Open Research Exeter (ORE)

• Cooperative oxygen sensing by the kidney and carotid body in blood pressure control 

  Patinha, D; Pijacka, W; Paton, JFR; Koeners, MP (Frontiers Media, 2017)

  Oxygen sensing mechanisms are vital for homeostasis and survival. When oxygen levels are too low (hypoxia), blood flow has to be increased, metabolism reduced, or a combination of both, to counteract tissue damage. These ...

• 5-hydroxymethylcytosine is highly dynamic across human fetal brain development 

  Spiers, H; Hannon, EJ; Schalkwyk, LS; Bray, NJ; Mill, J (BioMed Central, 2017-09-18)

  Background Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) ...

• DOES PREVENTATIVE OUTPATIENT COMPREHENSIVE GERIATRICS ASSESSMENT REDUCE HOSPITAL ADMISSIONS? A SYSTEMATIC REVIEW 

  Jones, LC; Attwood, D; Strain, WD (Oxford University Press, 2017-05-16)

  n/a

• Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement. 

  McDonald, TJ; Besser, RE; Perry, M; Babiker, T; Knight, BA; Shepherd, MH; Ellard, S; Flanagan, SE; Hattersley, AT (Springer Verlag, 2017-08-05)

  AIMS/HYPOTHESIS: The majority of infants with neonatal diabetes mellitus present with severe ketoacidosis at a median of 6 weeks. The treatment is very challenging and can result in severe neurological sequelae or death. ...

• Are we missing hypoglycaemia? Elderly patients with insulin-treated diabetes present to primary care frequently with non-specific symptoms associated with hypoglycaemia 

  Hope, SV; Taylor, PJ; Shields, BM; Hattersley, AT; Hamilton, W (Elsevier, 2017-09-11)

  Introduction We assessed if patients with known hypoglycaemia present on other occasions with non-specific symptoms associated with (but not diagnosed as) hypoglycaemia, potentially representing missed hypoglycaemia. ...

• Biological interpretation of genome-wide association studies using predicted gene functions 

  Pers, TH; Karjalainen, JM; Chan, Y; Westra, H-J; Wood, AR; Yang, J; Lui, JC; Vedantam, S; Gustafsson, S; Esko, T; Frayling, T; Speliotes, EK; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Boehnke, M; Raychaudhuri, S; Fehrmann, RSN; Hirschhorn, JN; Franke, L (Springer Nature, 2015-01-19)

  The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions ...

• Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans 

  Bailey, SJ; Blackwell, JR; Williams, E; Vanhatalo, A; Wylie, LJ; Winyard, PG; Jones, AM (Elsevier, 2016-09-30)

  This study tested the hypothesis that watermelon juice supplementation would improve nitric oxide bioavailability and exercise performance. Eight healthy recreationally-active adult males reported to the laboratory on two ...

• 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain 

  Winter, MJ; Windell, D; Metz, J; Matthews, P; Pinion, J; Brown, JT; Hetheridge, MJ; Ball, JS; Owen, SF; Redfern, WS; Moger, J; Randall, AD; Tyler, CR (Springer Nature, 2017-07-26)

  Functional neuroimaging, using genetically-encoded Ca(2+) sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological ...

• A CACNA1D mutation in a patient with persistent hyperinsulinaemic hypoglycaemia, heart defects, and severe hypotonia. 

  Flanagan, SE; Vairo, F; Johnson, MB; Caswell, R; Laver, TW; Lango Allen, H; Hussain, K; Ellard, S (Wiley, 2017-06)

  Congenital hyperinsulinaemic hypoglycaemia (HH) can occur in isolation or it may present as part of a wider syndrome. For approximately 40%-50% of individuals with this condition, sequence analysis of the known HH genes ...

• Analysis of large-scale sequencing cohorts does not support the role of variants in UCP2 as a cause of hyperinsulinaemic hypoglycaemia. 

  Laver, TW; Weedon, MN; Caswell, R; Hussain, K; Ellard, S; Flanagan, SE (Wiley, 2017-08-01)

  No abstract is available for this article.

• Dipeptidyl Peptidase-4 Inhibitor Development and Post-authorisation Programme for Vildagliptin - Clinical Evidence for Optimised Management of Chronic Diseases Beyond Type 2 Diabetes 

  Strain, WD; Paldanius, PM (Touch Medical Media (TMM), 2017-09)

  The last decade has witnessed the role of dipeptidyl peptidase-4 (DPP-4) inhibitors in producing a conceptual change in early management of type 2 diabetes (T2DM) by shifting emphasis from a gluco-centric approach to ...

