Now showing items 1-11 of 11

  • CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. 

    Macé, A; Tuke, MA; Deelen, P; Kristiansson, K; Mattsson, H; Nõukas, M; Sapkota, Y; Schick, U; Porcu, E; Rüeger, S; McDaid, AF; Porteous, D; Winkler, TW; Salvi, E; Shrine, N; Liu, X; Ang, WQ; Zhang, W; Feitosa, MF; Venturini, C; van der Most, PJ; Rosengren, A; Wood, AR; Beaumont, RN; Jones, SE; Ruth, KS; Yaghootkar, H; Tyrrell, J; Havulinna, AS; Boers, H; Mägi, R; Kriebel, J; Müller-Nurasyid, M; Perola, M; Nieminen, M; Lokki, M-L; Kähönen, M; Viikari, JS; Geller, F; Lahti, J; Palotie, A; Koponen, P; Lundqvist, A; Rissanen, H; Bottinger, EP; Afaq, S; Wojczynski, MK; Lenzini, P; Nolte, IM; Sparsø, T; Schupf, N; Christensen, K; Perls, TT; Newman, AB; Werge, T; Snieder, H; Spector, TD; Chambers, JC; Koskinen, S; Melbye, M; Raitakari, OT; Lehtimäki, T; Tobin, MD; Wain, LV; Sinisalo, J; Peters, A; Meitinger, T; Martin, NG; Wray, NR; Montgomery, GW; Medland, SE; Swertz, MA; Vartiainen, E; Borodulin, K; Männistö, S; Murray, A; Bochud, M; Jacquemont, S; Rivadeneira, F; Hansen, TF; Oldehinkel, AJ; Mangino, M; Province, MA; Deloukas, P; Kooner, JS; Freathy, RM; Pennell, C; Feenstra, B; Strachan, DP; Lettre, G; Hirschhorn, J; Cusi, D; Heid, IM; Hayward, C; Männik, K; Beckmann, JS; Loos, RJF; Nyholt, DR; Metspalu, A; Eriksson, JG; Weedon, MN; Salomaa, V; Franke, L; Reymond, A; Frayling, TM; Kutalik, Z (Nature Publishing Group, 2017-09-29)
    There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ...
  • Defining the role of common variation in the genomic and biological architecture of adult human height. 

    Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J; Lo, KS; Locke, AE; Mägi, R; Mihailov, E; Porcu, E; Randall, JC; Scherag, A; Vinkhuyzen, AA; Westra, HJ; Winkler, TW; Workalemahu, T; Zhao, JH; Absher, D; Albrecht, E; Anderson, D; Baron, J; Beekman, M; Demirkan, A; Ehret, GB; Feenstra, B; Feitosa, MF; Fischer, K; Fraser, RM; Goel, A; Gong, J; Justice, AE; Kanoni, S; Kleber, ME; Kristiansson, K; Lim, U; Lotay, V; Lui, JC; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Nalls, MA; Nyholt, DR; Palmer, CD; Pasko, D; Pechlivanis, S; Prokopenko, I; Ried, JS; Ripke, S; Shungin, D; Stancáková, A; Strawbridge, RJ; Sung, YJ; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van Setten, J; Van Vliet-Ostaptchouk, JV; Wang, Z; Yengo, L; Zhang, W; Afzal, U; Arnlöv, J; Arscott, GM; Bandinelli, S; Barrett, A; Bellis, C; Bennett, AJ; Berne, C; Blüher, M; Bolton, JL; Böttcher, Y; Boyd, HA; Bruinenberg, M; Buckley, BM; Buyske, S; Caspersen, IH; Chines, PS; Clarke, R; Claudi-Boehm, S; Cooper, M; Daw, EW; De Jong, PA; Deelen, J; Delgado, G; Denny, JC; Dhonukshe-Rutten, R; Dimitriou, M; Doney, AS; Dörr, M; Eklund, N; Eury, E; Folkersen, L; Garcia, ME; Geller, F; Giedraitis, V; Go, AS; Grallert, H; Grammer, TB; Gräßler, J; Grönberg, H; de Groot, LC; Groves, CJ; Haessler, J; Hall, P; Haller, T; Hallmans, G; Hannemann, A; Hartman, CA; Hassinen, M; Hayward, C; Heard-Costa, NL; Helmer, Q; Hemani, G; Henders, AK; Hillege, HL; Hlatky, MA; Hoffmann, W; Hoffmann, P; Holmen, O; Houwing-Duistermaat, JJ; Illig, T; Isaacs, A; James, AL; Jeff, J; Johansen, B; Johansson, Å; Jolley, J; Juliusdottir, T; Junttila, J; Kho, AN; Kinnunen, L; Klopp, N; Kocher, T; Kratzer, W; Lichtner, P; Lind, L; Lindström, J; Lobbens, S; Lorentzon, M; Lu, Y; Lyssenko, V; Magnusson, PK; Mahajan, A; Maillard, M; McArdle, WL; McKenzie, CA; McLachlan, S; McLaren, PJ; Menni, C; Merger, S; Milani, L; Moayyeri, A; Monda, KL; Morken, MA; Müller, G; Müller-Nurasyid, M; Musk, AW; Narisu, N; Nauck, M; Nolte, IM; Nöthen, MM; Oozageer, L; Pilz, S; Rayner, NW; Renstrom, F; Robertson, NR; Rose, LM; Roussel, R; Sanna, S; Scharnagl, H; Scholtens, S; Schumacher, FR; Schunkert, H; Scott, RA; Sehmi, J; Seufferlein, T; Shi, J; Silventoinen, K; Smit, JH; Smith, AV; Smolonska, J; Stanton, AV; Stirrups, K; Stott, DJ; Stringham, HM; Sundström, J; Swertz, MA; Syvänen, AC; Tayo, BO; Thorleifsson, G; Tyrer, JP; van Dijk, S; van Schoor, NM; van der Velde, N; van Heemst, D; van Oort, FV; Vermeulen, SH; Verweij, N; Vonk, JM; Waite, LL; Waldenberger, M; Wennauer, R; Wilkens, LR; Willenborg, C; Wilsgaard, T; Wojczynski, MK; Wong, A; Wright, AF; Zhang, Q; Arveiler, D; Bakker, SJ; Beilby, J; Bergman, RN; Bergmann, S; Biffar, R; Blangero, J; Boomsma, DI; Bornstein, SR; Bovet, P; Brambilla, P; Brown, MJ; Campbell, H; Caulfield, MJ; Chakravarti, A; Collins, R; Collins, FS; Crawford, DC; Cupples, LA; Danesh, J; de Faire, U; den Ruijter, HM; Erbel, R; Erdmann, J; Eriksson, JG; Farrall, M; Ferrannini, E; Ferrières, J; Ford, I; Forouhi, NG; Forrester, T; Gansevoort, RT; Gejman, PV; Gieger, C; Golay, A; Gottesman, O; Gudnason, V; Gyllensten, U; Haas, DW; Hall, AS; Harris, TB; Hattersley, AT; Heath, AC; Hengstenberg, C; Hicks, AA; Hindorff, LA; Hingorani, AD; Hofman, A; Hovingh, GK; Humphries, SE; Hunt, SC; Hypponen, E; Jacobs, KB; Jarvelin, MR; Jousilahti, P; Jula, AM; Kaprio, J; Kastelein, JJ; Kayser, M; Kee, F; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Kooner, JS; Kooperberg, C; Koskinen, S; Kovacs, P; Kraja, AT; Kumari, M; Kuusisto, J; Lakka, TA; Langenberg, C; Le Marchand, L; Lehtimäki, T; Lupoli, S; Madden, PA; Männistö, S; Manunta, P; Marette, A; Matise, TC; McKnight, B; Meitinger, T; Moll, FL; Montgomery, GW; Morris, AD; Morris, AP; Murray, JC; Nelis, M; Ohlsson, C; Oldehinkel, AJ; Ong, KK; Ouwehand, WH; Pasterkamp, G; Peters, A; Pramstaller, PP; Price, JF; Qi, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Ritchie, M; Rudan, I; Salomaa, V; Samani, NJ; Saramies, J; Sarzynski, MA; Schwarz, PE; Sebert, S; Sever, P; Shuldiner, AR; Sinisalo, J; Steinthorsdottir, V; Stolk, RP; Tardif, JC; Tönjes, A; Tremblay, A; Tremoli, E; Virtamo, J; Vohl, MC; Electronic Medical Records and Genomics (eMEMERGEGE) Consortium; MIGen Consortium; PAGEGE Consortium; LifeLines Cohort Study; Amouyel, P; Asselbergs, FW; Assimes, TL; Bochud, M; Boehm, BO; Boerwinkle, E; Bottinger, EP; Bouchard, C; Cauchi, S; Chambers, JC; Chanock, SJ; Cooper, RS; de Bakker, PI; Dedoussis, G; Ferrucci, L; Franks, PW; Froguel, P; Groop, LC; Haiman, CA; Hamsten, A; Hayes, MG; Hui, J; Hunter, DJ; Hveem, K; Jukema, JW; Kaplan, RC; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; Martin, NG; März, W; Melbye, M; Moebus, S; Munroe, PB; Njølstad, I; Oostra, BA; Palmer, CN; Pedersen, NL; Perola, M; Pérusse, L; Peters, U; Powell, JE; Power, C; Quertermous, T; Rauramaa, R; Reinmaa, E; Ridker, PM; Rivadeneira, F; Rotter, JI; Saaristo, TE; Saleheen, D; Schlessinger, D; Slagboom, PE; Snieder, H; Spector, TD; Strauch, K; Stumvoll, M; Tuomilehto, J; Uusitupa, M; van der Harst, P; Völzke, H; Walker, M; Wareham, NJ; Watkins, H; Wichmann, HE; Wilson, JF; Zanen, P; Deloukas, P; Heid, IM; Lindgren, CM; Mohlke, KL; Speliotes, EK; Thorsteinsdottir, U; Barroso, I; Fox, CS; North, KE; Strachan, DP; Beckmann, JS; Berndt, SI; Boehnke, M; Borecki, IB; McCarthy, MI; Metspalu, A; Stefansson, K; Uitterlinden, AG; van Duijn, CM; Franke, L; Willer, CJ; Price, AL; Lettre, G; Loos, RJ; Weedon, MN; Ingelsson, E; O'Connell, JR; Abecasis, GR; Chasman, DI; Goddard, ME; Visscher, PM; Hirschhorn, JN; Frayling, TM (Nature Publishing Group, 2014-10-05)
    Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in ...
