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Welcome to the research outputs of the University of Exeter Institute of Biomedical & Clinical Science, part of the University of Exeter Medical School

Recent Submissions

  • In vitro characterisation of cell-level neurophysiological diversity in the rostral nucleus reuniens of adult mice 

    Walsh, DA; Brown, JT; Randall, AD (Wiley, 2017-03-11)
    The nucleus reuniens (Re) is the largest of the midline thalamic nuclei. We have performed a detailed neurophysiological characterization of neurons in the rostral Re of brain slices prepared from adult male mice. At resting ...
  • Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. 

    Kumsta, R; Marzi, SJ; Viana, J; Dempster, EL; Crawford, B; Rutter, M; Mill, J; Sonuga-Barke, EJ (Nature Publishing Group, 2016-06-07)
    Exposure to adverse rearing environments including institutional deprivation and severe childhood abuse is associated with an increased risk for mental and physical health problems across the lifespan. Although the mechanisms ...
  • Considerations for management of patients with diabetic macular edema: Optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration. 

    Strain, WD; Cos, X; Prünte, C (Elsevier, 2017-01-29)
    Diabetes is a growing worldwide epidemic and a leading cause of blindness in working-age people around the world. Diabetic retinopathy (DR) and diabetic macular edema (DME) are common causes of visual impairment in people ...
  • Individualizing treatment targets for elderly patients with type 2 diabetes: factors influencing clinical decision making in the 24-week, randomized INTERVAL study. 

    Strain, WD; Abhijit, A; Paldanius, PM (Impact Journals, 2017-03-05)
    We tested the feasibility of setting individualized glycemic goals and factors influencing targets set in a clinical trial in elderly patients with type 2 diabetes. A 24-week, randomized, double-blind, placebo-controlled ...
  • Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation 

    Aizawa, K; Elyas, S; Adingupu, DD; Casanova, F; Gooding, KM; Strain, WD; Shore, AC; Gates, PE (Wiley, 2016-06)
    Previous studies have reported a vasoconstrictor response in the radial artery during a cuff-induced low-flow condition, but a similar low-flow condition in the brachial artery results in nonuniform reactivity. This variable ...
  • Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose 

    Kos, K; Wong, S; Tan, B; Gummesson, A; Jernas, M; Franck, N; Kerrigan, D; Nystrom, FH; Carlsson, LMS; Randeva, HS; Pinkney, JH; Wilding, JPH (American Diabetes Association, 2009-08)
    OBJECTIVE: Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is a mediator of collagen deposition and promotes fibrosis. Adipose tissue collagen has recently ...
  • COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity 

    McCulloch, LJ; Rawling, TJ; Sjöholm, K; Franck, N; Dankel, SN; Price, EJ; Knight, B; Liversedge, NH; Mellgren, G; Nystrom, F; Carlsson, LM; Kos, K (Endocrine Society, 2015-01)
    Fibrosis of adipose tissue (AT) increases AT rigidity, reduces its expandability, and contributes to metabolic dysfunction. Collagen type VI, α3 (COL6A3) encodes 1 subunit of a fibrotic extracellular matrix protein highly ...
  • An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy 

    Weedon, MN; Ellard, S; Prindle, MJ; Caswell, R; Lango Allen, H; Oram, R; Godbole, K; Yajnik, CS; Sbraccia, P; Novelli, G; Turnpenny, P; McCann, E; Goh, KJ; Wang, Y; Fulford, J; McCulloch, LJ; Savage, DB; O'Rahilly, S; Kos, K; Loeb, LA; Semple, RK; Hattersley, AT (Nature Publishing Group, 2013-08)
    DNA polymerase δ, whose catalytic subunit is encoded by POLD1, is responsible for lagging-strand DNA synthesis during DNA replication. It carries out this synthesis with high fidelity owing to its intrinsic 3'- to ...
  • Effects of Exendin-4 on human adipose tissue inflammation and ECM remodelling 

    Pastel, E; Joshi, S; Knight, B; Liversedge, N; Ward, R; Kos, K (Nature Publishing Group, 2016-12-12)
    BACKGROUND/OBJECTIVES: Subjects with type-2 diabetes are typically obese with dysfunctional adipose tissue (AT). Glucagon-like peptide-1 (GLP-1) analogues are routinely used to improve glycaemia. Although, they also aid ...
  • Mitochondrial genes are altered in blood early in Alzheimer's disease 

    Lunnon, K; Keohane, A; Pidsley, R; Newhouse, S; Riddoch-Contreras, J; Thubron, EB; Devall, M; Soininen, H; Kłoszewska, I; Mecocci, P; Tsolaki, M; Vellas, B; Schalkwyk, L; Dobson, R; Malik, AN; Powell, J; Lovestone, S; Hodges, A; AddNeuroMed Consortium (Elsevier, 2017-01-07)
    Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating ...
  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 

    Nalls, MA; Pankratz, N; Lill, CM; Do, CB; Hernandez, DG; Saad, M; DeStefano, AL; Kara, E; Bras, J; Sharma, M; Schulte, C; Keller, MF; Arepalli, S; Letson, C; Edsall, C; Stefansson, H; Liu, X; Pliner, H; Lee, JH; Cheng, R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group; Ikram, MA; Ioannidis, JPA; Hadjigeorgiou, GM; Bis, JC; Martinez, M; Perlmutter, JS; Goate, A; Marder, K; Fiske, B; Sutherland, M; Xiromerisiou, G; Myers, RH; Clark, LN; Stefansson, K; Hardy, JA; Heutink, P; Chen, H; Wood, NW; Houlden, H; Payami, H; Brice, A; Scott, WK; Gasser, T; Bertram, L; Eriksson, N; Foroud, T; Singleton, AB (Nature Publishing Group, 2014-09)
    We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide ...
  • Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway 

