Institute of Biomedical & Clinical Science
Recent Submissions
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Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD
(BMC / Society of Chinese Bioscientists in America, 23 July 2021)Background Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial ... -
Brain-body control of glucose homeostasis - insights from model organisms
(Frontiers Media, 31 March 2021)Tight regulation of blood glucose is essential for long term health. Blood glucose levels are defended by the correct function of, and communication between, internal organs including the gastrointestinal tract, pancreas, ... -
Evaluating the effects of subnormothermic perfusion with ap39 in a novel blood‐free model of ex vivo kidney preservation and reperfusion
(MDPI, 2 July 2021)The use of blood for normothermic and subnormothermic kidney preservation hinders the translation of these approaches and promising therapeutics. This study evaluates whether adding hydrogen sulfide donor AP39 to Hemopure, ... -
Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
(American Diabetes Association, 25 May 2021)Type 1 diabetes has a multifactorial autoimmune etiology, involving environmental prompts and polygenic predisposition. We hypothesized that pancreata from individuals with and at risk for type 1 diabetes would exhibit ... -
Transcriptomic meta-analysis of disuse muscle atrophy vs. resistance exercise-induced hypertrophy in young and older humans
(Wiley, 5 May 2021)Background: Skeletal muscle atrophy manifests across numerous diseases; however, the extent of similarities/differences in causal mechanisms between atrophying conditions in unclear. Ageing and disuse represent two of the ...