  • Genetic studies of body mass index yield new insights for obesity biology 

    Locke, Adam E.; Kahali, Bratati; Berndt, Sonja I.; Justice, Anne E.; Pers, Tune H.; Day, Felix R.; Powell, Corey; Vedantam, S; Buchkovich, ML; Yang, J; Croteau-Chonka, DC; Esko, T; Fall, T; Ferreira, T; Gustafsson, S; Kutalik, Z; Luan, J; Mägi, R; Randall, JC; Winkler, TW; Wood, Andrew R.; Workalemahu, T; Faul, JD; Smith, JA; Hua Zhao, J; Zhao, W; Chen, J; Fehrmann, R; Hedman, ÅK; Karjalainen, J; Schmidt, EM; Absher, D; Amin, N; Anderson, D; Beekman, M; Bolton, JL; Bragg-Gresham, JL; Buyske, S; Demirkan, A; Deng, G; Ehret, GB; Feenstra, B; Feitosa, MF; Fischer, Krista; Goel, A; Gong, J; Jackson, AU; Kanoni, S; Kleber, ME; Kristiansson, K; Lim, U; Lotay, V; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Medland, SE; Nalls, MA; Palmer, CD; Pasko, Dorota; Pechlivanis, S; Peters, MJ; Prokopenko, I; Shungin, D; Stančáková, A; Strawbridge, RJ; Ju Sung, Y; Tanaka, T; Teumer, A; Trompet, S; van der Laan, SW; van Setten, J; Van Vliet-Ostaptchouk, JV; Wang, Z; Yengo, L; Zhang, W; Isaacs, A; Albrecht, E; Ärnlöv, J; Arscott, GM; Attwood, AP; Bandinelli, S; Barrett, Amy; Bas, IN; Bellis, C; Bennett, Amanda; Berne, C; Blagieva, R; Blüher, M; Böhringer, S; Bonnycastle, Lori; Böttcher, Y; Boyd, HA; Bruinenberg, M; Caspersen, IH; Ida Chen, YD; Clarke, R; Daw, EW; de Craen, AJ; Delgado, G; Dimitriou, M; Doney, AS; Eklund, N; Estrada, K; Eury, E; Folkersen, L; Fraser, RM; Garcia, ME; Geller, F; Giedraitis, V; Gigante, B; Go, AS; Golay, A; Goodall, AH; Gordon, SD; Gorski, M; Grabe, HJ; Grallert, H; Grammer, TB; Gräßler, J; Grönberg, H; Groves, Christopher J.; Gusto, G; Haessler, J; Hall, P; Haller, T; Hallmans, G; Hartman, CA; Hassinen, M; Hayward, C; Heard-Costa, NL; Helmer, Q; Hengstenberg, C; Holmen, O; Hottenga, JJ; James, AL; Jeff, JM; Johansson, Å; Jolley, J; Juliusdottir, T; Kinnunen, L; Koenig, W; Koskenvuo, M; Kratzer, W; Laitinen, J; Lamina, C; Leander, K; Lee, NR; Lichtner, P; Lind, L; Lindström, J; Sin Lo, K; Lobbens, S; Lorbeer, R; Lu, Y; Mach, F; Magnusson, PK; Mahajan, A; McArdle, WL; McLachlan, S; Menni, C; Merger, S; Mihailov, E; Milani, L; Moayyeri, A; Monda, KL; Morken, MA; Mulas, A; Müller, G; Müller-Nurasyid, M; Musk, AW; Nagaraja, R; Nöthen, MM; Nolte, IM; Pilz, S; Rayner, NW; Renstrom, F; Rettig, R; Ried, JS; Ripke, S; Robertson, NR; Rose, LM; Sanna, S; Scharnagl, H; Scholtens, S; Schumacher, FR; Scott, WR; Seufferlein, T; Shi, J; Vernon Smith, A; Smolonska, J; Stanton, AV; Steinthorsdottir, V; Stirrups, K; Stringham, HM; Sundström, J; Swertz, MA; Swift, AJ; Syvänen, AC; Tan, ST; Tayo, BO; Thorand, B; Thorleifsson, G; Tyrer, JP; Uh, HW; Vandenput, L; Verhulst, FC; Vermeulen, SH; Verweij, N; Vonk, JM; Waite, LL; Warren, HR; Waterworth, D; Weedon, Michael N.; Wilkens, LR; Willenborg, C; Wilsgaard, T; Wojczynski, MK; Wong, A; Wright, AF; Zhang, Q; LifeLines Cohort Study; Brennan, EP; Choi, M; Dastani, Z; Drong, AW; Eriksson, P; Franco-Cereceda, A; Gådin, JR; Gharavi, AG; Goddard, ME; Handsaker, RE; Huang, J; Karpe, F; Kathiresan, S; Keildson, S; Kiryluk, K; Kubo, M; Lee, JY; Liang, L; Lifton, RP; Ma, B; McCarroll, SA; McKnight, AJ; Min, JL; Moffatt, MF; Montgomery, GW; Murabito, JM; Nicholson, G; Nyholt, DR; Okada, Y; Perry, John R.B.; Dorajoo, R; Reinmaa, E; Salem, RM; Sandholm, N; Scott, RA; Stolk, L; Takahashi, A; Tanaka, T; Van't Hooft, FM; Vinkhuyzen, AA; Westra, HJ; Zheng, W; Zondervan, KT; ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium; Heath, AC; Arveiler, D; Bakker, SJ; Beilby, John P.; Bergman, RN; Blangero, J; Bovet, P; Campbell, H; Caulfield, MJ; Cesana, G; Chakravarti, A; Chasman, DI; Chines, PS; Collins, FS; Crawford, DC; Cupples, LA; Cusi, D; Danesh, J; de Faire, U; den Ruijter, HM; Dominiczak, AF; Erbel, R; Erdmann, J; Eriksson, Johan G.; Farrall, M; Felix, SB; Ferrannini, E; Ferrières, J; Ford, I; Forouhi, NG; Forrester, T; Franco, OH; Gansevoort, RT; Gejman, PV; Gieger, C; Gottesman, O; Gudnason, V; Gyllensten, U; Hall, AS; Harris, Tamara; Hattersley, Andrew T.; Hicks, AA; Hindorff, LA; Hingorani, Aroon; Hofman, A; Homuth, G; Hovingh, GK; Humphries, SE; Hunt, SC; Hyppönen, E; Illig, T; Jacobs, KB; Jarvelin, MR; Jöckel, KH; Johansen, B; Jousilahti, P; Jukema, JW; Jula, AM; Kaprio, J; Kastelein, JJ; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Knekt, P; Kooner, JS; Kooperberg, C; Kovacs, P; Kraja, AT; Kumari, M; Kuusisto, J; Lakka, TA; Langenberg, C; Le Marchand, L; Lehtimäki, T; Lyssenko, V; Männistö, S; Marette, A; Matise, TC; McKenzie, CA; McKnight, B; Moll, FL; Morris, AD; Morris, AP; Murray, JC; Nelis, M; Ohlsson, C; Oldehinkel, AJ; Ong, KK; Madden, PA; Pasterkamp, G; Peden, JF; Peters, A; Postma, DS; Pramstaller, PP; Price, JF; Qi, L; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Ridker, PM; Rioux, JD; Ritchie, MD; Rudan, I; Salomaa, V; Samani, NJ; Saramies, J; Sarzynski, MA; Schunkert, H; Schwarz, PE; Sever, P; Shuldiner, AR; Sinisalo, J; Stolk, RP; Strauch, K; Tönjes, A; Trégouët, DA; Tremblay, A; Tremoli, E; Virtamo, J; Vohl, MC; Völker, U; Waeber, G; Willemsen, G; Witteman, JC; Zillikens, MC; Adair, LS; Amouyel, P; Asselbergs, FW; Assimes, TL; Bochud, M; Boehm, BO; Boerwinkle, E; Bornstein, SR; Bottinger, EP; Bouchard, C; Cauchi, S; Chambers, JC; Chanock, SJ; Cooper, RS; de Bakker, PI; Dedoussis, George V.; Ferrucci, L; Franks, PW; Froguel, P; Groop, Leif; Haiman, CA; Hamsten, A; Hui, J; Hunter, DJ; Hveem, K; Kaplan, RC; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; Martin, NG; März, W; Melbye, M; Metspalu, A; Moebus, S; Munroe, PB; Njølstad, I; Oostra, BA; Palmer, CN; Pedersen, NL; Perola, M; Pérusse, L; Peters, U; Power, C; Quertermous, T; Rauramaa, R; Rivadeneira, F; Saaristo, TE; Saleheen, D; Sattar, N; Schadt, EE; Schlessinger, D; Slagboom, PE; Snieder, H; Spector, TD; Thorsteinsdottir, U; Stumvoll, M; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; van der Harst, P; Walker, M; Wallaschofski, H; Wareham, NJ; Watkins, H; Weir, DR; Wichmann, HE; Wilson, JF; Zanen, P; Borecki, IB; Deloukas, P; Fox, CS; Heid, IM; O'Connell, JR; Strachan, DP; Stefansson, K; van Duijn, CM; Abecasis, Goncalo; Franke, L; Frayling, Timothy M.; McCarthy, MI; Visscher, PM; Scherag, A; Willer, CJ; Boehnke, M; Mohlke, KL; Lindgren, CM; Beckmann, JS; Barroso, I; North, KE; Ingelsson, E; Hirschhorn, JN; Loos, RJ; Speliotes, EK (Nature Publishing Group, 2015-02-12)
    Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure ...
