Browse by

 

Recent Submissions

  • Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes 

    Amos, GCA; Zhang, L; Hawkey, PM; Gaze, WH; Wellington, EM (Elsevier, 2014-02-16)
    The environment harbours a significant diversity of uncultured bacteria and a potential source of novel and extant resistance genes which may recombine with clinically important bacteria disseminated into environmental ...
  • Carbapenem resistance in bacteria isolated from soil and water environments in Algeria. 

    Djenadi, K; Zhang, L; Murray, AK; Gaze, WH (Elsevier, 2018-07-30)
    OBJECTIVES: Recent research has demonstrated that natural populations of bacteria carry large numbers of mobile genetic elements which may harbour antibiotic resistance determinants. The aim of this study was to investigate ...
  • AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner 

    Vlachaki Walker, JM; Robb, JL; Cruz, AM; Malhi, A; Weightman Potter, PG (Wiley, 2017-02-17)
    Aim To test the hypothesis that, given the role of AMP‐activated protein kinase (AMPK) in regulating intracellular ATP levels, AMPK may alter ATP release from astrocytes, the main sources of extracellular ATP (eATP) within ...
  • Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes 

    Weightman Potter, P; Vlachaki Walker, J; Robb, J; Chilton, J; Williamson, R; Randall, A; Ellacott, K; Beall, C (Springer Verlag, 2018)
    Aims/hypothesis Hypoglycaemia is a major barrier to good glucose control in type 1 diabetes. Frequent hypoglycaemic episodes impair awareness of subsequent hypoglycaemic bouts. Neural changes underpinning awareness of ...
  • Bigmelon: tools for analysing large DNA methylation datasets 

    Gorrie-Stone, TJ; Smart, MC; Saffari, A; Malki, K; Hannon, E; Burrage, J; Mill, J; Kumari, M; Schalkwyk, LC (Oxford University Press (OUP), 2018-08-23)
    Motivation The datasets generated by DNA methylation analyses are getting bigger. With the release of the HumanMethylationEPIC micro-array and datasets containing thousands of samples, analyses of these large datasets ...
  • Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation 

    Luijk, R; Wu, H; Ward-Caviness, CK; Hannon, E; Carnero-Montoro, E; Min, JL; Mandaviya, P; Müller-Nurasyid, M; Mei, H; van der Maarel, SM; Beekman, M; der Breggen, RV; Deelen, J; Lakenberg, N; Moed, M; Suchiman, HED; Arindrarto, W; van’t Hof, P; Jan Bonder, M; Deelen, P; Tigchelaar, EF; Zhernakova, A; Zhernakova, DV; van Dongen, J; Hottenga, JJ; Pool, R; Isaacs, A; Hofman, BA; Jhamai, M; van der Kallen, CJH; Schalkwijk, CG; Stehouwer, CDA; van den Berg, LH; van Galen, M; Vermaat, M; van Rooij, J; Uitterlinden, AG; Verbiest, M; Verkerk, M; Kielbasa, PSM; Bot, J; Nooren, I; van Dijk, F; Swertz, MA; van Heemst, D; Relton, C; Mill, J; Waldenberger, M; Bell, JT; Jansen, R; Zhernakova, A; Franke, L; ‘t Hoen, PAC; Boomsma, DI; van Duijn, CM; van Greevenbroek, MMJ; Veldink, JH; Wijmenga, C; van Meurs, J; Daxinger, L; Slagboom, PE; van Zwet, EW; Heijmans, BT; BIOS Consortium (Springer Nature, 2018-09-14)
    X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape ...
  • Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia 

    Ferguson, DCJ; Smerdon, GR; Harries, LW; Dodd, NJF; Murphy, MP; Curnow, A; Winyard, PG (Elsevier, 2018-08-22)
    In vivo, mammalian cells reside in an environment of 0.5-10% O2 (depending on the tissue location within the body), whilst standard in vitro cell culture is carried out under room air. Little is known about the effects of ...
  • GWAS for executive function and processing speed suggests involvement of the CADM2 gene 

    Ibrahim-Verbaas, CA; Bressler, J; Debette, S; Schuur, M; Smith, AV; Bis, JC; Davies, G; Trompet, S; Smith, JA; Wolf, C; Chibnik, LB; Liu, Y; Vitart, V; Kirin, M; Petrovic, K; Polasek, O; Zgaga, L; Fawns-Ritchie, C; Hoffmann, P; Karjalainen, J; Lahti, J; Llewellyn, DJ; Schmidt, CO; Mather, KA; Chouraki, V; Sun, Q; Resnick, SM; Rose, LM; Oldmeadow, C; Stewart, M; Smith, BH; Gudnason, V; Yang, Q; Mirza, SS; Jukema, JW; deJager, PL; Harris, TB; Liewald, DC; Amin, N; Coker, LH; Stegle, O; Lopez, OL; Schmidt, R; Teumer, A; Ford, I; Karbalai, N; Becker, JT; Jonsdottir, MK; Au, R; Fehrmann, RS; Herms, S; Nalls, M; Zhao, W; Turner, ST; Yaffe, K; Lohman, K; van Swieten, JC; Kardia, SL; Knopman, DS; Meeks, WM; Heiss, G; Holliday, EG; Schofield, PW; Tanaka, T; Stott, DJ; Wang, J; Ridker, P; Gow, AJ; Pattie, A; Starr, JM; Hocking, LJ; Armstrong, NJ; McLachlan, S; Shulman, JM; Pilling, LC; Eiriksdottir, G; Scott, RJ; Kochan, NA; Palotie, A; Hsieh, YC; Eriksson, JG; Penman, A; Gottesman, RF; Oostra, BA; Yu, L; DeStefano, AL; Beiser, A; Garcia, M; Rotter, JI; Nöthen, MM; Hofman, A; Slagboom, PE; Westendorp, RG; Buckley, BM; Wolf, PA; Uitterlinden, AG; Psaty, BM; Grabe, HJ; Bandinelli, S; Chasman, DI; Grodstein, F; Räikkönen, K; Lambert, JC; Porteous, DJ; Generation Scotland; Price, JF; Sachdev, PS; Ferrucci, L; Attia, JR; Rudan, I; Hayward, C; Wright, AF; Wilson, JF; Cichon, S; Franke, L; Schmidt, H; Ding, J; de Craen, AJ; Fornage, M; Bennett, DA; Deary, IJ; Ikram, MA; Launer, LJ; Fitzpatrick, AL; Seshadri, S; van Duijn, CM; Mosley, TH (Springer Nature, 2015-04-14)
    To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed ...
  • A Type 1 Diabetes Genetic Risk Score can identify patients with GAD65 autoantibody positive type 2 diabetes that rapidly progress to insulin therapy 

