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dc.contributor.authorNewman, Dave M.
dc.contributor.authorHeptinstall, John
dc.contributor.authorMatelon, Raphael J.
dc.contributor.authorSavage, Luke
dc.contributor.authorWears, M. Lesley
dc.contributor.authorBeddow, Jamie
dc.contributor.authorCox, Martin
dc.contributor.authorSchallig, Henk D.F.H.
dc.contributor.authorMens, Petra F.
dc.date.accessioned2013-05-29T15:21:18Z
dc.date.issued2008
dc.description.abstractWe report the development of magneto-optic technology for the rapid quantitative diagnosis of malaria that may also be realizable in a noninvasive format. Hemozoin, the waste product of malarial parasitic action on hemoglobin, is produced in a form that under the action of an applied magnetic field gives rise to an induced optical dichroism characteristic of the hemozoin concentration. Here we show that precise measurement of this induced dichroism may be used to determine the level of malarial infection because this correlates, albeit in a complex manner throughout the infection cycle, with the concentration of hemozoin in the blood and tissues of infected patients. Under conservative assumptions for the production of hemozoin as a function of parasitemia, initial results indicate that the technique can match or exceed other current diagnostic techniques. The validity of the approach is confirmed by a small preliminary clinical trial on 13 patients, and measurements on live parasitized cells obtained from in vitro culture verify the possibility of producing in vivo diagnostic instrumentation.en_GB
dc.identifier.citationVol. 95 (2), pp. 994 - 1000en_GB
dc.identifier.doi10.1529/biophysj.107.128140
dc.identifier.urihttp://hdl.handle.net/10871/9698
dc.language.isoenen_GB
dc.publisherBiophysical Societyen_GB
dc.relation.urlhttp://dx.doi.org/10.1529/biophysj.107.128140en_GB
dc.subjectBiological Markersen_GB
dc.subjectBlood Chemical Analysisen_GB
dc.subjectHemeproteinsen_GB
dc.subjectHumansen_GB
dc.subjectMagneticsen_GB
dc.subjectMalariaen_GB
dc.subjectOptics and Photonicsen_GB
dc.subjectPilot Projectsen_GB
dc.subjectReproducibility of Resultsen_GB
dc.subjectSensitivity and Specificityen_GB
dc.titleA magneto-optic route toward the in vivo diagnosis of malaria: preliminary results and preclinical trial dataen_GB
dc.typeArticleen_GB
dc.date.available2013-05-29T15:21:18Z
dc.identifier.issn0006-3495
exeter.place-of-publicationUnited States
dc.descriptionCopyright © 2008 Biophysical Societyen_GB
dc.identifier.eissn1542-0086
dc.identifier.journalBiophysical Journalen_GB


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