  • Genome-wide associations for birth weight and correlations with adult disease 

    Horikoshi, M; Beaumont, RN; Day, FR; Warrington, NM; Kooijman, MN; Fernandez-Tajes, J; Feenstra, B; van Zuydam, NR; Gaulton, KJ; Grarup, N; Bradfield, JP; Strachan, DP; Li-Gao, R; Ahluwalia, TS; Kreiner, E; Rueedi, R; Lyytikäinen, LP; Cousminer, DL; Wu, Y; Thiering, E; Wang, CA; Have, CT; Hottenga, JJ; Vilor-Tejedor, N; Joshi, PK; Boh, ET; Ntalla, I; Pitkänen, N; Mahajan, A; van Leeuwen, EM; Joro, R; Lagou, V; Nodzenski, M; Diver, LA; Zondervan, KT; Bustamante, M; Marques-Vidal, P; Mercader, JM; Bennett, AJ; Rahmioglu, N; Nyholt, DR; Ma, RC; Tam, CH; Tam, WH; CHARGE Consortium Hematology Working Group; Ganesh, SK; van Rooij, FJ; Jones, SE; Loh, PR; Ruth, KS; Tuke, MA; Tyrrell, J; Wood, AR; Yaghootkar, H; Scholtens, DM; Paternoster, L; Prokopenko, I; Kovacs, P; Atalay, M; Willems, SM; Panoutsopoulou, K; Wang, X; Carstensen, L; Geller, F; Schraut, KE; Murcia, M; van Beijsterveldt, CE; Willemsen, G; Appel, EV; Fonvig, CE; Trier, C; Tiesler, CM; Standl, M; Kutalik, Z; Bonàs-Guarch, S; Hougaard, DM; Sánchez, F; Torrents, D; Waage, J; Hollegaard, MV; de Haan, HG; Rosendaal, FR; Medina-Gomez, C; Ring, SM; Hemani, G; McMahon, G; Robertson, NR; Groves, CJ; Langenberg, C; Luan, J; Scott, RA; Zhao, JH; Mentch, FD; MacKenzie, SM; Reynolds, RM; Early Growth Genetics (EGG) Consortium; Lowe, WL; Tönjes, A; Stumvoll, M; Lindi, V; Lakka, TA; van Duijn, CM; Kiess, W; Körner, A; Sørensen, TI; Niinikoski, H; Pahkala, K; Raitakari, OT; Zeggini, E; Dedoussis, GV; Teo, YY; Saw, SM; Melbye, M; Campbell, H; Wilson, JF; Vrijheid, M; de Geus, EJ; Boomsma, DI; Kadarmideen, HN; Holm, JC; Hansen, T; Sebert, S; Hattersley, AT; Beilin, LJ; Newnham, JP; Pennell, CE; Heinrich, J; Adair, LS; Borja, JB; Mohlke, KL; Eriksson, JG; Widén, E; Kähönen, M; Viikari, JS; Lehtimäki, T; Vollenweider, P; Bønnelykke, K; Bisgaard, H; Mook-Kanamori, DO; Hofman, A; Rivadeneira, F; Uitterlinden, AG; Pisinger, C; Pedersen, O; Power, C; Hyppönen, E; Wareham, NJ; Hakonarson, H; Davies, E; Walker, BR; Jaddoe, VW; Järvelin, MR; Grant, SF; Vaag, AA; Lawlor, DA; Frayling, TM; Smith, GD; Morris, AP; Ong, KK; Felix, JF; Timpson, NJ; Perry, JR; Evans, DM; McCarthy, MI; Freathy, RM (Nature Publishing Group, 2016-09-28)
    Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and ...
  • The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study 

    Winkler, TW; Justice, AE; Graff, M; Barata, L; Feitosa, MF; Chu, S; Czajkowski, J; Esko, T; Fall, T; Kilpeläinen, TO; Lu, Y; Mägi, R; Mihailov, E; Pers, TH; Rüeger, S; Teumer, A; Ehret, GB; Ferreira, T; Heard-Costa, NL; Karjalainen, J; Lagou, V; Mahajan, A; Neinast, MD; Prokopenko, I; Simino, J; Teslovich, TM; Jansen, R; Westra, H-J; White, CC; Absher, D; Ahluwalia, TS; Ahmad, S; Albrecht, E; Alves, AC; Bragg-Gresham, JL; de Craen, AJM; Bis, JC; Bonnefond, A; Boucher, G; Cadby, G; Cheng, Y-C; Chiang, CWK; Delgado, G; Demirkan, A; Dueker, N; Eklund, N; Eiriksdottir, G; Eriksson, J; Feenstra, B; Fischer, K; Frau, F; Galesloot, TE; Geller, F; Goel, A; Gorski, M; Grammer, TB; Gustafsson, S; Haitjema, S; Hottenga, JJ; Huffman, JE; Jackson, AU; Jacobs, KB; Johansson, Å; Kaakinen, M; Kleber, ME; Lahti, J; Leach, IM; Lehne, B; Liu, Y; Lo, KS; Lorentzon, M; Luan, J; Madden, PAF; Mangino, M; McKnight, B; Medina-Gomez, C; Monda, KL; Montasser, ME; Müller, G; Müller-Nurasyid, M; Nolte, IM; Panoutsopoulou, K; Pascoe, L; Paternoster, L; Rayner, NW; Renström, F; Rizzi, F; Rose, LM; Ryan, KA; Salo, P; Sanna, S; Scharnagl, H; Shi, J; Smith, AV; Southam, L; Stančáková, A; Steinthorsdottir, V; Strawbridge, RJ; Sung, YJ; Tachmazidou, I; Tanaka, T; Thorleifsson, G; Trompet, S; Pervjakova, N; Tyrer, JP; Vandenput, L; van der Laan, SW; van der Velde, N; van Setten, J; van Vliet-Ostaptchouk, JV; Verweij, N; Vlachopoulou, E; Waite, LL; Wang, SR; Wang, Z; Wild, SH; Willenborg, C; Wilson, JF; Wong, A; Yang, J; Yengo, L; Yerges-Armstrong, LM; Yu, L; Zhang, W; Zhao, JH; Andersson, EA; Bakker, SJL; Baldassarre, D; Banasik, K; Barcella, M; Barlassina, C; Bellis, C; Benaglio, P; Blangero, J; Blüher, M; Bonnet, F; Bonnycastle, LL; Boyd, HA; Bruinenberg, M; Buchman, AS; Campbell, H; Chen, Y-DI; Chines, PS; Claudi-Boehm, S; Cole, J; Collins, FS; de Geus, Eco; de Groot, LCPGM; Dimitriou, M; Duan, J; Enroth, S; Eury, E; Farmaki, A-E; Forouhi, NG; Friedrich, N; Gejman, PV; Gigante, B; Glorioso, N; Go, AS; Gottesman, O; Gräßler, J; Grallert, H; Grarup, N; Gu, Y-M; Broer, L; Ham, AC; Hansen, T; Harris, Tamara; Hartman, CA; Hassinen, M; Hastie, N; Hattersley, Andrew T.; Heath, AC; Henders, AK; Hernandez, Dena; Hillege, Hans; Holmen, O; Hovingh, KG; Hui, J; Husemoen, LL; Hutri-Kähönen, N; Hysi, PG; Illig, T; De Jager, PL; Jalilzadeh, S; Jørgensen, T; Jukema, JW; Juonala, M; Kanoni, S; Karaleftheri, M; Khaw, KT; Kinnunen, L; Kittner, SJ; Koenig, W; Kolcic, I; Kovacs, P; Krarup, NT; Kratzer, W; Krüger, J; Kuh, D; Kumari, M; Kyriakou, T; Langenberg, C; Lannfelt, L; Lanzani, C; Lotay, V; Launer, LJ; Leander, K; Lindström, J; Linneberg, A; Liu, Y-P; Lobbens, S; Luben, R; Lyssenko, V; Männistö, S; Magnusson, PK; McArdle, WL; Menni, C; Merger, S; Milani, L; Montgomery, GW; Morris, AP; Narisu, N; Nelis, M; Ong, KK; Palotie, A; Pérusse, L; Pichler, I; Pilia, MG; Pouta, A; Rheinberger, M; Ribel-Madsen, R; Richards, M; Rice, KM; Rice, TK; Rivolta, C; Salomaa, V; Sanders, AR; Sarzynski, MA; Scholtens, S; Scott, RA; Scott, WR; Sebert, S; Sengupta, S; Sennblad, B; Seufferlein, T; Silveira, A; Slagboom, PE; Smit, JH; Sparsø, TH; Stirrups, K; Stolk, RP; Stringham, HM; Swertz, MA; Swift, AJ; Syvänen, A-C; Tan, S-T; Thorand, B; Tönjes, A; Tremblay, A; Tsafantakis, E; van der