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dc.contributor.authorVardaki, Martha Z.
dc.contributor.authorGardner, Benjamin
dc.contributor.authorStone, Nicholas
dc.contributor.authorMatousek, Pavel
dc.date.accessioned2015-12-18T10:58:21Z
dc.date.issued2015-06-09
dc.description.abstractIn this study we employed large volume liquid tissue phantoms, consisting of a scattering agent (Intralipid), an absorption agent (Indian ink) and a synthesized calcification powder (calcium hydroxyapatite (HAP)) similar to that found in cancerous tissues (e.g. breast and prostate), to simulate human tissues. We studied experimentally the magnitude and origin of Raman signals in a transmission Raman geometry as a function of optical properties of the medium and the location of calcifications within the phantom. The goal was to inform the development of future noninvasive cancer screening applications in vivo. The results provide insight into light propagation and Raman scattering distribution in deep Raman measurements, exploring also the effect of the variation of relative absorbance of laser and Raman photons within the phantoms. Most notably when modeling breast and prostate tissues it follows that maximum signals is obtained from the front and back faces of the tissue with the central region contributing less to the measured spectrum.en_GB
dc.description.sponsorshipSTFC BioMedical Networken_GB
dc.description.sponsorshipUniversity of Exeteren_GB
dc.description.sponsorshipEPSRCen_GB
dc.identifier.citationVol. 140, pp. 5112-5119en_GB
dc.identifier.doi10.1039/C5AN01118C
dc.identifier.grantnumberEP/K020374/1en_GB
dc.identifier.grantnumberSTMA00012en_GB
dc.identifier.urihttp://hdl.handle.net/10871/19022
dc.language.isoenen_GB
dc.publisherRoyal Society of Chemistryen_GB
dc.rightsCopyright © The Royal Society of Chemistry 2015. This is an Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en_GB
dc.subjectprostate canceren_GB
dc.subjectphantomsen_GB
dc.subjectRaman spectroscopyen_GB
dc.subjectdeep Ramanen_GB
dc.titleStudying the distribution of deep Raman spectroscopy signals using liquid tissue phantoms with varying optical propertiesen_GB
dc.typeArticleen_GB
dc.date.available2015-12-18T10:58:21Z
dc.identifier.issn0003-2654
dc.identifier.eissn1364-5528
dc.identifier.journalAnalysten_GB
refterms.dateFOA2018-12-05T10:25:41Z


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