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Welcome to the research outputs of the University of Exeter Institute of Biomedical & Clinical Science, part of the University of Exeter Medical School

Recent Submissions

  • A comparison of rpoB and 16S rRNA as markers in pyrosequencing studies of bacterial diversity 

    Vos, M; Quince, C; Pijl, AS; de Hollander, M; Kowalchuk, GA (Public Library of Science, 2012)
    BACKGROUND: The 16S rRNA gene is the gold standard in molecular surveys of bacterial and archaeal diversity, but it has the disadvantages that it is often multiple-copy, has little resolution below the species level and ...
  • ODoSE: a webserver for genome-wide calculation of adaptive divergence in prokaryotes 

    Vos, M; te Beek, TAH; van Driel, MA; Huynen, MA; Eyre-Walker, A; van Passel, MWJ (Public Library of Science, 2013)
    Quantifying patterns of adaptive divergence between taxa is a major goal in the comparative and evolutionary study of prokaryote genomes. When applied appropriately, the McDonald-Kreitman (MK) test is a powerful test of ...
  • No apparent costs for facultative antibiotic production by the soil bacterium Pseudomonas fluorescens Pf0-1 

    Garbeva, P; Tyc, O; Remus-Emsermann, MNP; van der Wal, A; Vos, M; Silby, M; de Boer, W (Public Library of Science, 2011)
    BACKGROUND: Many soil-inhabiting bacteria are known to produce secondary metabolites that can suppress microorganisms competing for the same resources. The production of antimicrobial compounds is expected to incur fitness ...
  • A genome-wide association study of early menopause and the combined impact of identified variants. 

    Perry, JRB; Corre, T; Esko, T; Chasman, DI; Fischer, K; Franceschini, N; He, C; Kutalik, Z; Mangino, M; Rose, LM; Vernon Smith, A; Stolk, L; Sulem, P; Weedon, MN; Zhuang, WV; Arnold, A; Ashworth, A; Bergmann, S; Buring, JE; Burri, A; Chen, C; Cornelis, MC; Couper, DJ; Goodarzi, MO; Gudnason, V; Harris, T; Hofman, A; Jones, M; Kraft, P; Launer, L; Laven, JSE; Li, G; McKnight, B; Masciullo, C; Milani, L; Orr, N; Psaty, BM; ReproGen Consortium; Ridker, PM; Rivadeneira, F; Sala, C; Salumets, A; Schoemaker, M; Traglia, M; Waeber, G; Chanock, SJ; Demerath, EW; Garcia, M; Hankinson, SE; Hu, FB; Hunter, DJ; Lunetta, KL; Metspalu, A; Montgomery, GW; Murabito, JM; Newman, AB; Ong, KK; Spector, TD; Stefansson, K; Swerdlow, AJ; Thorsteinsdottir, U; Van Dam, RM; Uitterlinden, AG; Visser, JA; Vollenweider, P; Toniolo, D; Murray, A (Oxford University Press (OUP), 2013-04-01)
    Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women ...
  • The transcriptional landscape of age in human peripheral blood 