Most, PJ; Völker, U; Vohl, M-C; Vonk, JM; Waldenberger, M; Walker, RW; Wennauer, R; Widén, E; Willemsen, G; Wilsgaard, T; Wright, AF; Zillikens, MC; van Dijk, SC; van Schoor, NM; Asselbergs, FW; de Bakker, PIW; Beckmann, JS; Beilby, J; Bennett, DA; Bergman, RN; Bergmann, S; Böger, CA; Boehm, BO; Boerwinkle, E; Boomsma, DI; Bornstein, SR; Bottinger, EP; Bouchard, C; Chambers, JC; Chanock, SJ; Chasman, DI; Cucca, F; Cusi, D; Dedoussis, G; Erdmann, J; Eriksson, JG; Evans, DA; de Faire, U; Farrall, M; Ferrucci, L; Ford, I; Franke, L; Franks, PW; Froguel, P; Gansevoort, RT; Gieger, C; Grönberg, H; Gudnason, V; Gyllensten, U; Hall, P; Hamsten, A; van der Harst, P; Hayward, C; Heliövaara, M; Hengstenberg, C; Hicks, AA; Hingorani, Aroon; Hofman, A; Hu, F; Huikuri, HV; Hveem, K; James, AL; Jordan, JM; Jula, A; Kähönen, M; Kajantie, E; Kathiresan, S; Kiemeney, LALM; Kivimaki, M; Knekt, PB; Koistinen, HA; Kooner, JS; Koskinen, S; Kuusisto, J; Maerz, W; Martin, NG; Laakso, M; Lakka, TA; Lehtimäki, T; Lettre, G; Levinson, DF; Lind, L; Lokki, M-L; Mäntyselkä, P; Melbye, M; Metspalu, A; Mitchell, BD; Moll, FL; Murray, JC; Musk, AW; Nieminen, MS; Njølstad, I; Ohlsson, C; Oldehinkel, AJ; Oostra, BA; Palmer, LJ; Pankow, JS; Pasterkamp, G; Pedersen, NL; Pedersen, O; Penninx, BW; Perola, M; Peters, A; Polašek, O; Pramstaller, PP; Psaty, BM; Qi, L; Quertermous, T; Raitakari, OT; Rankinen, T; Rauramaa, R; Ridker, PM; Rioux, JD; Rivadeneira, F; Rotter, JI; Rudan, I; den Ruijter, HM; Saltevo, J; Sattar, N; Schunkert, H; Schwarz, PEH; Shuldiner, AR; Sinisalo, J; Snieder, H; Sørensen, TIA; Spector, TD; Staessen, JA; Stefania, B; Thorsteinsdottir, U; Stumvoll, M; Tardif, J-C; Tremoli, E; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; Verbeek, ALM; Vermeulen, SH; Viikari, JS; Vitart, V; Völzke, H; Vollenweider, P; Waeber, G; Walker, M; Wallaschofski, H; Wareham, NJ; Watkins, H; Zeggini, E; Chakravarti, A; Clegg, DJ; Cupples, LA; Gordon-Larsen, P; Jaquish, CE; Rao, DC; Abecasis, GR; Assimes, TL; Barroso, I; Berndt, SI; Boehnke, M; Deloukas, P; Fox, CS; Groop, LC; Hunter, DJ; Ingelsson, E; Kaplan, RC; McCarthy, MI; Mohlke, KL; O'Connell, JR; Schlessinger, D; Strachan, DP; Stefansson, K; van Duijn, CM; Hirschhorn, JN; Lindgren, CM; Heid, IM; North, KE; Borecki, IB; Kutalik, Z; Loos, RJF (Public Library of Science, 2015-10-01)
    Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size ...
  • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

    Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N; Rivas, MA; Mahajan, A; Locke, AE; Cingolani, P; Pers, TH; Viñuela, A; Brown, AA; Wu, Y; Flannick, J; Fuchsberger, C; Gamazon, ER; Gaulton, KJ; Im, HK; Teslovich, TM; Blackwell, TW; Bork-Jensen, J; Burtt, NP; Chen, Y; Green, T; Hartl, C; Kang, HM; Kumar, A; Ladenvall, C; Ma, C; Moutsianas, L; Pearson, RD; Perry, JRB; Rayner, NW; Robertson, NR; Scott, LJ; van de Bunt, M; Eriksson, JG; Jula, A; Koskinen, S; Lehtimäki, T; Palotie, A; Raitakari, OT; Jacobs, SB; Wessel, J; Chu, AY; Scott, RA; Goodarzi, MO; Blancher, C; Buck, G; Buck, D; Chines, PS; Gabriel, S; Gjesing, AP; Groves, CJ; Hollensted, M; Huyghe, JR; Jackson, AU; Jun, G; Justesen, JM; Mangino, M; Murphy, J; Neville, M; Onofrio, R; Small, KS; Stringham, HM; Trakalo, J; Banks, E; Carey, J; Carneiro, MO; DePristo, M; Farjoun, Y; Fennell, T; Goldstein, JI; Grant, G; Hrabé de Angelis, M; Maguire, J; Neale, BM; Poplin, R; Purcell, S; Schwarzmayr, T; Shakir, K; Smith, JD; Strom, TM; Wieland, T; Lindstrom, J; Brandslund, I; Christensen, C; Surdulescu, GL; Lakka, TA; Doney, ASF; Nilsson, P; Wareham, NJ; Langenberg, C; Varga, TV; Franks, PW; Rolandsson, O; Rosengren, AH; Farook, VS; Thameem, F; Puppala, S; Kumar, S; Lehman, DM; Jenkinson, CP; Curran, JE; Hale, DE; Fowler, SP; Arya, R; DeFronzo, RA; Abboud, HE; Syvänen, A-C; Hicks, PJ; Palmer, ND; Ng, MCY; Bowden, DW; Freedman, BI; Esko, T; Mägi, R; Milani, L; Mihailov, E; Metspalu, A; Narisu, N; Kinnunen, L; Bonnycastle, LL; Swift, A; Pasko, D; Wood, AR; Fadista, J; Pollin, TI; Barzilai, N; Atzmon, G; Glaser, B; Thorand, B; Strauch, K; Peters, A; Roden, M; Müller-Nurasyid, M; Liang, L; Kriebel, J; Illig, T; Grallert, H; Gieger, C; Meisinger, C; Lannfelt, L; Musani, SK; Griswold, M; Taylor, HA; Wilson, G; Correa, A; Oksa, H; Scott, WR; Afzal, U; Tan, S-T; Loh, M; Chambers, JC; Sehmi, J; Kooner, JS; Lehne, B; Cho, YS; Lee, J-Y; Han, B-G; Käräjämäki, A; Qi, Q; Qi, L; Huang, J; Hu, FB; Melander, O; Orho-Melander, M; Below, JE; Aguilar, D; Wong, TY; Liu, J; Khor, C-C; Chia, KS; Lim, WY; Cheng, C-Y; Chan, E; Tai, ES; Aung, T; Linneberg, A; Isomaa, B; Meitinger, T; Tuomi, T; Hakaste, L; Kravic, J; Jørgensen, ME; Lauritzen, T; Deloukas, P; Stirrups, KE; Owen, KR; Farmer, AJ; Frayling, TM; O'Rahilly, SP; Walker, M; Levy, JC; Hodgkiss, D; Hattersley, AT; Kuulasmaa, T; Stančáková, A; Barroso, I; Bharadwaj, D; Chan, J; Chandak, GR; Daly, MJ; Donnelly, PJ; Ebrahim, SB; Elliott, P; Fingerlin, T; Froguel, P; Hu, C; Jia, W; Ma, RCW; McVean, G; Park, T; Prabhakaran, D; Sandhu, M; Scott, J; Sladek, R; Tandon, N; Teo, YY; Zeggini, E; Watanabe, RM; Koistinen, HA; Kesaniemi, YA; Uusitupa, M; Spector, TD; Salomaa, V; Rauramaa, R; Palmer, CNA; Prokopenko, I; Morris, AD; Bergman, RN; Collins, FS; Lind, L; Ingelsson, E; Tuomilehto, J; Karpe, F; Groop, L; Jørgensen, T; Hansen, T; Pedersen, O; Kuusisto, J; Abecasis, G; Bell, GI; Blangero, J; Cox, NJ; Duggirala, R; Seielstad, M; Wilson, JG; Dupuis, J; Ripatti, S; Hanis, CL; Florez, JC; Mohlke, KL; Meigs, JB; Laakso, M; Morris, AP; Boehnke, M; Altshuler, D; McCarthy, MI; Gloyn, AL; Lindgren, CM (American Diabetes Association, 2017-03-24)
    To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...
