The reliability of a breath‐hold protocol to determine cerebrovascular reactivity in adolescents
dc.contributor.author | Koep, JL | |
dc.contributor.author | Barker, AR | |
dc.contributor.author | Banks, R | |
dc.contributor.author | Banger, RR | |
dc.contributor.author | Sansum, KM | |
dc.contributor.author | Weston, ME | |
dc.contributor.author | Bond, B | |
dc.date.accessioned | 2020-07-01T15:18:24Z | |
dc.date.issued | 2020-06-30 | |
dc.description.abstract | Purpose Cerebrovascular reactivity (CVR) is impaired in adolescents with cardiovascular disease risk factors. A breath‐hold test is a noninvasive method of assessing CVR, yet there are no reliability data of this outcome in youth. This study aimed to assess the reliability of a breath‐hold protocol to measure CVR in adolescents. Methods Twenty‐one 13 to 15 year old adolescents visited the laboratory on two separate occasions, to assess the within‐test, within‐day and between‐day reliability of a breath‐hold protocol, consisting of three breath‐hold attempts. CVR was defined as the relative increase from baseline in middle cerebral artery mean blood velocity following a maximal breath‐hold of up to 30 seconds, quantified via transcranial Doppler ultrasonography. Results Mean breath‐hold duration and CVR were never significantly correlated (r < .31, P > .08). The within‐test coefficient of variation for CVR was 15.2%, with no significant differences across breath‐holds (P = .88), so the three breath‐hold attempts were averaged for subsequent analyses. The within‐ and between‐day coefficients of variation for CVR were 10.8% and 15.3%, respectively. Conclusions CVR assessed via a three breath‐hold protocol can be reliably measured in adolescents, yielding similar within‐ and between‐day reliability. Analyses revealed that breath‐hold length and CVR were unrelated, indicating the commonly reported normalization of CVR to breath‐hold duration (breath‐hold index) may be unnecessary in youth. | en_GB |
dc.identifier.citation | Published online 30 June 2020 | en_GB |
dc.identifier.doi | 10.1002/jcu.22891 | |
dc.identifier.uri | http://hdl.handle.net/10871/121739 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.rights | © 2020 The Authors. Journal of Clinical Ultrasound published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | cerebral blood flow | en_GB |
dc.subject | endothelial function | en_GB |
dc.subject | hypercapnic stimulus | en_GB |
dc.subject | reproducibility | en_GB |
dc.subject | transcranial Doppler ultrasound | en_GB |
dc.subject | youth | en_GB |
dc.title | The reliability of a breath‐hold protocol to determine cerebrovascular reactivity in adolescents | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2020-07-01T15:18:24Z | |
dc.identifier.issn | 0091-2751 | |
dc.description | This is the published version. Available on open access from Wiley via the DOI in this record | en_GB |
dc.identifier.journal | Journal of Clinical Ultrasound | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2020-06-18 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2020-06-30 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2020-07-01T14:39:49Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2020-07-01T15:18:29Z | |
refterms.panel | C | en_GB |
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Except where otherwise noted, this item's licence is described as © 2020 The Authors. Journal of Clinical Ultrasound published by Wiley Periodicals LLC.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.