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dc.contributor.authorDudas, RB
dc.contributor.authorMole, TB
dc.contributor.authorMorris, LS
dc.contributor.authorDenman, C
dc.contributor.authorHill, E
dc.contributor.authorSzalma, B
dc.contributor.authorEvans, D
dc.contributor.authorDunn, B
dc.contributor.authorFletcher, P
dc.contributor.authorVoon, V
dc.date.accessioned2016-11-23T09:41:00Z
dc.date.issued2016-10-27
dc.description.abstractBACKGROUND: Little is known about the frontolimbic abnormalities thought to underlie borderline personality disorder (BPD). We endeavoured to study regional responses, as well as their connectivity and habituation during emotion processing. METHODS: 14 BPD patients and 14 normal female controls (NC) controlled for menstrual phase underwent emotion-induction during an fMRI task using standardised images in a block design. We then performed psychophysiological interaction (PPI) analysis to investigate functional connectivity. RESULTS: BPD patients reported more disgust in questionnaires compared to controls. Relative to NC, they showed reduced left amygdala and increased dorsolateral prefrontal cortex (dlPFC) activation to all emotions collapsed versus neutral. Habituation of ventral striatal activity to repeated emotional stimuli was observed in controls but not in BPD. Finally, in the context of disgust (but not other emotions) versus neutral, BPD patients displayed enhanced left amygdala coupling with the dlPFC and ventral striatum. LIMITATIONS: Strict inclusion criteria reduced the sample size. CONCLUSIONS: In summary, BPD showed abnormal patterns of activation, habituation and connectivity in regions linked to emotion regulation. Amygdala deactivation may be mediated by abnormal top-down regulatory control from the dorsolateral prefrontal cortex. Aberrant emotion processing may play a unique role in the pathophysiology of BPD.en_GB
dc.identifier.citationAvailable online 27 October 2016en_GB
dc.identifier.doi10.1016/j.jad.2016.10.043
dc.identifier.otherS0165-0327(16)30945-4
dc.identifier.urihttp://hdl.handle.net/10871/24554
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/27838143en_GB
dc.rights.embargoreasonPublisher's policy.en_GB
dc.rightsThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.en_GB
dc.subjectAmygdalaen_GB
dc.subjectBorderline personality disorderen_GB
dc.subjectDisgusten_GB
dc.subjectFunctional connectivityen_GB
dc.subjectHabituationen_GB
dc.subjectImagingen_GB
dc.titleAmygdala and dlPFC abnormalities, with aberrant connectivity and habituation in response to emotional stimuli in females with BPD.en_GB
dc.typeArticleen_GB
dc.identifier.issn0165-0327
exeter.place-of-publicationNetherlandsen_GB
dc.descriptionPublished onlineen_GB
dc.descriptionJournal Articleen_GB
dc.identifier.eissn1573-2517
dc.identifier.journalJournal of Affective Disordersen_GB


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