  • New genetic loci link adipose and insulin biology to body fat distribution 

    Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, Krista; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, Felix R.; Esko, T; Fall, T; Kutalik, Z; Luan, J; Randall, JC; Scherag, A; Vedantam, S; Wood, Andrew R.; Chen, J; Fehrmann, R; Karjalainen, J; Kahali, B; Liu, CT; Schmidt, EM; Absher, D; Amin, N; Anderson, D; Beekman, M; Bragg-Gresham, JL; Buyske, S; Demirkan, A; Ehret, GB; Feitosa, MF; Goel, A; Jackson, AU; Johnson, T; Kleber, ME; Kristiansson, K; Mangino, M; Mateo Leach, I; Medina-Gomez, C; Palmer, CD; Pasko, Dorota; Pechlivanis, S; Peters, MJ; Prokopenko, I; Stančáková, A; Ju Sung, Y; Tanaka, T; Teumer, A; Van Vliet-Ostaptchouk, JV; Yengo, L; Zhang, W; Albrecht, E; Ärnlöv, J; Arscott, GM; Bandinelli, S; Barrett, A; Bellis, C; Bennett, AJ; Berne, C; Blüher, M; Böhringer, S; Bonnet, F; Böttcher, Y; Bruinenberg, M; Carba, DB; Caspersen, IH; Clarke, R; Daw, EW; Deelen, J; Deelman, E; Delgado, G; Doney, AS; Eklund, N; Erdos, MR; Estrada, K; Eury, E; Friedrich, N; Garcia, ME; Giedraitis, V; Gigante, B; Go, AS; Golay, A; Grallert, H; Grammer, TB; Gräßler, J; Grewal, J; Groves, Christopher J.; Haller, T; Hallmans, G; Hartman, CA; Hassinen, M; Hayward, C; Heikkilä, K; Herzig, KH; Helmer, Q; Hillege, Hans; Holmen, O; Hunt, SC; Isaacs, A; Ittermann, T; James, AL; Johansson, I; Juliusdottir, T; Kalafati, IP; Kinnunen, L; Koenig, W; Kooner, IK; Kratzer, W; Lamina, C; Leander, K; Lee, NR; Lichtner, P; Lind, L; Lindström, J; Lobbens, S; Lorentzon, M; Mach, F; Magnusson, PK; Mahajan, A; McArdle, WL; Menni, C; Merger, S; Mihailov, E; Milani, L; Mills, R; Moayyeri, A; Monda, KL; Mooijaart, SP; Mühleisen, TW; Mulas, A; Müller, G; Müller-Nurasyid, M; Nagaraja, R; Nalls, MA; Narisu, N; Glorioso, N; Nolte, IM; Olden, M; Rayner, NW; Renstrom, F; Ried, JS; Robertson, NR; Rose, LM; Sanna, S; Scharnagl, H; Scholtens, S; Sennblad, B; Seufferlein, T; Sitlani, CM; Vernon Smith, A; Stirrups, K; Stringham, HM; Sundström, J; Swertz, MA; Swift, AJ; Syvänen, AC; Tayo, BO; Thorand, B; Thorleifsson, G; Tomaschitz, A; Troffa, C; van Oort, FV; Verweij, N; Vonk, JM; Waite, LL; Wennauer, R; Wilsgaard, T; Wojczynski, MK; Wong, A; Zhang, Q; Hua Zhao, J; Brennan, EP; Choi, M; Eriksson, P; Folkersen, L; Franco-Cereceda, A; Gharavi, AG; Hedman, ÅK; Hivert, MF; Huang, J; Kanoni, S; Karpe, F; Keildson, S; Kiryluk, K; Liang, L; Lifton, RP; Ma, B; McKnight, AJ; McPherson, R; Metspalu, A; Min, JL; Moffatt, MF; Montgomery, GW; Murabito, JM; Nicholson, G; Nyholt, DR; Olsson, C; Perry, John R.B.; Reinmaa, E; Salem, RM; Sandholm, N; Schadt, EE; Scott, RA; Stolk, L; Vallejo, EE; Westra, HJ; Zondervan, KT; ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium; Amouyel, P; Arveiler, D; Bakker, SJ; Beilby, J; Bergman, RN; Blangero, J; Brown, MJ; Burnier, M; Campbell, H; Chakravarti, A; Chines, PS; Claudi-Boehm, S; Collins, FS; Crawford, DC; Danesh, J; de Faire, U; de Geus, Eco; Dörr, M; Erbel, R; Eriksson, Johan G.; Farrall, M; Ferrannini, E; Ferrières, J; Forouhi, NG; Forrester, T; Franco, OH; Gansevoort, RT; Gieger, C; Gudnason, V; Haiman, CA; Harris, Tamara; Hattersley, Andrew T.; Heliövaara, M; Hicks, AA; Hingorani, Aroon; Hoffmann, W; Hofman, A; Homuth, G; Humphries, SE; Hyppönen, E; Illig, T; Jarvelin, MR; Johansen, B; Jousilahti, P; Jula, AM; Kaprio, J; Kee, F; Keinanen-Kiukaanniemi, SM; Kooner, JS; Kooperberg, C; Kovacs, P; Kraja, AT; Kumari, M; Kuulasmaa, K; Kuusisto, J; Lakka, TA; Langenberg, C; Le Marchand, L; Lehtimäki, T; Lyssenko, V; Männistö, S; Marette, A; Matise, TC; McKenzie, CA; McKnight, B; Musk, AW; Möhlenkamp, S; Morris, AD; Nelis, M; Ohlsson, C; Oldehinkel, AJ; Ong, KK; Palmer, LJ; Penninx, BW; Peters, A; Pramstaller, PP; Raitakari, OT; Rankinen, T; Rao, DC; Rice, TK; Ridker, PM; Ritchie, MD; Rudan, I; Salomaa, V; Samani, NJ; Saramies, J; Sarzynski, MA; Schwarz, PE; Shuldiner, AR; Staessen, JA; Steinthorsdottir, V; Stolk, RP; Strauch, K; Tönjes, A; Tremblay, A; Tremoli, E; Vohl, MC; Völker, U; Vollenweider, P; Wilson, JF; Witteman, JC; Adair, LS; Bochud, M; Boehm, BO; Bornstein, SR; Bouchard, C; Cauchi, S; Caulfield, MJ; Chambers, JC; Chasman, DI; Cooper, RS; Dedoussis, George V.; Ferrucci, L; Froguel, P; Grabe, HJ; Hamsten, A; Hui, J; Hveem, K; Jöckel, KH; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; März, W; Munroe, PB; Njølstad, I; Oostra, BA; Palmer, CN; Pedersen, NL; Perola, M; Pérusse, L; Peters, U; Power, C; Quertermous, T; Rauramaa, R; Rivadeneira, F; Saaristo, TE; Saleheen, D; Sinisalo, J; Slagboom, PE; Snieder, H; Spector, TD; Thorsteinsdottir, U; Stumvoll, M; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; van der Harst, P; Veronesi, G; Walker, M; Wareham, NJ; Watkins, H; Wichmann, HE; Abecasis, GR; Assimes, TL; Berndt, SI; Boehnke, M; Borecki, IB; Deloukas, P; Franke, L; Frayling, Timothy M.; Groop, Leif; Hunter, DJ; Kaplan, RC; O'Connell, JR; Qi, L; Schlessinger, D; Strachan, DP; Stefansson, K; van Duijn, CM; Willer, CJ; Visscher, PM; Yang, J; Hirschhorn, JN; Zillikens, MC; McCarthy, MI; Speliotes, EK; North, KE; Fox, CS; Barroso, I; Franks, PW; Ingelsson, E; Heid, IM; Loos, RJ; Cupples, LA; Morris, AP; Lindgren, CM; Mohlke, KL (Nature Publishing Group, 2015-02-11)
    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and ...
