• Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort 

  Atkins, JL; Pilling, LC; Heales, CJ; et al. (IOS Press, 3 January 2021)

  Background: Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimated p.C282Y ...

• TriMaster: randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea - a MASTERMIND study protocol 

  Angwin, C; Jenkinson, C; Jones, A; et al. (BMJ Publishing Group, 21 December 2020)

  INTRODUCTION: Pharmaceutical treatment options for patients with type 2 diabetes mellitus (T2DM) have increased to include multiple classes of oral glucose-lowering agents but without accompanying guidance on which of these ...

• Does diversity beget diversity in microbiomes? 

  Madi, NJ; Vos, M; Murall, CL; et al. (eLife Sciences Publications, 20 November 2020)

  Microbes are embedded in complex communities where they engage in a wide array of intra- and inter-specific interactions. The extent to which these interactions drive or impede microbiome diversity is not well understood. ...

• Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020 

  Dennis, JM; Mateen, BA; Sonabend, R; et al. (American Diabetes Association, 23 October 2020)

  OBJECTIVE: To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting. RESEARCH DESIGN AND METHODS: This was a nationwide ...

• Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020 

  Dennis, JM; McGovern, AP; Vollmer, SJ; et al. (Lippincott, Williams & Wilkins / Society of Critical Care Medicine, 26 October 2020)

  OBJECTIVES: To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in ...

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