Institute of Biomedical & Clinical Science
Recent Submissions
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Natural recreational waters and the risk that exposure to antibiotic resistant bacteria poses to human health
(Elsevier, 29 October 2022)Antimicrobial resistance (AMR) is widely recognised as a considerable threat to human health, wellbeing and prosperity. Many clinically important antibiotic resistance genes are understood to have originated in the natural ... -
Islet autoantibody positivity in an adult population with recently diagnosed diabetes in Uganda
(Public Library of Science (PLoS), 23 May 2022)AIMS: This study aimed to investigate the frequency of islet autoantibody positivity in adult patients with recently diagnosed diabetes in Uganda and its associated characteristics. METHODS: Autoantibodies to glutamic acid ... -
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage
(Springer, 22 July 2022)AIMS/HYPOTHESIS: Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic ... -
Detection of antiviral tissue responses and increased cell stress in the pancreatic islets of newly diagnosed Type 1 diabetes patients: results from the DiViD study
(Frontiers Media, 26 July 2022)Aims/hypothesis: The Diabetes Virus Detection (DiViD) study has suggested the presence of low-grade enteroviral infection in pancreatic tissue collected from six of six live adult patients newly diagnosed with type 1 ... -
A biallelic loss-of-function PDIA6 variant in a second patient with polycystic kidney disease, infancy-onset diabetes, and microcephaly
(Wiley, 18 July 2022)We report a second patient with intrauterine growth retardation, congenital polycystic kidney disease, infancy-onset diabetes, microcephaly, and liver fibrosis caused by a homozygous PDIA6 loss-of-function variant. Our ...