  • New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism 

    Horikoshi, M; Yaghootkar, H; Mook-Kanamori, DO; Sovio, U; Taal, HR; Hennig, BJ; Bradfield, JP; St Pourcain, B; Evans, David M.; Charoen, P; Kaakinen, M; Cousminer, DL; Lehtimäki, T; Kreiner-Møller, E; Warrington, NM; Bustamante, M; Feenstra, B; Berry, DJ; Thiering, E; Pfab, T; Barton, SJ; Shields, BM; Kerkhof, M; Van Leeuwen, EM; Fulford, AJ; Kutalik, Z; Zhao, JH; Den Hoed, M; Mahajan, A; Lindi, V; Goh, L-K; Hottenga, JJ; Wu, Y; Raitakari, OT; Harder, MN; Meirhaeghe, A; Ntalla, I; Salem, RM; Jameson, KA; Zhou, K; Monies, DM; Lagou, V; Kirin, M; Heikkinen, J; Adair, LS; Alkuraya, FS; Al-Odaib, A; Amouyel, P; Andersson, EA; Bennett, Amanda; Blakemore, AIF; Buxton, JL; Dallongeville, J; Das, S; de Geus, Eco; Estivill, X; Flexeder, C; Froguel, P; Geller, F; Godfrey, KM; Gottrand, F; Groves, Christopher J.; Hansen, T; Hirschhorn, JN; Hofman, A; Hollegaard, MV; Hougaard, DM; Hyppönen, E; Inskip, HM; Isaacs, A; Jørgensen, T; Kanaka-Gantenbein, C; Kemp, JP; Kiess, W; Kilpeläinen, TO; Klopp, N; Knight, BA; Kuzawa, CW; Mcmahon, G; Newnham, JP; Niinikoski, H; Oostra, BA; Pedersen, L; Postma, DS; Ring, SM; Rivadeneira, F; Robertson, NR; Sebert, S; Simell, O; Slowinski, T; Tiesler, CMT; Tönjes, A; Vaag, A; Viikari, JS; Vink, JM; Vissing, NH; Wareham, NJ; Willemsen, G; Witte, DR; Zhang, H; Zhao, J; Wilson, JF; Stumvoll, M; Prentice, AM; Meyer, BF; Pearson, ER; Boreham, CAG; Cooper, Cyrus; Gillman, MW; Dedoussis, George V.; Moreno, LA; Pedersen, O; Saarinen, M; Mohlke, KL; Boomsma, DI; Saw, S-M; Lakka, TA; Körner, A; Loos, RJF; Ong, KK; Vollenweider, P; Van Duijn, CM; Koppelman, GH; Hattersley, Andrew T.; Holloway, JW; Hocher, B; Heinrich, J; Power, C; Melbye, M; Guxens, M; Pennell, CE; Bønnelykke, K; Bisgaard, H; Eriksson, Johan G.; Widén, E; Hakonarson, H; Uitterlinden, AG; Pouta, A; Lawlor, DA; Smith, GD; Frayling, Timothy M.; McCarthy, MI; Grant, SFA; Jaddoe, VWV; Jarvelin, M-R; Timpson, NJ; Prokopenko, I; Freathy, RM (Nature Publishing Group, 2013-01)
    Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight ...
  • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape 

    Ried, JS; Jeff M, J; Chu, AY; Bragg-Gresham, JL; van Dongen, J; Huffman, JE; Ahluwalia, TS; Cadby, G; Eklund, N; Eriksson, J; Esko, T; Feitosa, MF; Goel, A; Gorski, M; Hayward, C; Heard-Costa, NL; Jackson, AU; Jokinen, E; Kanoni, S; Kristiansson, K; Kutalik, Z; Lahti, J; Luan, J; Mägi, R; Mahajan, A; Mangino, M; Medina-Gomez, C; Monda, KL; Nolte, IM; Pérusse, L; Prokopenko, I; Qi, L; Rose, LM; Salvi, E; Smith, MT; Snieder, H; Stančáková, A; Ju Sung, Y; Tachmazidou, I; Teumer, A; Thorleifsson, G; van der Harst, P; Walker, RW; Wang, SR; Wild, SH; Willems, SM; Wong, A; Zhang, W; Albrecht, E; Couto Alves, A; Bakker, SJL; Barlassina, C; Bartz, TM; Beilby, J; Bellis, C; Bergman, RN; Bergmann, S; Blangero, J; Blüher, M; Boerwinkle, E; Bonnycastle, LL; Bornstein, SR; Bruinenberg, M; Campbell, H; Chen, Y-DI; Chiang, CWK; Chines, PS; Collins, FS; Cucca, F; Cupples, LA; D'Avila, F; de Geus, EJC; Dedoussis, G; Dimitriou, M; Döring, A; Eriksson, JG; Farmaki, A-E; Farrall, M; Ferreira, T; Fischer, K; Forouhi, NG; Friedrich, N; Gjesing, AP; Glorioso, N; Graff, M; Grallert, H; Grarup, N; Gräßler, J; Grewal, J; Hamsten, A; Harder, MN; Hartman, CA; Hassinen, M; Hastie, N; Hattersley, AT; Havulinna, AS; Heliövaara, M; Hillege, H; Hofman, A; Holmen, O; Homuth, G; Hottenga, J-J; Hui, J; Husemoen, LL; Hysi, PG; Isaacs, A; Ittermann, T; Jalilzadeh, S; James, AL; Jørgensen, T; Jousilahti, P; Jula, A; Marie Justesen, J; Justice, AE; Kähönen, M; Karaleftheri, M; Tee Khaw, K; Keinanen-Kiukaanniemi, SM; Kinnunen, L; Knekt, PB; Koistinen, HA; Kolcic, I; Kooner, IK; Koskinen, S; Kovacs, P; Kyriakou, T; Laitinen, T; Langenberg, C; Lewin, AM; Lichtner, P; Lindgren, CM; Lindström, J; Linneberg, A; Lorbeer, R; Lorentzon, M; Luben, R; Lyssenko, V; Männistö, S; Manunta, P; Leach, IM; McArdle, WL; Mcknight, B; Mohlke, KL; Mihailov, E; Milani, L; Mills, R; Montasser, ME; Morris, AP; Müller, G; Musk, AW; Narisu, N; Ong, KK; Oostra, BA; Osmond, C; Palotie, A; Pankow, JS; Paternoster, L; Penninx, BW; Pichler, I; Pilia, MG; Polašek, O; Pramstaller, PP; Raitakari, OT; Rankinen, T; Rao, DC; Rayner, NW; Ribel-Madsen, R; Rice, TK; Richards, M; Ridker, PM; Rivadeneira, F; Ryan, KA; Sanna, S; Sarzynski, MA; Scholtens, S; Scott, RA; Sebert, S; Southam, L; Sparsø, TH; Steinthorsdottir, V; Stirrups, K; Stolk, RP; Strauch, K; Stringham, HM; Swertz, MA; Swift, AJ; Tönjes, A; Tsafantakis, E; van der Most, PJ; Van Vliet-Ostaptchouk, JV; Vandenput, L; Vartiainen, E; Venturini, C; Verweij, N; Viikari, JS; Vitart, V; Vohl, M-C; Vonk, JM; Waeber, G; Widén, E; Willemsen, G; Wilsgaard, T; Winkler, TW; Wright, AF; Yerges-Armstrong, LM; Hua Zhao, J; Carola Zillikens, M; Boomsma, DI; Bouchard, C; Chambers, JC; Chasman, DI; Cusi, D; Gansevoort, RT; Gieger, C; Hansen, T; Hicks, AA; Hu, F; Hveem, K; Jarvelin, M-R; Kajantie, E; Kooner, JS; Kuh, D; Kuusisto, J; Laakso, M; Lakka, TA; Lehtimäki, T; Metspalu, A; Njølstad, I; Ohlsson, C; Oldehinkel, AJ; Palmer, LJ; Pedersen, O; Perola, M; Peters, A; Psaty, BM; Puolijoki, H; Rauramaa, R; Rudan, I; Salomaa, V; Schwarz, PEH; Shudiner, AR; Smit, JH; Sørensen, TIA; Spector, TD; Stefansson, K; Stumvoll, M; Tremblay, A; Tuomilehto, J; Uitterlinden, AG; Uusitupa, M; Völker, U; Vollenweider, P; Wareham, NJ; Watkins, H; Wilson, JF; Zeggini, E; Abecasis, GR; Boehnke, M; Borecki, IB; Deloukas, P; van Duijn, CM; Fox, C; Groop, LC; Heid, IM; Hunter, DJ; Kaplan, RC; McCarthy, MI; North, KE; O'Connell, JR; Schlessinger, D; Thorsteinsdottir, U; Strachan, DP; Frayling, T; Hirschhorn, JN; Müller-Nurasyid, M; Loos, RJF (Nature Publishing Group, 2016-11-23)
    Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a ...
