Institute of Biomedical & Clinical Science: Recent submissions
Now showing items 31-35 of 1232
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Performance of the SarQoL quality of life tool in a UK population of older people with probable sarcopenia and implications for use in clinical trials: findings from the SarcNet registry
(BMC, 27 April 2022)BACKGROUND: The Sarcopenia Quality of Life (SarQoL) questionnaire is a disease-specific sarcopenia quality of life tool. We aimed to independently assess SarQoL with a particular focus on its suitability as a clinical trial ... -
Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
(BMC, 4 June 2022)Abstract Background: Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference ... -
DunedinPACE, a DNA methylation biomarker of the pace of aging
(eLife Sciences Publications, 14 January 2022)Background: Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans. Previously, we showed that quantification of the pace of ... -
Self-harm and suicidality experiences of middle-age and older adults with vs. without high autistic traits.
(Springer, 26 May 2022)Suicide has been identified as a leading cause of premature death in autistic populations. Elevated autistic traits have also been associated with higher rates of self-harm, suicidal ideation, and suicidal self-harm in the ... -
Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes
(Springer, 30 April 2022)Aims/hypothesis A key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune response (beta cell suicide or homicide?). To investigate this, we ...