Institute of Medical Education: Recent submissions
Now showing items 111-115 of 299
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Characterisation of immunometabolic responses in astrocytes
(University of Exeter Medical School, 1 June 2020)Astrocytes play a role in the central nervous system (CNS) inflammatory response. In many immune cell types cellular inflammation and metabolism are linked, a phenomenon termed ‘immunometabolism’. This has led to attempts ... -
Effects of Cadmium on Neutrophil Biology and the Potential Role in Autoantigen Formation in Rheumatoid Arthritis
(University of Exeter College of Medicine and Health, 2 March 2020)Rheumatoid arthritis (RA) is an autoimmune disorder for which there is no known cause. The disease is characterized by progressive joint destruction, mediated by breakdown of immune tolerance by immune system dysfunction, ... -
Investigating APOE DNA methylation in Alzheimer's disease and its relationship to APOE ε4 genotype
(University of Exeter University of Exeter Medical School, 26 May 2020)Alzheimer’s disease is a neurodegenerative condition that is the leading cause of dementia in the elderly, which affected close to 50 million people worldwide in 2017. The disease is characterised by the presence of amyloid ... -
Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1
(Public Library of Science (PLoS), 15 May 2020)The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as ... -
Mitochondrial targeted Hydrogen Sulfide as a regulator of ageing in Caenorhabditis elegans.
(University of Exeter Exercise and Health Science, 11 May 2020)Introduction: Ageing remains a highly elusive process, with its associated physical and molecular decline continuing to place financial strain on UK healthcare systems. Mitochondrial function is known to play an important ...