Salomaa, V; Sanna, S; Schlessinger, D; Schmidt, MK; Southey, MC; Sovio, U; Stampfer, MJ; Stöckl, D; Storniolo, AM; Timpson, NJ; Tyrer, J; Visser, JA; Vollenweider, P; Völzke, H; Waeber, G; Waldenberger, M; Wallaschofski, H; Wang, Q; Willemsen, G; Winqvist, R; Wolffenbuttel, BHR; Wright, MJ; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium; Boomsma, DI; Econs, MJ; Khaw, K-T; Loos, RJF; McCarthy, MI; Montgomery, GW; Rice, JP; Streeten, EA; Thorsteinsdottir, U; van Duijn, CM; Alizadeh, BZ; Bergmann, S; Boerwinkle, E; Boyd, HA; Crisponi, L; Gasparini, P; Gieger, C; Harris, TB; Ingelsson, E; Järvelin, M-R; Kraft, P; Lawlor, D; Metspalu, A; Pennell, CE; Ridker, PM; Snieder, H; Sørensen, TIA; Spector, TD; Strachan, DP; Uitterlinden, AG; Wareham, NJ; Widen, E; Zygmunt, M; Murray, A; Easton, DF; Stefansson, K; Murabito, JM; Ong, KK (Nature Publishing Group, 2014-10-02)
    Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and ...