Emergence and maintenance of functional modules in signaling pathways

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Emergence and maintenance of functional modules in signaling pathways

Please use this identifier to cite or link to this item: http://hdl.handle.net/10036/3549


Title: Emergence and maintenance of functional modules in signaling pathways
Author: Soyer, Orkun S.
Citation: Vol. 7, article 205
Publisher: BioMed Central
Journal: BMC Evolutionary Biology
Date Issued: 2007
URI: http://hdl.handle.net/10036/3549
DOI: 10.1186/1471-2148-7-205
Links: http://dx.doi.org/10.1186/1471-2148-7-205
Abstract: Background: While detection and analysis of functional modules in biological systems have received great attention in recent years, we still lack a complete understanding of how such modules emerge. One theory is that systems must encounter a varying selection (i.e. environment) in order for modularity to emerge. Here, we provide an alternative and simpler explanation using a realistic model of biological signaling pathways and simulating their evolution.Results: These evolutionary simulations start with a homogenous population of a minimal pathway containing two effectors coupled to two signals via a single receptor. This population is allowed to evolve under a constant selection pressure for mediating two separate responses. Results of these evolutionary simulations show that under such a selective pressure, mutational processes easily lead to the emergence of pathways with two separate sub-pathways (i.e. modules) each mediating a distinct response only to one of the signals. Such functional modules are maintained as long as mutations leading to new interactions among existing proteins in the pathway are rare.Conclusion: While supporting a neutralistic view for the emergence of modularity in biological systems, these findings highlight the relevant rate of different mutational processes and the distribution of functional pathways in the topology space as key factors for its maintenance.
Type: Article
Description: © 2007 Soyer; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: escherichia-colinetwork motifstransduction pathwaysevolutionmodularityoriginmodelspecificitytopologyproteins
ISSN: 1471-2148

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