Institute of Biomedical & Clinical Science
Recent Submissions
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Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight.
(Oxford University Press, 13 December 2021)BACKGROUND: Higher birthweight is associated with higher adult BMI. Alleles that predispose to greater adult adiposity might act in fetal life to increase fetal growth and birthweight. Whether there are fetal effects of ... -
The power of genetic diversity in genome-wide association studies of lipids
(Nature Research, 9 December 2021)Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ... -
An expanded genome-wide association study of fructosamine levels identifies RCN3 as a replicating locus and implicates FCGRT as the effector transcript
(American Diabetes Association, 8 November 2021)Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful complement to glycated hemoglobin (HbA1c) for the diagnosis and monitoring of diabetes. To date, a single genome-wide association ... -
Glycated haemoglobin measurements from UK Biobank are different to those in linked primary care records: implications for combining biochemistry data from research studies and routine clinical care
(International Epidemiological Association / Oxford University Press (OUP), 13 January 2022)Data linkage of cohort or RCT data with routinely collected data is becoming increasingly commonplace, and this often involves combining biomarker measurements from different sources. However, sources may have different ... -
Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila.
(Public Library of Science, 8 November 2021)The discovery of human obesity-associated genes can reveal new mechanisms to target for weight loss therapy. Genetic studies of obese individuals and the analysis of rare genetic variants can identify novel obesity-associated ...