  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 

    Turcot, V; Lu, Y; Highland, HM; Schurmann, C; Justice, AE; Fine, RS; Bradfield, JP; Esko, T; Giri, A; Graff, M; Guo, X; Hendricks, AE; Karaderi, T; Lempradl, A; Locke, AE; Mahajan, A; Marouli, E; Sivapalaratnam, S; Young, KL; Alfred, T; Feitosa, MF; Masca, NGD; Manning, AK; Medina-Gomez, C; Mudgal, P; Ng, MCY; Reiner, AP; Vedantam, S; Willems, SM; Winkler, TW; Abecasis, G; Aben, KK; Alam, DS; Alharthi, SE; Allison, M; Amouyel, P; Asselbergs, FW; Auer, PL; Balkau, B; Bang, LE; Barroso, I; Bastarache, L; Benn, M; Bergmann, S; Bielak, LF; Blüher, M; Boehnke, M; Boeing, H; Boerwinkle, E; Böger, CA; Bork-Jensen, J; Bots, ML; Bottinger, EP; Bowden, DW; Brandslund, I; Breen, G; Brilliant, MH; Broer, L; Brumat, M; Burt, AA; Butterworth, AS; Campbell, PT; Cappellani, S; Carey, DJ; Catamo, E; Caulfield, MJ; Chambers, JC; Chasman, DI; Chen, Y-DI; Chowdhury, R; Christensen, C; Chu, AY; Cocca, M; Collins, FS; Cook, JP; Corley, J; Corominas Galbany, J; Cox, AJ; Crosslin, DS; Cuellar-Partida, G; D'Eustacchio, A; Danesh, J; Davies, G; Bakker, PIW; Groot, MCH; Mutsert, R; Deary, IJ; Dedoussis, G; Demerath, EW; Heijer, M; Hollander, AI; Ruijter, HM; Dennis, JG; Denny, JC; Angelantonio, E; Drenos, F; Du, M; Dubé, M-P; Dunning, AM; Easton, DF; Edwards, TL; Ellinghaus, D; Ellinor, PT; Elliott, P; Evangelou, E; Farmaki, A-E; Farooqi, IS; Faul, JD; Fauser, S; Feng, S; Ferrannini, E; Ferrieres, J; Florez, JC; Ford, I; Fornage, M; Franco, OH; Franke, A; Franks, PW; Friedrich, N; Frikke-Schmidt, R; Galesloot, TE; Gan, W; Gandin, I; Gasparini, P; Gibson, J; Giedraitis, V; Gjesing, AP; Gordon-Larsen, P; Gorski, M; Grabe, H-J; Grant, SFA; Grarup, N; Griffiths, HL; Grove, ML; Gudnason, V; Gustafsson, S; Haessler, J; Hakonarson, H; Hammerschlag, AR; Hansen, T; Harris, KM; Harris, TB; Hattersley, AT; Have, CT; Hayward, C; He, L; Heard-Costa, NL; Heath, AC; Heid, IM; Helgeland, Ø; Hernesniemi, J; Hewitt, AW; Holmen, OL; Hovingh, GK; Howson, JMM; Hu, Y; Huang, PL; Huffman, JE; Ikram, MA; Ingelsson, E; Jackson, AU; Jansson, J-H; Jarvik, GP; Jensen, GB; Jia, Y; Johansson, S; Jørgensen, ME; Jørgensen, T; Jukema, JW; Kahali, B; Kahn, RS; Kähönen, M; Kamstrup, PR; Kanoni, S; Kaprio, J; Karaleftheri, M; Kardia, SLR; Karpe, F; Kathiresan, S; Kee, F; Kiemeney, LA; Kim, E; Kitajima, H; Komulainen, P; Kooner, JS; Kooperberg, C; Korhonen, T; Kovacs, P; Kuivaniemi, H; Kutalik, Z; Kuulasmaa, K; Kuusisto, J; Laakso, M; Lakka, TA; Lamparter, D; Lange, EM; Lange, LA; Langenberg, C; Larson, EB; Lee, NR; Lehtimäki, T; Lewis, CE; Li, H; Li, J; Li-Gao, R; Lin, H; Lin, K-H; Lin, L-A; Lin, X; Lind, L; Lindström, J; Linneberg, A; Liu, C-T; Liu, DJ; Liu, Y; Lo, KS; Lophatananon, A; Lotery, AJ; Loukola, A; Luan, J; Lubitz, SA; Lyytikäinen, L-P; Männistö, S; Marenne, G; Mazul, AL; McCarthy, MI; McKean-Cowdin, R; Medland, SE; Meidtner, K; Milani, L; Mistry, V; Mitchell, P; Mohlke, KL; Moilanen, L; Moitry, M; Montgomery, GW; Mook-Kanamori, DO; Moore, C; Mori, TA; Morris, AD; Morris, AP; Müller-Nurasyid, M; Munroe, PB; Nalls, MA; Narisu, N; Nelson, CP; Neville, M; Nielsen, SF; Nikus, K; Njølstad, PR; Nordestgaard, BG; Nyholt, DR; O'Connel, JR; O'Donoghue, ML; Olde Loohuis, LM; Ophoff, RA; Owen, KR; Packard, CJ; Padmanabhan, S; Palmer, CNA; Palmer, ND; Pasterkamp, G; Patel, AP; Pattie, A; Pedersen, O; Peissig, PL; Peloso, GM; Pennell, CE; Perola, M; Perry, JA; Perry, JRB; Pers, TH; Person, TN; Peters, A; Petersen, ERB; Peyser, PA; Pirie, A; Polasek, O; Polderman, TJ; Puolijoki, H; Raitakari, OT; Rasheed, A; Rauramaa, R; Reilly, DF; Renström, F; Rheinberger, M; Ridker, PM; Rioux, JD; Rivas, MA; Roberts, DJ; Robertson, NR; Robino, A; Rolandsson, O; Rudan, I; Ruth, KS; Saleheen, D; Salomaa, V; Samani, NJ; Sapkota, Y; Sattar, N; Schoen, RE; Schreiner, PJ; Schulze, MB; Scott, RA; Segura-Lepe, MP; Shah, SH; Sheu, WH-H; Sim, X; Slater, AJ; Small, KS; Smith, AV; Southam, L; Spector, TD; Speliotes, EK; Starr, JM; Stefansson, K; Steinthorsdottir, V; Stirrups, KE; Strauch, K; Stringham, HM; Stumvoll, M; Sun, L; Surendran, P; Swift, AJ; Tada, H; Tansey, KE; Tardif, J-C; Taylor, KD; Teumer, A; Thompson, DJ; Thorleifsson, G; Thorsteinsdottir, U; Thuesen, BH; Tönjes, A; Tromp, G; Trompet, S; Tsafantakis, E; Tuomilehto, J; Tybjaerg-Hansen, A; Tyrer, JP; Uher, R; Uitterlinden, AG; Uusitupa, M; Laan, SW; Duijn, CM; Leeuwen, N; van Setten, J; Vanhala, M; Varbo, A; Varga, TV; Varma, R; Velez Edwards, DR; Vermeulen, SH; Veronesi, G; Vestergaard, H; Vitart, V; Vogt, TF; Völker, U; Vuckovic, D; Wagenknecht, LE; Walker, M; Wallentin, L; Wang, F; Wang, CA; Wang, S; Wang, Y; Ware, EB; Wareham, NJ; Warren, HR; Waterworth, DM; Wessel, J; White, HD; Willer, CJ; Wilson, JG; Witte, DR; Wood, AR; Wu, Y; Yaghootkar, H; Yao, J; Yao, P; Yerges-Armstrong, LM; Young, R; Zeggini, E; Zhan, X; Zhang, W; Zhao, JH; Zhao, W; Zhou, W; Zondervan, KT; CHD Exome+ Consortium; EPIC-CVD Consortium; ExomeBP Consortium; Global Lipids Genetic Consortium; GoT2D Genes Consortium; EPIC InterAct Consortium; INTERVAL Study; ReproGen Consortium; T2D-Genes Consortium; MAGIC Investigators; Understanding Society Scientific Group; Rotter, JI; Pospisilik, JA; Rivadeneira, F; Borecki, IB; Deloukas, P; Frayling, TM; Lettre, G; North, KE; Lindgren, CM; Hirschhorn, JN; Loos, RJF (Nature Publishing Group, 2017-12-22)
    Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which ...
