Institute of Biomedical & Clinical Science: Recent submissions
Now showing items 36-40 of 1232
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Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function.
(Oxford University Press, 9 May 2022)Large-scale genomic studies of schizophrenia implicate genes involved in the epigenetic regulation of transcription by histone methylation and genes encoding components of the synapse. However, the interactions between ... -
Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study.
(BMJ Publishing Group, 13 December 2021)OBJECTIVE: To determine whether CYP2C19 loss-of-function (LoF) alleles increase risk of ischaemic stroke and myocardial infarction (MI) in UK primary care patients prescribed clopidogrel. DESIGN: Retrospective cohort ... -
Senotherapeutic drugs: A new avenue for skincare?
(Lippincott, Williams & Wilkins / American Society of Plastic Surgeons, 29 November 2021)SUMMARY: Skin aging is an outward manifestation of other cellular and molecular aging processes occurring elsewhere in the body. These processes are known collectively as the "hallmarks" of aging, which are a series of ... -
Persistence of clinically relevant levels of SARS-CoV2 envelope gene subgenomic RNAs in non-immunocompromised individuals
(Elsevier, 7 December 2021)OBJECTIVES: This study aimed to evaluate the associations between COVID-19 severity and active viral load, and to characterize the dynamics of active SARS-CoV-2 clearance in a series of archival samples taken from patients ... -
Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence
(Wiley / Federation of European Biochemical Societies, 23 April 2022)The human genome is capable of producing hundreds of thousands of different proteins and non-coding RNAs from <20 000 genes, in a co-ordinated and regulated fashion. This is achieved by a collection of phenomena known as ...