dc.contributor.author | Witton, J | |
dc.contributor.author | Brown, JT | |
dc.contributor.author | Jones, MW | |
dc.contributor.author | Randall, AD | |
dc.date.accessioned | 2019-08-28T14:43:42Z | |
dc.date.issued | 2010-11-01 | |
dc.description.abstract | Aβ peptides derived from the cleavage of amyloid precursor protein are widely believed to play an important role in the pathophysiology of Alzheimer's disease. A common way to study the impact of these molecules on CNS function is to compare the physiology of transgenic mice that overproduce Aβ with non-transgenic animals. In the hippocampus, this approach has been frequently applied to the investigation of synaptic transmission and plasticity in the perforant and Schaffer collateral commissural pathways, the first and third components of the classical hippocampal trisynaptic circuit, respectively. Similar studies however have not been carried out on the remaining component of the trisynaptic circuit, the mossy fibre pathway. Using transverse hippocampal slices prepared from ~2 year old animals we have compared mossy fibre synaptic function in wild-type mice and their Tg2576 littermates which age-dependently overproduce Aβ. Input-output curves were not altered in slices from Tg2576 mice, but these animals exhibited a significant loss of the prominent frequency-facilitation expressed by the mossy fibre pathway. In addition to this change in short term synaptic plasticity, high frequency stimulation-induced, NMDA-receptor-independent LTP was absent in slices from the transgenic mice. These data represent the first description of functional deficits in the mossy fibre pathway of Aβ-overproducing transgenic mice. | en_GB |
dc.description.sponsorship | Pfizer | en_GB |
dc.description.sponsorship | Medical Research Council Industrial Collaborative Studentship | en_GB |
dc.identifier.citation | Vol. 3, No. 32, pp. 1-7 | en_GB |
dc.identifier.doi | 10.1186/1756-6606-3-32 | |
dc.identifier.other | 1756-6606-3-32 | |
dc.identifier.uri | http://hdl.handle.net/10871/38474 | |
dc.publisher | BMC (part of Springer Nature) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/21040543 | en_GB |
dc.rights | © 2010 Witton et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited. | en_GB |
dc.subject | Amyloid beta-Protein Precursor | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Hippocampus | en_GB |
dc.subject | Male | en_GB |
dc.subject | Mice | en_GB |
dc.subject | Mice, Inbred C57BL | en_GB |
dc.subject | Mice, Transgenic | en_GB |
dc.subject | Mutation | en_GB |
dc.subject | Neuronal Plasticity | en_GB |
dc.subject | Synaptic Transmission | en_GB |
dc.title | Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2019-08-28T14:43:42Z | |
exeter.place-of-publication | England | en_GB |
dc.description | This is the final version. Available from BMC via the DOI in this record | en_GB |
dc.identifier.journal | Molecular Brain | en_GB |
dcterms.dateAccepted | 2010-11-01 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.type | Book | en_GB |
refterms.dateFCD | 2019-08-28T14:41:00Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2019-08-28T14:43:47Z | |