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Disruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission.

dc.contributor.authorBanks, Paul J.
dc.contributor.authorBurroughs, Amelia C.
dc.contributor.authorBarker, Gareth R.I.
dc.contributor.authorBrown, JT
dc.contributor.authorWarburton, Elizabeth C.
dc.contributor.authorBashir, Zafar I.
dc.date.accessioned2015-09-04T15:11:37Z
dc.date.issued2015-07-27
dc.description.abstractFunctional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.en_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC)en_GB
dc.identifier.citationVol. 112 (35), pp. 11096–11101en_GB
dc.identifier.doi10.1073/pnas.1512064112
dc.identifier.grantnumber087855/z/08/zen_GB
dc.identifier.grantnumberBB/L001896/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/18176
dc.language.isoenen_GB
dc.publisherNational Academy of Sciencesen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26286993en_GB
dc.subjectD2Ren_GB
dc.subjectNMDA receptor hypofunctionen_GB
dc.subjectlong-term depressionen_GB
dc.subjectmedial prefrontal cortexen_GB
dc.subjectschizophreniaen_GB
dc.titleDisruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission.en_GB
dc.typeArticleen_GB
dc.date.available2015-09-04T15:11:37Z
dc.descriptionOpen access articleen_GB
dc.identifier.eissn1091-6490
dc.identifier.journalProceedings of the National Academy of Sciencesen_GB


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