Now showing items 1-17 of 17

    Issue DateTitleAuthor(s)
    1 August 2015Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.  Kazlauskaite, A; Martínez-Torres, RJ; Wilkie, S; et al.
    18 June 2012Brain penetrant LRRK2 inhibitor  Choi, Hwan Geun; Zhang, Jin-Wei; Deng, Xianming; et al.
    28 January 2012Characterization of TAE684 as a potent LRRK2 kinase inhibitor  Zhang, J; Deng, X; Choi, HG; et al.
    20 May 2015Critical role of the SPAK protein kinase CCT domain in controlling blood pressure  Zhang, J; Siew, K; Macartney, T; et al.
    20 May 2015Critical role of the SPAK protein kinase CCT domain in controlling blood pressure  Zhang, J; Siew, K; Macartney, T; et al.
    14 May 2015Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor  Hatcher, JM; Zhang, J; Choi, HG; et al.
    26 October 2016Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain  Zhang, J; Gao, G; Begum, G; et al.
    26 October 2016Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain  Zhang, J; Gao, G; Begum, G; et al.
    7 July 2012GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent- N-arylbenzamide LRRK2 kinase inhibitor  Reith, AD; Bamborough, P; Jandu, K; et al.
    1 June 2018Human With No Lysine Kinase 3 (WNK3): A Target Enabling Package (TEP)  Pinkas, DM; Bufton, JC; Bartual, SG; et al.
    12 October 2012Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity  Yao, C; Johnson, WM; Gao, Y; et al.
    8 March 2021Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression  Ostrosky-Frid, M; Chavez-Canales, M; Zhang, J; et al.
    4 March 2022Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase  Chen, Z; Zhang, J; Murillo-de-Ozores, AR; et al.
    13 August 2018Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains  Wang, J; Erazo, T; Ferguson, FM; et al.
    15 March 2014The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters  de Los Heros, P; Alessi, DR; Gourlay, R; et al.
    15 March 2014The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters  de Los Heros, P; Alessi, DR; Gourlay, R; et al.
    15 July 2014The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters  Alessi, DR; Zhang, J; Khanna, A; et al.