• Clinical effectiveness of CORTRAK (Enteral Access System) at Royal Devon and Exeter 

  Lim, WF; Chivers, N; Connolly, A; Strain, WD (Oxford University Press (OUP) for British Geriatrics Society, 2017-07-01)

• Understanding the barriers and improving care in type 2 diabetes: Brazilian perspective in time to do more in diabetes 

  Vencio, S; Paldánius, PM; Blüher, M; Giannella-Neto, D; Caiado-Vencio, R; Strain, WD (BioMed Central, 2017)

  BACKGROUND: Type 2 diabetes mellitus (T2DM) is a complex disease, particularly in a continental country like Brazil. We attempted to understand and evaluate the perceptions and routines of Brazilians with T2DM and physicians, ...

• Recessively Inherited LRBA Mutations Cause Autoimmunity Presenting as Neonatal Diabetes 

  Johnson, MB; De Franco, E; Lango Allen, H; Al Senani, A; Elbarbary, N; Siklar, Z; Berberoglu, M; Imane, Z; Haghighi, A; Razavi, Z; Ullah, I; Alyaarubi, S; Gardner, D; Ellard, S; Hattersley, AT; Flanagan, SE (American Diabetes Association, 2017-07-21)

  Young-onset autoimmune diabetes associated with additional autoimmunity usually reflects a polygenic predisposition, but rare cases result from monogenic autoimmunity. Diagnosing monogenic autoimmunity is crucial for ...

• Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells. 

  Chittajallu, R; Wester, JC; Craig, MT; Barksdale, E; Yuan, XQ; Akgül, G; Fang, C; Collins, D; Hunt, S; Pelkey, KA; McBain, CJ (Nature Publishing Group, 2017-07-28)

  Appropriate integration of GABAergic interneurons into nascent cortical circuits is critical for ensuring normal information processing within the brain. Network and cognitive deficits associated with neurological disorders, ...

• Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis 

  Vara, Dina; Watt, Joanna M; Fortunato, Tiago M; Mellor, Harry; Burgess, Matthew; Wicks, Kate; Mace, Kimberley; Shaun, Reeksting; Anneke, Lubben; Wheeler-Jones, Caroline PD; Pula, Giordano (Mary Ann Liebert, 2017)

  Aims: Deoxyribose-1-phosphate (dRP) is a pro-angiogenic paracrine stimulus released by cancer cells, platelets and macrophages and acting on endothelial cells. The objective of this study was to clarify how dRP stimulates ...

• Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease 

  Manso, Y; Holland, PR; Kitamura, A; Szymkowiak, S; Duncombe, J; Hennessy, E; Searcy, JL; Marangoni, M; Randall, AD; Brown, JT; McColl, BW; Horsburgh, K (Wiley, 2017-07-19)

  Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown ...

• Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder 

  Rutten, BPF; Vermetten, E; Vinkers, CH; Ursini, G; Daskalakis, NP; Pishva, E; de Nijs, L; Houtepen, LC; Eijssen, L; Jaffe, AE; Kenis, G; Viechtbauer, W; van den Hove, D; Schraut, KG; Lesch, K-P; Kleinman, JE; Hyde, TM; Weinberger, DR; Schalkwyk, L; Lunnon, K; Mill, J; Cohen, H; Yehuda, R; Baker, DG; Maihofer, AX; Nievergelt, CM; Geuze, E; Boks, MPM (Springer Nature, 2017-06-20)

  In order to determine the impact of the epigenetic response to traumatic stress on post-traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide blood DNA methylation profiles in relation ...

• Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21 

  Tabassum, R; Chauhan, G; Dwivedi, OP; Mahajan, A; Jaiswal, A; Kaur, I; Bandesh, K; Singh, T; Mathai, BJ; Pandey, Y; Chidambaram, M; Sharma, A; Chavali, S; Sengupta, S; Ramakrishnan, L; Venkatesh, P; Aggarwal, SK; Ghosh, S; Prabhakaran, D; Srinath, RK; Saxena, M; Banerjee, M; Mathur, S; Bhansali, A; Shah, VN; Madhu, SV; Marwaha, RK; Basu, A; Scaria, V; McCarthy, MI; DIAGRAM; INDICO; Venkatesan, R; Mohan, V; Tandon, N; Bharadwaj, D (American Diabetes Association, 2013-03)

  Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored ...

• Automated cytological detection of Barrett's neoplasia with infrared spectroscopy. 

  Old, O; Lloyd, G; Isabelle, M; Almond, LM; Kendall, C; Baxter, K; Shepherd, N; Shore, A; Stone, N; Barr, H (Springer Verlag, 2017-05-13)

  BACKGROUND: Development of a nonendoscopic test for Barrett's esophagus would revolutionize population screening and surveillance for patients with Barrett's esophagus. Swallowed cell collection devices have recently been ...

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