    Peters, MJ; Joehanes, R; Pilling, LC; Schurmann, C; Conneely, KN; Powell, J; Reinmaa, E; Sutphin, GL; Zhernakova, A; Schramm, K; Wilson, YA; Kobes, S; Tukiainen, T; NABEC/UKBEC Consortium; Ramos, YF; Göring, HHH; Fornage, M; Liu, Y; Gharib, SA; Stranger, BE; De Jager, PL; Aviv, A; Levy, D; Murabito, JM; Munson, PJ; Huan, T; Hofman, A; Uitterlinden, AG; Rivadeneira, F; van Rooij, J; Stolk, L; Broer, L; Verbiest, MMPJ; Jhamai, M; Arp, P; Metspalu, A; Tserel, L; Milani, L; Samani, NJ; Peterson, P; Kasela, S; Codd, V; Peters, A; Ward-Caviness, CK; Herder, C; Waldenberger, M; Roden, M; Singmann, P; Zeilinger, S; Illig, T; Homuth, G; Grabe, H-J; Völzke, H; Steil, L; Kocher, T; Murray, A; Melzer, D; Yaghootkar, H; Bandinelli, S; Moses, EK; Kent, JW; Curran, JE; Johnson, MP; Williams-Blangero, S; Westra, H-J; McRae, AF; Smith, JA; Kardia, SLR; Hovatta, I; Perola, M; Ripatti, S; Salomaa, V; Henders, AK; Martin, NG; Smith, AK; Mehta, D; Binder, EB; Nylocks, KM; Kennedy, EM; Klengel, T; Ding, J; Suchy-Dicey, AM; Enquobahrie, DA; Brody, J; Rotter, JI; Chen, Y-DI; Houwing-Duistermaat, J; Kloppenburg, M; Slagboom, PE; Helmer, Q; den Hollander, W; Bean, S; Raj, T; Bakhshi, N; Wang, QP; Oyston, LJ; Psaty, BM; Tracy, RP; Montgomery, GW; Turner, ST; Blangero, J; Meulenbelt, I; Ressler, KJ; Yang, J; Franke, L; Kettunen, J; Visscher, PM; Neely, GG; Korstanje, R; Hanson, RL; Prokisch, H; Ferrucci, L; Esko, T; Teumer, A; van Meurs, JBJ; Johnson, AD (Nature Publishing Group, 2015-10-22)
    Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis ...
  • Closely linked cis-acting modifier of expansion of the CGG repeat in high risk FMR1 haplotypes. 

    Ennis, S; Murray, A; Brightwell, G; Morton, NE; Jacobs, PA (Wiley, 2007-08-02)
    In its expanded form, the fragile X triplet repeat at Xq27.3 gives rise to the most common form of inherited mental retardation, fragile X syndrome. This high population frequency persists despite strong selective pressure ...
  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche 

