Institute of Medical Education: Recent submissions
Now showing items 61-65 of 299
-
Accounting for heterogeneity in resource allocation decisions: methods and practice in UK cancer technology appraisals
(Elsevier / International Society for Pharmacoeconomics and Outcomes Research, 28 April 2021)Objectives The availability of novel, more efficacious and expensive cancer therapies is increasing, resulting in significant treatment effect heterogeneity and complicated treatment and disease pathways. The aim of this ... -
Systematic assessment of outcomes following a genetic diagnosis identified through a large-scale research study into developmental disorders
(Springer Nature / American College of Medical Genetics and Genomics, 18 February 2021)Purpose The clinical and psychosocial outcomes associated with receiving a genetic diagnosis for developmental disorders are wide-ranging but under-studied. We sought to investigate outcomes from a subset of families ... -
Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort
(IOS Press, 3 January 2021)Background: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimated p.C282Y ... -
Role of the cation-chloride-cotransporters in the circadian system
(Elsevier / Shenyang Pharmaceutical University, 7 December 2020)The circadian system plays an immense role in controlling physiological processes in our body. The suprachiasmatic nucleus (SCN) supervises this system, regulating and harmonising the circadian rhythms in our body. Most ... -
'Not at the diagnosis point': Dealing with contradiction in autism assessment teams
(Elsevier, 19 October 2020)Social science literature has documented how the concept of diagnosis can be seen as an interactive process, imbued with uncertainty and contradiction, which undermines a straightforward notion of diagnosis as a way to ...