Institute of Medical Education: Recent submissions
Now showing items 51-55 of 299
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An investigation into the mechanisms of action of incretin-based anti-diabetic therapies in the human vasculature
(University of Exeter Medical School, 15 March 2021)Type 2 diabetes (T2DM) is associated with microvascular complications i.e. diabetic retinopathy, nephropathy and neuropathy, each having life altering effects. Dysfunction of the endothelial cells (ECs) that line all blood ... -
Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression
(American Physiological Society, 8 March 2021)The physiological role of the shorter isoform of WNK1 that is exclusively expressed in the kidney (KS-WNK1), with particular abundance in the distal convoluted tubule, remains elusive. KS-WNK1 despite lacking the kinase ... -
Use of SNP chips to detect rare pathogenic variants: retrospective, population based diagnostic evaluation
(BMJ Publishing Group, 16 February 2021)Objective To determine whether the sensitivity and specificity of SNP chips are adequate for detecting rare pathogenic variants in a clinically unselected population. Design Retrospective, population based diagnostic ... -
Using Mendelian Randomization to investigate the effect of maternal intra-uterine exposures on fetal growth
(University of Exeter Medical School, 15 March 2021)The aim of my thesis is to identify modifiable maternal exposures that causally affect offspring birth weight during pregnancy. Birth weight is a major correlate of both neonatal mortality and morbidity as well as adult ... -
Role of mir-483-5p in stress and anxiety
(University of Exeter College of Medicine and Health, 8 March 2021)Stress and anxiety disorders are often severely debilitating to the individual and contribute immensely to the health care costs. Surveys have estimated that 33.7% of the population is affected by these disorders at least ...