Emergence and maintenance of functional modules in signaling pathways

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Emergence and maintenance of functional modules in signaling pathways

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dc.contributor.author Soyer, Orkun S. en_US
dc.date.accessioned 2012-05-25T15:14:55Z en_US
dc.date.accessioned 2013-03-20T12:37:46Z
dc.date.issued 2007 en_US
dc.description.abstract Background: While detection and analysis of functional modules in biological systems have received great attention in recent years, we still lack a complete understanding of how such modules emerge. One theory is that systems must encounter a varying selection (i.e. environment) in order for modularity to emerge. Here, we provide an alternative and simpler explanation using a realistic model of biological signaling pathways and simulating their evolution.Results: These evolutionary simulations start with a homogenous population of a minimal pathway containing two effectors coupled to two signals via a single receptor. This population is allowed to evolve under a constant selection pressure for mediating two separate responses. Results of these evolutionary simulations show that under such a selective pressure, mutational processes easily lead to the emergence of pathways with two separate sub-pathways (i.e. modules) each mediating a distinct response only to one of the signals. Such functional modules are maintained as long as mutations leading to new interactions among existing proteins in the pathway are rare.Conclusion: While supporting a neutralistic view for the emergence of modularity in biological systems, these findings highlight the relevant rate of different mutational processes and the distribution of functional pathways in the topology space as key factors for its maintenance. en_GB
dc.identifier.citation Vol. 7, article 205 en_GB
dc.identifier.doi 10.1186/1471-2148-7-205 en_US
dc.identifier.uri http://hdl.handle.net/10036/3549 en_US
dc.language.iso en en_GB
dc.publisher BioMed Central en_GB
dc.relation.url http://dx.doi.org/10.1186/1471-2148-7-205 en_GB
dc.subject escherichia-coli en_GB
dc.subject network motifs en_GB
dc.subject transduction pathways en_GB
dc.subject evolution en_GB
dc.subject modularity en_GB
dc.subject origin en_GB
dc.subject model en_GB
dc.subject specificity en_GB
dc.subject topology en_GB
dc.subject proteins en_GB
dc.title Emergence and maintenance of functional modules in signaling pathways en_GB
dc.type Article en_GB
dc.date.available 2012-05-25T15:14:55Z en_US
dc.date.available 2013-03-20T12:37:46Z
dc.identifier.issn 1471-2148 en_US
exeter.article-number 205 en_US
exeter.contacts.depositing-owner-email Soyer, Orkun <O.S.Soyer@exeter.ac.uk> en_US
exeter.contacts.owner-email Soyer, Orkun <O.S.Soyer@exeter.ac.uk> en_US
dc.description © 2007 Soyer; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_GB
dc.identifier.journal BMC Evolutionary Biology en_GB
pubs.organisational-data /Symplectic Joint Venture en_US
pubs.organisational-data /Symplectic Joint Venture/Exeter en_US
pubs.organisational-data /Symplectic Joint Venture/Exeter/All Exeter Users en_US
pubs.organisational-data /Symplectic Joint Venture/Exeter/College of Engineering, Mathematics & Physical Sciences en_US
pubs.organisational-data /Symplectic Joint Venture/Exeter/College of Engineering, Mathematics & Physical Sciences/All Academic Staff (CEMPS) en_US
pubs.organisational-data /Symplectic Joint Venture/Exeter/College of Engineering, Mathematics & Physical Sciences/All Researchers (R+T&R) (CEMPS) en_US
pubs.organisational-data /Symplectic Joint Venture/Exeter/College of Engineering, Mathematics & Physical Sciences/Mathematics (Exeter) en_US


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