    Perry, JRB; Day, F; Elks, CE; Sulem, P; Thompson, DJ; Ferreira, T; He, C; Chasman, DI; Esko, T; Thorleifsson, G; Albrecht, E; Ang, WQ; Corre, T; Cousminer, DL; Feenstra, B; Franceschini, N; Ganna, A; Johnson, AD; Kjellqvist, S; Lunetta, KL; McMahon, G; Nolte, IM; Paternoster, L; Porcu, E; Smith, AV; Stolk, L; Teumer, A; Tšernikova, N; Tikkanen, E; Ulivi, S; Wagner, EK; Amin, N; Bierut, LJ; Byrne, EM; Hottenga, J-J; Koller, DL; Mangino, M; Pers, TH; Yerges-Armstrong, LM; Hua Zhao, J; Andrulis, IL; Anton-Culver, H; Atsma, F; Bandinelli, S; Beckmann, MW; Benitez, J; Blomqvist, C; Bojesen, SE; Bolla, MK; Bonanni, B; Brauch, H; Brenner, H; Buring, JE; Chang-Claude, J; Chanock, S; Chen, J; Chenevix-Trench, G; Collée, JM; Couch, FJ; Couper, D; Coviello, AD; Cox, A; Czene, K; D'adamo, AP; Davey Smith, G; De Vivo, I; Demerath, EW; Dennis, J; Devilee, P; Dieffenbach, AK; Dunning, AM; Eiriksdottir, G; Eriksson, JG; Fasching, PA; Ferrucci, L; Flesch-Janys, D; Flyger, H; Foroud, T; Franke, L; Garcia, ME; García-Closas, M; Geller, F; de Geus, EEJ; Giles, GG; Gudbjartsson, DF; Gudnason, V; Guénel, P; Guo, S; Hall, P; Hamann, U; Haring, R; Hartman, CA; Heath, AC; Hofman, A; Hooning, MJ; Hopper, JL; Hu, FB; Hunter, DJ; Karasik, D; Kiel, DP; Knight, JA; Kosma, V-M; Kutalik, Z; Lai, S; Lambrechts, D; Lindblom, A; Mägi, R; Magnusson, PK; Mannermaa, A; Martin, NG; Masson, G; McArdle, PF; McArdle, WL; Melbye, M; Michailidou, K; Mihailov, E; Milani, L; Milne, RL; Nevanlinna, H; Neven, P; Nohr, EA; Oldehinkel, AJ; Oostra, BA; Palotie, A; Peacock, M; Pedersen, NL; Peterlongo, P; Peto, J; Pharoah, PDP; Postma, DS; Pouta, A; Pylkäs, K; Radice, P; Ring, S; Rivadeneira, F; Robino, A; Rose, LM; Rudolph, A; Salomaa, V; Sanna, S; Schlessinger, D; Schmidt, MK; Southey, MC; Sovio, U; Stampfer, MJ; Stöckl, D; Storniolo, AM; Timpson, NJ; Tyrer, J; Visser, JA; Vollenweider, P; Völzke, H; Waeber, G; Waldenberger, M; Wallaschofski, H; Wang, Q; Willemsen, G; Winqvist, R; Wolffenbuttel, BHR; Wright, MJ; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium; Boomsma, DI; Econs, MJ; Khaw, K-T; Loos, RJF; McCarthy, MI; Montgomery, GW; Rice, JP; Streeten, EA; Thorsteinsdottir, U; van Duijn, CM; Alizadeh, BZ; Bergmann, S; Boerwinkle, E; Boyd, HA; Crisponi, L; Gasparini, P; Gieger, C; Harris, TB; Ingelsson, E; Järvelin, M-R; Kraft, P; Lawlor, D; Metspalu, A; Pennell, CE; Ridker, PM; Snieder, H; Sørensen, TIA; Spector, TD; Strachan, DP; Uitterlinden, AG; Wareham, NJ; Widen, E; Zygmunt, M; Murray, A; Easton, DF; Stefansson, K; Murabito, JM; Ong, KK (Nature Publishing Group, 2014-10-02)
    Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and ...
  • Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. 

    Melzer, D; Murray, A; Hurst, AJ; Weedon, MN; Bandinelli, S; Corsi, AM; Ferrucci, L; Paolisso, G; Guralnik, JM; Frayling, TM (BioMed Central, 2006-12-20)
    BACKGROUND: A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene has been found to be associated with type 2 diabetes in case-control studies. We aimed to estimate associations of the marker rs7903146 (C/T) ...
  • Lessons from genome-wide association studies in reproductive medicine: menopause. 

    Ruth, KS; Murray, A (Georg Thieme Verlag / Thieme Publishing, 2016-07)
    In recent years, common genetic variants have been identified by genome-wide association studies (GWASs) that have led to the detection of 44 genetic loci associated with approximately 6% of common variation in age at ...
  • Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes. 

    Ruth, KS; Campbell, PJ; Chew, S; Lim, EM; Hadlow, N; Stuckey, BGA; Brown, SJ; Feenstra, B; Joseph, J; Surdulescu, GL; Zheng, HF; Richards, JB; Murray, A; Spector, TD; Wilson, SG; Perry, JRB (Nature Publishing Group, 2015-05-27)
    Genetic factors contribute strongly to sex hormone levels, yet knowledge of the regulatory mechanisms remains incomplete. Genome-wide association studies (GWAS) have identified only a small number of loci associated with ...
  • Rare coding variants and X-linked loci associated with age at menarche 

