Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial
dc.contributor.author | Holt, RIG | |
dc.contributor.author | Gossage-Worrall, R | |
dc.contributor.author | Hind, D | |
dc.contributor.author | Bradburn, MJ | |
dc.contributor.author | McCrone, P | |
dc.contributor.author | Morris, T | |
dc.contributor.author | Edwardson, C | |
dc.contributor.author | Barnard, K | |
dc.contributor.author | Carey, ME | |
dc.contributor.author | Davies, MJ | |
dc.contributor.author | Dickens, CM | |
dc.contributor.author | Doherty, Y | |
dc.contributor.author | Etherington, A | |
dc.contributor.author | French, P | |
dc.contributor.author | Gaughran, F | |
dc.contributor.author | Greenwood, KE | |
dc.contributor.author | Kalidindi, S | |
dc.contributor.author | Khunti, K | |
dc.contributor.author | Laugharne, R | |
dc.contributor.author | Pendlebury, J | |
dc.contributor.author | Rathod, S | |
dc.contributor.author | Saxon, D | |
dc.contributor.author | Shiers, D | |
dc.contributor.author | Siddiqi, N | |
dc.contributor.author | Swaby, L | |
dc.contributor.author | Waller, G | |
dc.contributor.author | Wright, S | |
dc.date.accessioned | 2018-07-31T16:19:26Z | |
dc.date.issued | 2018-09-25 | |
dc.description.abstract | Background: Obesity is a major challenge for people with schizophrenia. Aim: We assessed whether STEPWISE, a theory-based, group structured lifestyle education programme could support weight reduction in people with schizophrenia. Methods: In this randomised controlled trial, we recruited adults with schizophrenia, schizoaffective disorder or first episode psychosis from ten mental health organisations in England. Participants were randomly allocated to the STEPWISE intervention or treatment as usual. The 12-month intervention comprised four 2.5 hour weekly group sessions, followed by two-weekly maintenance contact and group sessions at 4, 7 and 10 months. The primary outcome was weight change after 12 months. Key secondary outcomes included diet, physical activity, biomedical measures and patient related outcome measures. Cost-effectiveness was assessed and a mixed-methods process evaluation was included. Results: Between 10 March 2015 and 31 March 2016, we recruited 414 people (intervention 208, usual care 206) with 341 (84.4%) participants completing the trial. At 12 months, weight reduction did not differ between groups (mean difference 0.0 Kg, 95% CI -1.6 to 1.7, p=0.963); physical activity, dietary intake and biochemical measures were unchanged. STEPWISE was well-received by participants and facilitators. The healthcare perspective incremental cost-effectiveness ratio was £246,921 per quality-adjusted life-year gained. Conclusions: Participants were successfully recruited and retained, indicating a strong interest in weight interventions; however, the STEPWISE intervention was neither clinically nor cost-effective. Further research is needed to determine how to manage overweight and obesity in people with schizophrenia. | en_GB |
dc.description.sponsorship | This project was funded by the Health Technology Assessment Programme (project number 12/28/05) and will be published in full in the Health Technology Assessment journal series. Further information available online. This report presents independent research commissioned by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, the Medical Research Council (MRC), Clinical Commissioning Facility (CCF), the NIHR Evaluations, Trials and Studies Coordinating Centre (NETSCC), the Health Technology Assessment programme, or the Department of Health. The views and opinions expressed by the interviewees in this publication are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, MRC, CCF, NETSCC, the Health Technology Assessment programme or the Department of Health. | en_GB |
dc.identifier.citation | Vol. 214 (2), pp. 63-73 | en_GB |
dc.identifier.doi | 10.1192/bjp.2018.167 | |
dc.identifier.uri | http://hdl.handle.net/10871/33623 | |
dc.language.iso | en | en_GB |
dc.publisher | Cambridge University Press (CUP) | en_GB |
dc.rights | © The Royal College of Psychiatrists 2018. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.title | Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 0007-1250 | |
dc.description | This is the final version. Available on open access from Cambridge University Press via the DOI in this record. | en_GB |
dc.identifier.eissn | 1472-1465 | |
dc.identifier.journal | British Journal of Psychiatry | en_GB |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dcterms.dateAccepted | 2018-07-11 | |
rioxxterms.version | VoR | |
refterms.dateFCD | 2018-07-31T16:19:26Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2018-07-31T16:19:26Z |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © The Royal College of Psychiatrists 2018. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.