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dc.contributor.authorWilliams, CA
dc.contributor.authorSaynor, ZL
dc.contributor.authorTomlinson, OW
dc.contributor.authorBarker, AR
dc.date.accessioned2015-04-24T10:06:03Z
dc.date.issued2014-12
dc.description.abstractCardiopulmonary exercise testing is underutilized within the clinical management of patients with cystic fibrosis. But within the last 5 years, there has been considerable interest in its implementation, which has included deliberations by the European Cystic Fibrosis Society about incorporating this method within the clinical assessment of patients. This review examines the current use of cardiopulmonary exercise testing in assessing the extent and cause(s) of exercise limitation from a pediatric perspective. Examples of the measured parameters and their interpretation are provided. Critical synthesis of recent work in the oxygen uptake (VO2) kinetics response to and following exercise is also discussed, and although identified more as a research tool, its utilization advances researchers understanding of the cardiovascular, respiratory and muscular limitations to exercise tolerance. Finally, exercise and its application in therapeutic interventions are highlighted and a number of recommendations made about the utility of exercise prescription.en_GB
dc.identifier.citationVol. 8, No. 6, pp. 751 - 762en_GB
dc.identifier.doi10.1586/17476348.2014.966693
dc.identifier.urihttp://hdl.handle.net/10871/16986
dc.language.isoenen_GB
dc.publisherExpert Reviews (formerly Future Drugs)en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25395018en_GB
dc.relation.urlhttp://informahealthcare.com/doi/abs/10.1586/17476348.2014.966693en_GB
dc.rights.embargoreasonPublisher's policy.en_GB
dc.rightsThis is the authors accepted version published in Expert Review of Respiratory Medicine, 2014, Vol. 8, No. 6, pp. 751 – 762 available at http://informahealthcare.com/doi/abs/10.1586/17476348.2014.966693en_GB
dc.subjectIvacaftoren_GB
dc.subjectcardiopulmonary exercise testingen_GB
dc.subjectinspiratory muscle trainingen_GB
dc.subjectoxygen uptake kineticsen_GB
dc.subjectpediatricsen_GB
dc.subjectskeletal muscleen_GB
dc.titleCystic fibrosis and physiological responses to exercise.en_GB
dc.typeArticleen_GB
dc.identifier.issn1747-6348
exeter.place-of-publicationEngland
dc.descriptionJournal Articleen_GB
dc.descriptionCopyright © 2014 Informa Plc. All rights reserved.en_GB
dc.identifier.journalExpert Review of Respiratory Medicineen_GB


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