    Lunetta, KL; Day, FR; Sulem, P; Ruth, KS; Tung, JY; Hinds, DA; Esko, T; Elks, CE; Altmaier, E; He, C; Huffman, JE; Mihailov, E; Porcu, E; Robino, A; Rose, LM; Schick, UM; Stolk, L; Teumer, A; Thompson, DJ; Traglia, M; Wang, CA; Yerges-Armstrong, LM; Antoniou, AC; Barbieri, C; Coviello, AD; Cucca, F; Demerath, EW; Dunning, AM; Gandin, I; Grove, ML; Gudbjartsson, DF; Hocking, LJ; Hofman, A; Huang, J; Jackson, RD; Karasik, D; Kriebel, J; Lange, EM; Lange, LA; Langenberg, C; Li, X; Luan, J; Mägi, R; Morrison, AC; Padmanabhan, S; Pirie, A; Polasek, O; Porteous, D; Reiner, AP; Rivadeneira, F; Rudan, I; Sala, CF; Schlessinger, D; Scott, RA; Stöckl, D; Visser, JA; Völker, U; Vozzi, D; Wilson, JG; Zygmunt, M; EPIC-InterAct Consortium; Generation Scotland; Boerwinkle, E; Buring, JE; Crisponi, L; Easton, DF; Hayward, C; Hu, FB; Liu, S; Metspalu, A; Pennell, CE; Ridker, PM; Strauch, K; Streeten, EA; Toniolo, D; Uitterlinden, AG; Ulivi, S; Völzke, H; Wareham, NJ; Wellons, M; Franceschini, N; Chasman, DI; Thorsteinsdottir, U; Murray, A; Stefansson, K; Murabito, JM; Ong, KK; Perry, JRB (Nature Publishing Group, 2015-08-04)
    More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ∼3% of the trait variance. Here we test two overlooked sources of variation in 192,974 ...
  • Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. 

    Day, FR; Elks, CE; Murray, A; Ong, KK; Perry, JRB (Nature Publishing Group, 2015-06-18)
    Early puberty timing is associated with higher risks for type 2 diabetes (T2D) and cardiovascular disease in women and therefore represents a potential target for early preventive interventions. We characterised the range ...
  • Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways 

    Stolk, L; Perry, JRB; Chasman, DI; He, C; Mangino, M; Sulem, P; Barbalic, M; Broer, L; Byrne, EM; Ernst, F; Esko, T; Franceschini, N; Gudbjartsson, DF; Hottenga, J-J; Kraft, P; McArdle, PF; Porcu, E; Shin, S-Y; Smith, AV; van Wingerden, S; Zhai, G; Zhuang, WV; Albrecht, E; Alizadeh, BZ; Aspelund, T; Bandinelli, S; Lauc, LB; Beckmann, JS; Boban, M; Boerwinkle, E; Broekmans, FJ; Burri, A; Campbell, H; Chanock, SJ; Chen, C; Cornelis, MC; Corre, T; Coviello, AD; d'Adamo, P; Davies, G; de Faire, U; de Geus, EJC; Deary, IJ; Dedoussis, GVZ; Deloukas, P; Ebrahim, S; Eiriksdottir, G; Emilsson, V; Eriksson, JG; Fauser, BCJM; Ferreli, L; Ferrucci, L; Fischer, K; Folsom, AR; Garcia, ME; Gasparini, P; Gieger, C; Glazer, N; Grobbee, DE; Hall, P; Haller, T; Hankinson, SE; Hass, M; Hayward, C; Heath, AC; Hofman, A; Ingelsson, E; Janssens, ACJW; Johnson, AD; Karasik, D; Kardia, SLR; Keyzer, J; Kiel, DP; Kolcic, I; Kutalik, Z; Lahti, J; Lai, S; Laisk, T; Laven, JSE; Lawlor, DA; Liu, J; Lopez, LM; Louwers, YV; Magnusson, PKE; Marongiu, M; Martin, NG; Klaric, IM; Masciullo, C; McKnight, B; Medland, SE; Melzer, D; Mooser, V; Navarro, P; Newman, AB; Nyholt, DR; Onland-Moret, NC; Palotie, A; Paré, G; Parker, AN; Pedersen, NL; Peeters, PHM; Pistis, G; Plump, AS; Polasek, O; Pop, VJM; Psaty, BM; Räikkönen, K; Rehnberg, E; Rotter, JI; Rudan, I; Sala, C; Salumets, A; Scuteri, A; Singleton, A; Smith, JA; Snieder, H; Soranzo, N; Stacey, SN; Starr, JM; Stathopoulou, MG; Stirrups, K; Stolk, RP; Styrkarsdottir, U; Sun, YV; Tenesa, A; Thorand, B; Toniolo, D; Tryggvadottir, L; Tsui, K; Ulivi, S; van Dam, RM; van der Schouw, YT; van Gils, CH; van Nierop, P; Vink, JM; Visscher, PM; Voorhuis, M; Waeber, G; Wallaschofski, H; Wichmann, HE; Widen, E; Wijnands-van Gent, CJM; Willemsen, G; Wilson, JF; Wolffenbuttel, BHR; Wright, AF; Yerges-Armstrong, LM; Zemunik, T; Zgaga, L; Zillikens, MC; Zygmunt, M; LifeLines Cohort Study; Arnold, AM; Boomsma, DI; Buring, JE; Crisponi, L; Demerath, EW; Gudnason, V; Harris, TB; Hu, FB; Hunter, DJ; Launer, LJ; Metspalu, A; Montgomery, GW; Oostra, BA; Ridker, PM; Sanna, S; Schlessinger, D; Spector, TD; Stefansson, K; Streeten, EA; Thorsteinsdottir, U; Uda, M; Uitterlinden, AG; van Duijn, CM; Völzke, H; Murray, A; Murabito, JM; Visser, JA; Lunetta, KL (Nature Publishing Group, 2012-01-22)
    To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to ...
  • Dietary nitrate supplementation: effects on plasma nitrite and pulmonary O2 uptake dynamics during exercise in hypoxia and normoxia 

