Show simple item record

dc.contributor.authorMorgan, PT
dc.contributor.authorBowtell, JL
dc.contributor.authorVanhatalo, A
dc.contributor.authorJones, AM
dc.contributor.authorBailey, SJ
dc.date.accessioned2018-02-26T10:40:00Z
dc.date.issued2018-03
dc.description.abstractAIM: Acetaminophen is a commonly used medicine for pain relief and emerging evidence suggests that it may improve endurance exercise performance. This study investigated some of the physiological mechanisms by which acute acetaminophen ingestion might blunt muscle fatigue development. METHODS: Thirteen active males completed 60 × 3 s maximum voluntary contractions (MVC) of the knee extensors with each contraction separated by a 2 s passive recovery period. This protocol was completed 60 min after ingesting 1 g of maltodextrin (placebo) or 1 g of acetaminophen on two separate visits. Peripheral nerve stimulation was administered every 6th contraction for assessment of neuromuscular fatigue development, with the critical torque (CT), which reflects the maximal sustainable rate of oxidative metabolism, taken as the mean torque over the last 12 contractions. Surface electromyography was recorded continuously as a measure of muscle activation. RESULTS: Mean torque (61 ± 11 vs. 58 ± 14% pre-exercise MVC) and CT (44 ± 13 vs. 40 ± 15% pre-exercise MVC) were greater in the acetaminophen trial compared to placebo (both P < 0.05). Voluntary activation and potentiated twitch declined at a similar rate in both conditions (P > 0.05). However, the decline in electromyography amplitude was attenuated in the acetaminophen trial, with electromyography amplitude being greater compared to placebo from 210 s onwards (P < 0.05). CONCLUSION: These findings indicate that acute acetaminophen ingestion might be ergogenic by increasing CT and preserving muscle activation during high-intensity exercise.en_GB
dc.description.sponsorshipThis research was not sponsored by any funding body external to University of Exeteren_GB
dc.identifier.citationVol. 118, pp. 595 - 605en_GB
dc.identifier.doi10.1007/s00421-017-3794-7
dc.identifier.urihttp://hdl.handle.net/10871/31689
dc.language.isoenen_GB
dc.publisherSpringer Verlag (Germany)en_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/29332237en_GB
dc.rights© The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_GB
dc.subjectAnalgesicen_GB
dc.subjectCritical torqueen_GB
dc.subjectElectromyographyen_GB
dc.subjectNeuromuscular fatigueen_GB
dc.subjectSingle-leg exerciseen_GB
dc.titleAcute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exerciseen_GB
dc.typeArticleen_GB
dc.date.available2018-02-26T10:40:00Z
dc.identifier.issn1439-6319
exeter.place-of-publicationGermanyen_GB
dc.descriptionThis is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.en_GB
dc.identifier.journalEuropean Journal of Applied Physiologyen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record