dc.contributor.author | Locke, JM | |
dc.contributor.author | Harries, LW | |
dc.date.accessioned | 2015-09-30T12:32:07Z | |
dc.date.issued | 2008-05-21 | |
dc.description.abstract | In the eukaryotic cell a number of molecular mechanisms exist to regulate the nature and quantity of transcripts intended for translation. For monogenic diabetes an understanding of these processes is aiding scientists and clinicians in studying and managing this disease. Knowledge of RNA processing and mRNA surveillance pathways is helping to explain disease mechanisms, form genotype-phenotype relationships, and identifying new regions within genes to screen for mutations. Furthermore, recent insights into the regulatory role of micro RNAs (miRNAs) and RNA editing in the pancreas suggests that these mechanisms may also be important in the progression to the diabetic state. | en_GB |
dc.description.sponsorship | Peninsula Medical School (Exeter, UK) | en_GB |
dc.description.sponsorship | RCUK | en_GB |
dc.identifier.citation | Vol. 2, pp. 203 - 212 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/18344 | |
dc.language.iso | en | en_GB |
dc.publisher | Libertas Academica | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/19787084 | en_GB |
dc.rights | Copyright in this article, its metadata, and any supplementary data is held by its author or authors. It is published under the
Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0/. | en_GB |
dc.subject | MODY | en_GB |
dc.subject | isoforms | en_GB |
dc.subject | nonsense-mediated decay | en_GB |
dc.subject | splicing | en_GB |
dc.title | RNA processing and mRNA surveillance in monogenic diabetes. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2015-09-30T12:32:07Z | |
exeter.place-of-publication | New Zealand | |
dc.description | Journal Article | en_GB |
dc.identifier.journal | Gene Regulation and Systems Biology | en_GB |