Efficacy and moderators of cognitive therapy versus behavioural activation for adults with depression: study protocol of a systematic review and meta-analysis of individual participant data
dc.contributor.author | Driessen, E | |
dc.contributor.author | Cohen, ZD | |
dc.contributor.author | Lorenzo-Luaces, L | |
dc.contributor.author | Hollon, SD | |
dc.contributor.author | Richards, DA | |
dc.contributor.author | Dobson, KS | |
dc.contributor.author | Dimidjian, S | |
dc.contributor.author | Delgadillo, J | |
dc.contributor.author | Vázquez, FL | |
dc.contributor.author | McNamara, K | |
dc.contributor.author | Horan, JJ | |
dc.contributor.author | Gardner, P | |
dc.contributor.author | Oei, TP | |
dc.contributor.author | Mehta, AHP | |
dc.contributor.author | Twisk, JWR | |
dc.contributor.author | Cristea, IA | |
dc.contributor.author | Cuijpers, P | |
dc.date.accessioned | 2022-09-07T13:26:21Z | |
dc.date.issued | 2022-08-10 | |
dc.date.updated | 2022-09-07T13:10:14Z | |
dc.description.abstract | BACKGROUND: Cognitive therapy and behavioural activation are both widely applied and effective psychotherapies for depression, but it is unclear which works best for whom. Individual participant data (IPD) meta-analysis allows for examining moderators at the participant level and can provide more precise effect estimates than conventional meta-analysis, which is based on study-level data. AIMS: This article describes the protocol for a systematic review and IPD meta-analysis that aims to compare the efficacy of cognitive therapy and behavioural activation for adults with depression, and to explore moderators of treatment effect. (PROSPERO: CRD42022341602). METHOD: Systematic literature searches will be conducted in PubMed, PsycINFO, EMBASE and the Cochrane Library, to identify randomised clinical trials comparing cognitive therapy and behavioural activation for adult acute-phase depression. Investigators of these trials will be invited to share their participant-level data. One-stage IPD meta-analyses will be conducted with mixed-effects models to assess treatment effects and to examine various available demographic, clinical and psychological participant characteristics as potential moderators. The primary outcome measure will be depressive symptom level at treatment completion. Secondary outcomes will include post-treatment anxiety, interpersonal functioning and quality of life, as well as follow-up outcomes. CONCLUSIONS: To the best of our knowledge, this will be the first IPD meta-analysis concerning cognitive therapy versus behavioural activation for adult depression. This study has the potential to enhance our knowledge of depression treatment by using state-of-the-art statistical techniques to compare the efficacy of two widely used psychotherapies, and by shedding more light on which of these treatments might work best for whom. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Netherlands Organization of Scientific Research | en_GB |
dc.description.sponsorship | National Institutes of Health | en_GB |
dc.description.sponsorship | National Center for Advancing Translational Sciences and Clinical and Translational Sciences | en_GB |
dc.identifier.citation | Vol. 8, No. 5, article e154 | en_GB |
dc.identifier.doi | https://doi.org/10.1192/bjo.2022.560 | |
dc.identifier.grantnumber | G0701013 | en_GB |
dc.identifier.grantnumber | 016.Veni.195.215 6806 | en_GB |
dc.identifier.grantnumber | KL2TR002530 | en_GB |
dc.identifier.grantnumber | UL1TR002529 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/130729 | |
dc.identifier | ORCID: 0000-0002-8821-5027 (Richards, David A) | |
dc.language.iso | en | en_GB |
dc.publisher | Cambridge University Press / Royal College of Psychiatrists | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/35946068 | en_GB |
dc.rights | © The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Depressive disorders | en_GB |
dc.subject | behavioural activation | en_GB |
dc.subject | cognitive–behavioural therapies | en_GB |
dc.subject | individual participant data meta-analysis | en_GB |
dc.subject | moderators | en_GB |
dc.title | Efficacy and moderators of cognitive therapy versus behavioural activation for adults with depression: study protocol of a systematic review and meta-analysis of individual participant data | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2022-09-07T13:26:21Z | |
dc.identifier.issn | 2056-4724 | |
exeter.article-number | e154 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available on open access from Cambridge University Press via the DOI in this record. | en_GB |
dc.description | Data availability is not applicable to this article as no new data were created or analysed for this study protocol paper | en_GB |
dc.identifier.journal | BJPsych Open | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2022-08-10 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2022-09-07T13:20:57Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2022-09-07T13:26:27Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2022-08-10 |
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Except where otherwise noted, this item's licence is described as © The Author(s), 2022. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.