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dc.contributor.authorAmes, RM
dc.contributor.authorRash, BM
dc.contributor.authorHentges, KE
dc.contributor.authorRobertson, DL
dc.contributor.authorDelneri, D
dc.contributor.authorLovell, SC
dc.date.accessioned2016-07-07T10:47:43Z
dc.date.issued2010-07-21
dc.description.abstractPopulation-level differences in the number of copies of genes resulting from gene duplication and loss have recently been recognized as an important source of variation in eukaryotes. However, except for a small number of cases, the phenotypic effects of this variation are unknown. Data from the Saccharomyces Genome Resequencing Project permit the study of duplication in genome sequences from a set of individuals within the same population. These sequences can be correlated with available information on the environments from which these yeast strains were isolated. We find that yeast show an abundance of duplicate genes that are lineage specific, leading to a large degree of variation in gene content between individual strains. There is a detectable bias for specific functions, indicating that selection is acting to preferentially retain certain duplicates. Most strikingly, we find that sets of over- and underrepresented duplicates correlate with the environment from which they were isolated. Together, these observations indicate that gene duplication can give rise to substantial phenotypic differences within populations that in turn can offer a shortcut to evolutionary adaptation.en_GB
dc.description.sponsorshipThis work was funded by BBSRC grant BB/F007620/1.en_GB
dc.identifier.citationVol. 2, pp. 591 - 601en_GB
dc.identifier.doi10.1093/gbe/evq043
dc.identifier.urihttp://hdl.handle.net/10871/22435
dc.language.isoenen_GB
dc.publisherOxford University Pressen_GB
dc.relation.urlhttp://gbe.oxfordjournals.org/content/2/591.fullen_GB
dc.rightsThis is the final version of the article. Available from Oxford University Press via the DOI in this record.en_GB
dc.subjectgene duplicationen_GB
dc.subjectgene retentionen_GB
dc.subjectevolutionary adaptationen_GB
dc.subjectgenomicsen_GB
dc.titleGene Duplication and Environmental Adaptation within Yeast Populationsen_GB
dc.typeArticleen_GB
dc.date.available2016-07-07T10:47:43Z
dc.identifier.issn1759-6653
dc.descriptionPublisheden_GB
dc.identifier.journalGenome Biology and Evolutionen_GB


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