dc.contributor.author | Bahar-Fuchs, A | |
dc.contributor.author | Webb, S | |
dc.contributor.author | Bartsch, L | |
dc.contributor.author | Clare, L | |
dc.contributor.author | Rebok, G | |
dc.contributor.author | Cherbuin, N | |
dc.contributor.author | Anstey, KJ | |
dc.date.accessioned | 2017-10-20T10:04:41Z | |
dc.date.issued | 2017-10-03 | |
dc.description.abstract | BACKGROUND: Computerized Cognitive Training (CCT) has been shown to improve cognitive function in older adults with mild cognitive impairment (MCI) or mood-related neuropsychiatric symptoms (MrNPS), but many questions remain unresolved. OBJECTIVE: To evaluate the extent to which CCT benefits older adults with both MCI and MrNPS, and its effects on meta-cognitive and non-cognitive outcomes, as well as establish whether adapting difficulty levels and tailoring to individuals' profile is superior to generic training. METHODS: Older adults with MCI (n = 9), MrNPS (n = 11), or both (MCI+, n = 25) were randomized into a home-based individually-tailored and adaptive CCT (n = 21) or an active control condition (AC; n = 23) in a double-blind design. Interventions lasted 8-12 weeks and outcomes were assessed after the intervention, and at a 3-month follow-up. RESULTS: Participants in both conditions reported greater satisfaction with their everyday memory following intervention and at follow-up. However, participants in the CCT condition showed greater improvement on composite measures of memory, learning, and global cognition at follow-up. Participants with MrNPS in the CCT condition were also found to have improved mood at 3-month follow-up and reported using fewer memory strategies at the post-intervention and follow-up assessments. There was no evidence that participants with MCI+ were disadvantaged relative to the other diagnostic conditions. Finally, informant-rated caregiver burden declined at follow-up assessment in the CCT condition relative to the AC condition. CONCLUSIONS: Home-based CCT with adaptive difficulty and personal tailoring appears superior to more generic CCT in relation to both cognitive and non-cognitive outcomes. Mechanisms of treatment effect and future directions are discussed. | en_GB |
dc.description.sponsorship | The trial was supported by grants from the Australian
Dementia Collaborative Research Centre,
and the Alzheimer’s Australia Dementia Research
Foundation. | en_GB |
dc.identifier.citation | , Vol. 60, pp. 889 - 911 | en_GB |
dc.identifier.doi | 10.3233/JAD-170404 | |
dc.identifier.uri | http://hdl.handle.net/10871/29936 | |
dc.language.iso | en | en_GB |
dc.publisher | IOS Press | en_GB |
dc.relation.source | The dataset used and analyzed during the current
study is available from the corresponding author on
reasonable request. | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/28922158 | en_GB |
dc.rights | © 2017 – IOS Press and the authors. All rights reserved | en_GB |
dc.subject | Behavior change techniques | en_GB |
dc.subject | cognitive training | en_GB |
dc.subject | mild cognitive impairment | en_GB |
dc.subject | randomized controlled trial | en_GB |
dc.title | Tailored and Adaptive Computerized Cognitive Training in Older Adults at Risk for Dementia: A Randomized Controlled Trial | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-10-20T10:04:41Z | |
exeter.place-of-publication | Netherlands | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from IOS Press via the DOI in this record. | en_GB |
dc.identifier.journal | Journal of Alzheimer's Disease | en_GB |