  • Rare and low-frequency coding variants alter human adult height 

    Marouli, E; Graff, M; Medina-Gomez, C; Lo, KS; Wood, AR; Kjaer, TR; Fine, RS; Lu, Y; Schurmann, C; Highland, HM; Rüeger, S; Thorleifsson, G; Justice, AE; Lamparter, D; Stirrups, KE; Turcot, V; Young, KL; Winkler, TW; Esko, T; Karaderi, T; Locke, AE; Masca, NGD; Ng, MCY; Mudgal, P; Rivas, MA; Vedantam, S; Mahajan, A; Guo, X; Abecasis, G; Aben, KK; Adair, LS; Alam, DS; Albrecht, E; Allin, KH; Allison, M; Amouyel, P; Appel, EV; Arveiler, D; Asselbergs, FW; Auer, PL; Balkau, B; Banas, B; Bang, LE; Benn, M; Bergmann, S; Bielak, LF; Blüher, M; Boeing, H; Boerwinkle, E; Böger, CA; Bonnycastle, LL; Bork-Jensen, J; Bots, ML; Bottinger, EP; Bowden, DW; Brandslund, I; Breen, G; Brilliant, MH; Broer, L; Burt, AA; Butterworth, AS; Carey, DJ; Caulfield, MJ; Chambers, JC; Chasman, DI; Chen, Y-DI; Chowdhury, R; Christensen, C; Chu, AY; Cocca, M; Collins, FS; Cook, JP; Corley, J; Galbany, JC; Cox, AJ; Cuellar-Partida, G; Danesh, J; Davies, G; de Bakker, PIW; de Borst, GJ; de Denus, S; de Groot, MCH; de Mutsert, R; Deary, IJ; Dedoussis, G; Demerath, EW; den Hollander, AI; Dennis, JG; Di Angelantonio, E; Drenos, F; Du, M; Dunning, AM; Easton, DF; Ebeling, T; Edwards, TL; Ellinor, PT; Elliott, P; Evangelou, E; Farmaki, A-E; Faul, JD; Feitosa, MF; Feng, S; Ferrannini, E; Ferrario, MM; Ferrieres, J; Florez, JC; Ford, I; Fornage, M; Franks, PW; Frikke-Schmidt, R; Galesloot, TE; Gan, W; Gandin, I; Gasparini, P; Giedraitis, V; Giri, A; Girotto, G; Gordon, SD; Gordon-Larsen, P; Gorski, M; Grarup, N; Grove, ML; Gudnason, V; Gustafsson, S; Hansen, T; Harris, KM; Harris, TB; Hattersley, AT; Hayward, C; He, L; Heid, IM; Heikkilä, K; Helgeland, Ø; Hernesniemi, J; Hewitt, AW; Hocking, LJ; Hollensted, M; Holmen, OL; Hovingh, GK; Howson, JMM; Hoyng, CB; Huang, PL; Hveem, K; Ikram, MA; Ingelsson, E; Jackson, AU; Jansson, J-H; Jarvik, GP; Jensen, GB; Jhun, MA; Jia, Y; Jiang, X; Johansson, S; Jørgensen, ME; Jørgensen, T; Jousilahti, P; Jukema, JW; Kahali, B; Kahn, RS; Kähönen, M; Kamstrup, PR; Kanoni, S; Kaprio, J; Karaleftheri, M; Kardia, SLR; Karpe, F; Kee, F; Keeman, R; Kiemeney, LA; Kitajima, H; Kluivers, KB; Kocher, T; Komulainen, P; Kontto, J; Kooner, JS; Kooperberg, C; Kovacs, P; Kriebel, J; Kuivaniemi, H; Küry, S; Kuusisto, J; La Bianca, M; Laakso, M; Lakka, TA; Lange, EM; Lange, LA; Langefeld, CD; Langenberg, C; Larson, EB; Lee, I-T; Lehtimäki, T; Lewis, CE; Li, H; Li, J; Li-Gao, R; Lin, H; Lin, L-A; Lin, X; Lind, L; Lindström, J; Linneberg, A; Liu, Y; Liu, Y; Lophatananon, A; Luan, J; Lubitz, SA; Lyytikäinen, L-P; Mackey, DA; Madden, PAF; Manning, AK; Männistö, S; Marenne, G; Marten, J; Martin, NG; Mazul, AL; Meidtner, K; Metspalu, A; Mitchell, P; Mohlke, KL; Mook-Kanamori, DO; Morgan, A; Morris, AD; Morris, AP; Müller-Nurasyid, M; Munroe, PB; Nalls, MA; Nauck, M; Nelson, CP; Neville, M; Nielsen, SF; Nikus, K; Njølstad, PR; Nordestgaard, BG; Ntalla, I; O'Connel, JR; Oksa, H; Loohuis, LMO; Ophoff, RA; Owen, KR; Packard, CJ; Padmanabhan, S; Palmer, CNA; Pasterkamp, G; Patel, AP; Pattie, A; Pedersen, O; Peissig, PL; Peloso, GM; Pennell, CE; Perola, M; Perry, JA; Perry, JRB; Person, TN; Pirie, A; Polasek, O; Posthuma, D; Raitakari, OT; Rasheed, A; Rauramaa, R; Reilly, DF; Reiner, AP; Renström, F; Ridker, PM; Rioux, JD; Robertson, N; Robino, A; Rolandsson, O; Rudan, I; Ruth, KS; Saleheen, D; Salomaa, V; Samani, NJ; Sandow, K; Sapkota, Y; Sattar, N; Schmidt, MK; Schreiner, PJ; Schulze, MB; Scott, RA; Segura-Lepe, MP; Shah, S; Sim, X; Sivapalaratnam, S; Small, KS; Smith, AV; Smith, JA; Southam, L; Spector, TD; Speliotes, EK; Starr, JM; Steinthorsdottir, V; Stringham, HM; Stumvoll, M; Surendran, P; 't Hart, LM; Tansey, KE; Tardif, J-C; Taylor, KD; Teumer, A; Thompson, DJ; Thorsteinsdottir, U; Thuesen, BH; Tönjes, A; Tromp, G; Trompet, S; Tsafantakis, E; Tuomilehto, J; Tybjaerg-Hansen, A; Tyrer, JP; Uher, R; Uitterlinden, AG; Ulivi, S; van der Laan, SW; Van Der Leij, AR; van Duijn, CM; van Schoor, NM; van Setten, J; Varbo, A; Varga, TV; Varma, R; Edwards, DRV; Vermeulen, SH; Vestergaard, H; Vitart, V; Vogt, TF; Vozzi, D; Walker, M; Wang, F; Wang, CA; Wang, S; Wang, Y; Wareham, NJ; Warren, HR; Wessel, J; Willems, SM; Wilson, JG; Witte, DR; Woods, MO; Wu, Y; Yaghootkar, H; Yao, J; Yao, P; Yerges-Armstrong, LM; Young, R; Zeggini, E; Zhan, X; Zhang, W; Zhao, JH; Zhao, W; Zhao, W; Zheng, H; Zhou, W; EPIC-InterAct Consortium; CHD Exome+ Consortium; ExomeBP Consortium; T2D-Genes Consortium; GoT2D Genes Consortium; Global Lipids Genetics Consortium; ReproGen Consortium; MAGIC Investigators; Rotter, JI; Boehnke, M; Kathiresan, S; McCarthy, MI; Willer, CJ; Stefansson, K; Borecki, IB; Liu, DJ; North, KE; Heard-Costa, NL; Pers, TH; Lindgren, CM; Oxvig, C; Kutalik, Z; Rivadeneira, F; Loos, RJF; Frayling, TM; Hirschhorn, JN; Deloukas, P; Lettre, G (Nature Publishing Group, 2017-02-01)
    Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with ...