Institute of Biomedical & Clinical Science
Recent Submissions
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UK psychiatrists’ experience of withdrawal of antipsychotics prescribed for challenging behaviours in adults with intellectual disabilities and/or autism
(Royal College of Psychiatrists / Cambridge University Press (CUP), 17 September 2020)Background A high proportion of adults with intellectual disabilities are prescribed off-licence antipsychotics in the absence of a psychiatric illness. The National Health Service in England launched an initiative in ... -
Characterization of potential superspreader farms for bovine tuberculosis: A review
(Wiley, 16 September 2020)BACKGROUND: Variation in host attributes that influence their contact rates and infectiousness can lead some individuals to make disproportionate contributions to the spread of infections. Understanding the roles of such ... -
Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion
(Cell Press, 16 June 2020)Vitamin-D-binding protein (DBP) or group-specific component of serum (GC-globulin) carries vitamin D metabolites from the circulation to target tissues. DBP is highly localized to the liver and pancreatic α cells. Although ... -
Histological validation of a type 1 diabetes clinical diagnostic model for classification of diabetes
(Wiley / Diabetes UK, 7 July 2020)Aims: Misclassification of diabetes is common due to an overlap in the clinical features of type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and biomarker information have recently been developed ... -
L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils
(Public Library of Science, 24 August 2020)Parkinson disease is the most common neurodegenerative movement disorder, estimated to affect one in twenty-five individuals over the age of 80. Mutations in glucocerebrosidase 1 (GBA1) represent the most common genetic ...