A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025
van Lynden, C
International Journal of Geriatric Psychiatry
© 2018 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
OBJECTIVE: National and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. METHODS: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research. RESULTS: The taskforce developed 5 goals and 30 recommendations. The goals focused on preventing future cases of dementia through risk reduction, maximising the benefit of a dementia diagnosis, improving quality of life, enabling the dementia workforce to improve practice, and optimising the quality and inclusivity of health and social care systems. Recommendations addressed gaps in knowledge and limitations in research methodology or infrastructure that would facilitate research in prioritised areas. A 10-point action plan provides strategies for delivering the proposed research agenda. CONCLUSIONS: By creating complementary goals for research that mirror the need to find effective treatments, we provide a framework that enables a focus for new investment and initiatives. This will support a broader and more holistic approach to research on dementia, addressing prevention, surveillance of population changes in risk and expression of dementia, the diagnostic process, diagnosis itself, interventions, social support, and care for people with dementia and their families.
broad set of recommendations that included research milestones, butalso awareness raising, workforce development, training, and policy,and practice developments.14The US milestones related to researchinclude convening an annual working group to update on the state ofdementia care research, comparative effectiveness research, and prag-matic and adaptive research methods that might be particularly suit-able for international collaborations and activity.14Total investment in dementia care research is not routinely mea-sured in the United Kingdom but is far less than 0.1% of the estimated£26 billion annual cost of dementia to the UK economy.15Greaterinvestment in clinical and care research will support more effectiveuse of money spent supporting people with dementia, by ensuring thatit is spent well. Greater investment in the research outlined here maysave resources in the short, medium, and longer terms, as well asreducing excess harm, disability, and distress associated with ineffec-tive care. There will be sections of the population at high risk of futuredementia who may be benefitted by the drug discovery programmes inplace, but dementia is a complex disorder, and most of those whodevelop it are often in their ninth decade and older with multiple con-tributing factors.5|CONCLUSIONThe societal approach to research for dementia therefore needs toaddress the fact that there will be people with dementia in all societiesfor the foreseeable future. Thus, an equally strong focus to match drugdiscovery is urgently needed for the priorities outlined here supportingprevention, diagnosis, intervention, and care, vital for society as awhole and for people with dementia and their carers in particular.ACKNOWLEDGEMENTS
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.
Place of publication