Clinical and Biomedical Sciences: Recent submissions
Now showing items 61-65 of 330
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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency
(Rockefeller University Press, 18 April 2024)We previously reported two siblings with inherited PD-1 deficiency who died from autoimmune pneumonitis at 3 and 11 years of age after developing other autoimmune manifestations, including type 1 diabetes (T1D). We report ... -
Loss of transient receptor potential channel 5 causes obesity and postpartum depression
(Elsevier, 2 July 2024)Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the fight/flight response, socialization, and maternal care. Here, we identified microdeletions on chromosome Xq23 disrupting the brain-expressed ... -
Are the cardiovascular properties of GLP-1 receptor agonists differentially modulated by sulfonylureas? Insights from post-hoc analysis of EXSCEL.
(Elsevier, 25 April 2024)AIMS: To examine whether the cardiovascular effects of glucagon-like peptide-1 (GLP-1) receptor agonists are attenuated by concurrent sulfonylurea (SU) therapy in a post-hoc analysis of the Exenatide Study of Cardiovascular ... -
Regulation of STAT1 signalling in human pancreatic β-cells by the lysine deacetylase, HDAC6; a new therapeutic opportunity in type 1 diabetes?
(American Diabetes Association, 14 June 2024)Type 1 diabetes arises from the selective destruction of pancreatic β-cells by autoimmune mechanisms and intracellular pathways driven by Janus (JAK)-kinase mediated STAT isoforms (especially STAT1 & STAT2) are implicated ... -
Image analysis using the Fluorescence Imaging of Nuclear Staining (FINS) algorithm.
(Springer, 17 June 2024)Finding appropriate image analysis techniques for a particular purpose can be difficult. In the context of the analysis of immunocytochemistry images, where the key information lies in the number of nuclei containing ...