Institute of Medical Education: Recent submissions
Now showing items 46-50 of 299
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Breakdown of functional networks in mouse models of dementia
(University of Exeter College of Medicine and Health, 26 April 2021)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the major cause of dementia, for which there are no available treatments that can cure or stop its progression. Disorientation in both familiar and ... -
Intermittent compression induces transitory hypoxic stimuli, upstream vasodilation and enhanced perfusion of skin capillaries, independent of age and diabetes.
(American Physiological Society, 16 April 2021)The benefit of enhanced shear stress to the vascular endothelium has been well documented in conduit arteries but is less well understood in skin microcirculation. The study aim was to provide physiological evidence of the ... -
Relationship between synaptic dysfunction and degeneration in a rodent model of dementia
(University of Exeter College of Medicine and Health, 29 March 2021)Synaptic degeneration is currently the best biomarker correlate of cognitive decline in dementia. In the years prior to dementia onset, many neurophysiological changes are occurring hypothesised to preserve cognitive ... -
Perforated Multi-Electrode Array Recording in Hypothalamic Brain Slices
(Springer, 8 December 2020)The ability to record ensemble action potential (AP) discharge frequencies from large populations of neurons over extended periods of time in vitro offers clear advantages in neuroscience and circadian biology research. ... -
Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons
(Wiley / EMBO Press, 2 March 2021)There is no consensus on the best inhibitory optogenetic tool. Since Gi/o signalling is a native mechanism of neuronal inhibition, we asked whether Lamprey Parapinopsin (“Lamplight”), a Gi/o-coupled bistable animal opsin, ...