Clinical and Biomedical Sciences: Recent submissions
Now showing items 41-45 of 330
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Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
(Springer, 26 February 2024)AIMS/HYPOTHESIS: The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and therefore represent attractive therapeutic targets ... -
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry.
(Springer, 18 May 2024)Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing to its central role in Alzheimer's disease and other dementias, hundreds of distinct antibody clones ... -
Colorectal cancer risk stratification using a polygenic risk score in symptomatic primary care patients - a UK Biobank retrospective cohort study
(Springer Nature, 1 August 2024)Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Accurate cancer risk assessment approaches could increase rates of early CRC diagnosis, improve health outcomes for patients and reduce pressure on ... -
Guidance for estimating penetrance of monogenic disease-causing variants in population cohorts
(Nature Research, 29 July 2024)Penetrance is the probability that an individual with a pathogenic genetic variant develops a specific disease. Knowing the penetrance of variants for monogenic disorders is important for counseling of individuals. Until ... -
Evaluating the antibacterial efficacy of a silver nanocomposite surface coating against nosocomial pathogens as an antibiofilm strategy to prevent hospital infections
(Taylor & Francis, 25 July 2024)Antimicrobial nanocoatings may be a means of preventing nosocomial infections, which account for significant morbidity and mortality. The role of hospital sink traps in these infections is also increasingly appreciated. ...