    Kelly, J; Vanhatalo, A; Bailey, SJ; Wylie, LJ; Tucker, C; List, S; Winyard, PG; Jones, AM (American Physiological Society, 2014-10-01)
    We investigated the effects of dietary nitrate (NO3 (-)) supplementation on the concentration of plasma nitrite ([NO2 (-)]), oxygen uptake (V̇o2) kinetics, and exercise tolerance in normoxia (N) and hypoxia (H). In a ...
  • Prokaryote genome fluidity is dependent on effective population size 

    Vos, M; Andreani, NA (Nature Publishing Group, 2017)
  • The DDX6-4E-T interaction mediates translational repression and P-body assembly 

    Kamenska, A; Simpson, C; Vindry, C; Broomhead, H; Bénard, M; Ernoult-Lange, M; Lee, BP; Harries, LW; Weil, D; Standart, N (Oxford University Press (OUP), 2016-07-27)
    4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-(rocessing) bodies. 4E-T inhibits general protein synthesis by reducing ...
  • Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans 

    Lee, BP; Pilling, LC; Emond, F; Flurkey, K; Harrison, DE; Yuan, R; Peters, LL; Kuchel, GA; Ferrucci, L; Melzer, D; Harries, LW (Wiley, 2016-10)
    Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with replicative senescence in cultured cells. Here, we assess whether expression ...
  • Changing perspectives on the progression of type 1 diabetes 

    Morgan, N; Richardson, S (Wiley, 2016-05-10)
  • The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. 

    Munkley, J; Oltean, S; Vodák, D; Wilson, BT; Livermore, KE; Zhou, Y; Star, E; Floros, VI; Johannessen, B; Knight, B; McCullagh, P; McGrath, J; Crundwell, M; Skotheim, RI; Robson, CN; Leung, HY; Harries, LW; Rajan, P; Mills, IG; Elliott, DJ (Impact Journals, 2015-10-07)
    Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal ...
  • PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women 

    Galloway, TS; Fletcher, T; Thomas, OJ; Lee, BP; Pilling, LC; Harries, LW (Elsevier, 2015-02)
    Little is known about interactions between environmental and genetic risk factors for osteoarthritis (OA). Genetic factors include variation or mutation in genes involved in parathyroid hormone signalling. Exposure to the ...

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