Institute of Biomedical & Clinical Science: Recent submissions
Now showing items 26-30 of 1232
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Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank
(American Association for Cancer Research, 16 June 2022)Background: In European ancestry populations, iron overload disorder Hereditary Hemochromatosis (HH) is predominantly caused by HFE p.C282Y and p.H63D mutations. Male p.C282Y homozygotes have markedly increased hepatic ... -
A rare human variant that disrupts GPR10 signalling causes weight gain in mice
(Nature Research, 15 March 2023)Disruption of brain-expressed G-protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identified multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants ... -
Interpolation of FGM data for the improved identification of hypoglycaemic episodes
(University of Toronto, 15 April 2021)