    Grubb, A; McDonald, T; Rutters, F; Donnelly, L; Hattersley, A; Oram, R; Palmer, C; van der Heijden, A; Carr, F; Elders, P; Weedon, M; t' Hart, L; Pearson, E; Shields, B; Jones, AG (American Diabetes Association, 2018)
    Objective Progression to insulin therapy in clinically diagnosed type 2 diabetes is highly variable. GAD65 autoantibodies (GADA) are associated with faster progression, but their predictive value is limited. We aimed to ...
  • A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk 

    Redondo, MJ; Geyer, S; Steck, AK; Sharp, S; Wentworth, JM; Weedon, MN; Antinozzi, P; Sosenko, J; Atkinson, M; Pugliese, A; Oram, RA (American Diabetes Association, 2018-08-22)
    OBJECTIVE We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. RESEARCH DESIGN AND METHODS We studied the 1,244 TrialNet ...
  • Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains 

    Wang, J; Erazo, T; Ferguson, FM; Buckley, DL; Gomez, N; Muñoz-Guardiola, P; Diéguez-Martínez, N; Deng, X; Hao, M; Massefski, W; Fedorov, O; Offei-Addo, NK; Park, PMC; Dai, L; Dibona, A; Becht, K; Kim, ND; McKeown, MR; Roberts, JM; Zhang, J; Sim, T; Alessi, DR; Bradner, JE; Lizcano, JM; Blacklow, SC; Qi, J; Xu, X; Gray, NS (American Chemical Society, 2018-08-13)
    Bromodomains have been pursued intensively over the past several years as emerging targets for the devel-opment of anti-cancer and anti-inflammatory agents. It has recently been shown that some kinase inhibitors are able ...
  • The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells 

    Oram, RA; Jones, AG; Besser, REJ; Knight, BA; Shields, BM; Brown, RJ; Hattersley, AT; McDonald, TJ (Springer Verlag, 2013-10-12)
    AIMS/HYPOTHESIS: Classically, type 1 diabetes is thought to proceed to absolute insulin deficiency. Recently developed ultrasensitive assays capable of detecting C-peptide under 5 pmol/l now allow very low levels of C-peptide ...
  • Application of a novel molecular method to age free-living wild Bechstein's bats 

    Wright, PGR; Mathews, F; Schofield, H; Morris, C; Burrage, J; Smith, A; Dempster, EL; Hamilton, PB (Wiley, 2018-07-07)
    The age profile of populations fundamentally affects their conservation status. Yet, age is frequently difficult to assess in wild animals. Here, we assessed the use of DNA methylation of homologous genes to establish the ...
  • Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment. 

    Misra, S; Vedovato, N; Cliff, E; De Franco, E; Hattersley, AT; Ashcroft, FM; Oliver, NS (Wiley, 2018-06-13)
    BACKGROUND: Permanent neonatal diabetes caused by mutations in the KCNJ11 gene may be managed with high-dose sulfonylureas. Complete transfer to sulfonylureas is not successful in all cases and can result in insulin ...
  • Genetic risk scores in adult-onset type 1 diabetes - Authors' reply 

    Thomas, NJ; Jones, SE; Weedon, MN; Shields, BM; Hattersley, AT; Oram, RA (Elsevier, 2018-02-20)
  • Practical considerations in improving research through public involvement 

    Jenner, MK; Gilchrist, M; Baker, GC (BioMed Central, 2015-06-25)
    There is huge commitment to public and patient involvement (PPI) in UK clinical research. Despite there being wide agreement to practice PPI and national guidance on the subject, there are few practical examples of how to ...
  • Exocrine pancreatic dysfunction is common in hepatocyte nuclear factor 1β-associated renal disease and can be symptomatic 

    Clissold, RL; Fulford, J; Hudson, M; Shields, BM; McDonald, TJ; Ellard, S; Hattersley, AT; Bingham, C (Oxford University Press, 2018-01-30)
    Background: Heterozygous mutations in the HNF1B gene are the most common monogenic cause of developmental kidney disease. Extrarenal phenotypes frequently occur, including diabetes mellitus and pancreatic hypoplasia; the ...
  • Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. 

    Clissold, RL; Ashfield, B; Burrage, J; Hannon, E; Bingham, C; Mill, J; Hattersley, A; Dempster, EL (BioMed Central, 2018-07-18)
    Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb ...
  • The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice 

    Dumon, C; Diabira, D; Chudotvorova, I; Bader, F; Sahin, S; Zhang, J; Porcher, C; Wayman, G; Medina, I; Gaiarsa, J-L (eLife Sciences Publications Ltd, 2018-08-14)
    Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. g-aminobutyric acid (GABA) neurotransmission supports inhibition in the adult ...

View more