Institute of Biomedical & Clinical Science
Recent Submissions
-
The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
(Springer Verlag, 18 October 2019)Aims/hypothesis: In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of ... -
Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan
(Oxford University Press (OUP), 2019)Anti-Müllerian hormone (AMH) is required for sexual differentiation in the fetus, and in adult females AMH is produced by growing ovarian follicles. Consequently, AMH levels are correlated with ovarian reserve, declining ... -
Using the wax moth larva Galleria mellonella infection model to detect emerging bacterial pathogens
(PeerJ, 4 January 2019)Climate change, changing farming practices, social and demographic changes and rising levels of antibiotic resistance are likely to lead to future increases in opportunistic bacterial infections that are more difficult to ... -
Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
(American Diabetes Association , 2019)Objective Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have not captured all known information at non-HLA loci and particularly at HLA risk loci. We aimed to more completely incorporate HLA ... -
Risk of Bacterial Transmission in Bronchiectasis Outpatient Clinics
(Springer Verlag, 2 July 2018)Purpose of Review: The purpose of this review is to discuss the risk of bacterial cross-infection for bronchiectasis patients in the outpatient setting. Cross-infection has primarily been a matter of concern in cystic ...