Bone remodeling following mandibular reconstruction using fibula free flap
dc.contributor.author | Zheng, K | |
dc.contributor.author | Yoda, N | |
dc.contributor.author | Chen, J | |
dc.contributor.author | Liao, Z | |
dc.contributor.author | Zhong, J | |
dc.contributor.author | Wu, C | |
dc.contributor.author | Wan, B | |
dc.contributor.author | Koyama, S | |
dc.contributor.author | Sasaki, K | |
dc.contributor.author | Peck, C | |
dc.contributor.author | Swain, M | |
dc.contributor.author | Li, Q | |
dc.date.accessioned | 2022-05-20T08:29:12Z | |
dc.date.issued | 2022-01-22 | |
dc.date.updated | 2022-05-20T06:32:56Z | |
dc.description.abstract | To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up. | en_GB |
dc.description.sponsorship | Australian Research Council | en_GB |
dc.identifier.citation | Vol. 133, article 110968 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.jbiomech.2022.110968 | |
dc.identifier.grantnumber | IC170100022 | en_GB |
dc.identifier.grantnumber | DP180104200 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/129688 | |
dc.identifier | ORCID: 0000-0001-7121-0994 (Chen, Junning) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35139441 | en_GB |
dc.rights.embargoreason | Under embargo until 22 January 2023 in compliance with publisher policy | en_GB |
dc.rights | © 2022. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | Bone remodelling | en_GB |
dc.subject | Maxillofacial reconstruction | en_GB |
dc.subject | Placement design of fixation plate | en_GB |
dc.subject | Time-dependent remodelling algorithm | en_GB |
dc.subject | Clinical follow-up | en_GB |
dc.title | Bone remodeling following mandibular reconstruction using fibula free flap | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-05-20T08:29:12Z | |
dc.identifier.issn | 0021-9290 | |
exeter.article-number | 110968 | |
exeter.place-of-publication | United States | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.identifier.journal | Journal of Biomechanics | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2022-01-17 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2022-01-22 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-05-20T08:25:04Z | |
refterms.versionFCD | AM | |
refterms.panel | B | en_GB |
refterms.dateFirstOnline | 2022-02-06 |
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Except where otherwise noted, this item's licence is described as © 2022. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/