    Killick, R; Ribe, EM; Al-Shawi, R; Malik, B; Hooper, C; Fernandes, C; Dobson, R; Nolan, PM; Lourdusamy, A; Furney, S; Lin, K; Breen, G; Wroe, R; To, AWM; Leroy, K; Causevic, M; Usardi, A; Robinson, M; Noble, W; Williamson, R; Lunnon, K; Kellie, S; Reynolds, CH; Bazenet, C; Hodges, A; Brion, J-P; Stephenson, J; Simons, JP; Lovestone, S (Nature Publishing Group, 2014-01)
    Although the mechanism of Aβ action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the ...
  • Influence of coding variability in APP-Aβ metabolism genes in sporadic Alzheimer’s disease 

    Sassi, C; Ridge, PG; Nalls, MA; Gibbs, R; Ding, J; Lupton, MK; Troakes, C; Lunnon, K; Al-Sarraj, S; Brown, KS; Medway, C; Lord, J; Turton, J; ARUK Consortium; Morgan, K; Powell, JF; Kauwe, JS; Cruchaga, C; Bras, J; Goate, AM; Singleton, AB; Guerreiro, R; Hardy, J (Public Library of Science, 2016)
    The cerebral deposition of Aβ42, a neurotoxic proteolytic derivate of amyloid precursor protein (APP), is a central event in Alzheimer's disease (AD)(Amyloid hypothesis). Given the key role of APP-Aβ metabolism in AD ...
  • South Asians have elevated postexercise blood pressure and myocardial oxygen consumption compared to Europeans despite equivalent resting pressure 

    Chaturvedi, N; Bathula, R; Shore, AC; Panerai, R; Potter, J; Kooner, J; Chambers, J; Hughes, AD (Wiley for American Heart Association, 2012-10)
    BACKGROUND: Stroke mortality rate is higher in South Asians than in Europeans, despite equivalent or lower resting blood pressure (BP). Elevated recovery BP after exercise predicts stroke, independently of resting values. ...
  • Microalbuminuria could improve risk stratification in patients with TIA and minor stroke. 

    Elyas, S; Shore, AC; Kingwell, H; Keenan, S; Boxall, L; Stewart, J; James, MA; Strain, WD (Wiley Open Access, 2016-07-27)
    OBJECTIVE: Transient ischemic attacks (TIA) and minor strokes are important risk factors for recurrent strokes. Current stroke risk prediction scores such as ABCD2, although widely used, lack optimal sensitivity and ...
  • Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons 

    Pelkey, KA; Barksdale, E; Craig, MT; Yuan, X; Sukumaran, M; Vargish, GA; Mitchell, RM; Wyeth, MS; Petralia, RS; Chittajallu, R; Karlsson, R-M; Cameron, HA; Murata, Y; Colonnese, MT; Worley, PF; McBain, CJ (Elsevier (Cell Press), 2015-03-18)
    Circuit computation requires precision in the timing, extent, and synchrony of principal cell (PC) firing that is largely enforced by parvalbumin-expressing, fast-spiking interneurons (PVFSIs). To reliably coordinate network ...
  • Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells 

    Craig, MT; McBain, CJ (Society for Neuroscience, 2015-02-25)
    Information processing in neuronal networks relies on the precise synchronization of ensembles of neurons, coordinated by the diverse family of inhibitory interneurons. Cortical interneurons can be usefully parsed by ...
  • Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. 

    Gonçalves, I; Edsfeldt, A; Colhoun, HM; Shore, AC; Palombo, C; Natali, A; Fredrikson, GN; Björkbacka, H; Wigren, M; Bengtsson, E; Östling, G; Aizawa, K; Casanova, F; Persson, M; Gooding, K; Gates, P; Khan, F; Looker, HC; Adams, F; Belch, J; Pinnola, S; Venturi, E; Kozakova, M; Gan, L-M; Schnecke, V; Nilsson, J; SUMMIT consortium (BioMed Central, 2016-09-05)
    BACKGROUND: Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if ...
  • Dopamine suppresses persistent network activity via D(1) -like dopamine receptors in rat medial entorhinal cortex. 

    Mayne, EW; Craig, MT; McBain, CJ; Paulsen, O (Wiley, 2013-01-22)
    Cortical networks display persistent activity in the form of periods of sustained synchronous depolarizations ('UP states') punctuated by periods of relative hyperpolarization ('DOWN states'), which together form the slow ...
  • Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT(3A)R expression 

    Chittajallu, R; Craig, MT; McFarland, A; Yuan, X; Gerfen, S; Tricoire, L; Erkkila, B; Barron, SC; Lopez, CM; Liang, BJ; Jeffries, BW; Pelkey, KA; McBain, CJ (Nature Publishing Group, 2013-11)
    Forebrain circuits rely upon a relatively small but remarkably diverse population of GABAergic interneurons to bind and entrain large principal cell assemblies for network synchronization and rhythmogenesis. Despite the ...

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