Microstructural characterization of annulus fibrosus by ultrasonography: a feasibility study with an in vivo and in vitro approach
dc.contributor.author | Langlais, T | |
dc.contributor.author | Desprairies, P | |
dc.contributor.author | Pietton, R | |
dc.contributor.author | Rohan, P-Y | |
dc.contributor.author | Dubousset, J | |
dc.contributor.author | Meakin, JR | |
dc.contributor.author | Winlove, PC | |
dc.contributor.author | Vialle, R | |
dc.contributor.author | Skalli, W | |
dc.contributor.author | Vergari, C | |
dc.date.accessioned | 2019-06-27T08:23:47Z | |
dc.date.issued | 2019-06-20 | |
dc.description.abstract | The main function of the intervertebral disc is biomechanical function, since it must resist repetitive high loadings, while giving the spine its flexibility and protecting the spinal cord from over-straining. It partially owes its mechanical characteristics to the lamellar architecture of its outer layer, the annulus fibrosus. Today, no non-invasive means exist to characterize annulus lamellar structure in vivo. The aim of this work was to test the feasibility of imaging annulus fibrosus microstructure in vivo with ultrasonography. Twenty-nine healthy adolescents were included. Ultrasonographies of L3–L4 disc were acquired with a frontal approach. Annulus fibrosus was segmented in the images to measure the thickness of the lamellae. To validate lamellar appearance in ultrasonographies, multimodality images of two cow tail discs were compared: ultrasonography, magnetic resonance and optical microscopy. In vivo average lamellar thickness was 229.7 ± 91.5 μm, and it correlated with patient body mass index and age. Lamellar appearance in the three imaging modalities in vitro was consistent. Lamellar measurement uncertainty was 7%, with good agreement between two operators. Feasibility of ultrasonography for the analysis of lumbar annulus fibrosus structure was confirmed. Further work should aim at validating measurement reliability, and to assess the relevance of the method to characterize annulus alterations, for instance in disc degeneration or scoliosis. | en_GB |
dc.description.sponsorship | ParisTech Foundation | en_GB |
dc.description.sponsorship | Yves Cotrel Foundation | en_GB |
dc.description.sponsorship | Société Générale | en_GB |
dc.description.sponsorship | Covea | en_GB |
dc.description.sponsorship | DHU MAMUTH | en_GB |
dc.description.sponsorship | Société Française de Chirurgie Orthopédique et Traumatologie (SOFCOT) | en_GB |
dc.description.sponsorship | Devon Arthritis and Allied Reasearch Fund | en_GB |
dc.description.sponsorship | Henry Smith Charity | en_GB |
dc.identifier.citation | Published online 20 June 2019 | en_GB |
dc.identifier.doi | 10.1007/s10237-019-01189-3 | |
dc.identifier.uri | http://hdl.handle.net/10871/37701 | |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | © The Author(s) 2019. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_GB |
dc.subject | Intervertebral disc | en_GB |
dc.subject | Lamellae | en_GB |
dc.subject | MRI | en_GB |
dc.subject | Microscopy | en_GB |
dc.subject | Geometry | en_GB |
dc.title | Microstructural characterization of annulus fibrosus by ultrasonography: a feasibility study with an in vivo and in vitro approach | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-06-27T08:23:47Z | |
dc.description | This is the final version. Available on open access from Springer via the DOI in this record | en_GB |
dc.identifier.journal | Biomechanics and Modeling in Mechanobiology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2019-06-12 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2019-06-08 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2019-06-26T09:53:32Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2019-06-27T08:24:01Z | |
refterms.panel | B | en_GB |
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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.